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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Scientific Reports

Clinical evaluation of a sit-to-stand dual-posture mobility device for people with spinal cord injuries

Yukiyo Shimizu, Hideki Kadone, Yosuke Eguchi, Kai Sasaki, Shunsuke Kido, Diego Paez-Granados, Modar Hassan, Yang Chen, Shigeki Kubota, Masashi Yamazaki, Yasushi Hada, Kenji Suzuki

Abstract Wheelchair users face health risks from prolonged sitting and social barriers owing to the vertical gap between their seated position and standing able-bodied individuals. We present Qolo, a novel standing mobility device equipped with passive exoskeletons for intuitive sit-to-stand transitions. Three prototypes were iteratively evaluated with 13 unique participants with spinal cord injury (SCI) from cervical to lumbar levels (C5-L3): Qolo-1 (n = 4), Qolo-2 (n = 12), and Qolo-3 (n = 5), with 3 participants …

27.08.2026journal-article

Diabetology

Reply to Klonoff et al. Limitations of a Recent Study on Insulin Pen Needle Preferences in People with Diabetes. Comment on “Gentile et al. Enhancing Insulin Therapy Adherence Through Technology: Which Needles Do People with Diabetes Prefer? Diabetology 2026, 7, 56”

Sandro Gentile, Raffaella Fiorentino, Maddalena Lettieri, Giuseppina Guarino, Giampiero Marino, Elisabetta Tommasi, Vera Frison, Ersilia Satta, Maria Chiarello, Giuseppe Caccavale, Emilia Masuccio, Felice Strollo

This response letter addresses criticisms from a recent commentary regarding a real-world survey on insulin pen needle preferences. The authors clarify that their study was purposefully designed as an observational survey to capture genuine patient perceptions under routine clinical conditions, rather than functioning as a randomized controlled trial. Consequently, methodological constraints such as blinding were fundamentally inapplicable. Furthermore, the authors emphasize the limited relevance of the Hawthorne e …

27.08.2026journal-article

The Egyptian Journal of Internal Medicine

Molecular interaction mechanisms of muscle fiber type transition in aging sarcopenia and the role of exercise intervention

ShaoHui Zhang, Jialin Zhang, Tao Fu, Linliang Zhao, Kexin Li, Sifan Yan

Abstract Muscle fiber type transition is a core pathophysiological process in aging sarcopenia; however, existing research has often analyzed its underlying mechanisms in isolation. This review systematically characterizes the features of muscle fiber type transition in sarcopenia at the neural, cellular, and microenvironmental levels, and dissects the multidimensional molecular interaction mechanisms, including disrupted neural input, aberrant intracellular protein metabolism, and inflammaging. Based on this mecha …

27.08.2026journal-article

Diabetes Care

The Joint Effects of Life’s Essential 8 and Genetics on Mild Cognitive Impairment and Dementia Risk in People With Diabetes: Findings From the UK Biobank and All of Us

Xiu Wu, Yuanhao Zu, You Lu, Yue Zhao, David Crosslin, Vivian Fonseca, Demetrius Maraganore, Yilin Yoshida

OBJECTIVE We examined how cardiovascular health (CVH), measured by Life’s Essential 8 (LE8), and genetic risk are jointly associated with risks of mild cognitive impairment (MCI), dementia, and related cognitive outcomes in people with diabetes. RESEARCH DESIGN AND METHODS We analyzed 41,374 participants without dementia from the UK Biobank (UKB) and 9,766 from All of Us (AoU). LE8, comprising diet, physical activity, nicotine exposure, sleep, body mass index, lipids, blood glucose, and blood pressure, was scored f …

27.08.2026journal-article

Inquiry@Queen's Undergraduate Research Conference Proceedings

Continuous Glucose Monitoring Trends Among Ethnically Diverse People with Type 2 Diabetes

Katherine Zhu

Background: Ethnic background and social determinants of health influence glycemic management and type 2 diabetes (T2D) outcomes, with inequities in risk and complications across diverse populations, even at similar body mass index. Hemoglobin A1c, the standard glycemic biomarker, may perform differently across ethnic groups and does not fully capture glucose variability, highlighting the need for alternative metrics. Intermittently scanned continuous glucose monitoring (CGM) offers a more granular assessment, but …

27.08.2026journal-article

Cancer

Cancer statistics for Asian American, Native Hawaiian, and Pacific Islander people, 2026

Nikita Sandeep Wagle, Angela N. Giaquinto, Mandi Yu, Hyuna Sung, Tyler B. Kratzer, Kekoa Taparra, Jessica Star, Ahmedin Jemal, Rebecca L. Siegel

ABSTRACT Background Cancer statistics for Asian American and Native Hawaiian and Pacific Islander (NHPI) people are usually aggregated, masking substantial variation within this heterogeneous population. Herein, the American Cancer Society reports cancer incidence and survival for 8 Asian American and 3 NHPI ethnic groups. Methods The authors used population‐based cancer registry data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results program, for Asian American and NHPI ethnic groups …

27.08.2026journal-article

Frontiers in Nutrition

Joint trajectories of adiposity and systemic inflammation and incident diabetes among older adults: a bi-cohort prospective study with mediation analysis

Fubin Teng, Shichao Li, Di Liu

Background Obesity and chronic low-grade inflammation are established risk factors for type 2 diabetes, yet their joint longitudinal evolution and combined contribution to diabetes incidence remain poorly characterized in aging populations. Objective To identify joint trajectories of adiposity and systemic inflammation, evaluate their associations with incident diabetes, and quantify the mediating role of glycated hemoglobin (HbA1c) across two independent cohorts. Methods This prospective study included 3,733 diabe …

27.08.2026journal-article

JMIR Aging

Developing Digital Platforms to Help Older Adults Stay Physically and Socially Active: Co-Design Study to Develop a Toolkit and Evaluate Its Impact

Leonie Cooper, Hannah Bradwell, Colin B Shore, Simone A Tomaz, Rory Baxter, Gemma C Ryde, Swen E Gaudl, Richard Haynes, Catherine Hennessy, Ray B Jones, Anna C Whittaker, The GOALD Project

Abstract Background Digital technologies have the potential to support physical, cognitive, and social activity among older adults, but many small- and medium-sized enterprises (SMEs) lack the resources to conduct meaningful co-design with older adults. Toolkits derived from rigorous co-design processes may offer a scalable mechanism for translating end-user priorities into real-world product development. Objective The Generating Older Active Lives Digitally study aimed primarily to engage older adults in a co-desi …

27.08.2026journal-article

BMC Public Health

Engaging tuberculosis-affected people in investment decisions: applying a people-centered design approach in Viet Nam

Rachel Forse, Phuong-Tra Vu, Trang Nghiem, Luan Nguyen Quang Vo, Andrew James Codlin, Ngoc B. Pham, Ngan Huynh, Thanh Thi Nguyen, Luu Quang Vinh, Nguyen Thi Kim Ngan, Nguyen Thi Thuy, Pham Viet Phuong Khanh, Nguyen Duc Bang, Andrew Cross, Michael Wilson, Karolin Lüneburg, Montana Cherney, Tobias Silberzahn, Luong Van Dinh, Hoa Binh Nguyen, Lan Huu Nguyen, Ha Dang Thi Minh, Khai T. M. Nguyen, Tiep T. Hua, Jacqueline Huh, Kristi Sidney Annerstedt

Abstract Background Tuberculosis (TB) remains the leading cause of death from an infectious disease globally, yet financing for the TB response continues to fall far short of identified needs. Decisions about how resources are allocated are often made with limited engagement of people directly affected by TB, potentially overlooking lived experiences and community-defined priorities. This study was implemented in Viet Nam to align future TB investments with community-defined priorities and programmatic feasibility. …

27.08.2026journal-article

BMC Infectious Diseases

Factors associated with multidrug-resistant tuberculosis among people living with HIV in Addis Ababa, Ethiopia: a case-control study

Daniel Girma, Haymanot Berihun, Abel Temam, Abel Felege

Abstract Background Tuberculosis (TB) remains a leading cause of morbidity and mortality globally, particularly in developing countries. Multidrug-resistant TB (MDR-TB), defined as resistance to at least isoniazid and rifampicin, poses a serious public health challenge. People living with HIV (PLWHIV) are 16 times more likely to develop TB than HIV-negative individuals, and TB is the leading cause of death in this population. Despite this, evidence on the specific factors associated with MDR-TB among PLWHIV in Addi …

27.08.2026journal-article

Frontiers in Dementia

Polygenic score for sleep duration in relation to the risk of Alzheimer’s disease: results from the UK biobank

Angel T. Y. Wong, Sarah Floud, Gillian K. Reeves, Michael V. Holmes, Ruth C. Travis, Cornelia M. van Duijn, Aiden Doherty, Karl Smith-Byrne

Studies have suggested that sleep duration may be associated with Alzheimer’s disease risk; however, findings based on self-reported sleep duration are likely to be influenced by reverse causation and residual confounding bias. We derived weights for genetic variants associated with wearable-derived sleep duration using the LDpred2-auto method in 77,770 white British participants from the UK Biobank, following the generation of new genome-wide association summary statistics. We then used these weights to generate p …

27.08.2026journal-article

Safety and Risk of Pharmacotherapy

Strategies for Replacing Potentially Inappropriate Medications in Older Adults According to the Beers Criteria

S. A. Mishinova

INTRODUCTION. In geriatrics, the practice of empirical symptomatic use of medications without establishing a definitive diagnosis has become entrenched, while clinical guidelines are focused on specific disease entities. The updated document “Alternatives to Specific Medications According to the American Geriatrics Society Beers Criteria (2023)," published in 2025 by the American Geriatrics Society, provides recommendations with a high level of evidence. However, their direct transfer into Russian clinical practice …

27.08.2026journal-article

Frontiers in Public Health

eHealth literacy in older patients with cardiovascular disease: latent profile analysis and associated factors

Mengjie Xu, Qianqian Sun, Qiping Chen, Ying Xia

Objective This study aimed to explore the potential latent categories of electronic health (eHealth) literacy among older patients with cardiovascular diseases and analyze the factors associated with eHealth literacy profiles. Methods From November 1, 2025 to April 15, 2026, we employed the convenience sampling method to conduct a survey on a total of 459 patients from a tertiary A hospital in China. The demographic information questionnaire and the Electronic Health Literacy Scale were employed to collect the soci …

27.08.2026journal-article

Frontiers in Nutrition

Diagnostic variability in sarcopenia and sarcopenic obesity among older adults: a clinical and public health challenge

Táscya Morganna de Morais Santos, Gabriel Soares Bádue, Nykholle Bezerra Almeida, Celina de Azevedo Dias, Jessiane Rejane Lima Santos, Piettra Moura Galvão Pereira, Enaiane Cristina Menezes, Fabiana Andréa Moura, João Araújo Barros-Neto

Introduction Sarcopenia and sarcopenic obesity (SO) are highly prevalent among older adults; however, the lack of standardized diagnostic criteria compromises epidemiological comparability and clinical practice. Therefore, this study aimed to evaluate differences in the prevalence and diagnostic agreement of sarcopenia and SO according to different indicators of muscle strength and adiposity. Methods A cross-sectional study was conducted among 870 community-dwelling older adults. The prevalence and diagnostic agree …

27.08.2026journal-article

Frontiers in Nutrition

Comparative effects of pea protein vs. dairy proteins (α-lactalbumin and casein) on aminoacidemia, exercise performance, gut microbiota, hormonal responses, neurocognitive function, mood, and metabolic–inflammatory responses in older adults

Shuai Hao, Fulong Jin, Xiaowei Lei, Yichen He, Yin Liu

This narrative review comprehensively contrasts the physiological impacts of plant-based protein (focusing on pea protein isolates and matrices) vs. dairy-derived proteins (including intact casein and whey protein variants, emphasizing the rapid-digesting α-lactalbumin fraction). We establish a structured framework to separately report evidence from preclinical animal models and clinical human trials, evaluating acute (< 24 h) and chronic (>7 days) horizons across three domains: (i) neurocognitive function/mo …

27.08.2026journal-article

The Gerontologist

From ‘Old Man Yells at Cloud’ to Geronto-Futurism: Co-Imagining Holography and Aging

Stefan Schweigler

Abstract This article explores the discursive, industrial, artistic, and practical interconnections between older people, aging, and holography, arguing that their nexus mutually shapes how both concepts are culturally constituted. Methodologically, the paper utilizes a discourse and representation analysis to examine a heterogeneous corpus of actual wave-optic holography and pseudo-holographic lens-optic phantasmagorias—collectively addressed as “(quasi-)holographic” phenomena. Dissolving the boundaries between cu …

27.08.2026journal-article

Frontiers in Endocrinology

Effectiveness of community—based Baduanjin combined with resistance training on cardiometabolic risk factors in older adults with type 2 diabetes: a 16-week randomized controlled trial

Fengfeng Liu, Xiaoxiang Zhu, Haokai Leng, Changzhou Chen

Background Baduanjin and resistance training improve metabolism and function; however, it is unclear whether their combination reduces cardiometabolic risk in older adults with type 2 diabetes mellitus (T2DM). This study aimed to determine the effects of 16-week BDJ combined with resistance training on cardiometabolic risk parameters in older adults with T2DM. Methods An assessor-blinded, randomized controlled. A total of 123 participants were enrolled and randomly assigned to either an intervention group (IG) that …

27.08.2026journal-article

Social Sciences

Loneliness in Older People in Requena del Tapiche (Peruvian Amazon): A Qualitative Study of Reflexive Thematic Analysis

María Teresa Murillo-Llorente, Esther Legidos-García, Marcelino Pérez-Bermejo, Omar Cauli, Vanessa Ibáñez-del Valle

Background: Loneliness in older adults is a global public health problem. Although robust evidence exists regarding its consequences, the evidence base is marked by a bias towards high-income countries and urban contexts. The rural Peruvian Amazon is a territory virtually absent from the scientific literature on ageing and loneliness. Methods: We conducted a descriptive–interpretive qualitative study based on 34 semi-structured interviews with adults aged 60 years and over, recruited through Cáritas-Requena. Analys …

27.08.2026journal-article

Diabetes, Obesity and Metabolism

Real‐World Glycemic Outcomes of Open‐Source Automated Insulin Delivery During 12 Months Among People With Type 1 Diabetes Across Age Groups

Qiongyan Lin, Ziqing Lin, Ping Ling, Ying Ni, Mengyun Lei, Yanli Cao, Daizhi Yang, Wen Xu, Hongrong Deng, Yongwen Zhou, Jinhua Yan

ABSTRACT Aims To assess glycemic outcomes across different age groups and explore factors associated with glycemic target achievement during 12‐months open‐source android artificial pancreas (AAPS) use among people with type 1 diabetes (T1D). Methods This study included people with T1D who had used AAPS continuously for 12 months. Glycemic outcomes were assessed at 3, 6, and 12 months post‐initiation by age stratification (2–7, 8–12, 13–18, 19–30, 31–45, and > 45 years). Factors associated with achieving composite …

27.08.2026journal-article

Journal of Polymer Research

Radiation induced free radical stability and degradation behavior in GUR resin and 1900 resin types UHMWPE over 20 years of aging

Afsana Sharmin, Farhan Azim, Benjamin M. Walters, Muhammad S. Jahan

Abstract Radiation-induced free radical stability was evaluated using Electron Spin Resonance (ESR) for two medical-grade Ultra High Molecular Weight Polyethylene (UHMWPE) resins, GUR 4150 and 1900H, after 20 years of aging in air and vacuum at 23 °C, 37 °C, and 75 °C. Spectral analysis revealed oxygen-induced radicals in samples aged in air at 23 °C and 37 °C, with higher concentrations at 23 °C, whereas vacuum-aged samples retained primary radiation-induced radicals that decreased progressively with increasing te …

27.08.2026journal-article

World Electric Vehicle Journal

A Hierarchical Multi-Timescale Method with Aging-Aware Capacity Correction for Low-Temperature State-of-Charge Estimation of Lithium-Ion Batteries

Yuting Feng, Lichuan Zhang, Nazerke Yermek, Hany M. Hasanien, Mohammed Alharbi, Chuanyu Sun, Mingming Ge, Xuan Meng

Accurate state-of-charge (SOC) estimation is essential for range prediction, power allocation, and operational safety in electric vehicles. Low-temperature operation introduces coupled effects of capacity degradation and polarization dynamics, which challenge conventional fixed-capacity models and single-timescale estimation methods. This paper proposes a hierarchical multi-timescale SOC estimation framework that combines data-driven capacity prediction, online parameter identification, and nonlinear state estimati …

27.08.2026journal-article

Neuro-Oncology

37 Outcomes of a National Specialist Counselling Service for People Affected by Brain Tumours

Jen Boilestad, Joanna Moss

Abstract Introduction A brain tumour diagnosis profoundly affects physical, emotional and mental health. Surveys by The Brain Tumour Charity highlighted that 41% of people affected reported unmet emotional needs after diagnosis, and 91% shared that their mental health was impacted, yet less than half had access to counselling. In response, the Charity launched a free professional counselling service in 2022 to help patients and loved ones navigate the psychological challenges that accompany a brain tumour diagnosis …

27.08.2026journal-article

PLOS Aging and Health

The joint associations of pulmonary function and relative grip strength with metabolic syndrome in lung-healthy older adults: Cross-sectional findings from the Physical Activity and Aging Study

Joey M. Saavedra, Elizabeth C. Lefferts, Brian Downer, Duck-chul Lee

While lung disease is strongly associated with metabolic syndrome (MetS), the relationship between healthy pulmonary function and metabolic syndrome (MetS) in older adults remains unclear. It is also unknown if this association is independent of relative grip strength, a robust correlate of MetS. We examined the association between Z-score categories of the Forced Expiratory Volume in 1 second (FEV1) and prevalent MetS in a cohort of lung-healthy older adults. This cross-sectional study analyzed data from an ongoin …