PLOS Global Public Health
Anthony E. Chirwa, Charity Gunda, Shalom Songolo, Edna Nsomba, Neema Toto, Lumbani Makhaza, Mphatso Mailboy, Clara Ngoliwa, Linda Chamtunga, Modesta Reuben, Chikondi Chakwiya, Pemphero Liwonde, Andrew Sigoloti, Evaristar Kudowa, Godwin Tembo, Ben Morton, Bridgette Galafa, Faith Thole, Lorensio Chimgoneko, Brenald Dzonzi, Vitumbiko Nkhoma, Edward Mangani, Mphatso Mayuni, Alfred Muyaya, Fanny Kapakasa, Morrison P. Kamanga, Tiyamika Nthandira, Diana Mwaipaya, Nengie Chirwa, Ndaziona P. K. Banda, Marc Y. R. Henrion, Tarsizio Chikaonda, Kondwani C. Jambo, Blessings Kapumba, Stephen B. Gordon, Anna C. T. Gordon, Deborah Nyirenda, on behalf of the Malawi Accelerated Research in Vaccines by Experimental and Laboratory Systems (MARVELS) consortium
Controlled Human Infection Models (CHIM) in which volunteers are experimentally exposed to pathogens are used to study pathogenesis and down select among treatment and vaccine candidates. Scientifically, CHIM studies are best conducted among at-risk populations in which the infection is endemic, and who are likely to benefit from new interventions tested. Ethically, the perspectives of these communities should be carefully considered in designing such research. CHIM studies are often conducted among healthy adults, …