BMC Women's Health
Randomized controlled trial of adjunctive zinc-containing vaginal hydrogel following fluconazole therapy for vulvovaginal candidiasis
Abstract Background Recurrent and persistent vulvovaginal candidiasis remain clinically challenging, and supportive strategies that improve post-treatment microbiological stability are needed. Zinc-containing vaginal hydrogel may influence local host–pathogen interactions, but clinical data on its adjunctive use after fluconazole are limited. Methods This single-center, two-arm, parallel-group randomized clinical trial compared standard oral fluconazole therapy alone with fluconazole followed by adjunctive zinc-con …