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Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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22 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

PLOS Global Public Health

Past hurts, present hurdles: Analyzing the impact of adult socioeconomic status and healthcare access on cancer screening among childhood abuse survivors

Qaidar Alizai, Azza Sarfraz, Meher Angez, Areesh Mevawalla, Odysseas P. Chatzipanagiotou, Abdulaziz Elemosho, Rida Ejaz, Kizuki Yuza, Sebastian Ekenze, Timothy M. Pawlik

Childhood abuse is associated with long-term health consequences and may influence uptake of preventive healthcare. We evaluated whether adult socioeconomic experiences and healthcare access modify the association between childhood abuse and adherence to U.S. Preventive Services Task Force (USPSTF) cancer screening guidelines. We analyzed 2020 Behavioral Risk Factor Surveillance System (BRFSS) data among respondents who answered the childhood abuse item and were eligible for colorectal (CRC; 50–74years), cervical ( …

26.08.2026journal-article

Rare Metals

A Locally Retentive HfO 2 –STING Nano‐Radiosensitizer Hydrogel for Enhanced Radioimmunotherapy in Esophageal Cancer

Dongdong Wang, Yubao Lyu, Yu Du, Yiping Lu, Chang He, Bo Yin, Dayu Huang, An Wang

ABSTRACT Esophageal squamous cell carcinoma (ESCC) remains associated with frequent local recurrence and distant metastasis despite advances in radiochemotherapy and immunotherapy, highlighting the need for therapeutic strategies that improve both local tumor control and systemic antitumor immune responses. Herein, we developed an Hf‐based radio‐immunotherapeutic platform composed of HfO 2 @PDA/cGAMP‐PEG nanoparticles (HPG NPs) embedded in a catechol‐modified methacrylated chitosan photocurable adhesive hydrogel (H …

26.08.2026journal-article

Health Expectations

Does Current United Kingdom Childhood Cancer Research Address the James Lind Alliance Children's Cancer Priority Setting Partnership Priorities? A Grant Mapping Study

Alison Bish, Faith Gibson, Alexandra Brownsdon, Julia Chisholm, Jenny Harris, Rachel Hollis, Bob Phillips, Susie Aldiss

ABSTRACT Introduction The James Lind Alliance Children's Cancer Priority Setting Partnership identified 23 key research topics, as defined by children, survivors, families, carers, and professionals. Funders have expressed commitment to ensuring all priorities are addressed. The aim of our current project was to map UK‐funded childhood cancer research against the 23 priorities to highlight gaps and inform future funding, policy and research directions. Methods A retrospective grant mapping study. Potential UK funde …

26.08.2026journal-article

Drug and Alcohol Review

Implementing Prolonged Exposure Therapy in a Community Substance Use Treatment Program: A Qualitative Study

Steven Curto, Tasha Bulgin, Jordan A. Gette, Margaret Swarbrick, Angela Gonnella, Denise Hien, Sonya B. Norman, Shannon M. Kehle‐Forbes

ABSTRACT Introduction Post‐traumatic stress disorder (PTSD) commonly co‐occurs with substance use disorders (SUD), yet few community‐based SUD programs incorporate evidence‐based trauma‐focused. Prolonged exposure (PE), including its massed format (M‐PE) with session frequency of 3–4 times per week, is a gold standard intervention for PTSD; however, concerns about client readiness, logistical demands and relapse risk have limited its adoption within SUD settings. This study examined staff perspectives on the feasib …

26.08.2026journal-article

Frontiers in Oncology

Radiographically occult bone marrow metastasis in relapsed small cell lung cancer presenting with rapidly progressive thrombocytopenia: a case report

Jingli Li, Fang Liu, Shijia Yu, Meng He, Jian Sun, Zhe Chen, Ying Qian, E Qin

Background Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy that frequently relapses after initial chemoradiotherapy. Bone marrow involvement in SCLC has been reported previously, but relapse confined predominantly to the marrow may be difficult to recognize when skeletal imaging remains negative. We report a diagnostically discordant presentation of relapsed SCLC characterized by rapidly progressive thrombocytopenia, marked biochemical progression without corresponding radiographic evidence …

26.08.2026journal-article

American Journal of Hematology

SHR ‐2004, a Humanized Monoclonal Antibody Targeting Factor XI , for Preventing Venous Thromboembolism After Ovarian Cancer Surgery: A Randomized, Active‐Controlled Phase 2 Study

Guangyi Jiang, Jie Tang, Hongwei Zhao, Keqiang Zhang, Jun Gao, Bo Yang, Li Wang, Hongying Yang, Liang Chen, Ruifang An, Hui Zhang, Hualei Bu, Junying Tang, Xizhong Xu, Xiaohong Ruan, Bairong Xia, Ke Wang, Luwei Wei, Xiujie Sheng, Zhe Guo, Lihong Chen, Wei Wang, Jin Li, Danbo Wang, Ping Zhan, Yuhan Guo, Yuqi Wang, Yanli Dong, Jianqing Zhu

ABSTRACT This multicenter, randomized, open‐label, exploratory Phase 2 trial assessed SHR‐2004, an anti‐FXI antibody, for venous thromboembolism (VTE) prevention in patients undergoing ovarian cancer surgery—a population at particularly high thrombotic risk conducted at 25 sites in China. Patients with newly diagnosed Stage III–IV or recurrent ovarian cancer scheduled for surgery were randomly assigned (1:1) to receive subcutaneous SHR‐2004 (180 mg on Day 1 and 120 mg on Day 15) or enoxaparin–rivaroxaban (subcutane …

26.08.2026journal-article

BMC Oral Health

Temporal changes in treatment selection criteria for skeletal Class III: a comparison of surgical orthodontic and orthodontic camouflage treatments

Yurika Mizoguchi, Chie Tachiki, Yuki Iijima, Dai Ariizumi, Yasushi Nishii, Takashi Takaki, Masae Yamamoto, Akira Katakura

Abstract Background Advances in orthodontic treatment mechanics, particularly the introduction of particularly the increasing use of skeletal anchorage, may have altered the boundary between surgical orthodontic and orthodontic camouflage treatments in patients with skeletal Class III. This study explored temporal changes in treatment selection criteria and assessed the diagnostic performance of cephalometric parameters. Methods This study included 160 post-adolescent patients with skeletal Class III treated betwee …

26.08.2026journal-article

Physics in Medicine & Biology

Laser-driven particle accelerators for cancer therapy: a review of state-of-the-art techniques, challenges and opportunities

Roumani Alabd, Daniel R Franklin

Abstract Charged particle radiation therapy (such as electron, proton and heavy ion therapies) is presently delivered via large linear or circular electromagnetic particle accelerators. There is growing interest in laser plasma accelerators as an alternative source for therapeutic charged particle radiation, including protons, carbon ions, and very high energy electrons. Laser plasma accelerators offer the potential for extremely high dose rates in a very compact physical footprint. While these radiation sources ad …

26.08.2026journal-article

N.N. Priorov Journal of Traumatology and Orthopedics

FIRST EXPERIENCE OF USING A CUSTOM-MADE ACETABULAR IMPLANT WITH A ZINC-CONTAINING BIOCOATING IN CLINICAL PRACTICE FOR THE TREATMENT OF DEEP PERIPROSTHETIC SURGICAL SITE INFECTIONS

Irina А. Kirilova, Peter M. Larionov, Maxim V. Efimenko, Evgeniya A. Anastasieva, Vyacheslav A. Bazlov, Maxim V. Zelikman, Alexander A. Pronskikh, Mariya B. Sedelnikova, Tatiana V. Tolkacheva, Yuri P. Sharkeev, Vitaly V. Pavlov, Andrey A. Korytkin

Currently, periprosthetic joint infection (PJI) of the hip joint is one of the leading causes of revision hip arthroplasty. Our study focused on the clinical manifestations of acute infection caused by Staphylococcus/Klebsiella pneumoniae using a prototype prosthesis (acetabular component) with a zinc-containing calcium phosphate coating applied by microarc oxidation as a spacer under these conditions. The study revealed that the implant with the zinc-containing calcium phosphate coating does not have a bactericida …

26.08.2026journal-article

Pakistan Journal of Gastroenterology

<b>Ultra-Processed Food Intake, Cumulative Antibiotic Exposure, and Markers of Gut Inflammation as Risk Factors for Early-Onset Colorectal Cancer:</b><b><i>A Matched Case-Control Study in a Resource-Limited Community-Academic Health System</i></b>

Basit Ur Rehman, Fareed Ullah, Ahmed Shahbaz, Jawad Ahmed

Background: Early-onset colorectal cancer (EOCRC), diagnosed in adults younger than 50 years, has increased at approximately 1.5–2.0% per year in both high-income and South Asian populations. The independent and joint roles of ultra-processed food (UPF) consumption, cumulative antibiotic exposure, and systemic inflammation have not been examined in resource-limited settings. Methods: We conducted a retrospective 1:2 matched case-control study at the Bolan Medical Complex / Sandeman Provincial Hospital, Quetta (2018 …

26.08.2026journal-article

BMC Complementary Medicine and Therapies

Mindfulness-based intervention on treatment adherence in hemodialysis patients: a randomized controlled trial

Fatemeh Mirzaei Jirandehi, Seyedehzahra Hosseinigolafshani, Mehdi Ranjbaran, Mohammad Reza Sheikhi

Abstract Background Treatment adherence remains a persistent and critical clinical challenge among patients undergoing maintenance hemodialysis. In Iranian populations, reported rates of non-adherence vary significantly, ranging from 2% to 87%; this disparity reflects inconsistencies in measurement methodologies, clinical contexts, and adherence domains. Although mindfulness-based interventions (MBIs) have demonstrated potential for enhancing chronic disease self-management, their efficacy in improving treatment ad …

26.08.2026journal-article

Frontiers in Endocrinology

Limb salvage in diabetic foot necrotizing fasciitis complicated by extensively drug-resistant Acinetobacter baumannii: a case report of an integrative treatment approach

Yecen Tian, Yue Shi, Peng Liu, Qiang Xu, Changhai Zhang, Yunsha Zhang

Background When diabetic foot ulcers (DFUs) complicated by necrotizing fasciitis (NF) show persistent culture positivity for extensively drug-resistant Acinetobacter baumannii (XDR-AB), systemic antimicrobial options are severely limited, posing a severe challenge to limb salvage. Exploring integrative intervention strategies in this setting is of great clinical significance. Case presentation A 59-year-old patient was admitted with a 20-day history of a right foot ulcer and a 10-year history of poorly controlled t …

26.08.2026journal-article

npj Digital Medicine

OncoRAG: graph-based retrieval enabling clinical phenotyping from oncology notes using local mid-size language models

Patrick Salome, Maximilian Knoll, David Walz, Nicolò Cogno, Aylin S. Dedeoglu, Aimee Letong Qi, Steven J. Isakoff, Amir Abdollahi, Rachel B. Jimenez, Danielle S. Bitterman, Harald Paganetti, Ibrahim Chamseddine

Abstract Oncology notes contain the richest clinical detail, yet they remain largely inaccessible at scale because extracting structured phenotypes requires either substantial language model infrastructure, curated training data, or cloud computing under regulatory constraints. We developed OncoRAG, combining ontology enrichment, knowledge graph construction, graph-diffusion reranking, and structured prompting with a locally deployed 14B-parameter language model without model weight fine-tuning. Applied to three co …

26.08.2026journal-article

Current Oncology

DNA Damage Response Alterations Stratify Response to ICI-Based Therapy in Advanced NSCLC with High PD-L1 Expression

Fang Hao, Linlin Zhang, Diansheng Zhong

Background: Although high PD-L1 expression correlates with improved outcomes to immune checkpoint inhibitor (ICI), it remains an imperfect predictive biomarker. DNA damage response (DDR) pathway alterations are closely associated with antitumor immunity, shaping tumor immunogenicity and the immune microenvironment. This study evaluates the distribution and clinical impact of DDR alterations in advanced Non-small cell lung cancer (NSCLC) with Programmed death-ligand 1 (PD-L1) ≥ 50%, providing insights for personaliz …

26.08.2026journal-article

Biomolecules

MUTYH Activity Maintains Telomere Stability in Response to Chronic Telomeric 8-Oxoguanine Damage in Cancer Cells

Mariarosaria De Rosa, Theresa M. Heidenreich, Libby Childs, Benura Azeroglu, Sneh M. Toprani, Nader Aryamanesh, Pablo Galaviz, Hilda A. Pickett, Eros Lazzerini Denchi, Zachary D. Nagel, Patricia L. Opresko

Telomeres are highly susceptible to oxidative DNA damage, particularly 8-oxoguanine (8-oxoG), which is processed by glycosylase-initiated base excision repair (BER). OGG1 removes 8-oxoG opposite C, and MUTYH removes A misinserted opposite 8-oxoG to prevent mutations. While OGG1 has an established role in telomere protection, the contribution of MUTYH to telomere stability in cancer cells after oxidative DNA damage remains poorly understood. Using a chemoptogenetic system to induce targeted 8-oxoG lesions specifical …

26.08.2026journal-article

Antioxidants

Protective Effects of Antioxidant Mix Pre-Treatment Against Visible Light-Induced Damage in Dark Skin Phototype

Anna Guiotto, Malak Alghamdi, Robyn Hickerson, Michael Conneely, Hina Choudhary, Patricia Brieva, Yunsook Lim, Alessandra Pecorelli, Giuseppe Valacchi

Visible light (VL) accounts for approximately 50% of the solar radiation reaching Earth’s surface and has emerged as a major contributor to skin photoaging and pigmentation disorders, particularly in individuals with darker Fitzpatrick skin phototypes. Increasing evidence suggests that VL exposure induces oxidative stress, inflammation, and melanogenesis by generating reactive oxygen species. In this study, we investigated the protective effects of a topical antioxidant formulation (AOX Mix) containing 15% ascorbic …

26.08.2026journal-article

Current Oncology

Radiation-Induced Morphea of the Breast in a Patient with Pre-Existing Mycosis Fungoides: A Diagnostic Challenge

Tala Mobayed, Toufic Eid, Ossama Abbas, Hiba Moukadem, Nagi El Saghir, Zeina Ayoub

Radiation-induced morphea (RIM) is a rare, immune-mediated late complication of breast radiotherapy that may clinically mimic radiation fibrosis, malignancy, or other inflammatory dermatoses. Diagnosis is particularly challenging in patients with pre-existing cutaneous T-cell lymphoma (CTCL), in whom new post-radiation skin lesions may raise concern for lymphoma involvement or progression. To the best of our knowledge, based on a non-systematic search of the available literature, this is the first reported case of …

26.08.2026journal-article

Food Science and Human Wellness

Comparative screening identifies Lanmaoa asiatica polysaccharide as the most potent edible bolete polysaccharide against colorectal cancer with NRF2-GPX4-related redox imbalance

Qing Hu, Caiyun Zhang, Rongrong Sun, Mengyao Xia, Hao Meng, Huizhi Wang, Jianming Luo, Xichun Peng

Abstract Colorectal cancer (CRC) is one of the most common malignancies worldwide and remains a major cause of morbidity and mortality. Polysaccharides from edible boletes (BPs) have been reported to possess antitumor activity, but their direct effects on CRC remain poorly understood. In this study, polysaccharides derived from Suillus bovinus (SBP), a Boletus sp. closely related to B. recapitulatus (BP), Lanmaoa asiatica (LMP), and a Boletus sp. closely related to B. edulis (BEP) were evaluated in an AOM/DSS-induc …

26.08.2026journal-article

Frontiers in Immunology

Control of breast cancer patient-derived xenografts by CD70-targeted HIT-CAR T cells

Pieter L. Lindenbergh, Vinagolu K. Rajasekhar, Irina Linkov, Jorge Mansilla-Soto, Sophie A. Hanina, Michel Sadelain

CAR T cell therapies have shown clinical success in several tumor types, though not in breast cancer, for which advanced stages remain incurable. CD70 is expressed in a broad range of solid tumor types and is emerging as a molecular target for CAR T cells in renal and ovarian malignancies. Here we show that a subset of breast cancer cell lines and patient-derived xenografts express CD70, albeit to varying levels. Leveraging a recently developed HLA-independent T cell (HIT) receptor with greater sensitivity to CD70 …

26.08.2026journal-article

Frontiers in Oncology

Galectin-9, FABP4 and pentraxin-3 are associated with myocardial dysfunction and discriminate chemotherapy-related cardiac dysfunction in anthracycline-treated breast cancer: a single-centre retrospective study

Jincheng Ma, Zhiqiang Ma, Yanhui Cheng, Xiaoyun Li, Huiqing Song, Shuai Wang

Background Anthracycline-based chemotherapy improves breast cancer outcomes but may cause cancer therapy-related cardiac dysfunction (CTRCD). Biomarkers reflecting inflammatory and metabolic myocardial stress may complement imaging surveillance, but the combined value of galectin-9 (Gal-9), fatty-acid-binding protein 4 (FABP4) and pentraxin-3 (PTX-3) is unclear. Objective This study aimed to evaluate whether serum Gal-9, FABP4 and PTX-3 are associated with myocardial dysfunction and discriminate CTRCD. Methods This …

26.08.2026journal-article

Frontiers in Oncology

EUS features and clinical outcomes of gastric calcifying fibrous tumor: a retrospective analysis of 20 cases

Bing Bai, Qiuyu Liu, Bingxi Zhou, Baosong Liang, Shengli Kuang

Objective To analyze the endoscopic ultrasonography (EUS) features and clinical characteristics of gastric calcifying fibrous tumor (GCFT) to improve the endoscopic recognition of this entity. Methods A retrospective analysis was conducted on 20 consecutive patients with pathologically confirmed GCFT at Henan Provincial People’s Hospital from January 2018 to May 2025. EUS findings and clinical data were reviewed to summarize the endoscopic and clinical features of this rare lesion. Results Of the 20 patients, 12 (6 …

26.08.2026journal-article

Frontiers in Digital Health

A comparative study on the credibility of ischemic stroke treatment information on social media platforms: evidence from Weibo and REDnote

Jiayan Gu, Zihan Li, Jiajun Yang, Sen Miao, Juan Li, Lijuan Gu

Background Social media is a key channel for public health information, but its open nature leads to mixed quality of information regarding Ischemic Stroke (IS) treatment, which may mislead patient decisions. This study aimed to systematically compare IS treatment information published by professional and lay sources on two major Chinese social media platforms, Weibo and REDnote, in terms of content, engagement, and quality. Methods This study employed computational social science and Natural Language Processing (N …