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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

JAAPA

Precision oncology in breast cancer

Whitney Tobin

ABSTRACT Recent advances in breast cancer management have transformed treatment across molecular subtypes and expanded the role of precision oncology. Hormone receptor–positive (HR-positive), human epidermal growth factor receptor 2–positive (HER2-positive), HER2-low, and triple-negative breast cancer (TNBC) each demonstrate distinct biologic behavior requiring tailored therapeutic strategies. In HR-positive disease, cyclin-dependent kinase 4/6 (CDK4/6) inhibitors and next-generation selective estrogen receptor deg …

25.08.2026journal-article

Saudi Endodontic Journal

Preliminary comparative analysis of faculty and self-assessment in evaluating root canal treatment quality performed by dental students in a preclinical setting: A cross-sectional study

Ahmad Jabali

Abstract Introduction: Self and staff assessments represent a recent approach to evaluating preclinical performance, though not yet widely adopted. This preliminary study aimed to compare faculty assessments with student self-assessments of root canal treatment (RCT) quality and evaluate the influence of gender on assessment accuracy across rubric parameters. Materials and Methods: This cross-sectional study evaluated dental students ( N = 40; 20 males, 20 females) in their final practical examination for the precl …

25.08.2026journal-article

Nuclear Medicine Communications

Single-photon emission computed tomography/computed tomography-based radiomics of bone metastases for predicting epidermal growth factor receptor mutation status and targeted therapy efficacy in non-small-cell lung cancer

Xiangxiang Li, Shasha Hou, Shen Wang, Qiang Jia, Wei Zheng

Background This study aimed to develop a single-photon emission computed tomography/computed tomography (SPECT/CT)-based radiomics model using bone metastases to predict epidermal growth factor receptor (EGFR) mutation status and the efficacy of targeted therapy in patients with non-small-cell lung cancer. Methods This retrospective study included 240 patients with non-small-cell lung cancer. Among them, 205 were analyzed for the EGFR-mutation prediction model, and 210 for the targeted therapy efficacy model. Basel …

25.08.2026journal-article

Frontiers in Medicine

Fulminant development of a giant pelvic metastasis from microsatellite-stable early-onset sigmoid colon cancer with KRAS and TP53 co-mutations: a case report

Shouxin Wei, Sijia Yu, Yunsheng Lan

Background Early-onset colorectal cancer (EO-CRC) is often characterized by a highly aggressive nature and insidious onset. Herein, we report a rare case of fulminant, early-onset colon cancer presenting with a massive pelvic seeding metastasis driven by concurrent KRAS and TP53 mutations. This study aims to elucidate the molecular mechanisms underlying its hyper-progressive course and provide critical insights into clinical differential diagnosis. Case description A 44-year-old female presented with intermittent a …

25.08.2026journal-article

Frontiers in Chemistry

Repurposing of lansoprazole and nitazoxanide as NR2F2 inhibitors in the gastric cancer cell line GCIY: computational insights and siRNA-mediated in vitro tests

Giulia Culletta, Muhammad Sohaib Roomi, Maria Azzurra Caricasulo, Adriana Zanetti, Mineko Terao, Gabriela Paroni, Enrico Garattini, Marco Tutone

Background Nuclear receptors (NRs) are a superfamily of ligand-activated transcription factors that mediate the cellular response to hormones, vitamins, and dietary lipids, thus orchestrating numerous physiological processes and influencing multiple disease states. Within this superfamily, NR2Fs, also known as Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF), are a family of nuclear orphan receptors, due to the lack of known endogenous ligands. Among them, NR2F2 transcription factor activities inv …

25.08.2026journal-article

Scientific Reports

Predictors of long-term changes in mALBI grade in cirrhotic patients after sustained virological response with direct-acting antiviral treatment

Takao Watanabe, Yoshio Tokumoto, Hironori Ochi, Fujimasa Tada, Atsushi Hiraoka, Yoshiyasu Kisaka, Yoshinori Tanaka, Sen Yagi, Seiji Nakanishi, Makoto Morita, Kazuhiko Yamauchi, Makoto Higashino, Kana Hirooka, Atsushi Yukimoto, Yuki Okazaki, Teruki Miyake, Osamu Yoshida, Masashi Hirooka, Masanori Abe, Yoichi Hiasa

Abstract The long-term changes in liver function and outcomes in patients with cirrhosis after achieving a sustained virological response (SVR) with direct-acting antiviral (DAA) treatment remain unclear. Between 2014 and 2020, we screened 2,030 patients with chronic hepatitis C virus (HCV) infection who achieved an SVR with DAA treatment at participating institutions. Among them, 820 patients had cirrhosis. The median follow-up period was 70 (range, 14–89) months. After excluding patients without hepatocellular ca …

25.08.2026journal-article

Cancer Research Communications

Patient-Level KRAS G12C Prevalence Among Hispanic/Latino and Non-Hispanic White Patients in Real-World Clinicogenomic Cohorts

Daniel F. Pilco-Janeta, Myriam De la Cruz-Puebla, Daisy R. Guamán-Pilco, Diego Montenegro, William Miranda

Abstract KRAS G12C is a treatment-defining biomarker in non-small cell lung cancer (NSCLC), particularly lung adenocarcinoma (LUAD). Hispanic/Latino (H/L) patients remain undercharacterized in precision oncology datasets, and patient-level KRAS G12C prevalence has not been consistently quantified using strict ethnicity definitions. We analyzed MSK-CHORD and AACR GENIE after excluding the MSK contributing center. H/L required explicit Hispanic/Latino-origin annotation; non-Hispanic White (NH-W) required White race w …

25.08.2026journal-article

Cancers

Mind–Body Intervention for Post-Surgical Breast Cancer Patients in Southern Italy: A Pilot Feasibility Study of Qigong on Patient-Reported Symptom Burden and Emotional Well-Being

Graziella Marino, Eugenia Giglio, Martina Giuseffi, Giovanni Pace, Carlo Calabrese, Marzia Sichetti, Marisabel Mecca

Background: Post-surgical breast cancer (BC) survivors frequently experience clusters of persistent post-treatment physical and psychological symptoms, which can negatively affect their quality of life (QoL). Mind–body interventions such as Qigong may offer potential benefit, but evidence in oncology remains limited. Methods: We conducted a single-arm pilot feasibility study at the AMICO clinic (IRCCS-CROB, Southern Italy) to evaluate the feasibility, acceptability, safety, and exploratory pre–post symptoms associa …

25.08.2026journal-article

Bioscience Reports

Epigenetic mechanisms and clinical translation in ovarian cancer: from molecular pathways to precision therapy

Khaldoon Alsamman

Abstract Ovarian cancer remains one of the deadliest gynecological malignancies, mainly due to its late diagnosis, biological heterogeneity, and frequent development of chemoresistance. Recent evidence indicates that epigenetic dysregulation including aberrant DNA methylation, histone modifications, chromatin remodeling, and non-coding RNA networks plays an important role in the initiation, progression, and therapeutic response of ovarian cancer. Unlike genetic alterations, epigenetic modifications are reversible, …

25.08.2026journal-article

Physica Scripta

Impact of O 2 plasma post-treatment on the chemical, morphological and wetting properties of SiO x thin films deposited by PECVD from HMDSO vapors

D Daoudi, S Sahli, M Kihel, A Bellel, P Raynaud

Abstract In this study, the effects of radio-frequency (RF) discharge power on the properties of thin films elaborated by plasma-enhanced chemical vapor deposition (RF-PECVD) from hexamethyldisiloxane (HMDSO) precursor. The influence of oxygen plasma post-treatment on the structural, morphological, and surface properties of the synthetized films has been investigated. Optical emission spectroscopy revealed the presence of several reactive species, including SiH, SiO, CH, and H α . FTIR and FTIR-ATR analyses demonst …

25.08.2026journal-article

Journal of Experimental & Clinical Cancer Research

KRAS and SKIL mutations synergistically promote pancreatic tumorigenesis through the ubiquitin-proteasome-mediated degradation of Smad4

Chenxi Wang, Yarui Ma, Haixia Cheng, Junhu Yuan, Yixuan Zhang, Mei Liu, Xiaobing Wang, Yuchen Jiao

Abstract Background Pancreatic cancer development requires oncogenic KRAS plus additional genetic hits, yet these cooperating events remain poorly defined. Starting from a germline SKIL A512T mutation discovered in an infant with IPMN, we explored the synergistic role of SKIL and KRAS in tumorigenesis. Methods HEK293T cells with engineered SKIL A512T and/or KRAS G12V mutations were analyzed for proliferation, tumorigenicity, and signaling. Transcriptomics, ubiquitination assays, and protein interaction studies (Co- …

25.08.2026journal-article

Traumatology and Orthopedics of Russia

Cost-effectiveness analysis of patient-specific and standard vertebral body replacements in the surgical treatment of spinal tumors

Nikita S. Zaborovskii, Sergei V. Masevnin, Dmitrii A. Ptashnikov, Rashid M. Tikhilov

Abstract Background. The widespread integration of patient-specific vertebral body prostheses is hindered by their high manufacturing costs. A comprehensive understanding of the long-term cost-effectiveness of additive manufacturing is required for informed decision-making in spine surgery. Objective. To evaluate the cost-effectiveness of patient-specific 3D-printed polyetheretherketone (3D PEEK) prostheses compared to off-the-shelf constructs for anterior spinal column reconstruction in patients with spinal tumors …

25.08.2026journal-article

PLOS One

Burden of early-onset pancreatic cancer and its association with risk factors in women of childbearing age

Jiaxing Li, Jing Luo, Qihui Hu, Zhipeng Liu, Yule Luo, Yanbo Li, Paoyong Zou, Rui Tao

Introduction Early-onset pancreatic cancer (EOPC), diagnosed before age 50, is rising globally. Women of childbearing age (WCBA, 15–49 years) constitute nearly the same population as EOPC patients but have unique metabolic vulnerabilities. The intersection of EOPC trends with WCBA-specific metabolic risks remains underexplored. This study delineates the global EOPC burden among WCBA and its links to core metabolic determinants, providing an evidence base to guide targeted interventions in this priority population a …

25.08.2026journal-article

Scientific Reports

MicroRNA profiles of prostate cancer bone metastases and miR-375 as an inhibitor of the aggressive metastasis subtype MetB

Helena Järemo, Julius Semenas, Sofia Halin Bergström, Elin Thysell, Marie Lundholm, Eva Freyhult, Andreas Josefsson, Karin Welén, Camilla Thellenberg Karlsson, Sead Crnalic, Anders Bergh, Maria Brattsand, Pernilla Wikström

Abstract Novel treatments for metastatic prostate cancer (PC) are needed. Molecular subtypes of bone metastatic PC (MetA-C) were recently identified, with the proliferation-driven MetB subtype linked to very poor prognosis. Non-coding microRNAs (miRs) regulate gene expression and constitute potential therapeutic targets. This study aimed to explore miR profiles in bone metastases in relation to the MetA-C subtypes, with focus on the aggressive MetB subtype. Genome-wide microarray analysis of clinical bone metastasi …

25.08.2026journal-article

British Journal of Cancer

The role of DNA mismatch repair status in oesophagogastric cancer treated with perioperative chemotherapy: evidence from the MRC ST03 and OE05 trials

Panagiotis Ntellas, Tom Lund, Georgina A. Keogh, Manuel Salto-Tellez, Katharina von Loga, Tatiany Silveira, Susanna Riisnaes, Jon Laye, Ruth E. Langley, Matthew G. Nankivell, William H. Allum, Avani Athauda, David Cunningham, Heike I. Grabsch

Abstract Background Mismatch repair deficiency (MMRd) is a key determinant of tumour biology, however, its prognostic significance in patients with resectable oesophagogastric adenocarcinoma treated with perioperative cytotoxic chemotherapy remains uncertain. Methods MMR status was assessed in 1424 patients with oesophagogastric adenocarcinoma enroled in the MRC OE05 and ST03 trials, which investigated perioperative chemotherapy regimens. Associations between MMR status, clinicopathological variables, overall survi …

25.08.2026journal-article

Molecular Biology Reports

Enhanced mitochondrial fission promotes chemosensitivity via SHP-1 activity in triple-negative breast cancer

Elizabeth K. Croom, Lillian E. Walton, Alessandro J. Bono, Anne Zhang, Brock A. Humphries

Abstract Background Triple-negative breast cancer (TNBC) is an aggressive subtype with high chemoresistance and poor survival rates. While mitochondrial dynamics, fission and fusion, are implicated in chemoresistance, their precise roles remain largely unexplored. This study investigates how cytoplasmic phosphatases SHP-1 and SHP-2 regulate chemotherapeutic response in TNBC cells with altered mitochondrial dynamics. Methods We utilized click beetle green luciferase-expressing SUM149 and SUM159 TNBC cells engineered …

25.08.2026journal-article

Medicina

Beyond Simple Ratios: Can the Preoperative HALP Score Provide a More Effective Inflammatory Biomarker for Colon Cancer Survival?

Abdullah Durhan, Yusuf Murat Bağ, Mehmet Ali Çaparlar, İbrahim Kurtoğlu, Yasin Uçar, Koray Koşmaz, Abdullah Bulgurcu, Marlen Süleyman

Background and Objectives: Previous findings have suggested that inflammatory and nutritional biomarkers may help predict the prognosis in colorectal cancer patients; however, their predictive value and optimal use remain uncertain. Therefore, this study aimed to investigate the effects of several preoperatively measured inflammatory and nutritional biomarkers on the overall survival in patients undergoing surgery for colon cancer and to compare their predictive ability between themselves and with other clinical pa …

25.08.2026journal-article

Clinical Cancer Research

BRIGHTLINE-1: When a Negative Trial Reveals Two Active Therapies

Adel Shahnam, Mrinal M. Gounder

Abstract Although BRIGHTLINE-1 was headlined as a “negative trial,” brigimadlin showed clear biological activity, with the median PFS of 8.4 months, objective response rate of 22.3%, and translational evidence of p53 reactivation. Its failure largely reflects flawed control-arm assumptions, as doxorubicin outperformed retrospective expectations and established a new prospective benchmark in dedifferentiated liposarcoma. See related article by Schöffski et al., p. XX .

25.08.2026journal-article

Frontiers in Pharmacology

Comparison of Beiyi® and its reference product Enantone® as agonists of luteinizing hormone-releasing hormone against prostate cancer: a multicenter, randomized single-dose study

Yuyao Yi, Pengfei Shen, Tongsen Zheng, Ruigang Hou, Lianlian Fan, Yanxia Yu, Jian Li, Yu Fang, Chuan Hao, Pinghong You, Xiaoyu Lu, Xiongbing Lu, Qiang Wei, Ping Feng

Background Leuprolide acetate is a potent agonist of luteinizing hormone-releasing hormone that has been licensed to treat prostate cancer. The microsphere formulation of leuprolide acetate called Beiyi®, developed in China, has shown favorable pharmacokinetics, pharmacodynamics and safety similar to those of the reference drug Enantone® in healthy individuals. The present study examined whether the two formulations are bioequivalent in men with prostate cancer. Methods This multicenter, open-label study randomized …

25.08.2026journal-article

Journal of Clinical Investigation

FBXW5 blunts RIGI/MDA5-IFN signaling to drive immunoevasion and chemo-immune resistance in triple-negative breast cancer models

Xin Li, Tong Chen, Wenjing Zhao, Jiaxing Li, Yifan Shang, Bing Chen, Lijuan Wang, Ning Zhang, Xiaoli Kong, Yiran Liang, Yaming Li, Chen Li, Dianwen Han, Xi Chen, Shan Jiang, Chao Yang, Dan Luo, Tingting Ma, Qifeng Yang

Triple-negative breast cancer (TNBC), characterized by aggressive behavior and poor prognosis, presents a formidable clinical challenge. Despite guideline endorsement of chemoimmunotherapy as a standard treatment in TNBC, durable responses remain rare, largely due to an immunologically “cold” tumor microenvironment (TME). Through integrated analysis, we identified the F-box protein FBXW5 as a tumor-intrinsic immunosuppressive regulator, whose expression is elevated in immunologically “cold” TNBC and correlates with …

25.08.2026journal-article

BMC Medicine

Systemic immune activation in hereditary cancer predisposition syndromes: a cross-sectional study

István Kelemen, Klaudia Horti-Oravecz, Anikó Bozsik, Tímea Pócza, János Papp, István Likó, Patrícia Neuperger, Fanni Balogh, Ágnes Kemény, Petra Nagy, Viktória Vereczki, Szonja Polett Pósa, Lőrinc Sándor Pongor, Dorottya Kövesdi, Henriett Butz, Attila Patócs, Gábor János Szebeni, Vince Kornél Grolmusz

Abstract Background Immune surveillance mechanisms contribute to the elimination of precancerous lesions in hereditary cancer predisposition syndromes (HCPSs). Methods By combining single-cell transcriptomics, multiparametric mass cytometry and cytokine profiling of the systemic immune environment in 391 individuals among whom 227 are living with HCPSs we investigated phenotypic alterations in cancer-free individuals with HCPS. Results A decrease in peripheral B cell abundance and their more differentiated phenotyp …

25.08.2026journal-article

Molecules

Modification of Desulfurization Ash via Thermal CO2 Treatment: Oxidation Behavior, Carbonation Characteristics, and Mineral Transformation Mechanisms

Pengzhen Li, Ying Chen, Duo Li, Qian Wang, Hongyan Yan

Desulfurization ash (DA) is a kind of industrial solid waste generated during flue gas desulfurization. To overcome the limited utilization of reactive calcium-bearing constituents and the insufficient mineralogical stability of DA, this study proposes a thermal CO2 modification approach based on the synergistic coupling of oxidation and carbonation, and systematically investigates the associated evolution of mineral phases and microstructural features. The effects of reaction temperature, CO2 flow rate, and reacti …

25.08.2026journal-article

Revista ELO – Diálogos em Extensão

Educação em saúde na oncologia: cartilha educativa como estratégia de disseminação do conhecimento sobre quimioterapia para pacientes em tratamento

Larissa Cristina de Castro, Giovanna Pimentel Pereira, Karina De Araújo Alves Silva, Flávia De Oliveira, Rayssa Nogueira Rodrigues, Patrícia Peres de Oliveira, Danilo Donizetti Trevisan, Gabriela Gonçalves Amaral, Fernando De Pilla Varotti, Silmara Nunes Andrade

Este estudo relata o desenvolvimento da cartilha "Navegando pela Quimioterapia" para pacientes oncológicos, analisando sua construção sob a ótica da educação em saúde e extensão universitária. Criada por três discentes e quatro docentes de Enfermagem da UFSJ (2024-2025), o processo envolveu levantamento bibliográfico, redação acessível e design estratégico, resultando em 14 páginas e sete tópicos. A iniciativa integrou acadêmicos, profissionais e pacientes, com feedback positivo sobre a fidedignidade e clareza das …

25.08.2026journal-article

Asian Journal of Oncology

Managing breast cancer in young women: A survey on challenges and real world scenario

Sabyasachi Parida, Pragyan Roy

Objectives: Breast cancer (BC) is the most common cancer affecting women globally and is the leading cause of cancer death in 103 countries, including India. Recent studies have shown an upsurge in the incidence of breast BC in young Indian women. It is marked by aggressive histological grade, unfavorable hormone status, and higher death rate. The entire process of screening and treatment of young breast cancer (YBC) patients differs from that of postmenopausal BC patients. Relevant issues like fertility preservati …