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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Basic & Clinical Pharmacology & Toxicology

Plant‐Derived Heterocyclic Compounds: A Promising Review on Natural Remedies for Rheumatoid Arthritis Management and Their Mechanistic Insights in Inflammation and Joint Protection

Jindong Dai, Xue Xia, Xincheng Hu, Thangamani Kanagaraj, Kanagaraj Rajalakshmi, Mangirish Deshpande, Natarajan Kiruthiga, Dongwei Zhu, Yisun Fan

ABSTRACT Rheumatoid arthritis (RA) represents a persistent autoimmune disease that causes continuous joint inflammation and results in synovial tissue overgrowth and worsening cartilage breakdown together with degeneration of bones. The existing pharmaceutical treatments provide symptom management although they create important adverse effects and raise ongoing security concerns. Plant‐derived heterocyclic compounds present themselves as promising pharmaceutical substitution options because they demonstrate a wide …

27.08.2026journal-article

Magnetic Resonance Materials in Physics, Biology and Medicine

Recent advances in arterial spin labeling MRI for imaging brain tumors

Gabriel Hoffmann, Matthias J. P. van Osch

Abstract Perfusion MRI plays an important role in brain tumor assessment, especially for tumor grading and differentiation of tumor progression from pseudoprogression. Arterial spin labeling (ASL) MRI is a non-invasive method for measuring cerebral blood flow (CBF) using blood water as an endogenous tracer, which has great clinical potential for brain tumor imaging and might help to lower the use of gadolinium-based contrast agents. In this review, we discuss recent advances of the ASL method with a special focus o …

27.08.2026journal-article

Journal of Medical Internet Research

Stigmatizing Language in Gender-Expansive Patient Records: Corpus Development, Disparity Analysis, and Natural Language Processing–Based Detection Study

Liyang Xue, Mary Chayko, Vivek Kumar Singh

Background Stigmatizing language (SL) in electronic health records (EHRs) can influence clinical decision-making, propagate bias across care encounters, and undermine patient trust. Gender-expansive patients (GEPs) may be particularly vulnerable to documentation-based stigma; however, large-scale quantitative evidence and fairness-aware evaluation of automated SL detection methods remain limited. Objective This study aims to construct a gender-expansive-inclusive EHR corpus, quantify demographic disparities in SL u …

27.08.2026journal-article

International Journal of Sports Medicine

Post-Exercise Circulatory Occlusion Differently Affects Soleus Spinal/Supraspinal Excitability

André D. Gonçalves, Andréia Terra, Rodrigo Marques, Pedro Pezarat-Correia, Carolina Vila-Chã, Goncalo V Mendonca

Abstract Post-exercise circulatory occlusion allows the investigation of the effects of group III/IV muscle afferent feedback on central nervous system responsiveness. This study explored the effects of post-exercise circulatory occlusion on soleus H- and V-wave excitability. Following a randomized-crossover design, in 1 day, 16 healthy men (24.6±3.5 y) completed a 3-minute sustained plantar-flexion contraction at 40% of maximal voluntary isometric contraction. Then, for testing, a cuff was inflated around the ipsi …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Refined endoscopic technique combined with cold forceps polypectomy for diminutive colorectal polyps

Xue-Man Wang, Qin-Wei Xu, Yu-Zhen Bi, Quan Luo, Bo Lian, Jian Dong, Xin-Tong Jiang, Jun Zhang

BACKGROUND The most appropriate endoscopic management for small (≤ 5 mm) colorectal adenomas has not yet been well established. Although cold snare polypectomy (CSP) is recommended by the guidelines, cold forceps polypectomy (CFP) remains a popular technique because it is easy to perform. However, previous data have suggested that a modified CFP technique using jumbo biopsy forceps, post-resection narrow-band imaging (NBI), and submucosal injection can yield high en bloc resection rates. AIM To assess the performan …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Endoscopic management of common bile duct stump fistula after choledochojejunostomy: A case report

Wen-Fei Wang, Zhen-Yu Qiao, Zhuang Li, Ke-Zhong Zheng, Deng-Qun Sun, Ming-Hui Sheng

BACKGROUND Common bile duct (CBD) stump fistula after choledochojejunostomy is an exceedingly rare phenomenon. We report a unique case suffering from pancreaticobiliary reflux. CASE SUMMARY A 73-year-old man underwent Roux-en-Y end-to-side choledochojejunostomy for recurrent CBD stones. Fourteen days after surgery, the patient presented with high-amylase bile drainage (3192 U/L). Imaging revealed a CBD stump fistula. Endoscopic retrograde cholangiopancreatography showed pancreaticobiliary maljunction and sphincter …

27.08.2026journal-article

World Journal of Otorhinolaryngology - Head and Neck Surgery

Safety, Efficacy, and Mechanism of Action of Budesonide in Rhinitis and Rhinosinusitis: A Systematic Review

David W. Kennedy, Lei Cheng, De‐Yun Wang

ABSTRACT Objective Budesonide is a corticosteroid with unique pharmacokinetic and pharmacodynamic properties that has been a frontline treatment for patients with allergic rhinitis (AR) and chronic rhinosinusitis (CRS) since the 1990s. As research on budesonide continues to produce new insights, our aim was to synthesize recent investigations and provide up‐to‐date information on safety, clinical, and mechanism of action (MOA) outcomes. Data Sources Searches were restricted to PubMed from 2014/01/01 to 2025/02/26. …

27.08.2026journal-article

Neuro-Oncology

98 Barriers and opportunities in the integrated histopathological-molecular diagnosis of adult diffuse gliomas: a national survey of neuropathology units in UK&I

Vassili Crispi, Ute Pohl, Federico Roncaroli, Kathereena Kurian, Ashiward Merve, Peter Auguste, Arabella Scantlebury, Colin Watts, Victoria Wykes

Abstract Introduction Integrated histopathological–molecular diagnosis is central to the contemporary classification and management of adult diffuse gliomas. The delivery of timely integrated diagnosis remains operationally complex, resource-intensive, and variably implemented across healthcare systems. Methods We conducted an online cross-sectional national survey of all 23 neuropathology units covering 34 adult neurosurgical units across the United Kingdom and Ireland to characterise current diagnostic pathways f …

27.08.2026journal-article

Clinical Journal of Health Sciences

Investigation of the Relationship Between Psychopathological Symptoms, Acculturation, and University Adjustment Among Students from Eastern and Western Türkiye Studying in the TRNC

Merve Nehir Kurt, Mehmet Çakıcı, Atakan Taşkıran

The aim of this study was to compare the acculturation attitudes, university adjustment levels, and psychopathological symptoms of university students from the eastern and western regions of Türkiye studying in the Turkish Republic of Northern Cyprus (TRNC), and to examine the relationships among these variables. This descriptive cross-sectional study included a total of 100 university students enrolled at Near East University, comprising 50 students from the eastern regions and 50 students from the western regions …

27.08.2026journal-article

Tijdschrift voor Urologie

Klinische kenmerken en chirurgische behandeling van urogenitale endometriose: een retrospectief cohortonderzoek

Hanzhe Dong, Eefje Oude Lohuis, Johanna M. A de Bruin, Bob Theodoor Merks

Samenvatting Endometriose kan verscheidene orgaansystemen aantasten. Urogenitale endometriose (UGE) is een zeldzame vorm van diepe endometriose met betrokkenheid van blaas en/of ureters. In dit retrospectieve cohortonderzoek werden 80 vrouwen met UGE geïdentificeerd onder 1.568 geopereerde patiënten met diepe endometriose (2018–2024), overeenkomend met een prevalentie van 5,1 %. Blaasendometriose kwam voor bij 34 patiënten, ureterbetrokkenheid bij 32 en gecombineerde ziekte bij 14. Dysurie trad vaker op bij blaasbe …

27.08.2026journal-article

Frontiers in Medicine

Day-4 antipseudomonal and anti-MRSA de-escalation was not associated with higher mortality in critically ill patients with sepsis

Yuhang Zhang, Guoying Liao, Jianli Song, Yinsheng Liao, Lulu Zhang

Background Broad empiric antibiotics are often appropriate at the start of intensive care unit (ICU) sepsis care; however, continued antipseudomonal or anti-methicillin-resistant Staphylococcus aureus (MRSA) coverage may no longer be justified by the day-4 reassessment. We examined antibiotic de-escalation at this clinical decision point. Materials and methods We emulated two parallel target trials in Medical Information Mart for Intensive Care IV (MIMIC-IV) v3.1 and conducted a supportive multicenter analysis in t …

27.08.2026journal-article

Recycling

Life Cycle Assessment of Anaerobic Digestion Pathways for Winery Residues: Influence of Functional Unit Selection on Wastewater Treatment and Grape Pomace Valorization

Mara Silva, Vitor Coelho Barroso, José Pereira, Ana Catarina Faria

Winery activities generate large amounts of residues requiring sustainable management. Anaerobic digestion offers opportunities for resource recovery while reducing the environmental burdens associated with these residues. This study presents a gate-to-gate Life Cycle Assessment (LCA) of two anaerobic digestion pathways: winery wastewater treatment (Scenario A) and grape pomace valorization (Scenario B). Inventory data were obtained from pilot-scale operation and complemented with the Ecoinvent 3.10 database. Envir …

27.08.2026journal-article

Oral Surgery

Chondrosarcoma of the Temporomandibular Joint: A Case Report

Thamyryz Rafaela Almeida Simões, Lais de Oliveira Melo, Marcio Tadashi Tino, Gilberto Fenelon das Neves

ABSTRACT Objective Tumours affecting the temporomandibular joint (TMJ) are rare and may mimic common temporomandibular disorders, leading to delayed diagnosis. This study reports a case of TMJ chondrosarcoma initially presenting with long‐standing TMJ symptoms. Methods A 56‐year‐old female presented with right preauricular pain during mouth opening, closing and mastication for approximately 10 years. Clinical examination revealed a maximum interincisal opening of 20 mm with pain in the right TMJ. Cone‐beam computed …

27.08.2026journal-article

European Journal of Cancer Prevention

Impact of screening compliance on gastric cancer risk and eligibility for endoscopic treatment: a nationwide population-based cohort study

Jinju Choi, Joo Hyun Lim, Kyungdo Han, Cheol Min Shin, Byung-Ha Jeon, Ho-Kyoung Lee, Eun Hyo Jin, Seung Joo Kang

To evaluate the association between compliance with the Korean national gastric cancer screening program and both gastric cancer incidence and eligibility for endoscopic treatment. Using the Korean National Health Insurance Service database, we conducted a nationwide cohort study of individuals who underwent screening endoscopy in 2012 and 2014 without prior gastric cancer. Participants were classified as high compliance, moderate compliance, or low compliance according to screening history from 2008 to 2014. Gastr …

27.08.2026journal-article

Small

Sequential Integration of Microenvironment Regulation Utilizing Aggregation‐Induced Emission Luminogen‐Based Carbon Dots for Diabetic Wound Treatment

Judun Zheng, Miaomiao Kang, Minghai Zhao, Shuang Guo, Qihu Xie, Zhijin Fan, Sitong Zhou, Zhijun Zhang, Qin Zeng, Zeyu Liu, Yinghui Liu, Jialin Huang, Xu Chen, Bowen Shu, Bin Li, Kexiang Rao, Hongfang Liu, Xiaoping Zhong, Ronghua Yang, Yunxia Wu, Dong Wang, Yuhui Liao

ABSTRACT Effective management of diabetic wound healing remains challenging due to the complex wound microenvironment, characterized by persistent infections and inflammation, as well as obstacles in tissue repair, including impaired extracellular matrix (ECM) remodeling and re‐epithelialization. Herein, we propose a sequential integrating microenvironment regulation and re‐epithelialization promotion (SIMREP) strategy based on zinc‐doped glycyrrhizinate carbon dots loaded with aggregation‐induced emission luminoge …

27.08.2026journal-article

Journal of Occupational & Environmental Medicine

The Effectiveness of Ergonomic Training and Chiropractic Treatment in Industrial Workers with Nonspecific Chronic Neck Pain: A Randomized Controlled Trial

Deniz Balikçi, Beyzanur Dikmen Hoşbaş, Ömer Şevgin

OBJECTIVE: To evaluate whether adding chiropractic treatment to ergonomic training improves pain, function, and sleep in industrial workers with chronic nonspecific neck pain. METHODS: Forty-five male industrial workers were randomized (15 per group) to ergonomic training plus chiropractic treatment (CTG), plus sham manipulation (SMTG), or alone (CG) for four weeks. Pain (VAS), biopsychosocial impact (BNQ), disability (NDI), and sleep quality (PSQI) were assessed before and after. The group × time interaction was t …

27.08.2026journal-article

Discover Oncology

Ovarian cancer tumor immune microenvironment and its clinical trial implications

Barbora Vavrušáková, Renata Bartošová, Michal Hendrych, Tomáš Kazda, Lukáš Moráň, Marek Svoboda

Abstract Ovarian cancer is the most lethal gynecologic malignancy, primarily because of late-stage diagnosis, rapid disease progression, and marked molecular and immunologic heterogeneity. It remains the leading cause of gynecologic cancer-related death, affecting approximately 1 in 70 women in developed countries over their lifetimes. Tumor development and progression are orchestrated within the tumor immune microenvironment, a dynamic and complex structural niche that supports malignant transformation and immune …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Association of glucagon-like peptide-1 receptor agonists with atrial fibrillation recurrence after catheter ablation: a systematic review and meta-analysis

Dan He, Defu Lv, Jiaxin Tang, Xiaojuan Liao, Ping Mao, Zhu Tian

Background Current studies suggest a potential association between the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and atrial fibrillation (AF) recurrence after catheter ablation, but the findings remain controversial. Therefore, we conducted a meta-analysis to evaluate this association, aiming to provide evidence for clinical prevention and treatment. Methods We systematically searched PubMed, Embase, Web of Science, Cochrane Library, and four Chinese databases (CNKI, WanFang, VIP, and CBM) up to J …

27.08.2026journal-article

Clinical and Translational Gastroenterology

Diagnostic Performance of Six Tests for Helicobacter pylori Infection in Peptic Ulcer Bleeding: A Prospective Head-to-Head Comparison

Tanawat Geeratragool, Thanapat Atthakitmongkol, Supathep Tansirichaiya, Pubet Weeranawin, Somchai Leelakusolvong, Monthira Maneerattanaporn

Background: Rapid urease test (RUT) is widely used for diagnosing Helicobacter pylori (HP) because it is inexpensive and practical. However, its accuracy is reduced in peptic ulcer bleeding (PUB). We prospectively performed a head-to-head comparison of diagnostic tests in the same patients to evaluate their performance in this setting. Methods: After endoscopic hemostasis, gastric biopsies were obtained for RUT, histology, and PCR. Blood samples were collected for current infection marker (CIM) and anti-urease anti …

27.08.2026journal-article

Arthroscopy, Sports Medicine, and Rehabilitation

Availability and Pricing of Orthobiologic Knee Injections Vary by Practice Type but Not by Community Socioeconomic Vulnerability in Suburban New York

Tracy M. Tauro, Benjamin Hershfeld, Katharine Chen, Ran Lampert, Adam D. Bitterman, Randy M. Cohn, Nicholas A. Sgaglione

Purpose To assess the availability, price transparency, and pricing of platelet‐rich plasma (PRP), bone marrow aspirate concentration, and stem cell injections for knee osteoarthritis (OA) among orthopaedic sports medicine (OSM) practices and alternative clinics in suburban New York and to evaluate the impact of the economic status of a population on the availability and pricing of biologic injections. Methods Between July and September 2025, OSM practices and alternative clinics offering PRP, bone marrow aspirate …

27.08.2026journal-article

Developmental Medicine & Child Neurology

Deep brain stimulation outcomes and management of childhood‐onset dystonia and associated hyperkinetic movements disorders

Sinead Barkey, Laura Ainaga, Eva Maria Navarrete Muñoz, Verity McClelland, Keyoumars Ashkan, Richard Selway, Harutomo Hasegawa, Daniel E Lumsden, Jean‐Pierre Lin, Hortensia Gimeno

Abstract Aim To examine longitudinal changes in self‐selected goals and dystonia severity over 1 year, 2 years, and 5 years after deep brain stimulation (DBS) in children and young people (CYP) with dystonia and other hyperkinetic movement disorders, using CYP and caregiver reports. Method The retrospective cohort study included follow‐up to 5 years after DBS, with the number of participants varying across time points. In the CYP group, 62 participants were included at the 1‐year follow‐up, 50 at 2 years, and 17 at …

27.08.2026journal-article

JAMA Network Open

A Multilevel Intervention to Identify Individuals for Genetic Testing and Treatment

Kirsten A. Jorgensen, Nuria Agusti, Tara Coffin, Karla Barajas, Maria D. Iniesta, Erica M. Bednar, Alexa Kanbergs, Roni Nitecki Wilke, Isabel Beshar, Sara Pirzadeh-Miller, Sayoni Lahiri, Kathy Pratt, Kristofer Jennings, Heidy Bosch, Charles A. Leath, Beth Karlan, Melissa Frey, Ravi Sharaf, Karen Lu, J. Alejandro Rauh-Hain

Importance Cascade genetic testing (CGT) is a key strategy for cancer prevention in families with hereditary breast and ovarian cancer syndrome (HBOC) and Lynch syndrome (LS), yet uptake among at-risk relatives remains persistently low, particularly in medically underserved populations where structural and informational barriers limit access to genetic services. Objective To evaluate the feasibility and preliminary effects of IGNITE-TX (Identifying Individuals for Genetic Testing and Treatment), a scalable, bilingu …

27.08.2026journal-article

Journal of Clinical Medicine

Bad Ragaz Ring Method Versus Halliwick Method in Verbally Cooperative Children with Spastic Cerebral Palsy (GMFCS Levels I–II): A Pilot Comparison Study

Na-Yeon Ye, Eun-Ju Lee

Background/Objectives: Aquatic therapy is widely used for children with cerebral palsy (CP), but existing approaches such as the Halliwick method focus primarily on postural control and mobility with limited active resistance exercise. The Bad Ragaz Ring Method (BRRM) integrates proprioceptive neuromuscular facilitation (PNF) diagonal patterns with closed kinetic chain (CKC) exercise in the aquatic environment, yet its direct application to children with spastic CP has rarely been examined. This pilot study compare …

27.08.2026journal-article

Revista ft

Capacitação da equipe de clínica médica quanto às atualizações do manejo agudo hospitalar de fibrilação atrial de alta resposta ventricular

Victor Souza Nobre, Marilia Mendes de Saboya, Felipe de Araújo Lucena, Camila Amora Santos Albuquerque D’Alva, Natália Marinho Porto Lima, Luiza Targino Studart, José de Ribamar Barroso Jucá Neto

Atrial fibrillation with rapid ventricular response is a common condition in the hospital setting and requires prompt recognition, assessment of hemodynamic stability, and evidence-based therapeutic decision-making. Given the variability in clinical management and the need for professional updating, this study aims to train the Internal Medicine medical team on current recommendations for the acute hospital management of atrial fibrillation with rapid ventricular response, with the goal of standardizing clinical pr …