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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Journal of Occupational & Environmental Medicine

The Effectiveness of Ergonomic Training and Chiropractic Treatment in Industrial Workers with Nonspecific Chronic Neck Pain: A Randomized Controlled Trial

Deniz Balikçi, Beyzanur Dikmen Hoşbaş, Ömer Şevgin

OBJECTIVE: To evaluate whether adding chiropractic treatment to ergonomic training improves pain, function, and sleep in industrial workers with chronic nonspecific neck pain. METHODS: Forty-five male industrial workers were randomized (15 per group) to ergonomic training plus chiropractic treatment (CTG), plus sham manipulation (SMTG), or alone (CG) for four weeks. Pain (VAS), biopsychosocial impact (BNQ), disability (NDI), and sleep quality (PSQI) were assessed before and after. The group × time interaction was t …

27.08.2026journal-article

Discover Oncology

Ovarian cancer tumor immune microenvironment and its clinical trial implications

Barbora Vavrušáková, Renata Bartošová, Michal Hendrych, Tomáš Kazda, Lukáš Moráň, Marek Svoboda

Abstract Ovarian cancer is the most lethal gynecologic malignancy, primarily because of late-stage diagnosis, rapid disease progression, and marked molecular and immunologic heterogeneity. It remains the leading cause of gynecologic cancer-related death, affecting approximately 1 in 70 women in developed countries over their lifetimes. Tumor development and progression are orchestrated within the tumor immune microenvironment, a dynamic and complex structural niche that supports malignant transformation and immune …

27.08.2026journal-article

Developmental Medicine & Child Neurology

Deep brain stimulation outcomes and management of childhood‐onset dystonia and associated hyperkinetic movements disorders

Sinead Barkey, Laura Ainaga, Eva Maria Navarrete Muñoz, Verity McClelland, Keyoumars Ashkan, Richard Selway, Harutomo Hasegawa, Daniel E Lumsden, Jean‐Pierre Lin, Hortensia Gimeno

Abstract Aim To examine longitudinal changes in self‐selected goals and dystonia severity over 1 year, 2 years, and 5 years after deep brain stimulation (DBS) in children and young people (CYP) with dystonia and other hyperkinetic movement disorders, using CYP and caregiver reports. Method The retrospective cohort study included follow‐up to 5 years after DBS, with the number of participants varying across time points. In the CYP group, 62 participants were included at the 1‐year follow‐up, 50 at 2 years, and 17 at …

27.08.2026journal-article

Arthroscopy, Sports Medicine, and Rehabilitation

Availability and Pricing of Orthobiologic Knee Injections Vary by Practice Type but Not by Community Socioeconomic Vulnerability in Suburban New York

Tracy M. Tauro, Benjamin Hershfeld, Katharine Chen, Ran Lampert, Adam D. Bitterman, Randy M. Cohn, Nicholas A. Sgaglione

Purpose To assess the availability, price transparency, and pricing of platelet‐rich plasma (PRP), bone marrow aspirate concentration, and stem cell injections for knee osteoarthritis (OA) among orthopaedic sports medicine (OSM) practices and alternative clinics in suburban New York and to evaluate the impact of the economic status of a population on the availability and pricing of biologic injections. Methods Between July and September 2025, OSM practices and alternative clinics offering PRP, bone marrow aspirate …

27.08.2026journal-article

Physics in Medicine & Biology

MGTP-Seg: A Mask Guidance and Text Prompting Network for Gross Tumor Volume Segmentation in Esophageal Cancer Radiotherapy

Chengwei Chen, Hongfei Sun, Yuxuan Yao, Yao Zheng, Yuefei Feng, Qifeng Wang, Wencheng Zhang, Yang Liu, Lina Zhao, Dong Huang

Abstract Accurate delineation of the gross tumor volume (GTV) is critical for determining the efficacy of radiotherapy in esophageal cancer. Conventional segmentation methods either rely solely on end-to-end learning from imaging features, which often struggle to address small tumor volumes and ambiguous boundaries, or incorporate coarse masks as spatial priors but fail to integrate the pathological semantics essential for clinical decision-making. This disconnect can lead to segmentation results that are poorly al …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Long-term outcomes following successful treatment of acute mesenteric ischemic event: A population-based observational study

Karri Kase, Merli Koitmäe, Annika Reintam Blaser, Kadri Tamme, Peep Talving, Marko Murruste

BACKGROUND There is a lack of studies reporting long-term outcomes in patients surviving initial event of acute mesenteric ischemia (AMI). AIM To identify population-based outcomes and risk factors for mortality according to AMI subtypes. METHODS We performed overall survival analysis of all enrolled AMI patients and follow-up investigation on patients who survived beyond index admission. The demographics, diagnostic and management variables, in addition to causes of death, were accrued from the Estonian National E …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Severe postoperative infections following surgery for digestive system diseases

Ya Liu, Li Chen

BACKGROUND Postoperative infection following digestive system surgery is a critical complication that leads to high rates of morbidity and mortality. Current studies on the incidence and, more importantly, the risk and microbiological factors related to these infections in patients undergoing surgery on the digestive system are lacking. Identifying such factors can aid in detecting patients who may be at post-operative infection risk and enable the modification of perioperative practices. AIM To describe the incide …

27.08.2026journal-article

Journal of Veterinary Pharmacology and Therapeutics

Pharmacokinetics and Efficacy Assessment of Long‐Term Ivermectin Treatment in Canine Demodicosis: Drug Disposition and Clinical Outcomes Relationship

S. Martínez, M. J. Del Sole, L. Maté, S. Sánchez Bruni, A. Lifschitz, M. Ballent

ABSTRACT Canine demodicosis is an inflammatory skin disease caused by Demodex canis mites. While newer isoxazoline classes currently represent the standard of care where licensed and available, prolonged ivermectin treatment remains an effective and cost‐effective alternative under specific socioeconomic contexts or clinical challenges associated with specific presentations, such as refractory pododemodicosis. Prolonged ivermectin treatment remains the primary choice, especially in resource‐limited settings and cer …

27.08.2026journal-article

Clinical Orthopaedics & Related Research

Is Femoral Head Decentration Reversible After Periacetabular Osteotomy for the Treatment of Developmental Dysplasia of the Hip?

Florian Schmaranzer, Alexander F. Heimann, Michael B. Millis, Ata M. Kiapour, David Liu, Young-Jo Kim, Eduardo N. Novais

Background Femoral head decentration, seen on MRI as a fluid gap between the femoral head and acetabulum, has recently been introduced as a sign of hip instability. Although periacetabular osteotomy (PAO) effectively corrects bony morphology in developmental dysplasia of the hip (DDH), it is unknown whether femoral head decentration is reversible after acetabular reorientation or whether it persists because of factors such as femoral version or intraarticular degeneration. Questions/purposes (1) Does femoral head d …

27.08.2026journal-article

Clinical Implant Dentistry and Related Research

Peri‐Implant Soft Tissue Phenotype Remodeling Following Peri‐Implantitis Surgery: A Prospective Profilometric Analysis

Hee‐Sun Choi, Seung‐Hyun Park, Seulbin Im, Da‐Mi Kim, Eun‐Kyoung Pang, Ignacio Sanz‐Martin, Jae‐Kook Cha

ABSTRACT Aim To characterize longitudinal changes in peri‐implant soft tissue phenotype following surgical therapy of peri‐implantitis. Materials and Methods Twenty‐one patients with superimposable intraoral scan datasets at four timepoints—pre‐operative (T0), intra‐operative (T1), 3‐month (T2), and 12‐month (T3) follow‐up—were included. Soft tissue parameters including mean mucosal thickness (mMT), supracrestal tissue height (STH), keratinized mucosal area, and volumetric shrinkage were assessed. Clinical paramete …

27.08.2026journal-article

Movement Disorders Clinical Practice

Interrater and Intrarater Reliability of the TWSTRS ‐Delphi Motor Severity Scale for Cervical Dystonia

Glenn T. Stebbins, Charles H. Adler, Alberto Albanese, Richard L. Barbano, Anna Rita Bentivoglio, Carlo Colosimo, Maria Fiorella Contarino, Dirk Dressler, Stewart A. Factor, Susan H. Fox, Victor S.C. Fung, Christopher G. Goetz, Joseph Jankovic, Hyder A. Jinnah, Wolfgang H. Jost, Marina A.J. Tijssen, Elena Moro, Joel S. Perlmutter, Stephen G. Reich, Ramon L. Rodriguez, Lawrence Severt, Natividad P. Stover, Marie Vidailhet, Julianne Lee, Cynthia L. Comella, David A. Peterson

Abstract Background Cervical dystonia (CD) motor severity is typically quantified with the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). An expanded version of the Motor Severity section of the TWSTRS (“TWSTRS‐Delphi”) has been previously evaluated for its clinimetric properties but not for inter‐ and intrarater reliability. Objective In this study we quantified inter‐ and intrarater reliability of the Motor Severity section of the TWSTRS‐Delphi for CD. Methods Ten raters familiar with the TWSTRS‐Del …

27.08.2026journal-article

Clinical Case Reports

Digital Implant Rehabilitation in Multiple Idiopathic Root Resorption: A Case Report

Shoresh Afnan, Thomas Alexander Cursiter Hunter, Kåre Jan Attramadal, Jashan Singh Kamboj

ABSTRACT Multiple idiopathic root resorptions (MIRs) represent a rare condition with uncertain etiology and limited treatment options, and they may compromise the prognosis of affected teeth. A digitally guided interdisciplinary approach combining cone‐beam computed tomography (CBCT) diagnostics, virtual implant planning, and immediate implant‐supported restoration can provide predictable, functional, and esthetic outcomes in complex cases.

27.08.2026journal-article

Environments

Role of a Wastewater Treatment Plant in the Dissemination and Control of Antimicrobial Resistance in Wastewater and Receiving Water

Vanesa Benito, Naroa Lopez-Herguedas, Maite Cabañas, Santos Paunero, Ane Rivas-Macho, Iker Alvarez-Mora, Manu Soto, Felipe Goñi-de-Cerio

Wastewater treatment plants (WWTPs) are key nodes in the environmental dissemination of antimicrobial resistance (AMR), although their net role as sources or barriers of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARG) under full-scale conditions remains insufficiently understood. This study evaluated the occurrence and dynamics of ARB and ARG in a full-scale urban WWTP and its receiving river over a two-year monitoring campaign. Samples were collected from the WWTP influent and effluent, a …

27.08.2026journal-article

Light: Science & Applications

Label-free ovarian cancer histopathological diagnosis using two-photon autofluorescence microscopy with a joint denoising and segmentation framework

Zhengyuan Pan, Naikun Song, Shanshan Cheng, Wen Pang, Hongen Liao, Yu Wang, Bobo Gu

Abstract Two-photon autofluorescence (TPAF) microscopy is a promising modality for rapid, label-free assessment of unstained tissue, but is fundamentally limited by the poor visibility of nuclei, which are one of the gold-standard cancer biomarkers, due to their negative contrast nature. A restoration method capable of distinguishing these signal voids from stochastic noise to render quantitative pathology is lacking. Here, we proposed a deep learning framework of AFN-DeSeg (Auto-Fluorescence Nuclei Denoising and S …

27.08.2026journal-article

European Journal of Therapeutics

Mapping Gaps and Improvement Targets in Large Language Model-Generated Melanoma Patient Education in a Non-English Setting

Niyazi Çetin, Ahmet Uğur Atılan

Objective: Large language models (LLMs) are increasingly being used to develop medical education materials; however, it remains unclear how reliable, readable, or guideline-compliant the content generated by these models is for non-English-speaking patient groups. We evaluated the quality of Turkish melanoma patient education texts generated by seven frontier LLMs. Methods: A standardized 22-item Turkish prompt, built from international melanoma guidelines, was put to seven models in zero-shot sessions: ChatGPT 4.0 …

27.08.2026journal-article

Frontiers in Plant Science

Genome-wide identification of the superoxide dismutase gene family in Lycium barbarum and their expression profiles under abiotic stress and phytohormone treatment

Xiaoyu Cao, Xiaorong Bai, Yingwu Li, Xuedong Hui, Jinfeng Niu, Xiaojie Liang, Yue Yin, Wei An

Background Superoxide dismutases (SODs) are crucial metalloenzymes that constitute the first line of defense against reactive oxygen species in plants under abiotic stress. Wolfberry ( Lycium barbarum ) is an economically important medicinal plant with notable stress tolerance, however, a comprehensive genome-wide analysis of its SOD gene family has not yet been performed. Results We identified ten wolfberry SOD genes ( LbaSODs ) and classified them into three subfamilies: iron-SODs (Fe-SODs), manganese-SODs (Mn-SO …

27.08.2026journal-article

International Journal of Innovative Technologies in Social Science

CURRENT ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPIES FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: A NARRATIVE REVIEW OF AVAILABLE AGENTS AND TREATMENT STRATEGIES

Gabriela Luba, Wiktoria Napiórkowska, Aleksandra Izabela Masłowska, Agata Kotłowska, Julia Lenkiewicz, Marcin Trzciński, Oliwia Lenkiewicz, Anna Gwóźdź-Broczkowska, Jakub Jonakowski, Julia Katarzyna Nowak

Background: Neovascular age-related macular degeneration (nAMD) is a leading cause of irreversible central vision loss in older adults. Intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy has transformed disease management, but the expanding range of agents and evolving dosing strategies has complicated therapeutic decision-making. Objective: To summarize the anti-VEGF agents currently available for nAMD, compare their efficacy, safety and durability, and evaluate contemporary treatment strateg …

27.08.2026journal-article

Mathematics

A Condition-Disentangled Representation Optimization Framework for Domain Generalization Under Distribution Shift: Application to Fault Diagnosis

Shiqi Zhao, Yaqiong Lv, Xiaohu Zhang, Jian Hao

Domain generalization under distribution shift remains a fundamental challenge in representation learning, where predictive models trained on multiple source domains are expected to generalize to previously unseen operating conditions. For rotating machinery fault diagnosis, variations in operating conditions often introduce domain-specific characteristics that interfere with fault-related representations, resulting in significant performance degradation across unseen domains. To address this issue, this paper form …

27.08.2026journal-article

Journal of Clinical Medicine

Prevalence and Predictors of Self-Reported Swallowing Difficulty in Community-Dwelling Older Adults

Lana Fluk, Yuval Nachalon, Amit Shiff, Haya Fogel-Grinvald, Nogah Nativ-Zeltzer

Objectives: Dysphagia in older adults is associated with malnutrition, aspiration, and reduced quality of life. This study aimed to estimate the prevalence of self-reported swallowing difficulties among community-dwelling older adults in Israel and to identify demographic, medical, and socioeconomic predictors. Method: In this cross-sectional study, 1064 community-dwelling adults aged ≥ 60 years (mean 75.1 ± 7.5 years; 68.1% female) completed an online questionnaire capturing demographics, medical diagnoses, physic …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Combined inflammation/nutrition-based prognostic score for overall survival in gastric adenocarcinoma: A retrospective cohort study

Mehmet Hanifi Çanakcı, Ilgaz Kayılıoğlu, Ahmet Şimşek, Tolga Dinç

BACKGROUND Gastric cancer is the fifth most common malignancy and the fourth leading cause of cancer-related death. The tumor-node-metastasis (TNM) staging system, while fundamental, does not account for systemic inflammation and nutritional status, which impact survival. AIM To assess the prognostic value of a novel inflammation/nutrition-based combined score (INCS) for predicting overall survival in patients undergoing curative gastrectomy for gastric adenocarcinoma. METHODS This retrospective cohort study includ …

27.08.2026journal-article

Frontiers in Medicine

Machine learning prediction of adverse events during minutes 15–30 of recovery in patients event-free at 15 min after sedated gastrointestinal endoscopy

Siyuan Huang, Jiayao Zhang, Lu Yin, Meiyuan Luo, Anna Jia, Dihong Chen

Background Sedated gastrointestinal (GI) endoscopy is widely used for diagnosis and treatment but may be complicated by respiratory and hemodynamic adverse events (AEs) during post-anaesthesia recovery. Early risk identification may support targeted monitoring and efficient allocation of recovery-care resources. This study aimed to develop and internally evaluate machine-learning (ML) models for identifying respiratory and hemodynamic AEs occurring during 15–30 min after awakening following sedated GI endoscopy. Me …

27.08.2026journal-article

Medicine & Science in Sports & Exercise

Knee Cartilage Composition, Morphology, and Function in Asymptomatic Recreational Runners, Non-Runners, and Obese Adults: A Matched 4HAIE MRI Study

Lukáš Slovák, Jan Plešek, Lucie Šustková, David Zahradník, Jaroslav Uchytil, Jan Šustek, Jiri Skypala, Jan Urbaczka, Miloš Golián, Miika T. Nieminen, Victor Casula, Daniel Jandačka

Introduction: Identifying early alterations in asymptomatic individuals with different physical activity levels and/or BMI is essential for understanding joint health before clinical symptoms develop. Purpose: The aim of this study was to compare cartilage composition, morphology, and subjective knee function among age- and sex-matched recreational runners (R), non-runners (NR), and obese individuals with BMI ≥ 30 kg/m²) (O). Methods: This cross-sectional study included 183 asymptomatic adults (61 age- and sex-matc …

27.08.2026journal-article

Infection

Postoperative CT-derived spleen volumetry for recurrence risk stratification after curative-intent surgery for hepatic alveolar echinococcosis

Lukas Endrös, Jochen Schneider, Marc Martignoni, Christian Brückner, Markus Mergen, Daniel Spitzl, Felianty Teresa, Manuel Nickel, Mara Goetz, Daniel Martinez Heinemann, Christian Maegerlein, Jan S. Kirschke, Rickmer Braren, Lisa Steinhelfer

Abstract Purpose To evaluate automated CT-derived spleen volumetry as an opportunistic imaging biomarker for postoperative risk stratification in patients with surgically treated hepatic alveolar echinococcosis (AE) and to compare its prognostic performance with clinical and laboratory parameters. Methods This retrospective single-center cohort study included consecutive patients undergoing curative-intent R0 resection for hepatic AE. Baseline was defined as the immediate postoperative CT. Automated spleen segmenta …

27.08.2026journal-article

Supportive Care in Cancer

Coordination of care in the context of primary brain tumors: Australian healthcare professionals’ exploration of the unspoken impact and clinical implications

Megan S. Jeon, Hannah Isaac, Joanne Shaw, Dianne M. Legge, Sharon He, Thomas Carlick, Eng-Siew Koh, Georgia K. B. Halkett, Brian Kelly, Mark B. Pinkham, Raymond J. Chan, Tamara Ownsworth, Haryana M. Dhillon, for the BRAINS Investigator Group, Meera Agar, Thea Blackler, Helen Haydon, Robyn Leonard, Anna Nowak, Kerryn Pike, Nicole Rankin, Ursula Sansom-Daly, Joel Rhee, Annie Miller, Kristi Milley, Mona Faris, Rachel Campbell, Katarzyna Lion, Jill Chen, Tiffany Fazon, Melinda Lyne, Sian Virtue-Griffiths, Jessica Buster, Emma McDougall

Abstract Aim People with primary brain tumor (PBT) and their families experience high distress and face challenges navigating their disease and treatment, healthcare systems, and/or survivorship. Quality brain tumor care coordination (BTCC) enables continuous, timely care according to the individual care needs of patients. We aimed to explore healthcare professionals’ (HCPs) practices and perceptions of BTCC. Methods We conducted semi-structured interviews with 12 HCPs (92% female) working with people with PBT from …