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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Journal of Clinical Oncology

Medical Therapy for Hormone Receptor-Positive, HER2-Negative Stage I-III Breast Cancer: ASCO Living Guideline, Version 2026.1.0

Jennifer L. Caswell-Jin, Mark R. Somerfield, Muhammad Ali Khan, Gretchen G. Kimmick, Shilpi Gupta, Kara Kenan, Namrata Peswani, Dawn L. Hershman, Brenda J. Ernst, Brittany E. Harvey, Gregor Krings, Nicholas P. McAndrew, Irbaz Bin Riaz, Ines Vaz-Luis, Cynthia Villarreal-Garza, Japneet Kaur Oberoi, Muhammad Hussnain Sadiq, Huan He, Ramaa Chitale, Michael J. Hassett

PURPOSE To provide recommendations on use of medical therapies for patients with stage I-III hormone receptor-positive, HER2-negative breast cancer. METHODS An Expert Panel including patient representation completed a systematic review of the evidence and formulated recommendations for practice. Eligible studies included patients with stage I-III hormone receptor-positive, HER2-negative breast cancer and evaluated neoadjuvant or adjuvant chemotherapy, endocrine therapy, immunotherapy, or targeted therapy. Outcomes …

26.08.2026journal-article

Scientific Reports

Construction and validation of a nomogram for predicting lymphovascular invasion in advanced gastric cancer: a retrospective study of 1019 patients

Guangxu Zhu, Jianjun Qu, Shengjie Zhou, Chunxiao Liu, Xuren Lu, Xin Yin, Yunhao Jiao, Qingshun Zhu, Yuzhi Chen

Abstract This study aimed to identify independent risk factors for LVI in advanced gastric cancer (AGC) patients and to develop a nomogram for predicting LVI risk, thereby facilitating individualized clinical risk assessment. Clinicopathological data were retrospectively collected from 1019 AGC patients who underwent radical gastrectomy at the First Affiliated Hospital of Shandong Second Medical University between December 2019 and December 2024. Univariate and multivariate logistic regression analyses were perform …

26.08.2026journal-article

Cancer and Metastasis Reviews

Molecular biomarkers in metastatic clear cell renal cell carcinoma treated with first-line immune combinations: a systematic review of phase III randomized clinical trials by Meet-URO group

Anna Amela Valsecchi, Michele Maffezzoli, Maria Concetta Cursano, Fabrizio Di Costanzo, Andrea Malgeri, Mattia Alberto Di Civita, Brigida Maiorano, Carlo Messina, Giuseppe Procopio, Davide Bimbatti, Sebastiano Buti, Sara Elena Rebuzzi, Massimo Di Maio

Abstract Immune checkpoint inhibitor (ICI)–based combinations represent the standard first-line treatment for metastatic clear cell renal cell carcinoma (mRCC), although robust biomarkers for treatment selection remain undefined. We conducted a systematic review to identify biomarkers assessed in randomized clinical trials (RCTs) on first-line ICI-based regimens. Following PRISMA guidelines, we searched PubMed, Web of Science and Scopus (January 2018–October 2025) for phase III RCTs investigating first-line ICI-bas …

26.08.2026journal-article

Biomedicines

An L1CAM-Positive Fibroblast-Associated Stromal State Is Associated with Reduced T/NK Cytotoxicity Features in Colorectal Cancer

Jian Zou, Yingna Cai, Miao Sun, Lingyu Zhang, Chengkuan Zhao, Xiaolong Wu, Yi Liu, Jinyan Chen, Yuming Liang, Xiaoxu Zhao, Shuyao Zhang

Background/Objectives: L1 cell adhesion molecule (L1CAM) has been implicated in colorectal cancer progression, but its cellular source and immune microenvironmental context remain incompletely defined. This study aimed to characterize the expression pattern, cellular localization and immune-associated features of L1CAM in colorectal cancer using public bulk and single-cell datasets. Methods: TCGA, GTEx and CPTAC/UALCAN datasets were used to assess L1CAM expression, protein abundance and clinical associations across …

26.08.2026journal-article

Frontiers in Medicine

Hydroxyurea treatment for sickle cell disease in Nairobi informal settlements: a retrospective cohort study

Maria Vittoria De Vita, Matilu Mwau, Anastasia Omoding, Washington Njogu, Gianfranco Morino, Caleb Mike Mulongo, Annette Aigner, Lena Oevermann

Background Sickle Cell Disease (SCD) causes acute and chronic complications. Hydroxyurea (HU) reduces vaso-occlusive crises (VOCs) and improves patients’ outcomes. However, evidence on the real-world implementation and effectiveness of HU in resource-limited primary care settings, particularly those serving informal settlements, remains scarce. This study evaluates HU use and its effects in two Nairobi clinics serving informal settlements. Methods We retrospectively analyzed 2,206 clinical visits from 328 SCD (HbSS …

26.08.2026journal-article

Frontiers in Medicine

Laparoscopic ureteral anastomosis to a bladder diverticulum for the treatment of postoperative ureteral fistula: a case report

Jiansheng Xiao, Guohao Wu, Ping Li, Handa Zheng, Zhihui Chen, Feng Luo, Huilan Luo, Caiyong Lai, Dongming Ye

Objective To investigate the feasibility and potential indications of laparoscopic ureteral anastomosis to a bladder diverticulum for the treatment of ureteral fistula in the setting of complex reoperative pelvic surgery. Case presentation A 75-year-old man with a 7-year history of progressive dysuria underwent transabdominal laparoscopic bladder diverticulectomy and cystolithotomy combined with transurethral holmium laser enucleation of the prostate for benign prostatic hyperplasia–related bladder outlet obstructi …

26.08.2026journal-article

Annals of Surgical Oncology

KRAS and TP53 Circulating Tumor DNA are Prognostic in Localized Pancreatic Cancer

Krishay Sridalla, Dominic J. Vitello, Madison Cox, Larissa Masnyk, Amy Wells, Alex Horowitz, Dhavan Shah, Jasmine K. Machhi, Vishvetha Rengaraju, Anastasia Chibucos, Claire Shen, Lauren M. Janczewski, John Abad, Kevin Dawravoo, David J. Bentrem, Lawrence J. Jennings, Qiang Zhang, Akhil Chawla

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) carries high mortality despite neoadjuvant chemotherapy (NAC) and surgical resection, creating an urgent need for prognostic biomarkers to guide treatment. We aimed to determine whether circulating tumor DNA (ctDNA) detected by next-generation sequencing (NGS) predicts survival in patients with localized PDAC. Methods Patients with localized PDAC were prospectively enrolled at an academic institution between October 2020 and November 2024 (NCT04616131). Pa …

26.08.2026journal-article

Frontiers in Oncology

“From misdiagnosis to precision medicine: strengthening pediatric neuro-oncology care in LMICs toward equitable pLGG outcomes”

Lorena V. Baroni, Nichoans B. George, Erin E. Crotty, Eric Bouffet, Mohamed S. Abdelbaki

Pediatric brain tumors—particularly pediatric low-grade gliomas (pLGG)—represent a major survivorship inequity between high-income countries (HICs) and low- and middle-income countries (LMICs). While pLGG is highly curable in optimal-resource settings, outcomes in LMICs remain suboptimal due to delays in diagnosis, limited neurosurgical capacity, restricted access to molecular testing, and significant variability in pathology accuracy and treatment accessibility. Data from international pathology review programs hi …

26.08.2026journal-article

Frontiers in Medicine

Precision medicine and parental experience: a longitudinal study of psychosocial responses to germline genomic results in pediatric oncology

Meaghann S. Weaver, Jessica S. Flynn, Jiaming Li, Gabrielle M. Armstrong, Lynn W. Harrison, Belinda N. Mandrell, Zachary T. Wooten, Liza-Marie Johnson, Kim E. Nichols, Katianne M. Howard Sharp

Introduction Precision medicine has become central to pediatric oncology, with germline genomic sequencing commonly integrated into routine care. Families must interpret complex genomic findings during emotionally vulnerable periods, generating mixed reactions ranging from clarity and relief to anxiety and uncertainty. Palliative care clinicians, genetic counselors, psychologists, social workers, and oncology providers may each contribute to supporting families as they interpret and integrate these findings over th …

26.08.2026journal-article

Frontiers in Oncology

Minimal residual disease guides postoperative therapy in a patient with ALK-rearranged adenocarcinoma: a case report

Xinghong Xian, Ke Wang, Liwen Wang, Hua Ke

This case report explores the role of circulating tumor DNA (ctDNA)-based minimal residual disease (MRD) monitoring in predicting tumor recurrence or metastasis after consolidative surgery in a patient with ALK-rearranged non-small cell lung cancer (NSCLC). We present a case of a 43-year-old female patient with stage IVA ALK-rearranged NSCLC who initially responded to six months of Alectinib targeted therapy, underwent consolidative surgery with postoperative pathology confirming complete response in the resected p …

26.08.2026journal-article

Journal of the American Academy of Orthopaedic Surgeons

Anterior Cervical Diskectomy and Fusion versus Minimally Invasive Posterior Cervical Foraminotomy for the Treatment of Cervical Radiculopathy: A Meta-Analysis

Marc Boutros, Guy Awad, Christèle Asmar, Raphael Asmar, Francis C. Lovecchio

Background: Cervical radiculopathy can be managed surgically with anterior cervical diskectomy and fusion (ACDF) or minimally invasive posterior cervical foraminotomy (MIS-PCF). ACDF is widely used and provides indirect decompression and stabilization, while MIS-PCF preserves motion, avoids fusion-related complications, and may offer advantages in perioperative recovery. The aim of this meta-analysis was to compare surgical, patient-reported, and safety outcomes of MIS-PCF versus ACDF to guide clinical decision mak …

26.08.2026journal-article

The Laryngoscope

Implementation of a Novel Subspecialty Outpatient Palliative Medicine Head and Neck Cancer Clinic

Christine G. Gourin, Carole Fakhry, Nyall R. London, Leila J. Mady, Wayne M. Koch, Wojciech K. Mydlarz, David W. Eisele, Kaitlyn M. Frazier, Harry Quon, Aliyah Pabani, Brandi R. Page, Carmen Kut, Ana P. Kiess, Karim Boudadi, Chengcheng Gui, Christine Hann, Maie St. John

ABSTRACT Objectives Head and neck cancer (HNC) patients have high palliative care (PC) needs. We reviewed our initial experience with a novel subspecialty HNC outpatient PC clinic, led by a Hospice and Palliative Medicine fellowship‐trained HNC surgeon. Methods We retrospectively reviewed 142 patients referred to a novel subspecialty HNC PC clinic between July 2023 and March 2025. Symptom evaluation included the revised Edmonton Symptom Assessment System (ESAS‐r), Patient Health Questionnaire‐9 (PHQ‐9) for Depressi …

26.08.2026journal-article

Healthcare

Real-World Effectiveness and Safety of Esketamine Nasal Spray in Treatment-Resistant Depression: A Retrospective Observational Study

Mostafa A. Sayed Ali, Palanisamy Amirthalingam, Hanan Alshareef, Mohammed Zayed Alassiry, Ahmed Samir Elshenawy, Sayed Hosam Eldin Mansour, Ahmed Aljabri

Background/Objectives: This study evaluated the real-world effectiveness and safety of intranasal esketamine plus oral antidepressants compared with venlafaxine-based oral antidepressant therapy in adults with moderate-to-severe treatment-resistant depression (TRD). Methods: This retrospective cohort study used electronic medical records from a mental health hospital between January 2023 and December 2025. Adults with moderately severe or severe major depressive disorder who had not responded adequately to at least …

26.08.2026journal-article

Frontiers in Aging

Effect of sarcopenia and paraspinal muscle morphology on conservative treatment outcomes in lumbar spinal stenosis: a prospective cohort study

Zhangmeng Xu, Tao Xu, Jing Guo, Jinshun Zou, Jiajia Luo, Fan Chen, Xin Zhang, Ji Wu

Introduction The impact of sarcopenia on postoperative outcomes in lumbar spinal stenosis (LSS) is well documented, but its role in conservative treatment remains unclear. In this prospective cohort study, we examined the association between sarcopenia and outcomes after conservative treatment in elderly LSS patients and explored whether paraspinal cross-sectional area (CSA) and fat percentage mediate this relationship. Methods Elderly LSS patients undergoing conservative treatment at Sichuan Provincial Orthopedic …

26.08.2026journal-article

The Kaohsiung Journal of Medical Sciences

Pretreatment Prediction of Tumor Recurrence in Breast Cancer After Neoadjuvant Systemic Therapy Using Machine Learning With Clinical and CT Radiomics Features

Huei‐Yi Tsai, Jo‐Ching Wang, Wei‐Shiuan Chung, Jui‐Sheng Hsu, Shu‐Yen Lin, Ming‐Feng Hou, Ming‐Chung Chou

ABSTRACT This study aimed to develop machine learning models for predicting tumor recurrence in breast cancer before neoadjuvant systemic therapy (NST) by integrating clinical and radiomic features derived from pretreatment computed tomography (CT). We retrospectively enrolled 235 patients with 237 breast tumors who underwent contrast‐enhanced CT before NST. Datasets were randomly divided into five‐fold training and testing sets using semi‐random partitioning to ensure similar clinical characteristics between the t …

26.08.2026journal-article

Neurological Sciences

Cervical range of motion and patient-reported outcomes in patients undergoing surgical treatment for degenerative pathology of the subaxial cervical spine (C3–C7)

Claudio Cornali, Claudia Riva, Francesco Belotti, Emma Sala, Marco Mazzali, Nicola Pagani, Simona Serioli, Riccardo Bergomi, Marco Maria Fontanella, Luca Zanin

Abstract Background Degenerative subaxial cervical (C3–C7) disease often requires surgery when conservative care fails, yet the relationship between post-operative cervical range of motion (ROM) and patient-reported outcomes is poorly defined. We evaluated post-operative ROM and its cross-sectional association with clinical outcomes. Methods In a retrospective cohort with cross-sectional outcome assessment, 100 patients operated between 2015 and 2021 (anterior or posterior approach, with or without instrumentation) …

26.08.2026journal-article

Journal of modern medicine

METHODS FOR THE PREVENTION AND TREATMENT OF SEPSIS IN PATIENTS WITH DIABETES MELLITUS

K.J. Matmurotov, S.S Xudayorov, I.Y Yakubov, U.G. Voxidov

<p>Diabetes mellitus is an important risk factor for the development of infectious complications, particularly diabetic foot infections, purulent-necrotic soft tissue infections, and sepsis. Hyperglycemia, micro- and macroangi­opathy, peripheral neuropathy, reduced tissue perfusion, and delayed wound healing create favorable conditions for a severe course of infection.</p><p style="text-align: justify;">Objective. To evaluate a comprehensive strategy for the prevention and treatment of sepsis in patients with diabe …

26.08.2026journal-article

Frontiers in Oncology

Diagnostic value of peripheral blood leukocyte parameters, NE-WX, LY-Y, MO-WY, MO-Y, MO-Z, and NE-SFL, in lung cancer

Wenqian Tian, Youhua Yuan, Yahui Hu, Lu Bai, Lan Gao

Introduction We aimed to assess the diagnostic potential of six leukocyte parameters (NE-WX, LY-Y, MO-WY, MO-Y, MO-Z, and NE-SFL) for lung cancer by analysing 423 patients, 39 benign cases, and 346 healthy controls. Methods The results of these six leukocyte parameters were compared among groups using the Kruskal–Wallis H test. Multivariate logistic regression was used to analyze correlations between NE-WX, LY-Y, MO-WY, MO-Y, MO-Z, NE-SFL, and lung cancer diagnosis. Patients were randomly grouped into training and …

26.08.2026journal-article

Biology of Sex Differences

Pan-cancer single-cell atlas reveals sex-biased SPP1+ macrophage-associated crosstalk and its implications for immunotherapy

Huancheng Fu, Yajiao He, Yiqi Deng, Qilang Xiang, Shiting Huang, Huayun Yan, Zhixiang Ren, Heng Xu, Yang Shu

Abstract Advancements in cancer biology have increasingly highlighted the crucial role of sex in influencing cancer progression and therapeutic outcomes. Nevertheless, current research remains largely focused on overall populations, overlooking the impact of sex. This gap underscores the need for a detailed understanding of how sex differences manifest within the tumor microenvironment (TME). We performed a comprehensive analysis of sex differences by integrating a large-scale single-cell RNA sequencing atlas compr …

26.08.2026journal-article

Journal of Applied Clinical Medical Physics

Dosimetric impact of aperture‐restricted VMAT on heart dose in breast cancer treated with regional nodal irradiation

Anh Hong Duong, Mandeep Kaur, Sunil W. Dutta, Tsegawbizu Gebru, Jacob Adams, Mark Cicchino, Reshma Jagsi, Sheela Hanasoge, Oluwatosin Kayode, Eduard Schreibmann, Hania Al‐Hallaq, Matthew Thomas, Xiaofeng Yang, Shadab Momin, Justin Roper, Kirk Luca, Jie Ding

Abstract Background Volumetric modulated arc therapy (VMAT) is increasingly used for breast and chest wall (CW) treatment with regional nodal irradiation (RNI) because of its ability to sculpt dose around complex target volumes. However, VMAT can increase low‐dose radiation to surrounding normal tissues and particularly increase cardiac dose. Purpose To evaluate the dosimetric impact of a strategic aperture‐restricted beam geometry, compared with traditional open‐field geometry in VMAT planning for comprehensive le …

26.08.2026journal-article

Current Issues in Molecular Biology

Antibody–Drug Conjugates in Lung Cancer: Promise, Progress, and Persistent Challenges

Panagiotis Paliogiannis, Giorgia Fara, Angelo Zinellu, Alessandro Giuseppe Fois, Giuseppe Palmieri

Lung cancer is currently the most frequently diagnosed malignancy worldwide, accounting for approximately 12.4% of all cancers and, despite major advances in molecularly targeted therapies and immunotherapy, represents the leading cause of cancer-related mortality, In recent years, antibody–drug conjugates (ADCs) have emerged as a novel therapeutic strategy, combining the specificity of monoclonal antibodies with the potent cytotoxic activity of highly active payloads to selectively target tumor cells while limitin …

26.08.2026journal-article

Journal of Imaging Informatics in Medicine

Attention-Guided TransMorph for Real-Time Tumor Tracking in Cine-MRI

Konstantinos Georgas, Theodoros P. Vagenas, Ioannis A. Vezakis, Ioannis Kakkos, George K. Matsopoulos

Abstract Magnetic Resonance Imaging (MRI) is a key modality in cancer treatment, providing high soft tissue contrast for the visualization of tumors and internal anatomy. Radiotherapy, which is widely used in treatments, requires precise tumor segmentation to ensure targeting the true tumor and minimizing radiation exposure to healthy tissues. In this regard, real-time automatic tumor tracking from cine-MRI can provide accurate tumor localization supporting adaptive radiotherapy. Conventional image registration tec …

26.08.2026journal-article

Stem Cell Research & Therapy

GMP manufacturing, quality characterization, and GLP-based preclinical evaluation of human nasal turbinate–derived stem cells for the treatment of rheumatoid arthritis

Hyun Ji Lee, Jung Ho Jeon, Junwon Choi, Min Young Ahn, Ye Sol Park, Hyo Min Song, Seong Yeon Yoo, Youngjae Park, Seung-Ki Kwok, Sun Hwa Park, Sung Won Kim

Abstract Background Human nasal turbinate-derived stem cells (hNTSCs) are tissue-derived adult stem cells that are isolated from surgically discarded nasal turbinate tissue and exhibit robust proliferative capacity, and stable phenotypic properties. Unlike conventional MSCs, hNTSCs, although classified as tissue-derived adult stem cells, exhibit MSC-like phenotypes but display distinct gene expression patterns and functional properties that may be advantageous for indications of inflammatory and autoimmune disease. …

26.08.2026journal-article

Amino Acids

Spermidine in Colorectal cancer: friend or foe?

Sonia Coni, Rosa Bordone, Luca Campea, Shohei Ohno, Gianluca Canettieri, Enzo Agostinelli

Abstract Colorectal cancer (CRC) is a leading cause of cancer-related mortality, and its incidence is rising among individuals, especially young, underscoring the need for novel therapeutic strategies. CRC development is driven by genetic and epigenetic alterations in key oncogenic pathways and is accompanied by profound reprogramming of polyamine metabolism. In this context, spermidine (SPD), a central polyamine produced downstream of the MYC–ODC axis, is regarded as a pro-tumorigenic metabolite that sustains CRC …