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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
21.08.2026journal-article

JMIR Research Protocols

A Coordinated Approach to Perioperative Rehabilitation to Enhance Outcomes in Melanoma: Protocol for the CARE-Melanoma Pilot Randomized Controlled Trial

Jenna Smith-Turchyn, Jordon L Hvizd, Valerie Francescutti

Background Rehabilitation is beneficial for individuals with cancer across all phases of care, but access remains limited for many survivors, including individuals with melanoma. As new treatment strategies for melanoma are introduced, there is an opportunity to assess perioperative rehabilitation strategies for patients undergoing surgery during and after neoadjuvant treatment. Objective This paper describes the protocol for a 2-armed pilot randomized controlled trial with the overall objective of determining the …

21.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

The role of (voluntary) large language model use and individual needs in shaping work design

Valeria Maisch, Tanja Bipp, Marvin Walczok

Background Large Language Models (LLMs) are increasingly adopted in organizational practice to support task execution. However, their impact on work design, and ultimately on employee outcomes, remains unclear. Objective Drawing on theoretical frameworks regarding the effects of technologies on work design, we investigate potentially negative effects of LLM use on three work characteristics (decision-making autonomy, information processing, role overload) and on decision-making performance. We examine the mitigatin …

21.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

Cross-cultural adaptation and validation of the Turkish version of the knowledge and attitudes of pain (KNAP) questionnaire in physiotherapists and physiotherapy students

Gokhan Maras, Aycan Baslioglu Ezer, Gamze Gulsun Pala

Background The biopsychosocial approach has become increasingly central to modern physiotherapy, yet validated instruments for assessing this shift remain limited in Turkey. Objective This study aimed to translate and culturally adapt the Knowledge and Attitudes of Pain (KNAP) questionnaire into Turkish and to evaluate its psychometric properties among physiotherapists and physiotherapy students. Methods Following established cross-cultural adaptation guidelines, the KNAP was administered to 405 participants, inclu …

21.08.2026journal-article

Engineering Computations

Auxetic soft muscle actuators for enhanced flexibility in lower wearable rehabilitation robotics

Mostafa Boghdady, Ahmed Foaud, Omar Helal, Yousef Reda, Eman R. Soliman, Mostafa Orban, Hongbo Yang, Kai Guo, Mahmoud Elsamanty

Purpose The field of wearable robotics, which focuses on enhancing human compatibility, lightweight design and mobility, has gained prominence in advancing human rehabilitation. This study explores the potential of auxetic structures, characterized by a negative Poisson's ratio, for use in soft auxiliary muscles. Auxetic materials, which expand perpendicular to the applied force, offer unique mechanical properties beneficial for biomedical applications. Specifically, we investigate thermoplastic polyurethane (TPU) …

21.08.2026journal-article

Tạp chí Y học Quân sự

ĐẶC ĐIỂM LÂM SÀNG, CHỈ SỐ CRP, PCT, NLR VÀ MỐI LIÊN QUAN VỚI MỨC ĐỘ NẶNG, GIÁ TRỊ TIÊN LƯỢNG SAU 72 GIỜ ĐIỀU TRỊ Ở NGƯỜI BỆNH VIÊM PHỔI MẮC PHẢI CỘNG ĐỒNG

Lê Trọng Nhân, Nguyễn Thị Thu Thảo, Lê Thị Minh Thư, Nguyễn Thị Tuyết Hường, Nguyễn Thị Kim Hồng

Mục tiêu: Xác định đặc điểm lâm sàng, các chỉ số CRP, PCT, NLR và mối liên quan với mức độ nặng, giá trị tiên lượng sau 72 giờ điều trị ở người bệnh viêm phổi mắc phải cộng đồng. Đối tượng, phương pháp: Nghiên cứu đoàn hệ mô tả, theo dõi dọc 96 người bệnh viêm phổi mắc phải cộng đồng do căn nguyên vi khuẩn, điều trị nội trú tại Khoa Tổng hợp, Bệnh viện Đa khoa Hoàn Mỹ Cửu Long, từ tháng 6/2024-6/2025. Phân loại mức độ nặng theo CURB-65; đánh giá chỉ số CRP, PCT, NLR lúc nhập viện và sau 72 giờ điều trị. Phân tích t …

21.08.2026journal-article

Radiation Research

Safety and Efficacy of LATTICE Spatially Fractionated Radiation Therapy for Metastatic and/or Bulky Disease

Anchuan Li, Miaobin Mao, Qizhen Xu, Liuqing Jiang, Jianping Zhang, Xiaobo Li, Xiaodong Wu, Benhua Xu

LATTICE radiation therapy (LRT), a 3D spatially fractionated radiation therapy (SFRT), creates high-dose vertices through three-dimensional focusing to generate peak-valley dose distributions while sparing normal tissues. This study assessed its efficacy and toxicity in patients with metastatic and/or bulky tumors. Patients with unresectable bulky and/or metastatic tumors treated with LRT between 4/2017 and 2/2021 were enrolled and retrospectively reviewed. Descriptive statistics were used to summarize patient data …

21.08.2026journal-article

Journal of Occupational Rehabilitation

Cost-Effectiveness of IMPRovE: A Multicomponent Intervention to Increase Adherence to Guideline Recommendations for the Diagnosis and Management of Work-Related Mental Health Conditions in General Practice

D. Mortimer, V. Camões-Costa, K. Nolidin, S. Chakraborty, J. Kenardy, B. Brijnath, J. Enticott, M. Kidd, S. Reid, A. Collie, D. Mazza

Abstract Purpose To evaluate the cost and cost-effectiveness of a multicomponent intervention to increase general practitioners’ (GPs) adherence to guideline recommendations for diagnosis and management of work-related mental health conditions (the Guideline). Methods Economic evaluation from Australian health system and societal perspectives based on data from a pragmatic hybrid III parallel cluster randomised controlled trial (IMPRovE) that ran from December 2020 to December 2022. Results The IMPRovE intervention …

21.08.2026journal-article

International Journal of Cancer

Clinical Translation of Patient‐Derived Organoids: Perspectives for Personalized Therapy in Cancer

Haiyan Yue, Daniele Carchidi, Philipp Schmucker, Roland Seiler, Bernhard Kiss, Catarina Macedo‐Silva, Marianna Kruithof‐de Julio

ABSTRACT Patient‐derived organoids (PDO) are accelerating precision medicine. These biological platforms allow for the autologous in vitro expansion of material from cancer patients in a considerably short period of time. These three‐dimensional models can faithfully recapitulate aspects of tissue heterogeneity, architecture, and relevant cellular functions. Based on these characteristics, there has been a growing interest in exploring the potential of these models for translational research, as is the case with co …

20.08.2026journal-article

PLOS One

LEXF-ATT-XLM: A hybrid lexicon-enhanced attention model for hate speech detection in low-resource language Roman Urdu

Jaweria Jalil Awan, Muhammad Hamid, Tagrid Abdullah N. Alshalali

Hate speech detection in low-resource and informally written languages remains a significant challenge due to the lack of annotated corpora, orthographic variability, and complex code-mixing. Roman Urdu a non-standardized variant of Urdu written in the Latin script exemplifies these linguistic hurdles. In this paper, we propose LEXF-ATT-XLM, a novel hybrid deep learning architecture that synergizes contextual language modeling with explicit domain knowledge. Our model leverages XLM-RoBERTa for deep contextual embed …

20.08.2026journal-article

Archives of Craniofacial Surgery

Which intraoral parameters are prognostic factors for speech outcomes in incomplete cleft palate?

Ju Heon An, Hyung Joon Seo, Chi Hyun Lee, Go Woon Park, Yong Chan Bae

Background: The goal of cleft palate surgery is to improve speech articulation; however, factors predicting postoperative speech outcome remain unclear. This study aimed to identify anatomical parameters associated with speech outcome in patients with incomplete cleft palate.Methods: Ninety-eight patients with incomplete cleft palate who underwent palatoplasty and completed long-term follow-up of more than 4 years were included. All surgeries were performed by a single senior surgeon, and eight intraoral parameters …

20.08.2026journal-article

Epidemiologia

Clinical and Laboratory Profiles, Time to Presentation, and Antibacterial Therapy in Children with Aseptic Meningitis: A Comparison of Confirmed Enteroviral and Unidentified-Etiology Cases

Khatuna Devdariani, Bakhyt Kosherova, Xeniya Mkhitaryan, Yelena Pozdnyakova, Aynash Dyusembaeva, Gulsharbat Alshynbekova

Background/Objectives: Pediatric aseptic meningitis remains diagnostically challenging because early manifestations may be incomplete, cerebrospinal fluid (CSF) findings vary with disease stage, and etiologic confirmation is not always available. This study compared hospitalized children with PCR-confirmed enteroviral meningitis and meningitis of unidentified etiology, focusing on presentation timing, CSF patterns, and antibacterial therapy. Methods: This single-center retrospective observational study included 87 …

20.08.2026journal-article

International Journal of Scientific Reports

A preventable severe influenza A pneumonia after rituximab therapy for pemphigus vulgaris: a case report highlighting the critical role of vaccination

Nurcan Metin

Rituximab is an effective first-line therapy for pemphigus vulgaris (PV) but causes prolonged B-cell depletion, increasing susceptibility to infections. We report a 38-year-old man with PV who developed severe influenza A (H3) pneumonia 20 days after his second rituximab infusion, having declined influenza vaccination. Prior to rituximab, he received corticosteroids and azathioprine, but lesions persisted. Upon presentation, he experienced headache, myalgia, arthralgia, and fatigue. Laboratory tests revealed lympho …

20.08.2026journal-article

Archives of Plastic Surgery

Reliability of Perceptual Assessment According to Speech Stimuli in Thai Patients with Cleft Lip and/or Palate

Kalyanee Makarabhirom, Atchaphan Ruangsuk, Supaporn Chinchai, Natwipa Wanicharoen, Piyawan Jareontonyakorn, Pimpakan Hanpa, Saran Worasakwutiphong, Natthasart Unasri, Palita Yaemsuan

Abstract Cleft lip and/or palate (CLP) frequently leads to speech disorders, such as hypernasality, hyponasality, nasal air emission (NAE), and compensatory articulation disorders. Perceptual speech assessment is the gold standard for evaluating these features, especially in community-based programs. In Thailand, the Articulation, Resonation, Nasal Emission, and Nasal Turbulence Test is widely used, but its interrater reliability has not been formally assessed. This cross-sectional study included 32 Thai-speaking i …

20.08.2026journal-article

Cytotherapy and Longevity

Decoding Mesenchymal Stem Cell Heterogeneity by Single-Cell Transcriptomics: From Molecular Insights to Harnessing Heterogeneity for Precision Therapy of Musculoskeletal Degenerative Diseases

Wenbo Gao, Min Wu, Yuwen Liang, Penggang Luo, Denghui You, Li Yi, Gang Wu, Xiyin Ye, Shun Ruan, Yuanzan Zhu, Sangui Wang, Quanlei Wang

Mesenchymal stem/stromal cells (MSCs) hold great promise for treating musculoskeletal degenerative diseases such as osteoarthritis, sarcopenia, and osteoporosis, yet their clinical translation is severely hindered by cellular heterogeneity. This review systematically examines the multidimensional origins of MSCs heterogeneity, including donor background, tissue source, in vitro culture conditions, and intra-population functional diversity and highlights how single-cell RNA sequencing (scRNA-seq) has revolutionized …

20.08.2026journal-article

Developmental Science

Cortical Tracking of Speech Across Rhythm Classes in English‐, French‐, and Japanese‐Learning 4‐ and 8‐Month‐Old Infants

Varghese Peter, Marina Kalashnikova, Sandrien van Ommen, Reiko Mazuka, Denis Burnham, Thierry Nazzi

ABSTRACT It has been proposed that the world's languages fall into three rhythmic classes according to the units that determine their rhythmic structure: stress‐based (e.g., English), syllable‐based (e.g., French), and mora‐based (e.g., Japanese). These rhythmic differences modulate language‐specific processing in adults and young infants. It has also been proposed that the syllable is the default rhythmic unit across languages, more prominent in acquisition and processing. This study investigated the development o …

20.08.2026journal-article

Journal of Inherited Metabolic Disease

Occurrence of Infusion Associated Reactions and Antidrug Antibodies in Enzyme Replacement Therapy for Fabry Disease and the Effect of Preventive Measures

Maud Janssens, Sanne J. van der Veen, Laura van Dussen, André B. P. van Kuilenburg, Marion M. M. G. Brands, Mirjam Langeveld

ABSTRACT Male patients with the classical phenotype of Fabry disease (FD) are at risk of developing inhibiting antidrug antibodies (iADAs) against recombinant α‐galactosidase‐A, administered in the form of enzyme replacement therapy (ERT). The presence of ADAs is linked to infusion‐associated reactions (IARs) and reduced ERT effectiveness. This study evaluates the incidence of iADAs and IARs in ERT treated classical male FD patients, their interrelatedness and the effect of an adjusted ERT initiation protocol, aime …

20.08.2026journal-article

The Journal of ECT

Correlates of Implantable Port Placement in Patients Receiving Electroconvulsive Therapy

Daniel P. Larson, Mario Davidson, Donald Sengstack, James Luccarelli, Joshua R. Smith

Objectives: Establishing intravenous access before each electroconvulsive therapy (ECT) session can be challenging, contributing to delays, sedation-related interventions, and treatment discontinuation. Implantable ports may reduce these barriers, yet factors associated with port placement are not well understood. This study examined correlates of port placement among patients receiving ECT. Methods: We conducted a retrospective cohort study of patients who received ECT at a single academic center between 2017 and …

20.08.2026journal-article

Physics in Medicine & Biology

Biologically optimized 3D range modulators for fast conformal carbon ion therapy: in vitro validation, treatment planning, and robustness analysis

Sae Hyun Hailey Ahn, Domenico Ivan Filosa, Peter Lysakovski, Stephan Brons, Amir Abdollahi, Juergen Debus, Ivana Dokic, Thomas Tessonnier, Andrea Mairani

Abstract Objective.
Patient-specific 3D range modulators (RMs) allow rapid and conformal particle therapy with monoenergetic beams and may support motion management and ultra-high dose rate (UHDR) studies. For carbon ions, however, relative biological effectiveness (RBE) varies strongly with depth, so RM geometry should be optimized for biological effect rather than physical dose alone. This work presents a translational pathway for biologically optimized 3D RMs (bio-RMs) for carbon ion therapy, evaluated throu …

20.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Speech Perception in Children With Speech Sound Disorders: A Systematic Review and Meta-Analysis

Thushani Umesha Munasinghe, Bhavana Bhat, Hayo Terband

Purpose: This study aimed to evaluate the evidence on speech perception abilities of children with speech sound disorders (SSDs) to understand how the perceptual skills contribute to the diagnosis and characterization of SSDs. Method: We conducted a systematic and meta-analysis by searching four electronic databases for studies published between 2017 and 2025 that examined the speech perception skills of children with SSDs. We qualitatively evaluated the included studies based on study characteristics and methodolo …

20.08.2026journal-article

Frontiers in Aging Neuroscience

Acceptability and feasibility of an adapted Portuguese folk dance–based therapy in older adults with moderate-to-severe dementia and balance impairment

Ana Almeida, Vasco Caveirinha, Joana Felício, Rui Fontes, Patrícia João, Tânia Libório, Ana Piedade, Carlos Família, Catarina Godinho, Júlio Belo Fernandes

Introduction Population ageing has increased the prevalence of dementia, often accompanied by mobility impairments. It is essential to develop effective interventions and promote adherence among people with dementia. Culturally meaningful activities may enhance motivation, engagement, and rehabilitation outcomes. Methods A mixed-methods pilot study was developed to evaluate the acceptability and feasibility of an adapted Portuguese folk dance–based intervention among older adults with moderate to severe dementia an …

20.08.2026journal-article

Clinical Cancer Research

Long-term Follow-up of Third-generation Anti-CD30 CAR T-cell Therapy in Relapsed/Refractory CD30+ Lymphomas: A Single-Arm, Multicenter, Phase I/II Trial

Xiangmin Wang, Qing Zhang, Dongmei Yan, Yawen Wei, Hongzhi Geng, Kang Rong, Jiahui Sun, Xicheng Chen, Meina Zhang, Peiling Zhang, Yujie Li, Ruiyang Xie, Han Sun, Ziyuan Shen, Hongyuan Zhou, Tianci Li, Jiaoli Zhang, Yicheng Zhang, Tongcun Zhang, Linyan Xu, Ting Niu, Wenbin Qian, Qingyun Wu, Liang Huang, Caixia Li, Wei Sang

Abstract Purpose: This report presents long-term outcomes of third-generation anti-CD30 chimeric antigen receptor (CAR) T-cell therapy in patients with relapsed/refractory (r/r) CD30+ lymphoma. Patients and Methods: In this single-arm, multicenter, phase I/II trial, patients received a lymphodepletion regimen comprising fludarabine and cyclophosphamide, followed by infusion of anti-CD30 CAR T cells. Primary endpoints included safety and overall response rate (ORR), whereas secondary endpoints were progression-free …

20.08.2026journal-article

Journal of the American Heart Association

Assessing Brain Lesions and Predicting Functional Outcome in Patients With Anterior Circulation Stroke With Endovascular Therapy: Co‐ASPECTS

Jiaqi Luo, Xiaolin Zhao, Mengxuan Xiao, Guoshuai Yang, Pengxiang Li, Weihua Liu, Suyue Pan, Yidong Deng, Xianghong Liu, Kaibin Huang

Background This study aimed to develop and validate a practical and reliable tool for comprehensive assessment of brain lesions on immediate post‐endovascular therapy (EVT) noncontrast computed tomography (CT) and to predict 90‐day functional outcomes in patients with acute ischemic stroke. Methods We retrospectively reviewed consecutive patients with acute ischemic stroke undergoing EVT from 2 academic hospitals as the development cohort and used an independent national multicenter prospective cohort for external …

20.08.2026journal-article

Frontiers in Cell and Developmental Biology

Context-dependent functions of the aryl hydrocarbon receptor in gastrointestinal cancers: from microenvironmental regulation to precision targeted therapy

Jiao Ma, Shenghao Li, Yining Qiao, Zihan Gao, Jinzhe Liu, Yanru Song, Yu Liu, Xiaohui Ji, Jianbo Li, Jie Zhang, Liang Chang, Bingjie Huo

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with context-dependent roles in gastrointestinal (GI) tumor development. Depending on cellular context and microenvironment, AhR can preserve epithelial integrity, suppress inflammation, and inhibit tumor growth, but it can also promote immune evasion and metabolic reprogramming to drive tumor progression. Most existing reviews have focused on a single GI tumor type or functional dimension, and the concept of AhR as a context-dependent s …