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Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

The Oncologist

IUC26661-86 Real-world outcomes in patients with Metastatic Hormone-Sensitive Prostate Cancer treated with androgen deprivation therapy and Apalutamide - A single centre study

K Marchon, S Brown, K Swaminathan, S Adeyemi, G Kapur

Abstract Background Apalutamide, in combination with androgen deprivation therapy (ADT), is used to treat patients with metastatic hormone-sensitive prostate cancer (mHSPC). However, real-world evidence describing its effectiveness and tolerability remains limited. This study aimed to assess outcomes in mHSPC patients treated with apalutamide at a single centre. The primary objective was to evaluate treatment-related adverse events. Secondary objectives include overall survival, prostate-specific antigen (PSA) and …

21.08.2026journal-article

Aesthetic Plastic Surgery

Pilot Study of Combined Tranexamic Acid Therapy in Breast Reduction – Intravenous and Local Infiltration

Margarida Silva, Pedro Machado, António Sousa Barros, António Costa-Ferreira

Abstract Background Tranexamic acid (TXA) reduces perioperative blood loss in several surgical fields; however, its role in breast reduction surgery remains unclear. This study aimed to evaluate the effect of combined TXA therapy (intravenous and local infiltration) on postoperative outcomes of patients who underwent modified Liacyr Ribeiro breast reduction. Methods We conducted a controlled, non-randomized pilot study of patients who underwent bilateral reduction mammoplasty by the same surgeon. The intervention g …

21.08.2026journal-article

Nature Communications

CD11b agonist GB1275 potentiates oncolytic bacterial therapy against pancreatic cancer in mouse tumor models

Bin Zhang, Meng Guan, Xiao-Ting Xie, Jia-Hua Zou, Kai Cheng, Yuan-Di Zhao, Bo Liu, Jin-Xuan Fan, Qiu-Ran Xu

Abstract Oncolytic bacteria are microorganisms with cytotoxic activity capable of lysing cancer cells while simultaneously activating both innate and adaptive immune responses to exert anti-tumor effects. However, the innate immune activation targeting oncolytic bacteria within the tumor microenvironment (TME) is a limiting factor. Here we find that the CD11b-targeting agonist GB1275 can modulate bacteria-immune interaction and inhibit the infiltration of CD11b⁺ innate immune cells such as neutrophils and macrophag …

21.08.2026journal-article

Healthcare

Comparison and Agreement of Criteria for Classifying Improvement in Walking Ability During Inpatient Rehabilitation After Spinal Cord Injury

Urška Puh, Tea Čuk, Bojan Čeru, Gaj Vidmar

Background/Objectives: To evaluate classification of improvement and agreement of walking-ability improvement criteria derived from outcome measures of walking capacity and performance among inpatients with spinal cord injury (SCI). Methods: Retrospective analysis of admission and discharge data from adults with SCI in the single-centre database from years 2020 to 2023: Six-minute Walk Test (6MWT), Ten-metre Walk Test (10MWT), Walking Index for Spinal Cord Injury; selected items of Spinal Cord Independence Measure …

21.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Disability management and work ability in healthcare workers with a history of breast cancer: An occupational medicine perspective

Vincenzo Crispino, Elpidio Maria Garzillo, Livia Reggiani, Giuseppe Porciello, Angelo Lauro, Maria Grazia Lourdes Monaco, Monica Lamberti, Anna Rita Corvino

Background Breast cancer is the most common cancer among working-age women, with implications for employment continuity, particularly in the healthcare sector. Objective This study aims to characterize the clinical and professional profile of healthcare workers with a history of breast cancer and to assess their residual work capacity using the Work Ability Index (WAI) in relation to their work history, cancer treatments and post-diagnosis organizational adjustments. Methods an observational cross-sectional study w …

21.08.2026journal-article

Annals of Medicine & Surgery

Before the bolus: why anti-amyloid therapy must become part of every stroke code

Abdul S. Khaliq, Kaleem Khan

Anti-amyloid monoclonal antibodies provide disease-modifying treatment options for selected patients with early symptomatic Alzheimer disease, but introduce new challenges for acute stroke care. Amyloid-related imaging abnormalities (ARIA) are often asymptomatic; however, symptomatic ARIA may cause aphasia, focal weakness, visual disturbance, confusion, headache, or seizures, and can resemble acute ischemic stroke. Initial noncontrast computed tomography may be nondiagnostic in both conditions, and failure to ident …

21.08.2026journal-article

Journal of Computational and Cognitive Engineering

Improving Basal Insulin Prediction Through Outlier Filtering and Fuzzy Validation for Risk-Free Insulin Pump Therapy

Jeyalakshmi Jeyabalan, Karthikeyan Suresh

Diabetes has become more common in adults and even younger patients due to lifestyle changes. The advent of interventions for self and remote healthcare in a pervasive healthcare context has led to the use of insulin pumps to control blood sugar levels. The insulin pump operation needs the manual configuration of basal insulin levels, which brings the risk of hypoglycemia or hyperglycemia. The risk can be prevented by predicting and validating the safety of basal insulin before dosage, while also considering variou …

21.08.2026journal-article

Oral Surgery

Esthetic Zone Reconstruction Combining Root Retrieval and Guided Bone Regeneration With a Non‐Resorbable Membrane for Implant Rehabilitation: Case Report

Francisco Correia, Mafalda Azevedo, Marta Costa, Ricardo Faria‐Almeida

ABSTRACT Background After multiple traumatic episodes, an avulsion of tooth 21 resulted in noticeable hard‐ and soft‐tissue loss. Methods Soft‐tissue reconstruction began with a procedure performed through a four‐month root‐retrieval protocol, allowing for progressive coronal migration of the gingival tissues. One month after the atraumatic extraction, guided bone regeneration was performed using a combination of autologous bone, xenograft, and a titanium‐reinforced PTFE membrane to re‐establish adequate ridge volu …

21.08.2026journal-article

INTERNATIONAL JOURNAL OF MULTIDISCIPLINARY RESEARCH AND ANALYSIS

The Benefits of Care Support Groups in Sustaining Sobriety Among Alcohol Addicts in Rehabilitation Centers in Selected Counties in Kenya

Peter Irungu Kimathi, Dr. Lucy Gachenia, Dr. Elizabeth Njoroge

Alcohol addiction remains a significant public health challenge in Kenya, with approximately 3.2 million Kenyans struggling with alcohol dependency. Despite the establishment of rehabilitation centres offering care support groups, limited empirical evidence exists regarding their effectiveness in maintaining long-term sobriety in Kenyan contexts. This study established the benefits of care support groups in sustaining sobriety among alcohol addicts in rehabilitation centres in selected counties in Kenya. The study …

21.08.2026journal-article

Jurnal Pendidikan Progresif

Cognitive Behavioral Therapy Intervention: Enhancing Vocational High School Students’ Enthusiasm in Islamic Education

Rizqi Dwicahyanti, Askar Askar, Mirnawati Mirnawati

Cognitive Behavioral Therapy (CBT) represents one of the most well-established psychotherapeutic approaches, centered on the reconstruction of negative thoughts and maladaptive beliefs into more positive and psychologically tenable alternatives. This study examines the effectiveness of CBT in enhancing students' enthusiasm for learning in Islamic Religious Education (PAI) at SMK Negeri 3 Palu. Confronting the persistent challenge of diminished motivational engagement in Islamic Education contexts, the study investi …

21.08.2026journal-article

Pharmaceutics

Combining Gene Therapy with Current Modulator Treatments for Cystic Fibrosis: A Promising Area of Research

Xavier Buin, Rosy Ghanem, Ines Pankonien, Frédéric Becq, Margarida Amaral, Tristan Montier

Since the development of the first cystic fibrosis transmembrane conductance regulator (CFTR) modulator in 2012, these therapies have revolutionized patients’ health. They are now the most effective treatment for people with cystic fibrosis (pwCF). In fact, elexacaftor/tezacaftor/ivacaftor and vanzacaftor/tezacaftor/deutivacaftor, the latest combination therapies consisting of a CFTR potentiator and two CFTR correctors, improved lung function by 14% in pwCF. Other modulator therapies targeting CFTR mRNA and/or prot …

21.08.2026journal-article

Sustainability

A Framework for Assessing the Performance of Occupational Health and Safety Practices in Small- and Medium-Sized Enterprises

Miskeen Ali Gopang, Inayat Ali, Shakeel Ahmed Shaikh, Tauha Hussain Ali, Awais Khatri, Hussain Bux Marri

Small- and medium-sized enterprises (SMEs) currently face substantial challenges in maintaining their operating standards. Implementing occupational health and safety practices (OHSPs) can be an important strategy for success. This empirical study assessed the performance of OHSPs in SMEs. A framework was developed comprising four performance indicators: operations, customer satisfaction, finance, and employee satisfaction. Data were collected from 35 SMEs in the Sindh Industrial Trading Estate (SITE) in Kotri, Sin …

21.08.2026journal-article

The Ukrainian Journal of Clinical Surgery

Antimicrobial Resistance and Empiric Coverage Discordance in Acute Appendicitis Under Early Preoperative Antibiotic Therapy

R. Gelevski, G. Jota, B. Krsteska, R. Jovchevski, B. Trenchikj, A. Kaftandzieva

Objective. To determine the prevalence of antimicrobial resistance and the rate of empiric antibiotic coverage discordance in acute appendicitis under early preoperative antibiotic therapy.Materials and Methods. This prospective study included 50 adults undergoing appendectomy. All received preoperative ceftriaxone or ciprofloxacin. Luminal and mucosal cultures were obtained, and susceptibility testing was interpreted according to EUCAST 2026. ESBL production, carbapenem resistance, multidrug resistance (MDR), and …

21.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Association Between Quadriceps Myosteatosis and Muscle Strength and Physical Function in Patients With Knee Osteoarthritis- A Systematic Review

Reema Ummer Farook, Karvannan Harikesavan, Nithin Prakash

Objective: To synthesize the available evidence on the association between quadriceps myosteatosis and muscle strength and physical function in individuals with knee osteoarthritis. Design: A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Joanna Briggs Institute (JBI) guidelines and was prospectively registered with PROSPERO. PubMed, EMBASE, Web of Science, Scopus, and CINAHL were searched from inception to February 2026. Studies quan …

21.08.2026journal-article

Asia-Pacific Journal of Clinical Oncology

Impact of Immunotherapy Prescribing Restrictions on Time to Systemic Therapy and Outcomes in Metastatic Clear Cell Renal Carcinoma in Australia

Evon Jude, Elizabeth Liow, Jeremy Shapiro, Arun A. Azad, Megan Crumbaker, Ganes Pranavan, Christopher Hocking, Felicia Roncolato, Annabel Smith, Shirley Wong, Angelyn Anton, Julie Johns, Peter Gibbs, Ben Tran, Andrew Weickhardt

ABSTRACT Introduction Combination immunotherapy (Ipi/Nivo) was approved in Australia in 2019 for metastatic clear cell kidney cancer (mccRCC) patients with International Metastatic Database Consortium (IMDC) intermediate and poor‐risk. Although selected patients can safely delay treatment due to indolent disease, delaying treatment beyond 1 year in patients without other IMDC risk factors classifies them as favorable risk and prevents access to Ipi/Nivo. This study investigated the impact of Ipi/Nivo approval on ti …

21.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Exposure to norm in offshore decommissioning: A systematic review with an emphasis on occupational health and safety

Beatriz Bandeira dos Santos, Laís Bubach Carvalho Simão, Francisco José de Castro Moura Duarte

Background The decommissioning of oil and gas production systems has been increasing significantly as production facilities reach the end of their useful life. This brings forth challenges that are still underexplored, particularly regarding exposure to Naturally Occurring Radioactive Materials (NORM) and its implications for the health and safety of workers involved in these operations. Objective to investigate, through a systematic literature review, the reporting of Naturally Occurring Radioactive Materials (NOR …

21.08.2026journal-article

JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY

Recommendations for the prevention, monitoring, and treatment of infectious complications post-hematopoietic cell transplantation

Marcia Garnica, Fabianne Carlesse, Jessica Fernandes Ramos, Ana Verena Almeida Mendes, Larissa Gandolpho, Giovanni Luis Breda, Marcio Nucci, Clarisse Martins Machado

This chapter outlines recommendations for the control and management of infections following hematopoietic cell transplantation. Given the complexity and scope of the subject, the authors chose a format that considers the various interventions available to prevent, minimize, or when appropriate treat infections relevant to the hematopoietic cell transplantation setting. We consider the active and collaborative involvement of the transplant infectious disease specialist in transplantation centers to be essential in …

21.08.2026journal-article

Journal of Dementia and Alzheimer's Disease

A Systematic Review on the Effects of Speech and Language Therapy in Patients with Dementia

Ioanna Rodaki, Despina Moraitou, Theodora Papamitsou, Effrosyni Koutsouraki

Background/Objectives: Dementia is a progressive neurocognitive disorder characterized by decline in cognitive, communicative, and functional abilities. Speech and language therapists (SLTs) play a role in managing communication and cognitive–linguistic impairments while supporting families and caregivers. However, evidence regarding the effectiveness of speech and language therapy interventions remains heterogeneous, and evidence has not integrated cognitive–linguistic and caregiver-related outcomes. This systemat …

21.08.2026journal-article

JMIR Research Protocols

Effect of Remote Vital Signs Monitoring in People Receiving Long-Term Oxygen Therapy: Protocol for a Randomized Controlled Trial

Elinny Raissa Moreira dos Reis, Gabriela Martins Alencar, Amanda Maria Schneider, Mari Claussen Tani Fernandes, Juliana de Melo Batista dos Santos, Celso Ricardo Fernandes Carvalho

Background Individuals receiving long-term oxygen therapy (LTOT) are often confined to their homes and have impaired health-related quality of life (HRQoL). Despite technological advances, monitoring these individuals remains a challenge. Objective This study aims to evaluate the impact of remote monitoring on HRQoL, dyspnea, health status, symptoms of anxiety and depression, and adherence to data entry via a mobile app in individuals receiving LTOT. Methods This randomized controlled trial will recruit 60 particip …

21.08.2026journal-article

Frontiers in Immunology

Advances in CAR-T therapy for central nervous system lymphoma

Xiumei Feng, Jing Yang, Xiaofei Xu, Wen Kai, Yanxin Huang, Shanshan Zhang, Lin Su, Leisheng Zhang

Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the management of relapsed/refractory B-cell lymphomas, yet its initial use in central nervous system lymphoma has been hampered by safety concerns and limited efficacy. Current data are derived from small, heterogeneous trials, with unresolved questions regarding neurotoxicity mitigation, optimal treatment timing, long-term response durability, and predictive biomarkers, precluding widespread clinical implementation. This narrative review systematica …

21.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Hidden Risks of Multimodal Neuromodulation: Suspected Intrathecal Baclofen Pump Motor Stall Induced by a Vagus Nerve Stimulator Magnet

Priya Sharma, Brigid Deck, Gregor J. Dudiak, Weibin Shi, Thiru Annaswamy

The increasing use of implantable neuromodulation devices in patients with chronic post-stroke sequelae raises the possibility of unintended device–device interactions. We report a case of recurrent intrathecal baclofen pump motor stalls in a patient with longstanding spasticity following an intracranial hemorrhage, ultimately attributed to magnetic interference from a recently implanted vagus nerve stimulator (VNS) activator magnet. Recognition of this interaction led to prompt resolution and highlights the import …

21.08.2026journal-article

Frontiers in Medicine

Baseline CALLY index is associated with all-cause mortality in HBV-ACLF patients receiving ALSS therapy

Wanlong Ma, Jinhua Yuan, QiuYan Chen, Xia Wang, Le Zhang, Yanghua Ou, Yun Jiao, XiangChun Ding

Objective Chronic hepatitis B virus (HBV)-associated acute-on-chronic liver failure (HBV-ACLF) has a high mortality rate even with the use of artificial liver support systems (ALSS). Reliable prognostic biomarkers are lacking. This study investigates the association between the C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index, measured at diagnosis, and all-cause mortality in HBV-ACLF patients receiving ALSS treatment. Methods This single-center retrospective cohort study enrolled consecutive adult patient …

21.08.2026journal-article

Journal of Endovascular Therapy

Non-Contrast Magnetic Resonance Angiography for Endovascular Aneurysm Repair Planning in Abdominal Aortic Aneurysms: Acquisition Development and Comparison to Contrast-Enhanced Computed Tomography Angiography

Eva Aalbregt, Wilhelm Stehling, Aart Nederveen, Job van Helvoirt, Pim van Ooij, Eric Mathew Schrauben, Vincent Jongkind, Kak Khee Yeung

Objective: To develop a non-contrast magnetic resonance angiography (NC-MRA) that offers an ionizing radiation and contrast agent-free alternative to computed tomography angiography (CTA) for detailed assessment of abdominal aortic aneurysms (AAAs). Secondly, the suitability of NC-MRA for endovascular aneurysm repair (EVAR) planning compared to CTA was assessed. Methods: A motion-resolved 3-dimensional balanced steady-state free precession (bSSFP) magnetic resonance angiography (MRA) was performed at 3.0 T and opti …

21.08.2026journal-article

JMIR Research Protocols

A Coordinated Approach to Perioperative Rehabilitation to Enhance Outcomes in Melanoma: Protocol for the CARE-Melanoma Pilot Randomized Controlled Trial

Jenna Smith-Turchyn, Jordon L Hvizd, Valerie Francescutti

Background Rehabilitation is beneficial for individuals with cancer across all phases of care, but access remains limited for many survivors, including individuals with melanoma. As new treatment strategies for melanoma are introduced, there is an opportunity to assess perioperative rehabilitation strategies for patients undergoing surgery during and after neoadjuvant treatment. Objective This paper describes the protocol for a 2-armed pilot randomized controlled trial with the overall objective of determining the …