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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
18.08.2026journal-article

Antibiotics

Endophytic Fungal Metabolites as Modulators of Key Signaling Pathways in Chronic Diseases and Aging

Asiya Nazir, Prathap Bava, Arif Hussain, Touseef Amna, Mohammad Chand Jamali, Afsheen Raza, Jayanthi Barasarathi

Chronic diseases and aging-related disorders are driven by interconnected mechanisms, including oxidative stress, low-grade inflammation, metabolic dysregulation, and glycation. Targeting these overlapping pathways remains a major challenge for conventional single-target therapeutics. In this context, endophytic fungi have emerged as a promising source of bioactive metabolites with multi-target pharmacological potential. This review provides a mechanistic overview of endophyte-derived metabolites, including alkaloi …

17.08.2026journal-article

Arthritis Care & Research

Individuals with Multi‐Joint Osteoarthritis Demonstrate Larger Longitudinal Declines in Frailty: Data from the Canadian Longitudinal Study on Aging

Carson Halliwell, Rebecca Moyer, Myles W. O'Brien

Objective Test the hypothesis that multi‐joint osteoarthritis would modify the relation between time and frailty progression, where more affected joints would lead to larger declines over 6‐years compared to those without osteoarthritis using data from the Canadian Longitudinal Study on Aging. Methods Frailty was quantified using a frailty index at baseline, 3‐year, and 6‐year follow‐up. Osteoarthritis was self‐reported physician diagnosis of knee, hip, or hand. Participants were categorized as having none, one, tw …

17.08.2026journal-article

Journal of Public Health and Primary Care

Awareness, Acceptability, Utilization, and Unmet Need of Assistive Technologies among Older Adults in an Urban Community of Western Maharashtra

Sakshi Sharma, Akshay Misra, Indranil Samanta, Chetna Arora, Kunal Chatterjee

Abstract Background: Assistive technologies (ATs), such as spectacles, hearing aids, mobility aids, grab rails, and digital reminder tools, are essential for maintaining functional independence among older adults. However, evidence from Indian primary care settings on AT awareness, utilization, and unmet needs remains limited. Objectives: To assess the awareness, acceptability, utilization, and unmet need of ATs among older adults in an urban community of Western Maharashtra and identify factors associated with unm …

17.08.2026journal-article

Frontiers in Sleep

A comprehensive review of sleep disordered breathing in people with congenital heart disease

Kate Maxfield, Noah Weaver, Michelle Wei, Daniel Matloff, Meghana Partha, Michael D. Seckeler, Daniel Combs

Introduction Sleep disordered breathing (SDB) is known to be a comorbidity associated with congenital heart disease (CHD). This review evaluates the role of sleep disorders as a contributing factor to impairments in cardiovascular health, neurocognitive function, and health-related quality of life in individuals with CHD. Methods A narrative review was conducted across PubMed, Ovid, and Cochrane Library (1990–2025) searches for studies cross-referencing “congenital heart disease” or “Fontan circulation” with sleep- …

17.08.2026journal-article

International Journal of Software Engineering and Knowledge Engineering

A Survey of Machine Learning Techniques Used to Optimize BP Neural Networks for Software Aging Prediction

Abdulaziz Alshammari, Noraini Che Pa, Zhu Jiawen, Abdikadir Yusuf Mohamed, Amir Mohamed Talib, Abdulaziz Alsahli, Fahd Omar Alomary, Rodziah Atan

Software aging remains a persistent challenge in long-running software systems because performance degrades over time through resource exhaustion, memory leaks and related faults. To examine how supervised learning techniques are used to address this problem, this paper presents a search-based literature survey of 93 studies selected through predefined search strings and inclusion and exclusion criteria. The survey focuses on linear regression (LR), support vector machines (SVM), K-Nearest Neighbors (KNN) and backp …

17.08.2026journal-article

Healthcare

Association Between Phase Angle and AWGS 2025-Defined Sarcopenia in Community-Dwelling Older Adults

Masayuki Hoshi, Yui Miyazaki, Tomoka Ogata, Koei Ishida, Yuu Okabe, Misuzu Kusano, Tatsuya Nakanowatari, Toshimi Sato, Akihiko Asao, Natsumi Kimura, Maki Ogasawara, Yuko Horikoshi, Rie Sakuraba-Hirata, Akiomi Yoshihisa, Hiroshi Hayashi, Kazuaki Iokawa, Toshimasa Sone, Yoshitaka Shiba

Background/Objectives: Phase angle (PhA), derived from bioelectrical impedance analysis (BIA), has been proposed as an indicator of cellular health, nutritional status, and physical function. This study aimed to investigate the association between PhA, physical function, and sarcopenia defined according to the Asian Working Group for Sarcopenia (AWGS) 2025 criteria in community-dwelling older adults. In addition, we explored a preliminary PhA cutoff for discriminating women with prevalent sarcopenia. Methods: This …

17.08.2026journal-article

Healthcare

Clinical Blindness to Eating Disorders in Older Adults: A Qualitative Study of Primary Care Nurses’ Perspectives

Adriana V. Muñoz-Ortega, Lorenzo Mariano Juárez, Mikaela Willmer, Paula Conroy, Maria Engström, David Conde Caballero

Background/Objectives: Eating disorders (EDs) have historically been associated with young women, and their presence in older adults remains poorly recognized despite evidence that they can persist, recur, or emerge in later life. Primary care nurses are strategically positioned for community-based detection, yet their perspective has been scarcely explored. This study aimed to examine the experiences, perceptions, and described practices of primary care nurses regarding EDs and disordered eating in older adults, i …

17.08.2026journal-article

ARPHA Conference Abstracts

People, plant invaders and protection: understanding the human and social dimensions of plant invasions in protected areas

Maria Loreto Castillo, Ana Novoa, Pavel Pipek, Ivan Jarić, Alessandra Kortz, Rubén Rabaneda-Bueno, Reut Vardi, Josef Brůna, Petr Pyšek

Human influence is a key driver of plant invasions. Yet, invasion science has largely focused on ecological factors, often overlooking the human and social dimensions that shape the invasion process. The InvaSyn project aims to address this gap by identifying plant invasion syndromes that integrate these dimensions, ultimately improving our understanding of the context-dependent nature of biological invasions. To contribute to this aim, we draw on the Protected Areas and Invasive Alien Species (PROTIAS) database, d …

17.08.2026journal-article

Frontiers in Aging Neuroscience

P2X7 receptor-dependent microglia-astrocyte coupling in Alzheimer's disease: from eATP sensing to synaptic and proteostatic failure

Yiwen Li, Shiming Liu, Jiao Lan

Alzheimer's disease (AD) is characterized not only by amyloid-β and tau pathology but also by progressive failure of multicellular homeostasis. The P2X7 receptor (P2X7R), a low-affinity ATP-gated ion channel preferentially activated in extracellular ATP-rich pathological microenvironments, is well positioned to translate local tissue stress into sustained glial dysfunction. Although P2X7R has traditionally been studied as a microglial inflammasome-associated receptor, its broader significance may lie in coupling mi …

17.08.2026journal-article

Frontiers in Nutrition

The intake–adequacy gap in dysphagia nutrition: texture-modified foods, nutrient delivery and realised intake in older adults

Umar Shah, Darren Greetham, Steffen Hirth, Sadia Javed, Yashaswini Premjit, Pattanapong Tiwasing, John Lubaale, Haroon Rashid Naik, James Ball, Preston Walker, Rewati Raman Bhattarai, Stuart K. Johnson

Dysphagia is common among older adults in long-term care and is frequently managed using texture-modified foods (TMFs) aligned with the International Dysphagia Diet Standardisation Initiative (IDDSI). Although texture modification improves swallowing safety and standardisation, nutritional adequacy is often inferred from planned provision rather than verified at the level of actual consumption. This distinction is clinically important because swallowing impairment, fatigue, prolonged mealtimes, reduced appetite, se …

17.08.2026journal-article

Nutrition in Clinical Practice

Comparison of six nutritional screening tool‐based Global Leadership Initiative on Malnutrition criteria models for predicting activities of daily living in older patients with subacute stroke: A single‐center retrospective cohort study

Shinnosuke Ishida, Ryota Imai, Yu Kitaji, Satoshi Miyano, Yoshiyuki Kawano

Abstract Background The Global Leadership Initiative on Malnutrition (GLIM) recommends a two‐step diagnostic process consisting of initial screening for malnutrition risk followed by diagnostic assessment. We evaluated the association between GLIM‐defined malnutrition identified using six alternative first‐step screening tools and Functional Independence Measure (FIM)‐motor scores at discharge in older patients with subacute stroke. Methods This retrospective cohort study involved patients aged ≥70 years who were a …

17.08.2026journal-article

Nutrients

Muscle Strength and Physical Performance in Relation to Dietary Intake Among Older Men and Women

Małgorzata Kamila Pigłowska, Bartłomiej Konrad Sołtysik, Joanna Kostka, Tomasz Kostka, Agnieszka Guligowska

Background: The aim of this study was to examine the relationships between dietary intake and two key components of sarcopenia in older, sex- and age-matched men and women: muscle strength and physical performance. Methods: The study included 620 carefully selected community-dwelling adults aged 60 years and more (310 men and 310 women) matched by sex and age (±1 year; median age: 66 years). Body mass and body mass index were assessed. Dietary intake was evaluated using 24 h dietary recall questionnaire and analyze …

17.08.2026journal-article

LUMEN ET VIRTUS

PULSEIRA LOCALIZADORA SUSTENTÁVEL: TECNOLOGIA ASSISTIVA PARA A AUTONOMIA E SEGURANÇA DE IDOSOS, NEURODIVERGENTES E PESSOAS COM DOENÇAS NEURODEGENERATIVAS

Ana Clara Cerqueira Lima Dos Santos, Evelyn Rodrigues Da Silva, Rayka Ravena Lima Da Silva

O aumento da população idosa e a crescente prevalência de diagnósticos do Transtorno do Espectro Autista (TEA) e doenças neurodegenerativas, como o Alzheimer, evidenciam uma demanda urgente por tecnologias assistivas acessíveis para garantir a autonomia e segurança desses grupos. O presente trabalho teve como objetivo principal desenvolver e validar uma Pulseira Localizadora Sustentável, um dispositivo de baixo custo para monitoramento em tempo real de idosos, neurodivergentes e pessoas com doenças neurodegenerativ …

17.08.2026journal-article

FPOP Bulletin: Psychology of Older People

A paradigm shift in dementia care: From ‘Behaviours that Challenge’ to be managed to ‘Behavioural Expressions of Need’ to be met

Joanna Marshall, Sally Stapleton, Carolien Lamers

Following the publication of BPS Division of Clinical Psychology guidelines on psychosocial alternatives to psychotropic medication for Behaviours that Challenge in Dementia (James et al., 2024), momentum has been growing towards a paradigm shift (Kuhn, 1962). This paper outlines the developments in this work so far, which have included a panel discussion and vote at UK Dementia Congress, a presentation at North East and Cumbria Regional FPOP meeting, a publication in the Journal of Dementia Care, a position statem …

17.08.2026journal-article

Indonesian Contemporary Nursing Journal (ICON Journal)

Effectiveness of Self-Care Management–Based Interventions for Blood Pressure Control in Older Adults with Hypertension: A Systematic Review

Reni Zulfitri, Puteri Dianti, Auliana Tesa

Aims: Hypertension is a prevalent chronic condition among older adults, yet blood pressure control remains suboptimal due to clinical complexity, limited health literacy, and treatment adherence challenges. Self-care management–based interventions have been promoted to improve patient engagement and blood pressure control. This systematic review evaluated the effectiveness of self-care management–based interventions in improving blood pressure control among older adults with hypertension. Methods: A systematic lite …

17.08.2026journal-article

Corporate Law & Governance Review

Laws and regulations for the protection of older consumers in digital commerce in a developing country

Rosatorn Toobunterng, Nithima Yuenyong

The rapid expansion of digital commerce has increased opportunities for consumers while exposing older adults in developing countries to greater risks of fraud, privacy violations, and unequal access to legal remedies. As Thailand becomes an aging society, existing consumer protection laws may no longer adequately address these vulnerabilities (Organisation for Economic Co-operation and Development [OECD], 2023). This study examines the factors influencing online purchasing behavior among older consumers and evalua …

17.08.2026journal-article

Frontiers in Public Health

Effectiveness of sexual health interventions in reducing risky sexual behaviors among people living with HIV: a network meta-analysis and systematic review

Yixuan Li, Yanxiao Gao, Nancy Reynolds, Qiaoyue Lu, Ziqi Qin, Yuqiong Duan, Pingwu Wang, Tao Liu, Ling Jie Cheng, Wenru Wang, Honghong Wang, Xueling Xiao

Introduction Numerous sexual health interventions have been employed to promote safer sexual practices among people living with HIV (PLWH). However, their effectiveness remains uncertain. Objectives This review aimed to assess and rank the effectiveness of different sexual health interventions targeting risky sexual behaviors in PLWH. Methods We systematically searched PubMed, Elsevier, the Web of Science, CINAHL, and the Cochrane Library for studies published between January 2010 and June 2025. Randomized controll …

17.08.2026journal-article

Frontiers in Neurology

Dose–response and recovery trajectories of fall prevention rehabilitation in older patients with vertigo: a retrospective cohort study based on vestibular and gait impairment phenotypes

Xiao-Qing Zhang, Jing Qin, Hong-Min Wang, Li Liu, Jie Zhang, Ya-Hui Wang, Wen-Ting Wang, Rui-Ting Zhu, Hong-Lei Guo

Background Vertigo and dizziness are common in older adults and are associated with a significantly increased risk of falls. Fall prevention rehabilitation therapy (FPRT) is recommended, but current prescriptions remain largely empirical and do not account for heterogeneity in baseline vestibular and gait impairments. The dose–response relationship between rehabilitation hours and functional improvement, and how baseline phenotypes are associated with recovery trajectories, are poorly understood. Methods This retro …

17.08.2026journal-article

Salando Health Journal

Health Status, Family Support, and Independence in Activities of Daily Living among Adults Aged 45 Years and Older at Posbindu Tabeo, Central Sulawesi

Rina Tampake, Jurana Jurana, Dwi Yulia Vasya, Rahmat Kurniawan, Selvi Alfrida Mangundap

Background: Independence in performing activities of daily living (ADL) is an important indicator of functional health among middle-aged and older adults. Health status and family support are considered important factors associated with the ability to maintain daily functioning. This study aimed to analyze the association between health status, family support, and independence in ADL among adults aged 45 years and older at Posbindu Tabeo, Kayumalue Ngapa, within the working area of Tawaeli Public Health Center, Cen …

17.08.2026journal-article

Frontiers in Aging Neuroscience

Direct toll-like receptor 4 inhibition in Alzheimer’s disease models: a focused scoping review of inflammatory, amyloid-handling, and functional outcomes

Xiaolu Ren, Xinyu Jin, Ling Li, Fang Li

Objective This focused scoping review evaluated whether direct toll-like receptor 4 (TLR4) inhibition, antagonism, or genetic suppression in Alzheimer’s disease (AD)-related models was associated with concordant inflammatory, amyloid-β (Aβ)-handling, and functional outcomes. Methods Original AD- or Aβ-related animal, cellular, and ex vivo studies were eligible when they directly inhibited, antagonized, or genetically suppressed TLR4 signaling using pharmacological approaches, including TAK-242/CLI-095/resatorvid, I …

17.08.2026journal-article

Frontiers in Dementia

Dementia inclusive retail outlets: a scoping review of strategies to support people living with dementia in the retail industry

Megan Rose Readman, Sarah Fox, Abigail Godfrey, Annabel Farnood, Sarah K. Smith, Olivia Luijnenburg, Lettie Wareing, Manjot Brar, Rebecca Ramos, Megan Polden

Background Supermarket shopping is a valued everyday activity that supports autonomy and social engagement for people living with dementia (PLWD). However, engagement with retail environments can be challenging due to difficulties with product recognition and selection, navigation, and sensory overwhelm. Despite increasing efforts to develop dementia-friendly communities, there is currently no comprehensive synthesis of evidence examining how PLWD experience retail environments or which strategies effectively suppo …

17.08.2026journal-article

Adolescência e Saúde

Efficacy Of High Tone Power Therapy Combined With A Targeted Physical Therapy Program For Overactive Bladder In People With Multiple Sclerosis: A Randomized Controlled Trial

Mohamed H. Hussien, Eman S. Fayez, Salma H. Khalil, Amr M. Sayed, Jasmine M. Mahmoud, Mohamed H. Marzouk

Objective: Overactive bladder (OAB) is a predominant urinary tract disorder in people with multiple sclerosis (PwMS). We sought to assess the therapeutic effects for high tone therapy (HTT) in treatment of OAB symptoms and quality of life (QOL) in PwMS. Methods: A prospective, randomized controlled study included forty remitting relapsing MS patients of both sexes (RRMS) with moderate OAB symptoms were randomly allocated into 2 equal groups: The treatment group (GA) received HTT + targeted physical therapy program. …

17.08.2026journal-article

Journal of Enterprising Communities: People and Places in the Global Economy

Rethinking entrepreneurial orientation and performance: a 30 – year bibliometric review towards more contextual and sustainable perspectives

Ahmad Rafiki, Amir Hasnaoui, Sebastian Cruz, Redwan Yasin

Purpose This paper examines the evolution of research on Entrepreneurial Orientation (EO) and its relationship with firm performance over a 30-year period. While EO remains a central construct in entrepreneurship studies, concerns persist regarding its conceptual consolidation, limited contextual diversity, and the peripheral treatment of sustainability, gender and community-based perspectives. By reassessing the field through a systematic and bibliometric lens, the study aims to clarify dominant trajectories, iden …

17.08.2026journal-article

Perspectives on Sexual and Reproductive Health

How Common Is Abortion Coercion? Evidence From a Large US Sample of People Assigned Male at Birth

Karen Trister Grace, Elizabeth Miller, Elizabeth Tobin‐Tyler

ABSTRACT Objective Reproductive coercion encompasses a range of partner behaviors that violate reproductive autonomy, including contraceptive sabotage, coercion to become pregnant, and controlling pregnancy outcome (i.e., forced continuation or termination). Coerced abortion is often cited as a reason to restrict abortion access. We examined data on the prevalence of reproductive coercion behaviors including abortion coercion. Methods We conducted a cross‐sectional survey of 3199 people living in the United States …