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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

Neurology International

Rehabilitation Outcomes in Patients Who Regained Consciousness

Elena Aidinoff, Almothana Khatib, Anna Oksamitni, Ilana Gelernter, Lilach Front, Amiram Catz, Sharon Shaklai, Marina Motin, Corinne Serfaty, Deborah Rubin-Asher

Background/Objectives: Patients with prolonged disorder of consciousness (PDOC) who regained consciousness in intensive care for consciousness rehabilitation (ICCR) were referred to further brain rehabilitation (FBR). The current retrospective cohort study evaluated the functional and cognitive outcomes of FBR. Methods: We assessed outcomes in 258 PDOC patients during FBR and used multivariate regression analyses to examine the influence of demographic and clinical characteristics on outcomes. Results: During FBR, …

21.08.2026journal-article

Journal of Advances in Dental Practice and Research

Exercise-induced temporomandibular disorder in a young boxer managed successfully with physiotherapy: A detailed case report

Mehar Singh Malhi, Rajvir Singh

Temporomandibular joint disorder (TMD) comprises a group of musculoskeletal conditions affecting the temporomandibular joint (TMJ), masticatory muscles, and associated structures. Parafunctional habits such as clenching are well-recognized etiological factors; however, clenching associated with intense physical activity is often underreported. This case report describes a 21-year-old male boxer who presented with restricted mouth opening and jaw pain following repeated forceful clenching during weightlifting. Clini …

21.08.2026journal-article

International Journal of Web Information Systems

Explainable hate speech detection with multi-class rationale learning and multi-task learning

Yuta Honjo, Jianwei Zhang, Wei Zhang, Lin Li

Purpose High-performance hate speech detection models achieve high accuracy; however, their complex architectures make it difficult to interpret the basis of their predictions. Although methods focusing on explainability have been proposed, their effectiveness remains limited. This study aims to develop a hate speech detection model with improved explainability. Design/methodology/approach This study proposes an enhanced two-stage learning model for hate speech detection, consisting of rationale learning in the fir …

21.08.2026journal-article

Journal of Medicinal Chemistry

A Subcellular Keap1-Nrf2 Disruption Strategy for Atopic Dermatitis Therapy

Zixi Zhang, Jia Wu, Jingqi Liu, Daniel Shiu-Hin Chan, Chun-Yuen Wong, Jing Wang, Chung-Hang Leung, Wanhe Wang

Abstract Nuclear factor erythroid 2-related factor 2 (Nrf2) is a promising target for atopic dermatitis due to its role in skin barrier repair, yet effective modulators of Nrf2 are lacking. Here, we report an itaconate-iridium(III) complex conjugation strategy for the disruption of the Keap1-Nrf2 protein–protein interaction (PPI) for treating atopic dermatitis. The conjugate (1) specifically engages cytoplasmic Keap1 to restore Nrf2 activity, thus upregulating anti-inflammatory genes HO-1 and NQO1 while suppressing …

21.08.2026journal-article

African Journal of Health Nursing and Midwifery

Exploring the Contextual Factors Influencing the Implementation and Effectiveness of Community Health Worker–Led Malaria Community Case Management in Kailahun District, Sierra Leone

M. A., Koroma, L. S., Babawo, S., Mayhew, M. K., Rogers, B. E., Koroma, A. T., Bockarie, E. E., Babawo

Background. CHW-led malaria community case management (CCMm) extends services to rural, hard-to-reach communities in Kailahun District, Sierra Leone, where the malaria burden is heaviest; yet the same standardised intervention produces different outcomes across chiefdoms. This paper asks how contextual conditions enable or block the mechanisms through which CHWs produce outcomes. Methods. A qualitative realist evaluation using the Context–Mechanism–Outcome framework drew on six key informant interviews, three CHW c …

21.08.2026journal-article

Inflammatory Bowel Diseases

GLP-1 receptor agonist therapy is associated with increased symptomatic remission in ulcerative colitis: a matched cohort study

Budoor Alqinai, Swapna Gayam, Jennifer Hadam-Veverka

Abstract Background Ulcerative colitis (UC) remains associated with significant morbidity despite therapeutic advances. The impact of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on UC disease activity is not well defined. Methods We performed a retrospective cohort study using electronic health records from a single tertiary academic health system (2022-2024). Adults with UC initiating liraglutide or semaglutide for metabolic indications and maintained on therapy ≥ 12 weeks were included. A 1:1 matched co …

21.08.2026journal-article

Journal of Neuro-Oncology

Five-year changes in health-related quality of life after proton therapy in a primarily meningioma cohort: a prospective study

Per Fessé, Linda Åkeflo, Karin Ahlberg, Emelie Blomqvist, Per Fransson, Ingrid Kristensen, Kristin Kunni, Ulrica Langegård, Emma Ohlsson-Nevo, Katarina Sjövall

Abstract Purpose Long-term patient-reported outcomes after Proton beam therapy (PBT) remain insufficiently described for patients with benign intracranial and seller-region tumors. The aim of this study was to evaluate health-related quality of life (HRQoL) and brain tumor–specific symptoms over five years after PBT in a primarily meningioma cohort. Methods In this prospective cohort study, adults treated with PBT completed the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 and QLQ-BN20 …

21.08.2026journal-article

ACS Nano

Living Microbe-Driven Bioorthogonal Catalysts Enables Cytotoxin Generation, Cuproptosis and Lactate Depletion for Synergistic Tumor Therapy

Lili Xia, Xiangxuan Chao, Zitong Zhao, Xiaozhen Zhou, Chenyao Wu, Xinran Song, Wenli Zhou, Yuyao Li, Wei Feng, Yu Chen

Abstract Bioorthogonal chemistry provides a compelling strategy for in situ cytotoxin generation. However, the clinical translation of conventional bioorthogonal catalysts is impeded by poor tumor accumulation, insufficient targeting specificity, limited in vivo catalytic efficiency, and inadequate spatiotemporal control. Meanwhile, excessive lactate accumulation in the tumor microenvironment (TME) drives metabolic reprogramming, malignant progression, and therapeutic resistance. Here, we develop a living bacterial …

21.08.2026journal-article

The Canadian Journal of Psychiatry

Comparing Health System Costs for Recipients of Minimally Guided Internet-Based Cognitive Behavioural Therapy (iCBT) and Therapist-Guided CBT in Routine Care: A Cohort Study Using Ontario's Linked Health-Administrative Data: Comparaison des coûts pour le système de santé entre les personnes suivant une thérapie cognitivo-comportementale par Internet (TCCI) avec des orientations minimales et les personnes suivant une TCC menée par un ou une thérapeute en soins courants : étude de cohorte utilisant les données administratives de santé liées en Ontario

Evgenia Gatov, Claire De Oliveira, Gillian Strudwick, David Wiljer, Onil Bhattacharyya, Paul Kurdyak

Objective Internet-based Cognitive Behavioural Therapy (iCBT) is a scalable alternative to therapist-guided CBT, requiring fewer therapist resources. We compared health system costs in individuals receiving minimally guided iCBT (self-directed online modules with asynchronous therapist support) to those receiving therapist-guided CBT (scheduled, one-on-one sessions) in Ontario, Canada (January 2020–August 2021). Methods This retrospective cohort study leveraged linked health-administrative data to estimate person-c …

21.08.2026journal-article

Experimental Oncology

STUDY OF PREDICTIVE VALUE OF RAD51 EXPRESSION FOR THE EFFECTIVENESS OF PLATINUM-BASED THERAPY OF HIGH-GRADE SEROUS OVARIAN CARCINOMA

P. Gordiichuk, M. Doronina, O. Ponomarova, M. Gordiichuk, D. Shapochka, D. Melnyk, A. Tereshchenko

Background. The search for novel markers of predictive significance is an important issue in the management of ovarian cancer (OC) patients. Recently, the expression of the RAD51 protein, involved in homologous DNA repair has been shown to be predictive of platinum chemotherapy response in OC patients. Aim. To establish the relationship between the level of RAD51 protein expression in patients with high-grade serous ovarian carcinoma (SOC) after neoadjuvant platinum chemotherapy and the frequency of recurrence, dis …

21.08.2026journal-article

BMC Health Services Research

Adherence and clinical outcomes among patients with sickle cell disease receiving prophylactic therapy in Bamenda, Cameroon: a cross-sectional study

Leslie Tasha Mbapah, Dinayen Dieudonne Yusinyu, Geh Martin Meh, Midrelle Syntyche Tsague, Sandra Tabe Etaka, Mandeng Edgar Ma Liwa, Orock Clinton Achale, Che Desmond Shu, Ndzi Courage Mbing-Kuni, Djike Puepi Yolande Fokam

Abstract Background Long-term prophylactic therapy is central to sickle cell disease (SCD) care, but evidence on medication adherence and patient-reported outcomes in Cameroon remains limited. We assessed SCD medication adherence and compared clinical outcomes before and during clinic-based prophylactic therapy. Methods A cross-sectional study was conducted at St Maria Soledad Catholic Hospital in Bamenda, Cameroon, from August to October 2024. Participants with SCD who had received hydroxyurea and folic acid, with …

21.08.2026journal-article

Frontiers in Endocrinology

Correlation between the reduction of IL-6 and TNF-α with muscle mass restoration in hyperthyroid patients post-radioactive iodine therapy

Yuqian Ren, Cuijuan Zheng, Meng Wang, Yanzhi Wang

Objective To investigate whether dynamic resolution of IL-6 and TNF-α after radioactive iodine (RAI) therapy is a key determinant of muscle recovery in Graves’ disease and to evaluate their potential as longitudinal biomarkers. Methods A prospective cohort of 157 patients with Graves’ disease was enrolled. Skeletal muscle index (SMI) was assessed by dual-energy X-ray absorptiometry (DXA), and serum IL-6 and TNF-α were measured by enzyme-linked immunosorbent assay (ELISA). Patients were re-evaluated 6 months after 1 …

21.08.2026journal-article

International Journal of Molecular Sciences

Iron Oxide Nanozyme for Magnetothermal Activation of ER-TRPV1 Enables Efficient Intravesical Therapy of Bladder Cancer

Galong Li, Dongyan Li, Bin Lan, Yuanyuan Cheng, Hongxia Liang, Wenli Zhang, Xiaopan Xu, Hongbing Lu

Drug-mediated intravesical therapy is a widely used treatment approach for bladder cancer (BCa), which is limited by poor tumor accumulation and the toxicity of drugs. Herein, a facile approach utilizing magnetic hyperthermia therapy (MHT) for BCa treatment is reported through intravesical instillation of tumor-targeting iron oxide nanoparticles (IONPs), which are coated with anti-FGFR3 antibodies for specific binding to FGFR3 overexpressed on BCa cells. The antibody coating significantly enhanced targeting ability …

21.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Exploring the challenges that public transportation drivers face in Lebanon

Mahmoud Salam, Gladys Honein-AbouHaidar, Sawsan Abdulrahim

Background Public transportation drivers face numerous challenges, especially in countries experiencing economic crises. It is essential to gain a comprehensive understanding of these real-world issues. Objectives To explore the public transportation system in Lebanon and to identify the challenges faced by its drivers. Methods Following a convergent-parallel approach, interviews were held with stakeholders who provided insights into the transportation system and its regulatory policies. 63 taxi / bus drivers were …

21.08.2026journal-article

NeuroRehabilitation

Beyond Conventional Therapy in Parkinson's Disease Patients: The Impact of Visual Feedback Training on Balance and Trunk Control – A Prospective Cohort Study

Alessandro de Sire, Andrea Demeco, Andrea Parente, Andrea Racinelli, Angela Russo, Chiara Conte, Gianpaolo Ronconi, Marco Invernizzi, Nicola Marotta, Antonio Ammendolia

Background Postural instability and impaired balance are major contributors to disability and fall risk in individuals with Parkinson's disease (PD). Technology-assisted rehabilitation based on visual biofeedback may enhance the effects of conventional physiotherapy. This study aimed to evaluate the effects of a visual feedback training program combined with conventional physiotherapy on balance, mobility, and functional independence in patients with PD. Methods In this prospective cohort study, 21 patients with PD …

21.08.2026journal-article

Physiotherapy Research International

Alterations in Spatiotemporal Parameters in Patients With Lower‐Limb Amputation: A Systematic Review With Meta‐Analysis

Luis Augusto Mendes Fontes, Guilherme Auler Brodt, Adna Thalita do Nascimento Silva, Isabela Regina de Lima Andrade, Livia Barboza de Andrade

ABSTRACT Objectives To evaluate differences in spatiotemporal gait parameters in individuals with transfemoral (TFA) and transtibial amputation (TTA) compared with physically able individuals. Methods This systematic review with meta‐analysis was conducted according to the MOOSE guidelines. Cross‐sectional studies or clinical trials that assessed spatiotemporal gait parameters in adults with unilateral TFA or TTA were included. Searches were performed in Medline (via PubMed), CINAHL, Scopus, LILACS, Cochrane Librar …

21.08.2026journal-article

Computational Intelligence

Dual‐Path Higher‐Order Information Interaction With Time‐Frequency Attention and Multi‐Scale Feature Extraction Based Nested U‐Net for Speech Enhancement

Shaik AreefaBegam, Sunny Dayal Vanambathina

ABSTRACT Speech enhancement plays a crucial role in enhancing the perceptual quality and intelligibility of speech signals that are degraded by noise. Conventional U‐Net‐based architectures effectively capture local spectral patterns but exhibit limited long‐range dependency modeling and may propagate residual noise through skip connections. Transformer‐based approaches enhance global context modeling but often incur high computational cost and insufficient preservation of fine‐grained spectral cues, limiting real‐ …

21.08.2026journal-article

Journal of modern medicine

INFLUENCE OF INDIVIDUALIZED EARLY REHABILITATION ON INFLAMMATION, ENDOTHELIAL DYSFUNCTION, AND PULMONARY HEMODYNAMIC PARAMETERS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

A.Kh Abdullaev, J.O. Matkomilov

<p>This study evaluated the effect of an early comprehensive rehabilitation program—comprising physical ther­apy (exercise therapy), a herbal preparation, and magnetotherapy in addition to standard treatment and standard rehabilitation—on inflammation, endothelial dysfunction, and pulmonary hemodynamics in 127 patients with chronic obstructive pulmonary disease (COPD). The results demonstrated that in the main group, the levels of TNF-α de­creased significantly by 43.91–51.58%, VEGF by 49.50–50.46%, and Endothelin- …

21.08.2026journal-article

Medicine

Evaluating the efficacy and safety of macrolide therapy in primary ciliary dyskinesia

Masoumeh Ghasempour Alamdari, Paniz Pourpashang, Simin Khayatzadeh Kakhki, Malihe Sadat Rahimi Azghadi, Niloufar Ghanbari, Parisa Ashournia, Arezoo Akhlaghi, Ghazal Shariatpanahi

Background: Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterized by impaired ciliary function, defective mucociliary clearance, recurrent respiratory infections, and progressive respiratory morbidity. Macrolides, particularly azithromycin, have antibacterial, anti-inflammatory, and immunomodulatory properties and may therefore provide therapeutic benefit in PCD. This systematic review evaluated the efficacy and safety of macrolide therapy in patients with PCD. Methods: This systematic review wa …

21.08.2026journal-article

International Journal of Research Publication and Reviews

Integrating Infection Prevention and Occupational Therapy to Improve Rehabilitation Outcomes Among Medically Vulnerable Patients

Bridget Asamoah

Healthcare-associated infections remain a major threat to patient safety, recovery, and continuity of care, particularly among medically vulnerable populations whose underlying conditions, reduced immunity, prolonged hospitalization, or functional limitations increase susceptibility to infection. Rehabilitation services must therefore balance intensive therapeutic participation with measures that minimize exposure, transmission, and preventable complications. This paper examines the integration of infection prevent …

21.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Efficacy of Transcranial Direct Current Stimulation in Acute Ischemic Stroke

Qianqian Yao, Xiantong Gao, Quanye Ding, Zhuokun Li

Objective: To evaluate the efficacy and safety of transcranial direct current stimulation (tDCS) initiated strictly within the acute ischemic stroke. Design: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted via PubMed, Embase, and Cochrane Library. Outcomes included neurological deficit, upper limb and lower limb motor function, and functional independence. Data were synthesized using random-effects models to calculate weighted mean differences (WMD) and standardized mean d …

21.08.2026journal-article

Frontiers in Psychiatry

Efficacy of structured psychoeducational group therapy grounded in Yalom’s interpersonal principles for parents of adolescents with depression

Tongtong Wang, Qiyong Li, Tao Ding, Songying Fang, Menglan Zu, Yanli Zhao, Lin Ma

Objective To explore the efficacy of structured psychoeducational group therapy grounded in Yalom’s interpersonal therapeutic principles on parental anxiety, depressive symptoms, and family cohesion and adaptability among parents of adolescents with depression, and to provide clinical evidence for parent-focused family psychological support for adolescents with depression. Methods A total of 90 parents (45 couples) of adolescents aged 12–18 with depression were recruited from the outpatient department of a psychiat …

21.08.2026journal-article

Scientific Reports

Interpretable rehabilitation-oriented motion anomaly detection using wearable sensor data

Kumar Dorthi, Kiran Kumar Mamidi, Ravi Kanth Kotha, Neelima Bayyapu

Abstract Accurate detection of motion anomalies during physical rehabilitation is important for patient safety and recovery monitoring. Traditional assessment methods rely on visual observation. This often leads to subjective and inconsistent evaluations. To address this limitation, we propose a Support Vector-Guided Decomposition (SVGD) framework for semi-supervised rehabilitation-oriented motion anomaly detection using wearable sensor data. The framework integrates low-rank and sparse matrix decomposition with ma …

21.08.2026journal-article

Healthcare

Social Determinants of Healthcare Access: Horizontal Inequity in Rehabilitation Utilization and the Limits of Care in Mediating the Income–Depression Gradient in Türkiye

Derya Azim, Muhammed Emre Güvey, Sevde Betül Kara, Sümeyra Gündem, Ecenur Aydemir, Salim Yılmaz

Background/Objectives: Structural inequalities in access to healthcare persist even within systems that have achieved near-universal coverage, reflecting the enduring influence of social determinants of health on service utilization. This study examines horizontal inequity in rehabilitation and specialist care in Türkiye and investigates whether access inequality mediates the well-documented income–depression gradient. Methods: Analyzing the nationally representative 2022 Türkiye Health Survey (adults aged ≥15; N = …