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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Public Health

Cost-effectiveness of tremelimumab plus durvalumab versus sorafenib for unresectable hepatocellular carcinoma in China: an economic evaluation based on five-year overall survival data from the HIMALAYA trial

Rui Feng, Ping Liang, Yajing Wang, Dong Li, Huixian Jia, Ying Zheng, Liman Huo, Qi Lv

Objective To assess the cost-effectiveness of tremelimumab plus durvalumab [the Single Tremelimumab Regular Interval Durvalumab (STRIDE) regimen] versus sorafenib as first-line treatment for unresectable hepatocellular carcinoma in China using 5-year follow-up data from the HIMALAYA trial. Methods A three-state partitioned survival model comprising progression-free survival, progressed disease, and death was developed from the perspective of the Chinese healthcare system. Individual patient data were reconstructed …

27.08.2026journal-article

Frontiers in Immunology

Datopotamab deruxtecan in breast cancer treatment: a systematic review of clinical efficacy and safety

Julia Piekarz, Natalia Picheta, Jakub Pobideł, Natalia Gierulska, Krzysztof Kułak, Rafał Tarkowski

Background Breast cancer (BC) remains the most common malignant tumor in women worldwide and a leading cause of cancer-related deaths. Despite therapeutic advances, patients with advanced BC, particularly triple-negative breast cancer (TNBC), still face limited effective treatment options. Antibody-drug conjugates (ADCs) represent a compelling strategy that combines precise tumor targeting with cytotoxic payloads, effectively bridging targeted delivery with microenvironmental disruption. Datopotamab deruxtecan (Dat …

27.08.2026journal-article

F1000Research

How to measure the perimeter from digital images

David Legland

Image analysis aims at extracting quantitative information from digital images. As for any measurement method, the measures obtained from image analysis present some measurement errors that should be better considered during interpretation of results. This work investigates the quality of measures obtained from image analysis based on measurements on synthetic shapes with various geometries, sizes, positions and orientations, by focusing on the methods available in common image analysis software. The perimeter is u …

27.08.2026journal-article

Clinical Psychology & Psychotherapy

Are Metacognitive Beliefs and Cognitive Flexibility Associated With Cannabis Use Disorder In Adolescents? A Case–Control Study

Neval Kızıl, Masum Öztürk, Fatma Subaşı Turgut, Yağmur Soysal, Ayfer Gözü Pirinççioğlu

ABSTRACT Objective Cannabis is among the most commonly used substances by adolescents and is frequently associated with the development of addiction. Various individual, environmental and psychological factors are associated with the onset and maintenance of cannabis use disorder (CUD). Our study aimed to compare levels of depression, anxiety, stress, perceived cognitive flexibility and metacognitive beliefs in adolescents diagnosed with CUD with those in a healthy control (HC) group. Another objective was to inves …

27.08.2026journal-article

Frontiers in Psychology

Artificial intelligence-assisted speaking in Spanish as a foreign language: effects on foreign language emotions and willingness to communicate

Yifan Miao, Pingping Hu

Introduction Although AI-powered conversational tools are increasingly used in foreign language education, little is known about their longitudinal effects on learners’ emotional experiences and willingness to communicate (WTC), particularly among beginner learners of languages other than English. Grounded in Positive Psychology, Control-Value Theory, and the WTC framework, this study examined the effects of AI-assisted speaking practice using TalkPal AI on foreign language enjoyment (FLE), foreign language anxiety …

27.08.2026journal-article

JURPIKAT

Akselerasi Validasi Spasial melalui Plotting Data Digital PTSL di Loket Yuridis Kantor Pertanahan

Toton Fanshurna, Nadia Ludyanti Esya Putri, Calista Putri Fitriana, Rensi Haiziah

Pendaftaran Tanah Sistematis Lengkap (PTSL) tak sekadar menghasilkan dokumen, melainkan membentuk basis data pertanahan yang menuntut ketepatan serta keterhubungan informasi yuridis dan spasial. Masalah timbul saat data digital dalam jumlah besar memerlukan penataan ulang akibat ketidaksesuaian informasi.Kegiatan pengabdian ini bertujuan mendukung percepatan validasi spasial melalui plotting data digital PTSL di Loket Yuridis Kantor Pertanahan Kabupaten Jember. Metode dilakukan secara partisipatif, meliputi identif …

27.08.2026journal-article

Responsible Enterprise Pedagogy

Fair and equitable digital literacy and technology education: addressing the education gap through social entrepreneurship

Amy Abdou, Irene van Driel, Dadi Chen

Purpose This study examines two small social enterprises – a social business and a non-profit – founded by the same entrepreneur that provide digital literacy and technology education in the Netherlands. By comparing two distinct social enterprise models and their approaches to equitable supplemental education, the paper explores the relationships among entrepreneurial logics, organizational practices and external stakeholder involvement, including the role of government. Design/methodology/approach Drawing on thre …

27.08.2026journal-article

Journal of Fish Health

Growth Performance and Pathological Responses of Tissue Culture and Local <i>Kappaphycus alvarezii</i> Seedlings in Marine Waters of Punti Village, Bima Bay, Indonesia

Alis Mukhlis, Nadirah Karimatul Ilmi, Sanca Rahmatullah, Anita Prihatini Ilyas, Ardyen Saputra

Kappaphycus alvarezii is an economically important carrageenan-producing red alga, and tissue culture has been promoted as a means of improving seedling quality and field growth performance in Indonesian seaweed farming; however, field-based evidence comparing tissue-culture and conventional (local) seedlings under commercial cultivation conditions remains limited. This study therefore compared the growth performance and disease susceptibility of tissue-culture-derived and local Kappaphycus alvarezii seedlings cult …

27.08.2026journal-article

Al Qodiri : Jurnal Pendidikan, Sosial dan Keagamaan

Mental Health from the Perspective of Positive Psychology and the Concept of Patience and Gratitude in Islam

Rudi Herianto

Mental health is increasingly understood as a multidimensional condition involving psychological functioning, meaningful relationships, positive emotions, and the ability to respond constructively to life challenges. Positive psychology provides an important framework for understanding these dimensions through human strengths, flourishing, meaning, and well-being. However, psychological perspectives alone may not fully capture the spiritual dimensions of mental health within Muslim communities. This study examines …

27.08.2026journal-article

Pilot and Feasibility Studies

The Mother Nature Programme: a single-arm mixed-methods feasibility study of a group nature-based intervention for mothers experiencing postnatal mental health difficulties and their infants

Katherine Hall, Rosa Roberts, Katrina Turner, Lucinda Stanton, Sherien Elsheikh, Christopher Barnes, Beverly Shirkey, Lucy Duggan, Paul Moran, Jonathan Evans

Abstract Background Postnatal mental health difficulties are common and often under-treated. Nature-based interventions have potential mental health benefits, but little research has focussed on their applicability postnatally. This study examined the acceptability and feasibility of delivering a co-designed, 5-week group nature-based intervention, The Mother Nature Programme (MNP), for mothers experiencing postnatal mental health difficulties and their infants, in preparation for a future trial. Methods A single-a …

27.08.2026journal-article

BMC Oral Health

Oral findings and antiresorptive therapy exposure duration in postmenopausal women with osteoporosis: a cross-sectional cohort study

Safiyye Süslü, Håvard J Haugen, Tormod Bjartveit Krüger, Bente B. Herlofson, Janne Elin Reseland, Erik Fink Eriksen

Abstract Background Oral findings are common among older adults, but it is unclear whether they vary with the duration of antiresorptive therapy (ART) exposure or relate to the severity of osteoporosis in postmenopausal women. Methods In this cross-sectional cohort ( n = 129), postmenopausal women undergoing osteoporosis assessment/follow-up were stratified by ART exposure duration: no current ART control (G1, n = 50), short ART (G2, 3–5 years; n = 39), and long ART (G3, > 5 years; n = 40). The prespecified primary …

27.08.2026journal-article

Biosensors

Artificial Intelligence in Electrochemical Sensing: A Network Evidence Map of Translational Barriers and Pathways to Point-of-Care Deployment

Muhammad Saqib, Elena I. Korotkova, Kunquan Li, Neda Firoz, Mrinal Vashisth, Amrit L. Hui, Olga I. Lipskikh, Pradip Kumar Kar

The integration of artificial intelligence (AI) and machine learning (ML) with electrochemical sensing has revolutionized analytical diagnostics by overcoming traditional limitations such as signal drift, peak overlapping, and matrix interference. However, despite the exponential growth of this field, a unified framework evaluating translational feasibility remains absent. This review critically analyzes AI/ML architectures applied to electrochemical sensors and biosensors from 2016 to 2025. To the best of our know …

27.08.2026journal-article

Materials

Antibacterial Interventions for Orthodontic Appliances; Surface Modifications, Coatings and Bulk-Incorporated Antibacterial Agents: Materials, Mechanisms and Clinical Application—A Scoping Review

Berta Furió-Alonso, Javier Gil, Danica Nikolic Jovanovic, Andreu Puigdollers-Pérez

Biofilm accumulation on orthodontic appliances is a recognized risk factor for white spot lesion formation and caries during treatment. Antibacterial surface modifications and coating strategies have been proposed as appliance-level preventive approaches. Studied interventions in the literature span true thin-film surface coatings, plasma-based and ion-implantation surface modifications, and bulk-incorporated antibacterial agents in appliance matrix materials. Yet the extent to which in vitro efficacy translates to …

27.08.2026journal-article

Journal of Plastic Surgery and Hand Surgery

Clinical outcomes of a defect-adapted strategy for free fibular great toe flaps in finger reconstruction: a retrospective series of 35 cases

Yangyang Liu, Huajian Zhou, Haoran Jiang, Jun Zhu, Renjie Li, Mingyu Jia

Background: To evaluate the clinical outcomes of a personalized surgical strategy for small-to-medium finger defects, utilizing either free dorsal toe or plantar proper digital artery flaps. Methods: We retrospectively analyzed 35 patients with finger defects (March 2021–January 2025). Patients were assigned by defect characteristics to Group A (pulp defects, n = 21; plantar proper digital artery flap) or Group B (dorsal/lateral defects, n = 14; modified dorsal toe artery flap preserving the plantar proper neurovas …

27.08.2026journal-article

Journal of the National Comprehensive Cancer Network

Fostering Improvements in Equitable Care Delivery: Insights From the Health Equity Report Card (HERC) Pilot in Academic Cancer Centers

Ashley Orr, Taneal D. Carter, Mallory Stubblebine, Heather McKee Hurwitz, Tiffany Go, Leticia Mercado, Darryl Outlaw, Elizabeth Bouchard, Levent Dumenci, Crystal S. Denlinger, Alyssa A. Schatz

Background: The Health Equity Report Card (HERC) was developed to support institutions in measuring equitable care practices and implementing improvement efforts. An objective of this study was to determine whether academic cancer centers can use their baseline HERC scores to identify institution-specific strategies to improve equitable care delivery. Methods: This quality improvement study collected quantitative and qualitative data from 5 NCCN Member Institutions about their quality improvement efforts in respons …

27.08.2026journal-article

Clinical Cancer Research

Focused Ultrasound-Enhanced Drug Delivery to Brain Tumors: Quantitative and Translational Insights from CNS Physiologically Based Pharmacokinetic Modeling

Andrew Wu, Charuka Wickramasinghe, Yuanyuan Jiang, Xun Bao, Jing Li

Abstract Purpose: Successful clinical translation of focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening strategy to brain cancer therapy has been hindered by limited quantitative understanding of CNS pharmacokinetics. Using a physiologically based pharmacokinetic (PBPK) modeling framework, this study aimed to quantitatively characterize FUS-modulated CNS pharmacokinetics and identify key determinants of potential clinical benefits. Experimental Design: A previously validated 9-compartment CNS PBPK m …

27.08.2026journal-article

Ege Eğitim Dergisi

In-Service English Teachers' Attitudes toward Artificial Intelligence in Education

Pelin Derinalp

The rapid advancement of technology requires teachers to adapt to this change. Artificial intelligence (AI) is increasingly being used in education and is gaining influence. Therefore, examining teachers' attitudes toward AI is important for the effective integration of technology. This study investigates the attitudes of English teachers in Türkiye toward AI. Using qualitative descriptive research design, participants were first asked to provide written definitions of AI. Subsequently, four focus group discussions …

27.08.2026journal-article

JAMA Health Forum

Mental Health and Construction—Intervening to Prevent Collapse

Rosa M. Gonzalez-Guarda, Molly Hayes, Luke Smith

This JAMA Forum discusses mental health and substance abuse problems among US construction workers and proposes a national strategy to ensure that evidence-based prevention, early identification, and treatment reach this population.

27.08.2026journal-article

Karya Journal of Health Science

THE EFFECT OF EDUCATION GIVEN TO HEMODIALYSIS PATIENTS ON SELF-CARE AGENCY AND FLUID CONTROL: A RANDOMIZED CONTROLLED TRIAL

Zeynep Yılmaz, Mağfiret Kara Kaşıkçı, Fatmanur İrgin

Objective: This study investigated the effects of education on hemodialysis management provided to patients receiving hemodialysis treatment on self-care agency and fluid control.Method: The study was conducted using a randomized controlled experimental design. Participants receiving hemodialysis treatment were divided into two groups: the intervention group (n=26) and the control group (n=28). Data were collected using the Descriptive Information Form, Self-Care Agency Scale, and Fluid Control in Hemodialysis Pati …

27.08.2026journal-article

Journal of Medical and Dental Investigations

Can digital impression methods eliminate the current problems of conventional impression techniques?

Yakup Kantaci

Conventional impression materials remain a cornerstone of routine dental practice, yet they carry well-documented drawbacks, including a pronounced gag reflex, limited patient comfort, potential soft-tissue trauma, dimensional changes with temperature and elapsed time, the need for disinfection, cross-infection risk, and susceptibility to distortion during transport, storage, and laboratory handling. Digital impression systems have been introduced to overcome these limitations, and their use in dentistry—particular …

27.08.2026journal-article

Engineering, Construction and Architectural Management

Information technology integration capability, digital marketing capability and construction enterprise performance: a moderated mediation analysis

Xiaolin Li, Ziyu Wang, Ruirui Zhang, Linpu Guo, Qiaoyan Yuan, Songbo Zhu

Purpose This study intends to explore whether information technology integration capability (ITIC), digital marketing capability and cross-channel integration capability (CIC) can improve construction enterprise performance (CEP) in China's construction industry amid global informatization, as well as the moderating role of digital platform capability between ITIC/digital marketing capability and CIC. Design/methodology/approach A theoretical model based on the research hypotheses proposed in this study was develop …

27.08.2026journal-article

Journal of Applied Research in Higher Education

Preparing sustainability-ready graduates: how identity and digital media literacy shape pro-environmental engagement in higher education

Edy Sabara, Jamaluddin Jamaluddin, Nurul Mukhlisah Abdal, Muhammad Asriadi, Wirawan Setialaksana

Purpose This study extends the theory of planned behaviour (TPB) by integrating ecomedia literacy and ecocultural identity to explain pro-environmental behaviour (PEB) among university students in Indonesia. It examines how cognitive, affective and socio-digital factors jointly shape sustainability engagement in higher education. Design/methodology/approach A quantitative, non-experimental cross-sectional design used an online survey distributed from 17 to 30 November, 2025 to 514 students across Indonesian univers …

27.08.2026journal-article

Philosophical Transactions of the Royal Society B: Biological Sciences

Functions of the EGFR in health and disease

Thomas Bauer, Martin Holcmann, Maria Sibilia

Abstract The epidermal growth factor receptor (EGFR) is a critical mediator of cellular physiology, and its deregulation is implicated in a broad spectrum of pathological conditions, ranging from skin disorders to epithelial malignancies and brain tumours. Although lack of EGFR signalling primarily affects skin and brain development and tissue homeostasis, aberrant EGFR activation through overexpression or mutation converts the receptor into a potent oncogenic driver. This occurs particularly in human cancers such …

27.08.2026journal-article

Wellcome Open Research

The chromosomal genome sequence of a staghorn coral, Acropora cf. manni (Scleractinia: Acroporidae)

David J Combosch, Andrew H Baird, David R Burdick, Hector Torrado, Dareon Rios, Sebastian Metz, Michael Sweet, Graeme Oatley, Elizabeth Sinclair, Eerik Aunin, Noah Gettle, Camilla Santos, Michael Paulini, Haoyu Niu, Victoria McKenna, Rebecca O’Brien, Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team, Wellcome Sanger Institute Scientific Operations: Sequencing Operations, Wellcome Sanger Institute Tree of Life Core Informatics team, EBI Aquatic Symbiosis Genomics Data Portal Team, Aquatic Symbiosis Genomics Project Leadership

We present a genome assembly from a colony sample of Acropora cf. manni (staghorn coral; Cnidaria; Anthozoa; Scleractinia; Acroporidae). The assembly contains two haplotypes with total lengths of 459.26 megabases and 489.30 megabases. Most of haplotype 1 (94.39%) is scaffolded into 14 chromosomal pseudomolecules. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 18.48 kilobases. Metagenome binning recovered one bacterial bin from the phylum Chlamydiota.