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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

European Journal of Therapeutics

Mapping Gaps and Improvement Targets in Large Language Model-Generated Melanoma Patient Education in a Non-English Setting

Niyazi Çetin, Ahmet Uğur Atılan

Objective: Large language models (LLMs) are increasingly being used to develop medical education materials; however, it remains unclear how reliable, readable, or guideline-compliant the content generated by these models is for non-English-speaking patient groups. We evaluated the quality of Turkish melanoma patient education texts generated by seven frontier LLMs. Methods: A standardized 22-item Turkish prompt, built from international melanoma guidelines, was put to seven models in zero-shot sessions: ChatGPT 4.0 …

27.08.2026journal-article

Frontiers in Plant Science

Genome-wide identification of the superoxide dismutase gene family in Lycium barbarum and their expression profiles under abiotic stress and phytohormone treatment

Xiaoyu Cao, Xiaorong Bai, Yingwu Li, Xuedong Hui, Jinfeng Niu, Xiaojie Liang, Yue Yin, Wei An

Background Superoxide dismutases (SODs) are crucial metalloenzymes that constitute the first line of defense against reactive oxygen species in plants under abiotic stress. Wolfberry ( Lycium barbarum ) is an economically important medicinal plant with notable stress tolerance, however, a comprehensive genome-wide analysis of its SOD gene family has not yet been performed. Results We identified ten wolfberry SOD genes ( LbaSODs ) and classified them into three subfamilies: iron-SODs (Fe-SODs), manganese-SODs (Mn-SO …

27.08.2026journal-article

International Journal of Innovative Technologies in Social Science

CURRENT ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPIES FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: A NARRATIVE REVIEW OF AVAILABLE AGENTS AND TREATMENT STRATEGIES

Gabriela Luba, Wiktoria Napiórkowska, Aleksandra Izabela Masłowska, Agata Kotłowska, Julia Lenkiewicz, Marcin Trzciński, Oliwia Lenkiewicz, Anna Gwóźdź-Broczkowska, Jakub Jonakowski, Julia Katarzyna Nowak

Background: Neovascular age-related macular degeneration (nAMD) is a leading cause of irreversible central vision loss in older adults. Intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy has transformed disease management, but the expanding range of agents and evolving dosing strategies has complicated therapeutic decision-making. Objective: To summarize the anti-VEGF agents currently available for nAMD, compare their efficacy, safety and durability, and evaluate contemporary treatment strateg …

27.08.2026journal-article

Mathematics

A Condition-Disentangled Representation Optimization Framework for Domain Generalization Under Distribution Shift: Application to Fault Diagnosis

Shiqi Zhao, Yaqiong Lv, Xiaohu Zhang, Jian Hao

Domain generalization under distribution shift remains a fundamental challenge in representation learning, where predictive models trained on multiple source domains are expected to generalize to previously unseen operating conditions. For rotating machinery fault diagnosis, variations in operating conditions often introduce domain-specific characteristics that interfere with fault-related representations, resulting in significant performance degradation across unseen domains. To address this issue, this paper form …

27.08.2026journal-article

Journal of Clinical Medicine

Prevalence and Predictors of Self-Reported Swallowing Difficulty in Community-Dwelling Older Adults

Lana Fluk, Yuval Nachalon, Amit Shiff, Haya Fogel-Grinvald, Nogah Nativ-Zeltzer

Objectives: Dysphagia in older adults is associated with malnutrition, aspiration, and reduced quality of life. This study aimed to estimate the prevalence of self-reported swallowing difficulties among community-dwelling older adults in Israel and to identify demographic, medical, and socioeconomic predictors. Method: In this cross-sectional study, 1064 community-dwelling adults aged ≥ 60 years (mean 75.1 ± 7.5 years; 68.1% female) completed an online questionnaire capturing demographics, medical diagnoses, physic …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Combined inflammation/nutrition-based prognostic score for overall survival in gastric adenocarcinoma: A retrospective cohort study

Mehmet Hanifi Çanakcı, Ilgaz Kayılıoğlu, Ahmet Şimşek, Tolga Dinç

BACKGROUND Gastric cancer is the fifth most common malignancy and the fourth leading cause of cancer-related death. The tumor-node-metastasis (TNM) staging system, while fundamental, does not account for systemic inflammation and nutritional status, which impact survival. AIM To assess the prognostic value of a novel inflammation/nutrition-based combined score (INCS) for predicting overall survival in patients undergoing curative gastrectomy for gastric adenocarcinoma. METHODS This retrospective cohort study includ …

27.08.2026journal-article

Frontiers in Medicine

Machine learning prediction of adverse events during minutes 15–30 of recovery in patients event-free at 15 min after sedated gastrointestinal endoscopy

Siyuan Huang, Jiayao Zhang, Lu Yin, Meiyuan Luo, Anna Jia, Dihong Chen

Background Sedated gastrointestinal (GI) endoscopy is widely used for diagnosis and treatment but may be complicated by respiratory and hemodynamic adverse events (AEs) during post-anaesthesia recovery. Early risk identification may support targeted monitoring and efficient allocation of recovery-care resources. This study aimed to develop and internally evaluate machine-learning (ML) models for identifying respiratory and hemodynamic AEs occurring during 15–30 min after awakening following sedated GI endoscopy. Me …

27.08.2026journal-article

Medicine & Science in Sports & Exercise

Knee Cartilage Composition, Morphology, and Function in Asymptomatic Recreational Runners, Non-Runners, and Obese Adults: A Matched 4HAIE MRI Study

Lukáš Slovák, Jan Plešek, Lucie Šustková, David Zahradník, Jaroslav Uchytil, Jan Šustek, Jiri Skypala, Jan Urbaczka, Miloš Golián, Miika T. Nieminen, Victor Casula, Daniel Jandačka

Introduction: Identifying early alterations in asymptomatic individuals with different physical activity levels and/or BMI is essential for understanding joint health before clinical symptoms develop. Purpose: The aim of this study was to compare cartilage composition, morphology, and subjective knee function among age- and sex-matched recreational runners (R), non-runners (NR), and obese individuals with BMI ≥ 30 kg/m²) (O). Methods: This cross-sectional study included 183 asymptomatic adults (61 age- and sex-matc …

27.08.2026journal-article

Infection

Postoperative CT-derived spleen volumetry for recurrence risk stratification after curative-intent surgery for hepatic alveolar echinococcosis

Lukas Endrös, Jochen Schneider, Marc Martignoni, Christian Brückner, Markus Mergen, Daniel Spitzl, Felianty Teresa, Manuel Nickel, Mara Goetz, Daniel Martinez Heinemann, Christian Maegerlein, Jan S. Kirschke, Rickmer Braren, Lisa Steinhelfer

Abstract Purpose To evaluate automated CT-derived spleen volumetry as an opportunistic imaging biomarker for postoperative risk stratification in patients with surgically treated hepatic alveolar echinococcosis (AE) and to compare its prognostic performance with clinical and laboratory parameters. Methods This retrospective single-center cohort study included consecutive patients undergoing curative-intent R0 resection for hepatic AE. Baseline was defined as the immediate postoperative CT. Automated spleen segmenta …

27.08.2026journal-article

Supportive Care in Cancer

Coordination of care in the context of primary brain tumors: Australian healthcare professionals’ exploration of the unspoken impact and clinical implications

Megan S. Jeon, Hannah Isaac, Joanne Shaw, Dianne M. Legge, Sharon He, Thomas Carlick, Eng-Siew Koh, Georgia K. B. Halkett, Brian Kelly, Mark B. Pinkham, Raymond J. Chan, Tamara Ownsworth, Haryana M. Dhillon, for the BRAINS Investigator Group, Meera Agar, Thea Blackler, Helen Haydon, Robyn Leonard, Anna Nowak, Kerryn Pike, Nicole Rankin, Ursula Sansom-Daly, Joel Rhee, Annie Miller, Kristi Milley, Mona Faris, Rachel Campbell, Katarzyna Lion, Jill Chen, Tiffany Fazon, Melinda Lyne, Sian Virtue-Griffiths, Jessica Buster, Emma McDougall

Abstract Aim People with primary brain tumor (PBT) and their families experience high distress and face challenges navigating their disease and treatment, healthcare systems, and/or survivorship. Quality brain tumor care coordination (BTCC) enables continuous, timely care according to the individual care needs of patients. We aimed to explore healthcare professionals’ (HCPs) practices and perceptions of BTCC. Methods We conducted semi-structured interviews with 12 HCPs (92% female) working with people with PBT from …

27.08.2026journal-article

Journal of the American Geriatrics Society

Impact of ACE Units and Geriatrics Consults on Adherence to the 4Ms and Patient Outcomes

Sandra Zeng, Julia Adler‐Milstein, Robert Thombley, James D. Harrison, Melody Luo, W. John Boscardin, Sarah Ngo, Stephanie Rogers

ABSTRACT Background The Age‐Friendly Health Systems (AFHS) movement, guided by the 4Ms framework has been widely adopted to improve care for older adults. While specialized inpatient models such as Acute Care for Elders (ACE) units and Geriatrics Consults aim to improve outcomes, gaps remain in understanding how these models align with 4Ms adherence and their relationship to patient outcomes. Methods We conducted a retrospective observational study of 28,833 hospital encounters for patients aged ≥ 65 at an academic …

27.08.2026journal-article

Reports

Verification Index for the Repositioning of a Single Implant Analog in the Correct Place: A Clinical Technical Case Report

Socratis Thomaidis

Background and Clinical Significance: Implant impressions can present inaccuracies, affected by many factors, such as impression technique, impression material, and parallelism or lack thereof among the implants. The use of a verification index can assess the accuracy of the mastercast and can be used in order to adjust the inaccuracy of the mastercast. This article presents a technical variation in established verification-index procedures, followed by implant analog repositioning, which can be used in case of an …

27.08.2026journal-article

Journal of Eating Disorders

Improvements in sleep, weight, and eating-disorder symptoms following off-label leptin treatment in an adolescent with chronic anorexia nervosa and insomnia: a case report

Alexander Dück, Hang Zhu, Judith Melinat, Monika Kruzer, Christoph Berger, Michael Kölch, Martin Reinhardt, Hannes Brehme, Annelie Zimmermann, Linda Frintrop, Olaf Reis

Abstract We report off-label administration of human recombinant leptin (metreleptin) over a 12-day period in a 17-year-old female adolescent with chronic anorexia nervosa (AN) and clinically significant insomnia. Two observation windows are distinguished throughout: a short-term window between day 1 (pre) and day 12 (post) of dosing, and a longer-term window between day 12 and the two-month follow-up (d + 60), capturing both changes temporally associated with leptin administration and the course of continued weigh …

27.08.2026journal-article

Neuro-Oncology

145 Implementing Vorasidenib in Clinical Practice: A Single-Centre Real-World Service Evaluation

Brooke Smart, Lorna Raymond, Antonia Creak, Liam Welsh, Ella Nicklin, Matteo Isolani, Ozofu Omuemu, Francesca Solda, Nicola Rosenfelder

Abstract Introduction The phase 3 INDIGO trial demonstrated significantly improved progression-free survival with Vorasidenib in patients with residual/recurrent IDH-mutant grade 2 oligodendroglioma and astrocytoma, supporting its integration into routine neuro-oncology practice. We undertook a real-world service evaluation at the Royal Marsden Hospital to assess toxicity, monitoring burden, and implications for wider UK implementation ahead of the anticipated appraisal by the National Institute for Health and Care …

27.08.2026journal-article

Neuro-Oncology

101 Independent replication and validation of nanopore-based long read sequencing and methylome classification for rapid brain tumour diagnosis

Vassili Crispi, Luke Ames, Joanne Stockton, Sana Manan, Nicola Chadderton, Lisa James, Sahar Sanai, Tracy Bright, Rajwinder Rai, Santosh Nagaraju, Ute Pohl, Philipe Taniere, Andrew Beggs, Colin Watts, Victoria Wykes

Abstract Introduction Integrated histopathological-molecular analysis is essential to diagnose and guide precision therapies in brain tumours. Whilst standard of care (SoC) diagnostics takes weeks, long read sequencing (LRS) on Oxford Nanopore Technology (ONT) platform and bioinformatics research tools provide rapid diagnosis within hours/days. We independently replicated ONT-LRS diagnostic assay within the NHS. Methods Patients undergoing brain tumour surgery were prospectively consented for surplus tissue samplin …

27.08.2026journal-article

Neuro-Oncology

42 The case for rapid molecular diagnosis; The power of PPIE

Simon Newman, Rachel Roberts, Helen Bulbeck, Lillie Pakzad-Shahabi, Ameeta Retzer, Stuart Smith, Matt Loose, Victoria Wykes

Abstract Introduction With over a hundred distinct molecular diagnostic entities, timely and accurate diagnosis is essential. A Network of Excellence (NoE) is being proposed to deliver rapid (<3 days) molecular diagnosis. To inform the funding application for the NoE, a PPIE survey was developed as a joint initiative between The Brain Tumour Charity, Brainstrust, BERTI-West Midlands and Imperial College London. Methods The survey ran between 13-19 January 2026 and was shared through major brain tumour patient an …

27.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Effects of psychological interventions on competitive anxiety and athletic performance in golfers: a systematic review and meta-analysis

Longhui Li, Zilong Zhao, Xuewen Li, Yang Yi

Abstract Background Competitive anxiety is common in golf and can negatively affect athletic performance. Psychological interventions are widely used to manage competitive anxiety and enhance performance; however, evidence specific to golfers has not yet been systematically synthesized. This study aims to evaluate the effects of psychological interventions on competitive anxiety and athletic performance in golfers. In addition, subgroup analyses were conducted to explore potential sources of variation in interventi …

27.08.2026journal-article

Nutrients

Development and Internal Validation of a Clinical Risk Score for Hypovitaminosis D in Italian Adults Aged ≥50 Years Attending Osteoporosis and Metabolic Bone Disease Centers

Ranuccio Nuti, Luigi Gennari, Bruno Frediani, Stefano Gonnelli, Daniela Merlotti, Carla Caffarelli, Giovanni Minisola, Antonino Catalano, Nazzarena Malavolta, Monica Pinto, Giulia Letizia Mauro, Vito Mascolo, Cristiano Maria Francucci, Vincenzo Vinicola, Anna Capozzi, Maria Punzo, Orazio Falla, Luca Dalle Carbonare, Serena Guiducci, Rosario Coltraro, Agostino Gaudio, Domenico Maria Carlucci, Alessandra Randazzo, Eleonora Mastria, Colin Gerard Egan, Mariangela Morelli, Giovanni Tripepi

Background/Objectives: Hypovitaminosis-D is a highly prevalent condition worldwide, associated with adverse skeletal and extra-skeletal outcomes. Increasing demand for serum 25-hydroxyvitamin D (25(OH)D) testing points toward the need for simple tools to identify individuals at risk and optimize laboratory use. We aimed to develop and validate a clinical risk score for predicting hypovitaminosis-D based on easily assessable risk factors. Methods: This cross-sectional study included 1408 adults aged ≥50 years (1286 …

27.08.2026journal-article

Effectiveness of Adherence-Focused Interventions and Contemporary Predictors of Treatment Success in Drug-Sensitive Tuberculosis in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis (2018–2023)

Effectiveness of Adherence-Focused Interventions and Contemporary Predictors of Treatment Success in Drug-Sensitive Tuberculosis in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis (2018–2023)

Moh. Khairul Hassan

Drug-sensitive tuberculosis (TB) treatment success in low- and middle-income countries (LMICs) has historically fallen short of the WHO's 85% benchmark. Predictors of treatment success are well described, but newer adherence-focused interventions, including digital tools introduced since 2018, have not been synthesized alongside contemporary evidence on predictors. Methods. A systematic review and meta-analysis followed PRISMA guidelines and covered the period from January 2018 to April 2023 across PubMed, ScienceD …

27.08.2026journal-article

Clinical Cancer Research

Adrenergic regulation of cancer immunity

Jingjing Zhu, Pierre-Hubert Desimpel, Constance Gérard, Benoit J. Van den Eynde

Abstract The nervous and immune systems engage in extensive bidirectional crosstalk that shapes tumor progression and therapeutic response. Among the neuro-immune pathways involved in cancer, adrenergic receptor signaling has emerged as a key regulator of the tumor microenvironment. In this review, we summarize current understanding of the distinct roles of β- and α2-adrenergic receptor signaling in cancer immunity and their therapeutic implications. β2-adrenergic receptor signaling promotes immune suppression by i …

27.08.2026journal-article

Frontiers in Medicine

Nanomaterials-enabled point-of-care diagnostics for pathogens

Jiao Wu, Dengchao Wang, Wanping Ye, Juan He, Yayun Jiang

Nanomaterials, with their unique physicochemical properties, have emerged as important enabling components for improving the performance of point-of-care testing (POCT) technologies for pathogen detection. Many conventional POCT methods still face challenges in sensitivity, specificity, multiplexing capability, and quantitative accuracy, particularly when applied to low-abundance pathogens in complex clinical samples. This review first summarizes the functional roles of representative nanomaterials in pathogen POCT …

27.08.2026journal-article

European Journal of Heart Failure

Treatment effects of dapagliflozin in patients with aortic stenosis undergoing transcatheter aortic valve implantation across left ventricular ejection fraction

Sergio Raposeiras Roubín, Rafael Gonzalez-Manzanares, Ignacio Amat-Santos, María Melendo Viu, David Dobarro, Diego López Otero, Luis Nombela Franco, Livia Gheorge, Jorge Sanz-Sánchez, Baladrón Zorita Carlos, Soledad Ojeda, Andrés Iñiguez Romo, Antonio Jesús Muñoz García, Victoria Vilalta, Gabriela Veiga Fernández, Juan Gabriel Córdoba Soriano, Ander Regueiro, Miriam Sandín Rollán, Xacobe Flores Ríos, Aitor Uribarri, Roberto Martín Reyes, Rafael Romaguera, Pablo Avanzas, Sergio García Blas, Juan A Franco-Peláez, Javier Martín Moreiras, José Ramón Gonzalez Juanatey, Gabriela Tirado, German Calle, José Luis Díez, Sandra Santos-Martínez, Rocío González Ferreiro, Erika Muñoz García, Xavier Carrillo Suarez, Xoan Sanmartín, Nieves Gonzalo, Alejandro Gutierrez Barri, Lluis Asmarats, Felipe Díaz Del Hoyo, Santiago Camacho Freire

Abstract Aims Sodium–glucose cotransporter 2 (SGLT2) inhibitors improve outcomes in heart failure (HF) across the left ventricular ejection fraction (LVEF) spectrum, but patients with severe valvular heart disease have been excluded from pivotal trials. We investigated the efficacy and safety of dapagliflozin across the full range of baseline LVEF in elderly patients undergoing transcatheter aortic valve implantation (TAVI). Methods and results DapaTAVI was a pragmatic, multicentre, randomized, open-label trial wit …

27.08.2026journal-article

Frontiers in Medicine

An easy-to-use model for screening type 2 myocardial infarction in geriatric patients with acute coronary syndrome: a retrospective cohort study

Yun-yue Luo, Hui Wang, Xiao-ya Ma, Yue Li, Wu-lin Li, Yue Liu, Yu-xin Wang, Wen-hui Kang, Jian-jun Xia, Fei Wang

Objective In this study, we aimed to develop and validate an easy-to-use model for screening type 2 myocardial infarction (T2MI) in geriatric patients with acute coronary syndrome (ACS). Method From January 2017 to December 2022, 891 geriatric patients who were clinically diagnosed with ACS and who underwent coronary angiography visited the Chest Pain Center of the Emergency Department at Jiading District Central Hospital affiliated Shanghai University of Medicine & Health Sciences were included. Univariate and …

27.08.2026journal-article

Journal of Craniofacial Surgery

Upper Eyelid Blepharoplasty Reduces Perceived Age: An Artificial Intelligence-Based Analysis

Zeynep Erdoğan Çetin, Begüm Yılmaz, Ahmet Can Çiftçi

Upper eyelid blepharoplasty is a commonly performed procedure for periorbital rejuvenation; however, objective evaluation of its aesthetic outcomes remains limited. This study aimed to assess changes in perceived age following upper blepharoplasty using an artificial intelligence (AI)-based age estimation model. In this retrospective cohort study, patients who underwent isolated upper blepharoplasty between January 2022 and January 2025 were included. Standardized preoperative and postoperative (3–6 mo) facial phot …