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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Journal of Reconstructive Microsurgery

Gaps in Breast Reconstruction Patient Educational Resources: Comparing Patient and Surgeon Perspectives

Erica Lee, Lily Zhu, Helen Xun, Chao L. Azad, Pooja Yesantharao, Faraah Bekheet, Justin M. Sacks, Lily R. Mundy, Jennifer Sheng, Kristen P. Broderick

Abstract Breast reconstruction is an important component of cancer care following mastectomy, improving psychosocial well-being and quality of life. However, not all patients are satisfied with their outcomes. Patient satisfaction with preoperative information is a strong predictor of postoperative satisfaction, but it remains unclear how patient and surgeon perspectives differ regarding the quality and availability of educational resources and which areas of education most need improvement. A cross-sectional surve …

27.08.2026journal-article

PLOS Digital Health

Extracting adverse event nature, severity, timelines and resulting interventions from clinical notes of patients receiving CAR-T cell therapy using large language models

Jordan Guillot, Brenda Miao, Arvind Suresh, Madhumita Sushil, Christopher Y. K. Williams, Rohit Vashisht, Tomiko T. Oskotsky, Marina Sirota, Atul J. Butte

Chimeric Antigen Receptor T-cell (CAR‑T) therapy, genetically engineered patient T cells targeting tumor antigens, has transformed care for hematologic malignancies but requires careful tracking of adverse events (AEs) often documented only in unstructured electronic health record (EHR) notes. We evaluated a Large Language Model (LLM)–based approach in UCSF’s secure environment to extract AEs, dates, grades, and interventions within 30 days post‑infusion for six commercial CAR‑T products (2012–2023), benchmarking a …

27.08.2026journal-article

Head & Neck

Aggressive Mandibular Squamous Cell Carcinoma Mimicking Periodontal Disease in a Non‐Transplanted Patient With Fanconi Anemia

Cassius Carvalho Torres‐Pereira, Laura Grein Cavalcanti, Marta Aparecida Alberton Nuernberg, Juliana Lucena Schussel, José Miguel Amenábar Céspedes

ABSTRACT Background Fanconi anemia (FA) is associated with markedly increased risk for early‐onset oral squamous cell carcinoma (OSCC). Methods We report an aggressive mandibular squamous cell carcinoma in a 26‐year‐old non‐transplanted woman with FA initially interpreted as localized periodontal disease adjacent to a tongue leukoplakia. Results Initial examination demonstrated mild gingival inflammation and localized alveolar bone loss involving the right mandibular molars. Forty‐five days later, the patient retur …

27.08.2026journal-article

Blood Coagulation & Fibrinolysis

Glycoprotein 1bM assay and von Willebrand disease: a change in diagnosis

David Lazris, Craig Seaman

The diagnosis of von Willebrand disease (VWD) is complicated by limitations of traditional laboratory tests, such as the VWF ristocetin cofactor (VWF:RCo) assay. Newer assays, such as the VWF glycoprotein 1bM (VWF:GP1bM) assay, are more reliable and not affected by the D1472H polymorphism; thus, current hematology societal guidelines recommend these newer assays for diagnosing VWD. This study aims to perform a descriptive analysis of the impact of the VWF:GP1bM assay on the diagnosis of VWD among previously diagnos …

27.08.2026journal-article

International Journal of Cosmetic Science

New insights from data analysis of 12 global clinical studies on hair shedding

Yingjie Li, Shengnan Lin, Sarah Paterson, Tony Dadd, Jiayin Gu, Ranjit K. Bhogal, Zulfa Hudaya, Hepsy Y. Selliah, Mingming Pu, Jianing N. Sun

Abstract Excessive hair shedding continues to be a major concern for individuals, negatively affecting their wellbeing and confidence. This research analysed 12 clinical studies involving 805 participants (323 males and 482 females) across eight countries (China, Indonesia, UK, India, Brazil, Thailand, Turkey and US) with concerns about hair loss. Two recent studies in China and a study in Indonesia were investigated in depth, focusing on hair shedding and breakage conditions, and age‐related differences in hair sh …

27.08.2026journal-article

Frontiers in Medicine

Advanced and underlying therapeutic strategies in transformed small cell lung cancer

Mingfeng Wei, Zheng Li, Kaiyuan Zhu, Shixiang Guo, Lefei Hu, Fuzhi Yang, Xiaoyu Chen, Xuelin Zhang, Shuai Jiang, Xunxia Zhu, Xiaoyong Shen

Transformed small-cell lung cancer (T-SCLC) is a clinically important form of histologic transformation and a mechanism of acquired resistance in non-small-cell lung cancer (NSCLC). It is associated with poor prognosis, with a median overall survival of only about 9–13 months. This review summarizes recent advances in the mechanisms, diagnosis, monitoring, and treatment of T-SCLC. Repeat biopsy remains the gold standard for confirming histologic transformation, whereas molecular profiling and liquid biopsy may faci …

27.08.2026journal-article

The Annals of The Royal College of Surgeons of England

Evaluating large language models in patient education: a comparative analysis addressing frequently asked questions in peri-acetabular osteotomy

TP Davis, B Guevel, K Logishetty, AG Dick, J Hutt

Introduction Large language models (LLMs) are increasingly used as sources of information across many fields, including healthcare. As patients turn to these models for health-related queries, evaluating the accuracy and reliability of their responses is essential. Peri-acetabular osteotomy (PAO) is performed on younger patients – a group more likely to use digital tools like LLMs for health information. This study assesses the accuracy and readability performance of two leading LLMs, ChatGPT and Google Gemini, in …

27.08.2026journal-article

Clinical Spine Surgery

Revisiting the Incidence and Risk Factors for Cervical Postlaminectomy Kyphosis

Takashi Hirase, Colten Rowan, Thomas Jacob, Max Sadlowski, Sree M. Vemu, Austin Nguyen, Gregory S. Kazarian, Kevin J. DiSilvestro, Rex A.W. Marco, Todd J. Albert, Han J. Kim

Study Design: Systematic review. Objective: To perform a systematic review that investigates the incidence and risk factors for cervical postlaminectomy kyphosis. Summary of Background Data: There is a wide range of incidences and risk factors for cervical postlaminectomy kyphosis reported within the literature. Definitive recommendations on indications and technical considerations to minimize this complication remain elusive. Methods: A systematic review was registered with PROSPERO and conducted in accordance wit …

27.08.2026journal-article

Aperture Neuro

Large-Scale Open Science Simulated Data to Study the Development of Brain and Behavior Relationships: Epidemiologic, Clinical, and Neuroimaging Characteristics

Tonya White, Neda Sadeghi, Luke Norman, Vince Calhoun, Philip Shaw

Both brain and behavior undergo considerable changes during adolescence, a time synonymous with the emergence several psychiatric disorders, including mood and psychotic disorders. Multiple studies have explored the interaction between brain and behavior during childhood and adolescence, with both mixed and convergent findings between the studies. One challenge is that different longitudinal models can be applied to both the same or similar dataset and yet yield different results. Without knowing the ground truth, …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Clinical effects of nutritional risk screening 2002-guided individualized nutritional intervention in postoperative colorectal cancer patients: A time-period comparison study

Xiu-Lian Zhang, Qing-Qi Hong, Li-Zhen Lin

BACKGROUND Postoperative malnutrition prevalence among colorectal cancer (CRC) patients is high and has an essential impact on the recovery process and quality of life. Traditional models of nutritional management are not individualized and have limited efficacy. New insights have emerged from the application of enhanced recovery after surgery concept that can help us improve patients post-operative nutritional status. AIM To investigate the effects of nutritional risk (NR) assessment associated with individualized …

27.08.2026journal-article

Sports Health: A Multidisciplinary Approach

Imaging and Clinical Factors Associated With Return to Play and Recurrence After Quadriceps Muscle Strain Injury

Samuel Pietsch, Brady Green, Anthony G. Schache, Andrew Rotstein, Milo MacBain, Michael Paks, Tania Pizzari

Background: Limited information is available about factors that impact prognosis after quadriceps muscle strain injury, particularly injuries involving the rectus femoris. This study aims to determine whether baseline clinical and radiological findings are associated with time to return to play (RTP) and injury recurrence after rectus femoris muscle strain injury in elite Australian Football players. Hypothesis: Baseline magnetic resonance imaging (MRI) findings related to the specific anatomical location and sever …

27.08.2026journal-article

PLOS Medicine

A clinical decision support tool for accurate hip fracture prediction: A nationwide cohort study

Kristian F. Axelsson, Henrik Litsne, Konstantinos Konstantinou, Hussnain Khalid, Aldina Pivodic, Mattias Lorentzon

Background Although hip fractures are commonly associated with functional decline, increased morbidity, and mortality, accurate models for both short- and long-term prediction that do not rely on in-person assessment remain lacking. The aim was to develop and validate a high-performing clinical decision support tool, that can be used for population screening without the need for patient assessment, for predicting hip fracture risk. Methods and findings All individuals aged ≥50 years living in Sweden at baseline (ra …

27.08.2026journal-article

PLOS Global Public Health

Delayed diagnosis as a barrier to Zero Leprosy: Lived experiences from Pakistan

Anil Fastenau, Rhea Brüggemann, Abdul Salam, Charlotte Nehring, Maresa Neuerer, Hamideh Ebrahimi, Alexandra Asboeck, Matthew Willis, Sophie C. W. Unterkircher, Fabian Schlumberger, Heleen Neeltje Willemijn Duighuisen

Despite progress in leprosy control, delayed diagnosis remains a barrier to achieving Zero Leprosy, particularly in low-endemic settings. Diagnostic delay not only sustains hidden transmission but also leads to preventable disability and lifelong consequences for affected individuals. Pakistan, although classified as low endemic, continues to report a high proportion of new leprosy cases presenting with grade 2 disability (G2D), indicating delays in case detection. This study explored the reasons for delayed lepros …

27.08.2026journal-article

Frontiers in Medicine

The double-edged role of SPAG6 in male reproductive toxicity: pro-invasive in leukemia, protective in germ cells

Jing Luo, Jiaxiu Yin, Junli Mou, Kexin Lin, Lin Liu, Yao Zhang

Background Male testis is highly susceptible to irreversible damage from acute myeloid leukemia (AML) infiltration and subsequent chemotherapy. As a gene critical for sperm function, the role of SPAG6 in AML testicular infiltration and chemotherapy-induced injury remains poorly elucidated. Methods SPAG6 expression was knocked down in C1498 leukemia cell line, and its impact on testicular infiltration was evaluated in vivo . RNA sequencing was performed to identify altered pathways. In parallel, SPAG6 was silenced i …

27.08.2026journal-article

Frontiers in Medicine

Development and internal validation of a prognostic nomogram for recurrence in chronic rhinosinusitis with nasal polyps after functional endoscopic sinus surgery

Yang Yang, Congli Geng, Jiahua Luo, Min Wang, Xiaopei Yuan, Yan Liu, Shichang Li, Zhimin Xing

Objectives Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently recurs after functional endoscopic sinus surgery (FESS). This study aimed to develop and internally validate a prognostic nomogram for predicting the two-year recurrence-free rate (RFR) in patients with CRSwNP after FESS. Methods A total of 404 patients with CRSwNP who underwent FESS were retrospectively enrolled and randomly divided into a training cohort (n = 303) and an internal validation cohort (n = 101). Recurrence was defined as the firs …

27.08.2026journal-article

Türk Tıp Dergisi

Clinical Evaluation and Management of Household Cleaning Product Ingestions in a Pediatric Emergency Department

Aytac Goktug, Mehmet Muhsin Kefçi, Gülser Esen Besli, Çiğdem Ulukaya Durakbaşa

Objective: To evaluate the demographic, clinical, and prognostic characteristics of household cleaning product ingestion in a pediatric emergency department. Methods: This retrospective study evaluated pediatric patients admitted to the emergency department after ingesting household cleaning products. The ingested agents were categorized into high- and low-risk groups. Demographic profiles, prehospital interventions, clinical symptoms, physical examination findings, and endoscopic outcomes were analyzed to compare …

27.08.2026journal-article

The Chemical Record

Graphene‐Based Composites for Cancer and Antimicrobial Applications: From Structural Design to Clinical Practice

Jing Xu, Yujia Han, Haixiang Zeng, Hongxia Li, Xiaohui Niu, Xiaoyu Liu, Li Chen, Deyi Zhang, Dongqiang Zhang, Kunjie Wang

Through synergistic interactions with functional components such as metals, metal oxides, polymers, and biomolecules, graphene‐based composites can simultaneously exhibit properties including photothermal conversion, drug delivery, imaging, and molecular recognition, demonstrating significant application potential in cancer diagnosis and treatment as well as antimicrobial therapy. Given that existing research has primarily focused on graphene materials themselves and that a systematic summary of the relationship be …

27.08.2026journal-article

Journal of Cutaneous and Aesthetic Surgery

Critical analysis of the Limberg flap

Vishwa Deep, Veena Kumari Singh, Ansarul Haq, Sarsij Sharma

Limberg flap is a very popular and useful flap design for management of small to medium defects, especially on the face, head, and neck, as well as trunk, gluteal and sacral area. Its predictability and simple design make it a handy flap for wound closure and achieving satisfactory results for both the surgeon and the patient. The nuances, basic concepts and principles behind this flap are yet not understood by many operating surgeons. It is done easily, but without understanding what is the basis of this flap, lea …

27.08.2026journal-article

Frontiers in Immunology

Development and clinical implementation of a local automated kidney allocation platform integrating virtual crossmatch

Mohammad Awaji, Saber AlZahrani, Rafah Bamrdouf, Dalal AlAbduladheem, Amani Mohammed, Mariam Alzahrani, Shaima Alkebasi, Bashaer Mohammad Alshallali, Abdullah Saad Alreaan, Sara Mohammed Bosbait, Sumayah Askandarani, Najib Ashoor Musaied, Khalid Beleed Akkari, Mohammed AlQahtani, Abdulnaser Mohammed Alabadi

Background Highly sensitized kidney transplant candidates possess preformed anti-human leukocyte antigen (HLA) antibodies that substantially reduce their likelihood of receiving a compatible deceased-donor organ. Manual virtual crossmatch (VXM) workflows are sequential and labor-intensive, often limiting histocompatibility laboratories to screening only a subset of eligible candidates during time-sensitive donor evaluations and potentially overlooking compatible recipients. Methods We designed and developed an auto …

27.08.2026journal-article

Clinical Science

Maternal microchimerism: foreign friend, hidden enemy

Nikola Malinská, Ilja Stříž, Jan Černý

Abstract Maternal microchimerism (MMc) encompasses the transfer and long-term persistence of maternal cells within the offspring—beginning in utero via the placenta and continuing after birth through breastfeeding. Once viewed as an immunological oddity, MMc is now recognized as a dynamic, multifaceted process that permeates the entire field of developmental physiology. Maternal cells, including tissue-specific, immune, and stem/progenitor populations, are not mere passengers; they integrate and functionally engage …

27.08.2026journal-article

Clinical Science

Combined 31P and 1H MRS show that impaired muscle O2 supply limits ATP synthesis during exercise in systemic sclerosis

Graham J. Kemp

Abstract Muscle weakness and fatigue feature in many diseases, but the underlying pathophysiology can be difficult to study in vivo. In patients with the chronic autoimmune disease systemic sclerosis (SSc), considerable disability results from small-vessel vasculopathy and progressive fibrosis. Alongside cardiopulmonary limitations on exercise capacity, there is increasing evidence of peripheral dysfunction. In a study reported in this issue, Layec and colleagues investigate this in exercising skeletal muscle in vi …

27.08.2026journal-article

Otolaryngology–Head and Neck Surgery

Intraoperative PTH Monitoring in Primary Hyperparathyroidism: A Risk‐Stratified Approach

Sholem Hack, David Z Allen, Eric Remer, Eran E Alon, Gianna L Rosamilia, Ugur Nur Basmaci, Ron J Karni

Abstract Objective To evaluate whether routine intraoperative parathyroid hormone (ioPTH) monitoring is necessary in all cases of sporadic primary hyperparathyroidism (pHPT) in the era of advanced preoperative localization and to propose a conservative, risk‐stratified operative framework. Data Sources PubMed, Scopus, and Embase were searched for English‐language publications from January 2020 through January 2026, supplemented by key guidelines, consensus statements, and high‐impact reviews. Review Methods This na …

27.08.2026journal-article

Indian Journal of Plastic Surgery

The Use of Reverse Flow Free Radial Forearm Flap in Head and Neck Reconstruction

Gautam Biswas, Karnav Bharat Panchal

Abstract The free radial forearm flap (RAFF) is one of the most common flaps used in head and neck reconstruction. Exposure of tendons, limited skin volume, and graft loss are its known drawbacks. The reverse flow RAFF (RF-RAFF) where the skin island is designed over the proximal forearm offers many advantages over the conventional radial forearm free flap. A larger volume of skin is available with the bed being covered with muscle suitable for split-thickness skin graft. Though the use of RF pedicled RAFF is routi …