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Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
18.08.2026journal-article

Journal of the American Heart Association

Interactive Effects of Plasma Alzheimer Disease Biomarkers and White Matter Hyperintensities on Cognitive Decline and Clinical Progression in Nondemented Adults

Jing Yang, Xinyuan Zhao, Yidan Liu, Yangwei Cai, Yuhua Fan, and the Alzheimer's Disease Neuroimaging Initiative

Background Alzheimer disease pathology and cerebral small‐vessel disease frequently coexist in older adults, yet how their interaction influences early clinical progression remains poorly understood, particularly in individuals without dementia. We aimed to investigate how plasma Alzheimer disease biomarkers and white matter hyperintensities (WMHs) interact to influence cognitive trajectories and the risk of progression to cognitive impairment and dementia. Methods We studied 463 nondemented participants from the A …

18.08.2026journal-article

European Geriatric Medicine

Nonspecific symptoms explain functional limitations in older adults better than disease-specific symptoms

Sandra L. Wezeman, René J. F. Melis, Cillian Hourican, Rick Quax, Thomas M. Gill, Marcel G. M. Olde Rikkert, Geeske Peeters

Abstract Purpose Older adults often have multiple diseases and age-related physiologic changes that may present with nonspecific symptoms such as fatigue or dizziness. Identifying symptoms that are most strongly associated with functioning may guide symptom management. This study examined the association of nonspecific and disease-specific symptoms with functional limitations in community-dwelling older adults over a 23-year period. Methods Data were from the Precipitating Events Project, a longitudinal cohort stud …

18.08.2026journal-article

Military Medicine

Potential Marker of Accelerated Aging: Worsening of Gait Speed in Post-9/11 Veterans in the TRACTS Longitudinal Cohort

Elisa F Ogawa, James W Whitworth, Michelle M Pebole, Anna Etchin, Dylan Katz, Madeleine K Nowak, William P Milberg, Catherine B Fortier

Abstract Introduction Veterans may experience negative changes in gait at younger ages because of military-related exposures and prevalent health conditions, such as traumatic brain injury (TBI), posttraumatic stress disorder (PTSD), depression, and metabolic syndrome (MetS). This study aimed to evaluate gait speed by age and examine factors associated with gait speed among veterans. Materials and Methods Post-9/11 U.S. veterans were included in this study (n = 100, mean 42 ± 11 years). Gait speed was assessed unde …

18.08.2026journal-article

JMIR Formative Research

Gerontechnology Acceptance in Thai Older Adult Care Facilities—Sensor Network and Machine Learning Adoption: Mixed Methods Study

Metta Ongkasuwan, Uree Cheasakul, Akechai Judkrue, Pair Sajampun

Abstract Background Thailand is undergoing a rapid demographic transition, with an estimated 28% of the population expected to be aged 60 years or older by 2030. This shift creates an urgent demand for technology-enhanced solutions for older adults. Despite growing interest in Internet of Things (IoT) sensor networks and machine learning applications for older adult care, the patterns of technology acceptance and implementation readiness in Thai older adult care facilities remain underexplored. Objective This study …

18.08.2026journal-article

Frontiers in Aging Neuroscience

Trajectories of chronic disease burden, depressive symptoms, and functional limitations related to falls in middle-aged and older adults: a matched longitudinal study

Mengmeng Wang, Yaohui Cui, Lincheng Duan, Xiaowei Qin

Background Falls are often treated as isolated events, but the physiological, psychological, and functional trajectories surrounding a first fall remain poorly understood. We examined chronic disease burden, depressive symptoms, and activities of daily living (ADL) limitations before and after first fall reports in England and the United States. Methods We conducted a matched longitudinal analysis of adults aged ≥50 years in the English Longitudinal Study of Ageing (ELSA) and the Health and Retirement Study (HRS). …

18.08.2026journal-article

Frontiers in Immunology

Exercise interventions remodel the aging microenvironment to improve prognosis in older patients with cancer

Wen Fang, Yihan Wang, Zhenyu Yang, Hongyun Zheng, Yang Wu, Ruogu Chen, Ruilong Wang, Huayu Tang, Menghao Tang, Xinming Ye

Cancer in older adults has become a significant public health challenge, with increasing incidence and limited efficacy of conventional treatments due to aging-related biological changes, such as chronic inflammation, immune decline, metabolic dysfunction, and cellular senescence. These alterations create a pro-tumor environment, weakening antitumor capacity and reducing treatment sensitivity. Exercise medicine has emerged as a promising systemic intervention, regulating multiple physiological systems, including me …

18.08.2026journal-article

Diabetology

Association Between Glycemic Burden, Diabetes Duration, and MMSE-Defined Cognitive Impairment in Middle-Aged and Older Adults: A Comparative Cross-Sectional Study

Rachid Aithammou, Mohamed Ben-El-Caid

Background/Objectives: Diabetes mellitus is associated with cognitive impairment, but evidence from southern Morocco remains limited. This study examined the associations of diabetes status, HbA1c, and diabetes duration with Mini-Mental State Examination (MMSE) performance among adults aged 45 years or older in Dakhla. Methods: This hospital-based comparative cross-sectional study included 100 participants (50 with diabetes and 50 without diabetes). Data were collected through a structured bilingual questionnaire a …

18.08.2026journal-article

Sports Medicine

The Optimal Exercise Modality and Dose for Blood Pressure Management in Middle-Aged and Older Adults: A Systematic Review with Bayesian Model-Based, and Dose–Response Network Meta-Analysis of RCTs

Zhongxu Hu, Matthew Weston, Samuhaer Azhati, Xianyang Xin, Xingyi Niu, Jinfa Gu

Abstract Background Exercise is an established non-pharmacological strategy for lowering blood pressure (BP), but the comparative effectiveness and optimal dose of different exercise modalities in middle-aged and older adults remain unclear. Objective This study aimed to systematically compare the effects of different exercise modalities and doses on resting systolic and diastolic BP (SBP/DBP) in middle-aged and older adults (≥ 45 years). Methods Randomized controlled trials (RCTs) were identified from six electron …

18.08.2026journal-article

Australasian Psychiatry

Benzodiazepine prescribing at discharge from adult and older persons psychiatric inpatient units: A systematic review and meta-analysis

Justin McMahon, John McMaster, David Maletsky, Hesitha Abeysundera

Objective Psychiatric inpatient discharge is a prescribing transition at which benzodiazepines initiated for short-term symptom control may unintentionally continue beyond discharge. Existing guidance is limited for prescribing decisions. We aimed to estimate benzodiazepine discharge prevalence from adult and older persons psychiatric inpatient units and examine between-study heterogeneity. Methods We searched five databases from inception to 31 December 2022, updated the search on 27 November 2025 (PROSPERO: CRD42 …

18.08.2026journal-article

Journal of Applied Gerontology

Impact of Project ECHO on Primary Care Providers’ Knowledge, Confidence, and Skills in Geriatric and Dementia Care: A Scoping Review

Dominic Roby, Kallol Kumar Bhattacharyya, Ashish Joshi, Berneet Kaur, Kristina Wick, Anne Gifford, James Eaton, Daniel Ibarra-Scurr, Katherine Gifford, Raymond R. Romano

Background The shortage of geriatric specialists in the United States has increased reliance on primary care providers to diagnose and manage dementia, yet many lack adequate training in geriatric care. Objectives To examine how dementia and geriatric-focused Extension for Community Healthcare Outcomes (ECHO) programs influence provider knowledge, confidence, and clinical skills. Methods A scoping review was conducted using PubMed, Google Scholar, and PsycINFO to identify studies published between 2015 and 2025. El …

18.08.2026journal-article

Journal of Applied Gerontology

Caregiver- and Care Recipient–Related Factors Linked to Pain in Family Caregivers of Persons Living with Dementia

Mona Mohammadifirouzeh, Kyeung Mi Oh, Mary-Lynn Brecht, Raeanne C. Moore, Jennifer L. Martin, Brent T. Mausbach, Yeonsu Song

Background Family caregivers of persons living with dementia (PLWD) often experience significant psychological, financial, and social stress, increasing their risk for both mental and physical health problems. Objective This study examined factors associated with caregivers’ perceived pain in the context of dementia care. Methods This was cross-sectional study using baseline data from a dyadic clinical trial evaluating a behavioral sleep intervention for PLWD and their family caregivers. A total of 148 caregivers w …

18.08.2026journal-article

PLOS One

Rate of nicotine metabolism on risk of myocardial infarction among people with HIV who smoke cigarettes

Derartu Ahmed, Warren B. Bilker, Xiaoyan Han, Rachel F. Tyndale, Jessica Merlin, Stephen E. Kimmel, Jeffrey Martin, Michael Plankey, Katerina Christopoulos, Leila S. Hojat, Laura Bamford, Sonia Napravnik, Robert Schnoll, Rebecca Ashare, Robert Gross

Background The prevalence of cigarette use in people with HIV (PWH) is 2–3 times higher than the general population. Cigarette use increases risk of myocardial infarction (MI). Faster nicotine metabolism, quantified by the nicotine metabolite ratio (NMR) is associated with greater risk for nicotine dependence and lung cancer, but its association with MI is unknown. Methods We conducted a nested case-control study within the Center for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort. Cases were P …

18.08.2026journal-article

Frontiers in Digital Health

Social Media engagement and perceived social isolation among older adults in a changing digital environment: evidence from HINTS 2022–2024

Jingjing Gao

Background The rapid expansion of social media and emerging artificial intelligence (AI)-mediated digital environments has transformed how older adults communicate, access information, and engage with online communities. Social media platforms may provide opportunities for social connectedness and emotional support, particularly among older adults who face mobility limitations, retirement-related social changes, or reduced in-person interactions. At the same time, increased reliance on digital environments may also …

18.08.2026journal-article

Frontiers in Psychiatry

Perceived temporal reorganization during psychiatric hospitalization among people with schizophrenia: a qualitative interview study

Yujuan Qin, Qin Mao, Hualei Li, Faqiang Zhang, Suhong Wang, Dongyang Wang, Jianying Wang

Background Schizophrenia involves not only disturbances in thought, perception, and self-experience, but also disruptions in subjective temporality. During psychiatric hospitalization, recovery experiences may involve not only symptom stabilization but also patients’ efforts to make sense of continuity between past, present, and future. This study explored how inpatients with schizophrenia described their time perspective during hospitalization. Methods This qualitative interview study recruited 15 clinically stabl …

18.08.2026journal-article

Smart Cities

Data-Driven Child-Friendly Street Renewal for Health Equity in Older Urban Districts: Latent Activity–Health Profiles in Xi’an, China

Zhanhao Zhang, Xin Dong, Weijie Hou, Sitong Liu

Data-driven urban governance increasingly seeks to incorporate the needs of different population groups, yet child-sensitive evidence for public street-space renewal remains limited in older urban districts. Most studies still evaluate environmental conditions through population averages, with insufficient attention to heterogeneous child groups that may require differentiated planning responses. Based on an analytic sample of 314 children retained from 343 usable questionnaire responses collected from children age …

18.08.2026journal-article

Journal of Sleep Research

Risk of Hypertension and Mortality Among People With Narcolepsy or Idiopathic Hypersomnia: A Retrospective Cohort Analysis of the Danish National Patient Registry

Poul Jørgen Jennum, Michael Ibsen, Sam Mettam, Sarah C. Markt, Douglas S. Fuller, Jessica K. Alexander, Rikke Ibsen, Jakob Kjellberg, Caroleen Drachenberg

ABSTRACT To assess the prevalence of hypertension, risk of developing hypertension, and risk of mortality among individuals with narcolepsy or idiopathic hypersomnia in Denmark, we performed a retrospective, nationwide, cohort analysis of the Danish National Patient Registry (DNPR). Adults (aged ≥ 18 years) diagnosed with narcolepsy or idiopathic hypersomnia between 1 January 1998 and 31 December 2020 were matched 1:4 with non‐narcolepsy/non‐idiopathic hypersomnia controls based on key demographics (age, sex, marit …

18.08.2026journal-article

Frontiers in Nutrition

Skeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations

Chunhong Xu, Weilu Cai, Jing Li, Ying Ma

Athletic performance and exercise adaptation are influenced by intricately coordinated interactions among mitochondrial bioenergetics, methylation-dependent metabolic pathways, and the regulation of central neurotransmitters. The potential of Cordyceps-based supplementation to enhance mitochondrial ATP production, optimize oxygen utilization, and improve fatigue resistance has been extensively studied. Nevertheless, the exploration of its integration with complementary metabolic modulators remains inadequately addr …

18.08.2026journal-article

JMIR Aging

Measuring Implicit Attitudes Toward Digital Health Technologies in Older Adults Using an Influence-Aware Affect Misattribution Procedure: Development and Feasibility Study

Anna Vinnikova, Jinyue Zhan, Kailing Jin, Xianfeng Ding, Wei Sang, Weina Xu, Qian Yang

Abstract Background Older adults often express positive attitudes toward digital health technologies in surveys, yet adoption remains low. Self-report measures may not capture automatic affective reactions such as anxiety or distrust. Implicit paradigms such as the affect misattribution procedure (AMP) can reveal these automatic attitudes, but parameters optimized for younger adults may not be suitable for older adults because of age-related slowing and changes in visual processing. Objective This study aimed to ad …

18.08.2026journal-article

Journal of National Institute of Neurosciences Bangladesh

Evaluation of Post Stroke Dementia in Different Types of Stroke Patients

Imran Sarker, AKM Anwar Ullah, Abdul Kader Shaikh, Afzal Momin, MS Jahirul Hoque Chowdhury, Mohammad Enayet Hussain, Mohammad Kafil Uddin, Nayeem Anwar, Dewan Mushfiqur Rahman, Niloy Ranjan Roy

Background: Post-stroke dementia is defined as any dementia occurring after stroke, and includes vascular dementia (VaD), degenerative dementia (mostly Alzheimer’s disease, AD) and mixed dementia (coexistence of vascular and degenerative changes). We aimed to evaluate the patients of stroke developing this vascular cognitive impairment event by this study. Objective: The purpose of the present study was to evaluate post stroke dementia (PSD) after different types of strokes and to find out the determinants of demen …

18.08.2026journal-article

SLEEP

An actigraphy-based algorithm to assess daytime napping in people with narcolepsy type 1

Raul Torres, Rahul Ghosal, Melissa Naylor, Simerpal K Gill, Yelena Pyatkevich, Sarah L Bermingham, Derek L Buhl, Brian Tracey, Marta Karas, Francesco Onorati, Vadim Zipunnikov, Dmitri Volfson

Abstract Study Objectives Excessive daytime sleepiness is a defining symptom of narcolepsy, affecting daily functioning and quality of life. We developed and evaluated an actigraphy-based nap detection algorithm to objectively estimate daytime naps, a key manifestation of excessive daytime sleepiness. Methods The nap detection algorithm was developed using data from the Multi-Ethnic Study of Atherosclerosis. This dataset included manually annotated naps from 2237 participants with 7 days of wrist-worn actigraphy. T …

18.08.2026journal-article

Frontiers in Forests and Global Change

Navigating the dual nature of wildfire in the Anthropocene: a framework for assessing impacts on nature’s contributions to people and pathways to adaptive management

Lacour M. Ayompe, Micah Elias

Wildfires historically shaped and sustained global biomes, but climate change, strict fire exclusion policies, and rapid expansion into the wildland–urban interface have fueled an era of unprecedented, high-severity “megafires.” This review synthesizes current literature on the dual nature of wildland fires, categorizing their impacts on material, non-material, and regulating Nature’s Contributions to People (NCP) using the IPBES framework. Grounded in case studies from regions experiencing acute megafires includin …

18.08.2026journal-article

Frontiers in Medicine

The relationship between alexithymia, meaning in life, and quality of life in older breast cancer patients: a cross-sectional study based on variable-centered and person-centered perspectives

Qi Lv, Yawen Deng

Background Alexithymia, characterized by difficulties in identifying and expressing emotions, has been linked to diminished quality of life in older breast cancer patients, a vulnerable population facing multifaceted psychosocial challenges. While prior research has explored these associations, investigations have predominantly adopted a variable-centered approach, overlooking the potential statistical mediating role of meaning in life. Moreover, no studies have examined the heterogeneity of alexithymia and meaning …

18.08.2026journal-article

Diabetic Medicine

The effect of telemonitoring on quality of life in people with insulin‐treated type 2 diabetes: A secondary analysis of a randomised controlled trial

Rúni Knoph, Jannie Toft Damsgaard Nørlev, Thomas Kronborg, Peter Vestergaard, Morten Hasselstrøm Jensen, Stine Hangaard

Abstract Aims Telemonitoring in type 2 diabetes (T2D) care has demonstrated positive trends in terms of glycaemic control. However, evidence regarding its impact on patient‐reported outcomes, such as general and diabetes‐specific quality of life (QoL), remains inconclusive. In particular, the effect of telemonitoring in people with insulin‐treated T2D is underexplored. This study aimed to evaluate the effect of telemonitoring on general and diabetes‐specific QoL compared with usual care in people with insulin‐treat …

18.08.2026journal-article

Mini-Reviews in Medicinal Chemistry

Nicotinamide Adenine Dinucleotide and Its Anti-aging Effects in the Context of Longevity and Menopause

Elifsena Canan Alp Arici, Esra Küpeli Akkol, Eduardo Sobarzo-Sánchez, Zeliha Selamoglu

Menopause is a complex biological condition associated with progressive estrogen depletion and increased susceptibility to several age-associated disorders. During this process, several biological mechanisms, such as mitochondrial dysfunction, oxidative stress, chronic inflammation, genomic instability, and immunosenescence, contribute to the progression of biological aging and metabolic imbalance. In this sense, nicotinamide adenine dinucleotide (NAD⁺) has progressively attracted attention because of its important …