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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Materials

Antibacterial Interventions for Orthodontic Appliances; Surface Modifications, Coatings and Bulk-Incorporated Antibacterial Agents: Materials, Mechanisms and Clinical Application—A Scoping Review

Berta Furió-Alonso, Javier Gil, Danica Nikolic Jovanovic, Andreu Puigdollers-Pérez

Biofilm accumulation on orthodontic appliances is a recognized risk factor for white spot lesion formation and caries during treatment. Antibacterial surface modifications and coating strategies have been proposed as appliance-level preventive approaches. Studied interventions in the literature span true thin-film surface coatings, plasma-based and ion-implantation surface modifications, and bulk-incorporated antibacterial agents in appliance matrix materials. Yet the extent to which in vitro efficacy translates to …

27.08.2026journal-article

Journal of Plastic Surgery and Hand Surgery

Clinical outcomes of a defect-adapted strategy for free fibular great toe flaps in finger reconstruction: a retrospective series of 35 cases

Yangyang Liu, Huajian Zhou, Haoran Jiang, Jun Zhu, Renjie Li, Mingyu Jia

Background: To evaluate the clinical outcomes of a personalized surgical strategy for small-to-medium finger defects, utilizing either free dorsal toe or plantar proper digital artery flaps. Methods: We retrospectively analyzed 35 patients with finger defects (March 2021–January 2025). Patients were assigned by defect characteristics to Group A (pulp defects, n = 21; plantar proper digital artery flap) or Group B (dorsal/lateral defects, n = 14; modified dorsal toe artery flap preserving the plantar proper neurovas …

27.08.2026journal-article

Clinical Cancer Research

Focused Ultrasound-Enhanced Drug Delivery to Brain Tumors: Quantitative and Translational Insights from CNS Physiologically Based Pharmacokinetic Modeling

Andrew Wu, Charuka Wickramasinghe, Yuanyuan Jiang, Xun Bao, Jing Li

Abstract Purpose: Successful clinical translation of focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening strategy to brain cancer therapy has been hindered by limited quantitative understanding of CNS pharmacokinetics. Using a physiologically based pharmacokinetic (PBPK) modeling framework, this study aimed to quantitatively characterize FUS-modulated CNS pharmacokinetics and identify key determinants of potential clinical benefits. Experimental Design: A previously validated 9-compartment CNS PBPK m …

27.08.2026journal-article

Revista Goiana de Medicina

Teratoma ovariano maduro gigante em gestante de primeiro trimestre

Nayane Peixoto Soares, Gabriela Mesquita Pontes, Fernanda Mendonça Salles Ghannam, Henri Naves e Siqueira, Daniel Fernandes Correia Júnior, Waldemar Naves do Amaral

Introduction: Mature cystic teratoma is the most frequent ovarian neoplasm in reproductive-aged women, posing maternal and fetal risks when diagnosed during pregnancy. Objectives: To report the diagnosis and surgical management of a giant ovarian teratoma in a first-trimester pregnant patient. Methods: A descriptive case report study of a 17-year-old primigravida with a 30 cm adnexal mass concomitant with a 12-week intrauterine pregnancy. Results: Exploratory laparotomy with partial drainage of the contents was per …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Artificial intelligence-empowered echocardiography: an updated review of clinical management in hypertrophic cardiomyopathy

Miao Zhang, Shanshan Yuan, Hongyan Dai, Guoan Wang

Hypertrophic cardiomyopathy (HCM) is a common and highly heterogeneous inherited cardiomyopathy characterized by complex clinical phenotypes and diverse disease trajectories, posing significant challenges for early diagnosis, precise phenotypic classification, and risk stratification. Owing to its noninvasive nature, repeatability, and wide availability, echocardiography remains the cornerstone imaging modality for the diagnosis and longitudinal management of HCM. However, conventional echocardiographic analysis re …

27.08.2026journal-article

International Journal of Molecular Sciences

Effect of Dupilumab on Allergen-Specific IgE Levels and Clinical Tolerance in Patients with Food Allergy: A Systematic Review

Magdalena Grześk-Kaczyńska, Szymon Kaczyński, Bernadetta Kosztulska, Magdalena Rydzyńska, Tomasz Rosada, Natalia Ukleja-Sokołowska

Food allergy is a growing global health concern associated with significant dietary restrictions, impaired quality of life, and risk of severe allergic reactions. Dupilumab, a monoclonal antibody targeting the interleukin-4 receptor alpha (IL-4Rα), inhibits IL-4 and IL-13 signaling and has demonstrated efficacy across multiple type 2 inflammatory diseases. This systematic review aimed to evaluate the effects of dupilumab on food allergy outcomes in pediatric and adult patients. Across studies, dupilumab treatment w …

27.08.2026journal-article

Frontiers in Immunology

Datopotamab deruxtecan in breast cancer treatment: a systematic review of clinical efficacy and safety

Julia Piekarz, Natalia Picheta, Jakub Pobideł, Natalia Gierulska, Krzysztof Kułak, Rafał Tarkowski

Background Breast cancer (BC) remains the most common malignant tumor in women worldwide and a leading cause of cancer-related deaths. Despite therapeutic advances, patients with advanced BC, particularly triple-negative breast cancer (TNBC), still face limited effective treatment options. Antibody-drug conjugates (ADCs) represent a compelling strategy that combines precise tumor targeting with cytotoxic payloads, effectively bridging targeted delivery with microenvironmental disruption. Datopotamab deruxtecan (Dat …

27.08.2026journal-article

Clinical Psychology & Psychotherapy

Are Metacognitive Beliefs and Cognitive Flexibility Associated With Cannabis Use Disorder In Adolescents? A Case–Control Study

Neval Kızıl, Masum Öztürk, Fatma Subaşı Turgut, Yağmur Soysal, Ayfer Gözü Pirinççioğlu

ABSTRACT Objective Cannabis is among the most commonly used substances by adolescents and is frequently associated with the development of addiction. Various individual, environmental and psychological factors are associated with the onset and maintenance of cannabis use disorder (CUD). Our study aimed to compare levels of depression, anxiety, stress, perceived cognitive flexibility and metacognitive beliefs in adolescents diagnosed with CUD with those in a healthy control (HC) group. Another objective was to inves …

27.08.2026journal-article

Exploration of Asthma & Allergy

Lessons from rheumatoid arthritis and inflammatory bowel disease: The importance of patient-centred outcomes in severe asthma

Joseph W. Lanario, Matthew Masoli, Michael E. Hyland

Biologic therapies have transformed care for people with severe asthma, yet treatment response has traditionally been assessed using clinician-derived measures, including lung function, exacerbation rates, and oral corticosteroid use. These metrics, while clinically important, frequently fail to capture what matters most to patients: their ability to participate in daily life, maintain relationships, and sustain work and social roles. The publication of the Core Outcome Measures Set for Severe Asthma (COMSA) and th …

27.08.2026journal-article

Clinical Case Reports

Severe Multiorgan Failure Triggered by Infection in an Adult With Decades of Untreated Sickle Cell Disease: A Case Report

Sara Shahidi, Gisha Mohan

ABSTRACT A 67‐year‐old man with decades of untreated sickle cell disease developed septic shock with multiorgan failure, splenic infarction, and marrow fibrosis; his genotype could not be confirmed. He recovered with intensive supportive care, with hydroxyurea initiated for long‐term disease modification, illustrating catastrophic infection‐triggered decompensation despite prolonged clinical quiescence.

27.08.2026journal-article

Philosophical Transactions of the Royal Society B: Biological Sciences

Targeting EGFR in lung cancer: lessons in signal transduction and treatment-induced mutagenesis

Arturo Simoni-Nieves, Marieke Van Daele, Harrison B. Konsker, Yosef Yarden

Abstract The epidermal growth factor receptor (EGFR) plays pivotal role in cancer promotion and progression, particularly in non-small cell lung cancer (NSCLC), where activating EGFR mutations drive tumour growth. Targeted therapies, such as tyrosine kinase inhibitors (TKIs), have improved patient survival rates, but resistance inevitably develops through mechanisms ranging from secondary mutations to bypass signalling pathways and histological transformation. A key factor in resistance development is the emergence …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Transjugular intrahepatic portosystemic shunt via the caudate lobe portal vein due to anatomic variation: Two case reports

Tao Xu, Xiao-Huan Lai, Qiao-Xia Ye, Li-Guan Liu, Zheng-Ju Xu

BACKGROUND The target sites for transjugular intrahepatic portosystemic shunt (TIPS) treatment of esophageal and gastric varices are typically the left and right branches of the portal vein and its confluence. In clinical practice, the puncture needle may inadvertently puncture secondary branches or other smaller branches of the portal vein. It was observed that when the caudate lobe portal vein (CLPV) was successfully targeted, a covered stent can be effectively placed. CASE SUMMARY This study reports two patients …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Incidence and risk factors of poor wound healing following emergency surgery for intestinal tuberculosis

Qian He, Juan-Min Xue, Jian-Feng Weng, Xia-Nan Li, Cai-Xia Zhang

BACKGROUND Intestinal tuberculosis accounts for 11%-16% of extrapulmonary tuberculosis cases and frequently mimics Crohn’s disease or intestinal neoplasms due to nonspecific clinical presentations. When complicated by obstruction, perforation, or hemorrhage, emergency surgery becomes necessary. These patients often present with malnutrition, anemia, and immune dysfunction, substantially increasing the risk of poor postoperative wound healing a complication that prolongs hospitalization and predisposes patients to i …

27.08.2026journal-article

Magnetic Resonance Materials in Physics, Biology and Medicine

Recent advances in arterial spin labeling MRI for imaging brain tumors

Gabriel Hoffmann, Matthias J. P. van Osch

Abstract Perfusion MRI plays an important role in brain tumor assessment, especially for tumor grading and differentiation of tumor progression from pseudoprogression. Arterial spin labeling (ASL) MRI is a non-invasive method for measuring cerebral blood flow (CBF) using blood water as an endogenous tracer, which has great clinical potential for brain tumor imaging and might help to lower the use of gadolinium-based contrast agents. In this review, we discuss recent advances of the ASL method with a special focus o …

27.08.2026journal-article

Journal of Applied Clinical Medical Physics

Fast fourier transform based spectral features for machine learning prediction of gamma passing rates in virtual VMAT PSQA: A feasibility study

Bing Yan, Hu Peng, Xudong Xue, Chichao Zheng, Aidong Wu

Abstract Purpose This study aimed to evaluate the feasibility of fast Fourier transform (FFT) based spectral features for predicting volumetric modulated arc therapy (VMAT) gamma passing rates (GPRs) in virtual patient‐specific quality assurance (PSQA). Methods A total of 481 VMAT treatment plans were retrospectively collected. Multileaf collimator (MLC) trajectories and monitor units (MU) were extracted from control points (CPs) and interpolated onto a uniform gantry‐angle grid. FFT‐based power spectra were then c …

27.08.2026journal-article

Medical Sciences

Clinical Remission Trajectories Beyond 12 Months in Severe Asthma Patients Continuing a Single Biologic: A Real-World Single SANI Center Cohort

Simone Negrini, Stefania Nicola, Francesco Sardanapoli, Rocco Francesco Rinaldo, Marco Russo, Iuliana Badiu, Anna Quinternetto, Luca Lo Sardo, Francesco Blasi, Pierluigi Paggiaro, Enrico Heffler, Giovanni Rolla, Caterina Bucca, Giorgio Walter Canonica, Fulvia Ribolla, Paolo Solidoro, Luisa Brussino

Background: Clinical remission is an emerging therapeutic goal in severe asthma treated with biologics. However, remission may evolve beyond the conventional 12-month assessment, and limited real-world data are available on patients who continue the same biologic after incomplete remission at 12 months. We evaluated longitudinal remission trajectories in patients with severe T2-high asthma continuing the same biologic therapy. Methods: This retrospective real-world single-center SANI cohort included adults with sev …

27.08.2026journal-article

Archiv Euromedica

SOCIAL MEDIA AND MENTAL HEALTH SELF-DIAGNOSIS: RISKS, BENEFITS, AND CLINICAL IMPLICATIONS FOR ADOLESCENTS AND YOUNG PEOPLE

Bogna Błachowska, Wojciech Frączyk, Agata Świątek, Kamil Andruszkiewicz, Bartosz Machnio, Natalia Jasińska, Mateusz Krysiak, Natalia Turzyńska, Katarzyna Mania, Julia Bąk, Agnieszka Stankowska

Background Adolescents increasingly use social media platforms, including TikTok, Instagram, and Reddit, to obtain information about mental health and psychiatric disorders. Such content may facilitate mental health literacy, validation, and help seeking, but may also expose users to misinformation, oversimplified diagnostic narratives, and algorithmically reinforced content. Aim To examine the potential benefits and risks of mental health self-diagnosis through social media among adolescents and young people, with …

27.08.2026journal-article

Basic & Clinical Pharmacology & Toxicology

Plant‐Derived Heterocyclic Compounds: A Promising Review on Natural Remedies for Rheumatoid Arthritis Management and Their Mechanistic Insights in Inflammation and Joint Protection

Jindong Dai, Xue Xia, Xincheng Hu, Thangamani Kanagaraj, Kanagaraj Rajalakshmi, Mangirish Deshpande, Natarajan Kiruthiga, Dongwei Zhu, Yisun Fan

ABSTRACT Rheumatoid arthritis (RA) represents a persistent autoimmune disease that causes continuous joint inflammation and results in synovial tissue overgrowth and worsening cartilage breakdown together with degeneration of bones. The existing pharmaceutical treatments provide symptom management although they create important adverse effects and raise ongoing security concerns. Plant‐derived heterocyclic compounds present themselves as promising pharmaceutical substitution options because they demonstrate a wide …

27.08.2026journal-article

Frontiers in Medicine

Treatment and clinical outcomes among stage II–IVA nasopharyngeal carcinoma patients with undetectable pretreatment Epstein-Barr viral DNA

Ci-ming Sun, Zhen Xu, Cheng-hao Li, Jun-xiang Chen, Xin-yi Su, Jing-xia Song, Shuang-hong Song, Qing-qing Xu, Yan-Ling Wu

Background This study analyzed the efficacy of multiple combined chemotherapy modalities on the long-term survival outcomes in stage II–IVA nasopharyngeal carcinoma (NPC) patients with undetectable pretreatment Epstein-Barr viral DNA (pre-DNA). Patients and methods We retrospectively analyzed 2,440 patients with stage II–IVA NPC with undetectable pre-DNA. Patients received any of the following treatment modalities: intensity-modulated radiotherapy (IMRT) alone; concurrent chemoradiotherapy (CCRT); induction chemoth …

27.08.2026journal-article

Journal of Medical Internet Research

Stigmatizing Language in Gender-Expansive Patient Records: Corpus Development, Disparity Analysis, and Natural Language Processing–Based Detection Study

Liyang Xue, Mary Chayko, Vivek Kumar Singh

Background Stigmatizing language (SL) in electronic health records (EHRs) can influence clinical decision-making, propagate bias across care encounters, and undermine patient trust. Gender-expansive patients (GEPs) may be particularly vulnerable to documentation-based stigma; however, large-scale quantitative evidence and fairness-aware evaluation of automated SL detection methods remain limited. Objective This study aims to construct a gender-expansive-inclusive EHR corpus, quantify demographic disparities in SL u …

27.08.2026journal-article

International Journal of Sports Medicine

Post-Exercise Circulatory Occlusion Differently Affects Soleus Spinal/Supraspinal Excitability

André D. Gonçalves, Andréia Terra, Rodrigo Marques, Pedro Pezarat-Correia, Carolina Vila-Chã, Goncalo V Mendonca

Abstract Post-exercise circulatory occlusion allows the investigation of the effects of group III/IV muscle afferent feedback on central nervous system responsiveness. This study explored the effects of post-exercise circulatory occlusion on soleus H- and V-wave excitability. Following a randomized-crossover design, in 1 day, 16 healthy men (24.6±3.5 y) completed a 3-minute sustained plantar-flexion contraction at 40% of maximal voluntary isometric contraction. Then, for testing, a cuff was inflated around the ipsi …

27.08.2026journal-article

Clinical Journal of Health Sciences

The Mediating Role of Rumination in the Relationship Between University Students' Attachment Dimensions and Future Anxiety

İlayda Üçer, Manolya Çalışır

The purpose of this study is to examine the mediating role of ruminative thought processes in the relationship between attachment dimensions and future anxiety among college students. To this end, 420 participants were included in the study. Participants completed the Sociodemographic Information Form, the Experiences in Close Relationships Inventory II, the Rumination Response Scale, and the Future Anxiety Scale for College Students online. According to the study results, there are positive correlations between th …

27.08.2026journal-article

Veterinary Medicine and Science

Clinical Case and Follow‐Up of Babesia banethi Infection in a Red Fox

Mariaelisa Carbonara, Michela Prioletti, Antonio Camarda, Stefano Castellana, Giuseppe Menga, Giovanna Girardi, Gad Baneth, Domenico Otranto

ABSTRACT Background Red foxes play an important role in the circulation of ticks and tick‐borne pathogens, including Babesia spp. While for Babesia vulpes many studies are available on its epidemiology in fox populations as well as pathogenicity in dogs, no data are reported for the recently described Babesia banethi infecting red foxes. Objective Here we describe the clinical and parasitological follow‐up of a naturally occurring B. banethi infection in a red fox from southern Italy. Case presentation An adult mal …

27.08.2026journal-article

Journal of Clinical Medicine

Initial Clinical Experience with Percutaneous Endocardial Septal Pulsed Field Ablation in Hypertrophic Obstructive Cardiomyopathy: A First-in-Human Case Series

Haoruo Zhang, Yanfeng Tian, Songqing Yang, Rui Cao, Haoran Jing, Chunlin Gong, Jiaoyue Zhong, Yuran Chen, Siting Hong, Zhaojun Wang

Background: Pulsed field ablation is a nonthermal ablation modality with a potentially favorable tissue selectivity profile. However, its application in septal reduction therapy for hypertrophic obstructive cardiomyopathy remains unexplored clinically. We investigated the feasibility and short-term outcomes of percutaneous endocardial septal pulsed field ablation in patients with symptomatic hypertrophic obstructive cardiomyopathy. Methods: Five patients with symptomatic hypertrophic obstructive cardiomyopathy and …