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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

Stem Cell Research & Therapy

GMP manufacturing, quality characterization, and GLP-based preclinical evaluation of human nasal turbinate–derived stem cells for the treatment of rheumatoid arthritis

Hyun Ji Lee, Jung Ho Jeon, Junwon Choi, Min Young Ahn, Ye Sol Park, Hyo Min Song, Seong Yeon Yoo, Youngjae Park, Seung-Ki Kwok, Sun Hwa Park, Sung Won Kim

Abstract Background Human nasal turbinate-derived stem cells (hNTSCs) are tissue-derived adult stem cells that are isolated from surgically discarded nasal turbinate tissue and exhibit robust proliferative capacity, and stable phenotypic properties. Unlike conventional MSCs, hNTSCs, although classified as tissue-derived adult stem cells, exhibit MSC-like phenotypes but display distinct gene expression patterns and functional properties that may be advantageous for indications of inflammatory and autoimmune disease. …

26.08.2026journal-article

Amino Acids

Spermidine in Colorectal cancer: friend or foe?

Sonia Coni, Rosa Bordone, Luca Campea, Shohei Ohno, Gianluca Canettieri, Enzo Agostinelli

Abstract Colorectal cancer (CRC) is a leading cause of cancer-related mortality, and its incidence is rising among individuals, especially young, underscoring the need for novel therapeutic strategies. CRC development is driven by genetic and epigenetic alterations in key oncogenic pathways and is accompanied by profound reprogramming of polyamine metabolism. In this context, spermidine (SPD), a central polyamine produced downstream of the MYC–ODC axis, is regarded as a pro-tumorigenic metabolite that sustains CRC …

26.08.2026journal-article

Frontiers in Public Health

Evaluating AI-generated patient education materials for endometrial cancer surgery: a comparative analysis of response quality, reliability, and readability between ChatGPT and DeepSeek models

Ling Tian, Long-yu Tang, Ming-tao Yang, Yan Wang, Hong-ni He, Tian-wen He, Ying Tang, Chuan Lin, Hui-quan Hu, Jun Li

Purpose This study aimed to evaluate and compare the quality, reliability, and readability of patient education materials on endometrial cancer surgery generated by ChatGPT (GPT-5) and DeepSeek (R1). Materials and methods This cross-sectional study analyzed the responses generated by ChatGPT and DeepSeek to totally 41 questions covering four domains: surgical planning, preoperative evaluation, postoperative care, and long-term follow-up. Reliability was assessed through the DISCERN and EQIP instruments, quality was …

26.08.2026journal-article

Frontiers in Surgery

Current real-life survival after segmentectomy for lung cancer

Xavier Cansouline, Abdoul-Khadry Gassama, Abdelhakim Elmraki, Béatrice Lipan, Damien Sizaret, Delphine Carmier, Antoine Legras

Introduction Segmentectomy for non-small cell lung cancer (NSCLC) is increasingly performed for small-sized lesions. However, prognostic factors associated with poor outcomes after this lung-sparing oncologic surgery remain uncertain. Methods We conducted a single-center retrospective study including 100 consecutive patients who underwent single or multiple segmentectomies for NSCLC in real-world practice. Results In univariate analyses, compromise segmentectomy (HR 3.52; p = 0.005), complex segmentectomy (HR 2.56; …

26.08.2026journal-article

Frontiers in Pediatrics

The social and economic burden of retinopathy of prematurity: screening, treatment, and health policy perspectives in a transnational narrative review

Maria Ester Canepa, Massimiliano Serafino, Pasquale Striano, Luca A. Ramenghi

Retinopathy of prematurity (ROP) is a leading preventable cause of childhood blindness, particularly among premature infants. This transnational narrative review synthesizes international evidence on the economic and social burden of ROP from 2003 to 2025, focusing on the cost-effectiveness of screening, diagnostic imaging, and treatment strategies. A structured PubMed search using the terms “ROP neonate social cost” and “economic impact of ROP” was supplemented through the “Similar Articles” and “Cited Articles” f …

26.08.2026journal-article

ACTA MEDICA IRANICA

Functional Outcomes and Complications in the Treatment of Floating Knee Injuries

Shahin Talebi, Salman Ghaffari, Mohammad Tehrani, Akbar Ehsani, Reza Zandi

Ipsilateral femur and tibia fractures (floating knee injury) is a complex injury with severe associated injuries. The aim of this study was to assess the characteristics and treatment outcomes in patients with floating knee in a single trauma center. A retrospective study was conducted among patients with floating knee treated between January 2012 and January 2019 in a single trauma center. Patients with knee osteoarthritis, inflammatory arthritis, pathologic fracture, and with a history of previous fracture in ips …

26.08.2026journal-article

Frontiers in Bioengineering and Biotechnology

Stimuli-responsive bioengineered platforms for precision cancer therapy

Hossein Omidian, Renae L. Wilson

Stimuli-responsive bioengineered platforms are redefining cancer therapy by shifting therapeutic design from systemic drug exposure toward context-dependent activation within malignant tissue. These systems are engineered to sense and respond to tumor-associated or externally applied cues, including acidic pH, redox imbalance, hypoxia, enzymatic activity, reactive oxygen species, temperature variation, light, ultrasound, and magnetic fields. Across the reviewed evidence, their principal value lies not merely in dru …

26.08.2026journal-article

Movement Disorders Clinical Practice

How Do Oral Medications, Botulinum Toxin Use, and Treatment Burden Change after Deep Brain Stimulation for Dystonia?

Hikaru Kamo, Emma Leone, Rohini Kumar, Chase Antilla, Isabelle Gerzenshtein, Arunmozhimaran Elavarasi, Aparna Wagle Shukla

Abstract Background Deep brain stimulation (DBS) is an established therapy for dystonia; however, the long‐term trajectory of adjunctive treatment burden, including oral medications and botulinum toxin (BoNT) injections, and the likelihood of achieving medication‐free status remain poorly understood, despite important implications for adverse effects, injection burden, and quality of life. Objective Determine long‐term changes in adjunctive medication burden and the durability of medication‐free status among dyston …

26.08.2026journal-article

Clinical Hematology International

Delphi expert consensus on phlebotomy limitations and treatment challenges in HFE -related hemochromatosis

Jeremy Shearman, Domenico Girelli, Dominik J. Schaer, Sant-Rayn Pasricha, Kris V. Kowdley, John K. Olynyk, Gregory J. Kato, Sonya Abraham, Soraya Benchikh El Fegoun, Charlotte Pollet, Uta Merle

HFE -related hemochromatosis (HC) is caused by hepcidin dysregulation and is characterized by excessive iron absorption and accumulation in the liver, heart, and endocrine glands, which leads to complications including arthropathy, cirrhosis, and hepatocellular carcinoma. Standard of care (SoC) typically involves phlebotomy, with iron chelators used less frequently. However, these therapies may cause side effects and negatively impact quality of life, making them troublesome for some patients. Using the Delphi meth …

26.08.2026journal-article

Cancer Medicine

Neurological Adverse Events Associated With Immune Checkpoint Inhibitors Identified Through Disproportionality Analysis of the FDA Adverse Event Reporting System

Tao Chen, Kexin Shu, Hongyi Xiao, Yonghua Yuan, Fujun Zhang, Yu Liu

ABSTRACT Background Neurological immune‐related adverse events (N‐irAEs) from immune checkpoint inhibitors (ICIs) are rare but potentially fatal. This study aimed to characterize their real‐world profile to support early detection and management. Methods We analyzed ICI‐associated individual case safety reports (ICSRs) in the FDA Adverse Event Reporting System (FAERS) from April 2011 to June 2023. Disproportionality analyses used the reporting odds ratio (ROR) and the Bayesian confidence propagation neural network …

26.08.2026journal-article

Neurology International

The Incidence and Electroencephalographic Features in Brain Tumor-Related Epilepsy

Lejla Zonić, Renata Hodžić, Dževdet Smajlović, Larisa Kovačević, Samra Kadić-Vukas, Lejla Tandir-Lihić, Mirsad Hodžić

Methods: This retrospective–prospective study included 90 patients with BT. Based on the type of BT, the participants were divided into three groups of 30 patients each: patients with gliomas, with meningiomas and with brain metastasis. Demographic data such as age, sex, alcohol and cigarette consumption were collected. In all three study groups, the time of onset of the first ES, type, characteristics, and frequency were analyzed as well as abnormalities on electroencephalography (EEG). EEG was reviewed for any ab …

26.08.2026journal-article

Transportation Research Record: Journal of the Transportation Research Board

Cold-Bonded Lightweight Aggregates and their Application in Road Subgrade Soil Treatment

Zhenzhen He, Yu Liu, Zhanping You, Yongbo Wang, Jingang Wang

To promote the application of cold-bonded granulation technology in road engineering, this study used silty soil as the raw material and cement as the cold binder to convert silty soil with poor engineering performance into cold-bonded lightweight aggregates (CBLA) with tailored performance characteristics. The effects of different cement contents on the physical and mechanical properties of CBLA were systematically investigated. The evaluation indicators included granulation ratio, particle morphology, bulk densit …

26.08.2026journal-article

Frontiers in Clinical Diabetes and Healthcare

Real-world outcomes of sitagliptin and sitagliptin/metformin single-pill combination treatment in diverse type 2 diabetes populations (DIVERSITY study)

Andrej Janez, Mirjana Bojic, Tomislav Bozek, Zdravko Kamenov, Tatjana Milenkovic, Gabriela Radulian, Tamás Várkonyi

Introduction Real-world evidence on dipeptidyl peptidase-4 (DPP-4) inhibitors is limited by selective populations in randomized trials. The international, prospective DIVERSITY study evaluated the effectiveness, safety, and treatment acceptability of sitagliptin and sitagliptin/metformin single-pill combination (SPC) in routine clinical practice across diverse type 2 diabetes (T2D) populations. Methods This non-interventional, multicenter study enrolled adults with T2D eligible for sitagliptin or sitagliptin/metfor …

26.08.2026journal-article

Journal of the Endocrine Society

A Single Dose Trial of Mizagliflozin for the Treatment of Post-bariatric Hypoglycemia

Helen M Lawler, Tracey L McLaughlin, Soroush Shakeri, Ethan F Stortz, Aanchal Gupta, Vatsala Singh, Nicole Turk, Susan Walker, William Wilkison, Bentley Cheatham

Abstract Context Post-bariatric hypoglycemia (PBH) is a complication of bariatric surgery characterized by severe postprandial hypoglycemia for which there is no approved therapy. Objective To evaluate efficacy and safety of mizagliflozin, an SGLT1 inhibitor, for treatment of PBH. Methods This was a Phase 2, open label, randomized, single dose, crossover study. Nine participants with PBH were randomized to receive a baseline mixed meal tolerance test (MMTT), and single doses of mizagliflozin before each of two addi …

26.08.2026journal-article

Asian Journal of Biology

mRNA Cancer Vaccines: A Critical Appraisal of Applications, Persistent Challenges and Realistic Future Perspectives

Prakash Bharti, Anshul Singh, Hrithika Panday, R. C. Tripathi

Messenger RNA (mRNA) vaccines entered oncology on the strength of a technology validated at population scale for infectious disease prophylaxis, and the therapeutic cancer vaccine field has been reshaped accordingly. The platform permits rapid design-to-dose intervals, encoding of many epitopes within a single product, cell-free manufacture and a dosing schedule compatible with combination immunotherapy. Enthusiasm has nevertheless outpaced the maturity of the clinical evidence. This critical narrative review evalu …

26.08.2026journal-article

Journal of Surgical Oncology

Extended Versus Non‐Extended Lymphadenectomy in Radical Cystectomy for Bladder Cancer: A Systematic Review and Meta‐Analysis

Maria Fernanda Dias Azevedo, Pedro Henrique Souza Brito, Lucas Kallas‐Silva, Bruno Liebl, Beatriz Taveira Constantinou, Bianca Caroline Benedicto, Lucas Paschoalino de Oliveira, Mauricio Dener Cordeiro, William Carlos Nahas, Walid Shabana, Walid Shahrour, Leopoldo Alves Ribeiro‐Filho, Caio Vinicius Suartz

ABSTRACT Pelvic lymph node dissection is an essential component of radical cystectomy (RC) for bladder cancer (BC), but the optimal extent of lymphadenectomy remains uncertain. We conducted a systematic review and meta‐analysis to compare oncologic and perioperative outcomes between extended and non‐extended lymphadenectomy during RC for BC. PubMed/MEDLINE, Embase, and ClinicalTrials. gov were searched up to October 2025 following PRISMA guidelines and PROSPERO registration. Randomized controlled trials (RCTs) and …

26.08.2026journal-article

The Neuroradiology Journal

Diagnostic performance of the proposed DECT NI-RADS criteria for imaging surveillance of post-treatment head and neck squamous cell carcinoma: A preliminary study

Thiparom Sananmuang, Bhuwid Chinwatanawongwan, Thanwa Sudsang

Background The value of dual-energy CT (DECT) in enhancing the diagnostic performance of the NI-RADS criteria has not been investigated. Purpose To compare the diagnostic performance of the proposed DECT NI-RADS with conventional contrast-enhanced (CECT) NI-RADS. Materials and methods This retrospective study included 47 patients with head and neck squamous cell carcinoma (HNSCC) who underwent surgery, chemotherapy, or radiation therapy, followed by post-treatment DECT neck scans. Three circular regions of interest …

26.08.2026journal-article

Plastic & Reconstructive Surgery

Is Joint Denervation a Durable Treatment for Thumb Carpometacarpal Osteoarthritis? A Multicenter Long-Term Outcome Study

Niek J. Nieuwdorp, Camille Blaaker, Esmee Kwee, Erik T. Walbeehm, Ruud W. Selles, Kyle R. Eberlin, J. Michiel Zuidam, Hand-Wrist Study Group, Caroline A. Hundepool

Background: Joint denervation for thumb carpometacarpal (CMC) osteoarthritis (OA) remains less commonly used, primarily due to concerns about the long-term durability of symptom relief. This study aims to assess the long-term reoperations and outcomes after CMC denervation and to identify prognostic factors associated with postoperative pain. Methods: This multicenter prospective study included patients with thumb CMC OA who underwent joint denervation. The primary outcome was the rate of reoperation due to recurre …

26.08.2026journal-article

Thyroid®

Suppressed cGAS–STING DNA Sensing Drives Immune Evasion in Anaplastic Thyroid Cancer

Xu-guang Zhu, Manju Acharya, Eunmi Hwang, Nathan Wong, Naris Nilubol, Sheue-yann Cheng

Background: Anaplastic thyroid cancer (ATC) is a highly lethal malignancy with poor survival and limited therapeutic options. The mechanisms driving immune evasion in ATC remain poorly understood. The cyclic GMP–AMP synthase–stimulator of interferon genes (cGAS–STING) pathway is a key mediator of innate immune sensing and antitumor immunity. Methods: We investigated the role of cGAS–STING signaling in ATC using three complementary models (i) a genetically engineered mouse model harboring triple mutations in Thrb1 , …

26.08.2026journal-article

BMC Cancer

Reconstruction of epithelial transcriptional trajectories reveals heterogeneous progression and early therapy-resistance programs in high-grade serous carcinoma precursors

Michail Sideris, Eleni Maniati, Tanjina Kader, Sandro Santagata, Ronny Drapkin, Frances Balkwill, Ranjit Manchanda

Abstract Background Serous-tubal intraepithelial-carcinoma (STIC) is considered the principal precursor of tubo-ovarian high-grade serous-carcinoma (HGSC), yet its biological uniformity, progression risk and potential response to poly(ADP-ribose) polymerase-inhibitors (PARPi) remain poorly defined. Methods We performed trajectory-based transcriptomic reconstruction of Fallopian-tube epithelial regions spanning histologically normal-appearing epithelium, precursor lesions, STIC, and invasive carcinoma using pseudoti …

26.08.2026journal-article

Journal of Biochemical and Molecular Toxicology

Autocrine Control of CD276 by SPARC in Liver Cancer and Its Contribution to Immune Escape and Resistance to Immunotherapy

Mengying Tang, Jing Liu

ABSTRACT Hepatocellular carcinoma (HCC) frequently demonstrates resistance to immunotherapeutic interventions, a phenomenon largely linked to mechanisms of immune escape. Among the modulators of the tumor microenvironment, SPARC (Secreted Protein Acidic and Rich in Cysteine), a matricellular glycoprotein, has been associated with diverse oncogenic processes in multiple cancer types. However, the contribution of SPARC to immune regulation through CD276 signaling remains insufficiently characterized. To clarify this …

26.08.2026journal-article

Otolaryngology–Head and Neck Surgery

Treatment Strategies and Outcome in Minimally Invasive, Gland‐Preserving Treatment for Multiple Sialolithiasis

Elisabeth Wimmer, Sophie Kansy, Moritz Allner, Robin Rupp, Antoniu‐Oreste Gostian, Sarina Mueller, Michael Koch

Abstract Objective(s) Minimally invasive procedures are well established for patients with sialolithiasis involving single stones. For patients with multiple sialolithiasis, few data are available regarding the treatment approaches and outcomes with gland‐preserving therapies. The aim of this study was to review current treatment concepts and postinterventional outcomes in these patients and to propose a treatment algorithm. Study Design Retrospective study. Setting University hospital and tertiary referral center. …

26.08.2026journal-article

Cancers

Comparative Outcomes of Open, Laparoscopic, and Robotic Right Colectomy for Colon Cancer: Postoperative Recovery, Surgical Quality, and 3-Year Survival—A Monocentric Retrospective Study

Krzysztof Nowakowski, Leonie Wesselmann, Michael Leitz, Fabian Nimczewski, Annika Hoyer, Kira Baginski, Wolfgang Hiller, Jens Hoeppner, Zsolt Madarasz

Background/Objectives: Minimally invasive approaches are increasingly used in right colectomy for colon cancer; however, comparative data, including open, laparoscopic, and robotic techniques, remain limited, particularly regarding postoperative recovery and oncological outcomes. Methods: This retrospective monocentric study included 89 patients undergoing elective right colectomy for colon cancer between July 2018 and December 2022. Of these, 30 patients underwent open, 29 laparoscopic, and 30 robotic-assisted sur …