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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Anaesthesiology Intensive Therapy

Disrupted thyroid hormone homeostasis in critical illness: clinical correlates and associations with hormone supplementation in a single-center retrospective observational study

Alicja Filipczyk, Szymon Zdanowski, Jan Kasprzyk, Karolina Niedzielska, Artur Rakhatsevich, Magdalena Anna Wujtewicz, Tomasz J. Stefaniak, Karol P. Steckiewicz

Background Thyroid hormone disturbances are a hallmark of critical illness and are commonly attributed to non-thyroidal illness syndrome. The clinical relevance of thyroid hormone supplementation in the intensive care unit (ICU) remains uncertain. This study aimed to characterize thyroid hormone concentrations in relation to disease severity in critically ill patients receiving thyroid hormone supplementation. Methods In this single-center retrospective study, data from 98 ICU patients receiving thyroid hormone sup …

27.08.2026journal-article

Frontiers in Oncology

Feasibility, reliability, and clinical value of genomic assay on pre-therapeutic biopsy for endocrine receptor-positive HER2-negative early breast cancer

Gilles Houvenaeghel, Maxime Souquet Bressand, Valérie Juhan Duguet, Monique Cohen, Catherine Bouteille, Laura Sabiani, Julien Barrou, Loic Juquel, Véronique Brunel, Olivia Quilichini

Endocrine receptor-positive (ER+) and HER2-negative breast cancer (BC) represents approximately 80% of all BCs. Most patients are treated with upfront surgery; however, 15%–30% will develop late recurrences. Genomic assay indication is usually based on postoperative pathological data including histology subtype, tumor size, lymph node status, SBR grade, and Ki67. Performing genomic testing on core needle biopsy specimens prior to surgery may offer several advantages. In this manuscript, we assess the feasibility, r …

27.08.2026journal-article

Clinical Journal of Health Sciences

Vaginismus and Dyspareunia: A Comparative Review of Female Sexual Pain Disorders

Melike Çarıkçı, Ayhan Çakıcı

Vaginismus and dyspareunia are among the most prevalent female sexual pain disorders and have a substantial impact on sexual functioning, psychological well-being, and intimate relationships. Although these disorders were historically classified as separate diagnostic entities, they were unified under the diagnosis of Genito-Pelvic Pain/Penetration Disorder (GPPPD) in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Nevertheless, this diagnostic integration has generated ongoing deb …

27.08.2026journal-article

Clinics and Practice

Scientific Clinical Trial Publication Productivity in Medical Oncology: A Comparative Analysis and Data Review of Northern and Southern Italy

Vittorio Gebbia, Sergio Rizzo, Dario Piazza, Daniela Sambataro, Giuseppa Scandurra, Maria Rosaria Valerio

Background: Italy exhibits a socioeconomic divide between its northern and southern regions, which extends into healthcare delivery and biomedical research. Medical oncology is particularly affected by this structural imbalance. This paper examines geographic disparities in clinical trial scientific publication output, citation impact, research funding, and collaboration networks in medical oncology between northern and southern Italy. Methods: A narrative bibliometric analysis was conducted using data from PubMed …

27.08.2026journal-article

Clinical Psychology & Psychotherapy

Imagery Interventions and Cognitive‐Behavioural Therapy for Psychological Complaints Related to Bullying: A Systematic Review and Meta‐Analysis

Meng Liang, Gerly Tamm, Olivia De Laere, Yannick Vander Zwalmen, Ernst H. W. Koster

ABSTRACT Bullying is associated with internalizing symptoms and impaired everyday functioning. Cognitive‐behavioural therapy (CBT) and imagery interventions have been studied as treatments to improve mental health after such experiences. This meta‐analysis aimed to evaluate the effects of individual CBT and imagery interventions in targeting internalizing symptoms (negative affect, depression, anxiety and post‐traumatic stress symptoms) and improving self‐perception and coping in bullying victims. Systematic search …

27.08.2026journal-article

Journal of Intensive Care Medicine

Correlation Study Between Inflammatory Markers and Pathogenic Characteristics in Patients with Severe Pneumonia in Intensive Care Units

Xiufang Lu, Yali Kang, Lin Liu, Jingping Liu, Qiuyue Zhang, Jinjing Tian, Chuntang Tong

Objective To determine pathogen-specific inflammatory biomarker profiles, develop predictive models for Gram-negative infections and evaluate the added value of serial biomarker monitoring in critically ill patients with severe pneumonia in intensive care units (ICUs). Methods This retrospective cohort study included 126 adults admitted to a tertiary ICU between 1 June 2021 and 31 May 2024. Procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6) were measured at admission and on ICU days 3, 5 and 7. …

27.08.2026journal-article

Crystals

A Review of Fatigue Performance Research on Aluminum Alloy Forming, Heat Treatment, Additive Manufacturing and Surface Modification Technologies

Baicheng Liu, Hongliang Zhang, Shenghan Li, Yurii Luhovskyi, Zhisheng Nong

Aluminum alloy is a lightweight, high-strength material based on aluminum matrix with the addition of elements such as copper, magnesium, silicon, zinc, manganese, or lithium. Featuring low density, high specific strength, excellent formability, and outstanding corrosion resistance, it is widely applied in the fields of aerospace, rail transit, automotive lightweighting, and additive manufacturing. In the aerospace sector, fatigue failure constitutes the primary failure mode of load-bearing components. This paper r …

27.08.2026journal-article

Frontiers in Medicine

Between scientific capital and emotional capital: a cross-sectional study on the empathetic clinical gaze in Swedish medical education

Lena Halawi, Atika Khalaf

Introduction Clinical empathy was examined among Swedish medical students to understand how empathic engagement evolves during training. The study explored both quantitative patterns and qualitative reflections related to the Empathetic Clinical Gaze (ECG). Methods Clinical empathy was examined using a cross-sectional quantitative survey of 251 Swedish medical students with the Empathetic Clinical Gaze scale (ECG scale). To contextualize the quantitative findings, a secondary qualitative content analysis of brief t …

27.08.2026journal-article

Egyptian Journal of Radiology and Nuclear Medicine

A lightweight deep learning pipeline for MRI-based differential diagnosis of Alzheimer’s disease and mild cognitive impairment

Zahra Hasankhani, Gelareh Valizadeh, Davoud Khezerloo, Hamidreza Saligheh Rad, Mona Fazel Ghaziyani

Abstract Background Alzheimer’s disease (AD) accounts for 60–70% of dementia cases, with mild cognitive impairment (MCI) as a prodromal stage. Early diagnosis is critical. This study aimed to develop and validate a lightweight deep learning pipeline for automated classification of AD, MCI, and cognitively normal (CN) using routine 1.5 T MRI. Method We analyzed 567 ADNI participants (95 CN, 368 MCI, 104 AD ). Preprocessing of T1-weighted MRI included skull stripping, resampling, and intensity normalization. Eleven c …

27.08.2026journal-article

Neuro-Oncology

21 Adult ependymoma in England: Incidence, treatment, and outcomes from GlioCova

Kerlann Le Calvez, Radvile Mauricaite, Peter Treasure, Thomas C Booth, Stephen J Price, Andrew Brodbelt, Jonathan J Gregory, Seema Dadhania, Lillie Pakzad-Shahabi, Maureen Dumba, Ingela Oberg, Sally Vernon, Jawad Basharat, Matt Williams

Abstract Introduction England has a long-running system for national cancer data collection. In this work we present data on incidence, treatment and survival in all adult ependymoma patients in England diagnosed between 2013 and 2018. Methods Gliocova uses a linked pseudo-anonymised data set of all adult patients in England diagnosed with a primary brain tumour between 2013 and 2018. We identified all adult patients with an ependymoma based on ICD-10 diagnosis and tumour morphology. Results In the 6-year period of …

27.08.2026journal-article

Journal of Health and Social Behavior

Clinical Advocacy: How Physicians Fight Back against Bureaucratic and Financial Pressures

Alexandra E Brewer, Stefan Timmermans

The commercialization and corporatization of U.S. health care have intensified bureaucratic and economic constraints on clinical decision-making. Drawing on data from a 21-month ethnography of hospital-based clinicians, we introduce clinical advocacy as the often invisible work clinicians undertake to secure care that they judge medically appropriate when third parties external to the patient–provider relationship restrict medical practice. We identify four recurrent strategies of clinical advocacy: directly appeal …

27.08.2026journal-article

Clinical and Translational Science

Hematological Malignancy Trials in Chinese Mainland, 2013–2022: A Landscape Analysis with Exploratory Macro‐Level Temporal Correlations

Jianwei Qi, Jiajia Gao, Zhenxiao Huang, Bingxuan Li, Yi Yue, Lijun Liu, Meimei Xu, Liang Huang, Shuo Chen, Qing Ji, Zhen Song, Qiujin Shen, Shihui Ma, Shuhua Yi, Xiaochen Wang, Tao Cheng, Lihong Shi, Lei Zhang

ABSTRACT Given the increasing disease burden of hematological malignancies in Chinese Mainland, a systematic analysis of clinical trials is essential to advancing translational medicine, as these trials serve as the critical nexus between laboratory discoveries and clinical applications. This study integrated registration data from the Center for Drug Evaluation, Chinese Clinical Trial Registry, and ClinicalTrials.gov for trials recorded between 2013 and 2022. Using joinpoint regression and descriptive temporal‐cor …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Motivational interviews and digital health guidance improve postoperative weight management in obese children

Xiao-Qian Dun, Si Chen

BACKGROUND Childhood obesity is a major public health issue, with obesity rates reaching 20.8% among 14-year-olds and increasing with age. Metabolic and bariatric surgery is the most effective treatment for moderate to severe obesity, but postoperative weight regain and reduced quality of life often occur due to poor lifestyle adherence. Digital health guidance interventions have shown benefits in improving disease understanding and quality of life, yet single interventions have limited effectiveness. Motivational …

27.08.2026journal-article

Frontiers in Oncology

Hypothermia and recovery outcomes before and after implementation of a multimodal perioperative temperature-management bundle in minimally invasive radical rectal cancer surgery

Qian Liu, Ling Liu, Chenxi Han, Chunmei Cao, Jiefang Ji, Aihua Zhu

Background Inadvertent perioperative hypothermia is common during minimally invasive rectal cancer surgery. We assessed whether a five-component multimodal temperature-management bundle was associated with improved perioperative outcomes. Methods This single-center retrospective before-and-after study included 247 adults undergoing laparoscopic or robot-assisted radical rectal cancer surgery from 2021 to 2025 (pre-implementation, n = 123; post-implementation, n = 124). The primary outcome was any intraoperative nas …

27.08.2026journal-article

Breastfeeding Medicine

Association Between Nipple Length and Early Breastfeeding Success in Postpartum Women: A Descriptive Correlational Study

Zeynem Yildirim Balkan, Serap Özdemir, Serap Balci

Background: Breastfeeding is essential for improving newborn health and maternal-infant bonding. Objectives: To examine the association between nipple length and early breastfeeding success assessed using the LATCH score in postpartum women. Methods: This descriptive correlational study was conducted in the delivery room and obstetric clinic of a university hospital. The researchers aimed to include the entire eligible population without performing sample size calculations. A total of 335 mother-infant pairs were e …

27.08.2026journal-article

Medicine Bulletin

Identification of Predictive Signatures for Osimertinib‐Associated Interstitial Lung Disease: Integrating Ensemble Machine Learning and Temporal Dynamics

Yilin Ye, Lianxin Zhu, Yunxiang Xie, Peng Sun, Cui Chen, Zhihua Zhu

ABSTRACT The shift toward chronic management of EGFR‐mutant lung cancer underscores the urgent need to identify molecular features potentially relevant to osimertinib‐associated interstitial lung disease (ILD). This study aimed to investigate candidate molecular mechanisms of this toxicity by integrating putative osimertinib target profiles with ILD‐associated transcriptomic networks. To prioritize high‐confidence candidate features and improve cross‐algorithm robustness, we implemented an ensemble machine learning …

27.08.2026journal-article

The Egyptian Journal of Internal Medicine

Clinicopathological evaluation of crescentic glomerulonephritis: a retrospective single-center study

Ahmet Dogukan Kansu, Murvet Yilmaz

Abstract Aim Crescentic glomerulonephritis (GN) represents a group of diseases characterized by rapid and severe kidney damage within weeks or months. This study aimed to evaluate the demographic, laboratory, histopathological features, treatment approaches, and renal survival of patients with crescentic GN followed in a nephrology clinic. Materials and methods Eighty patients with crescentic glomeruli identified on kidney biopsy were retrospectively analyzed. Five patients were excluded due to transplantation biop …

27.08.2026journal-article

Visualization in Medicine

Поляризационная микроскопия в медико биологических исследованиях

Татьяна Юрьевна Яковлева, Александр Викторович Бармасов, Анна Михайловна Бармасова, Татьяна Сергеевна Демьянова, Анастасия Андреевна Зуйкова, Ангелина Владимировна Семёнова

Поляризационная микроскопия представляет собой высокоинформативный метод оптического анализа, предназначенный для визуализации структур биологических тканей и жидкостей, характеризующихся молекулярной упорядоченностью и оптической анизотропией. В отличие от классической световой микроскопии, регистрирующей преимущественно изменения интенсивности и спектрального состава проходящего света, поляризационная микроскопия позволяет выявлять изменения состояния поляризации световой волны при ее взаимодействии с исследуемым …

27.08.2026journal-article

Visualization in Medicine

Лучевая диагностика аневризмы верхней брыжеечной артерии. Клинический случай

Вероника Сергеевна Передереева, Борис Львович Севрюгов, Алексей Анатольевич Денисов, Дмитрий Леонидович Дубицкий, Кирилл Владимирович Игнашев

Аневризмы брюшного отдела аорты и ее висцеральных ветвей в детском возрасте — редкая патология, чаще всего ассоциированная с группой наследственных заболеваний (например, синдром Марфана, синдром Элерса–Данлоса, синдром Лоеса–Дитца), когда присутствуют мутации в генах, отвечающих за синтез коллагена или других белков, ответственных за формирование соединительной ткани. Клинические проявления долгое время могут оставаться незамеченными из за отсутствия характерных признаков и индивидуальных особенностей в каждом кон …

27.08.2026journal-article

Journal of Clinical Medicine

Longitudinal Peripartum Assessment of Retinal Nerve Fiber Layer Thickness and Optic Nerve Sheath Diameter in Women with Preeclampsia and Normotensive Pregnant Controls

Raffaella L. Fantin, Franziska Huter, Alexander Franchi, Daniel Egger, Reinhard Angermann, Lisa Schlosser, Samira Abdel Azim, Katharina Knoll

Background/Objectives: Preeclampsia is associated with endothelial dysfunction and neurological morbidity. Non-invasive ocular imaging may offer insight into subclinical ocular changes associated with neurological involvement. This prospective single-center pilot study evaluated retinal nerve fiber layer (RNFL) thickness, optic nerve sheath diameter (ONSD), and angiogenic biomarkers in women with and without preeclampsia across the peripartum period. Methods: Pregnant women with preeclampsia and normotensive contro …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

B cells and B-cell receptor repertoire features in coronary heart disease: immunopathogenic roles, clinical relevance, and therapeutic potential

Xianli Peng, Xiaoyan He

Coronary heart disease (CHD) refers to coronary atherosclerotic disease, including stable coronary artery disease (CAD), acute coronary syndrome (ACS), and acute myocardial infarction (AMI), and remains a leading cause of morbidity and mortality worldwide. Beyond lipid accumulation and vascular injury, accumulating evidence indicates that adaptive immunity, particularly B-cell immunity, contributes to plaque initiation, progression, destabilization, and post-ischemic remodeling. B cells influence CHD through antibo …

27.08.2026journal-article

Orphanet Journal of Rare Diseases

The undiagnosed rare disease clinic program of Indiana University School of Medicine: lessons learned from the first 100 cases enrolled (Phase-I pilot)

Khurram Liaqat, Rachel Hart, Marco Abreu, Kevin Booth, Amy Breman, Yann Gibert, Brett H. Graham, Benjamin M. Helm, Reynold C. Ly, Lili Mantcheva, Tae-Hwi L. Schwantes-An, Marwan K. Tayeh, Kayla Treat, Stephanie M. Ware, Leah Wetherill, Francesco Vetrini, Erin Conboy

Abstract Background The Undiagnosed Rare Disease Clinic (URDC) of Indiana University, established in January 2020, is a multidisciplinary collaborative clinic that focuses on providing genetic diagnoses for patients and families dealing with the uncertainty of an undiagnosed rare disease and/or diagnostic odyssey. Methods To identify rare disease-causing variants underlying the suspected undiagnosed genetic conditions in our patient cohort, the URDC team implemented the following procedure. After sequencing, each c …

27.08.2026journal-article

Physical and Engineering Sciences in Medicine

Development of a customized three-dimensional bolus using transparent gel wax and its application in electron beam therapy

Young Jin Won, Jung Ju Jo, Su Ah Yu, Su Jung Shim, Kum Bae Kim, Jung Hoon Kim, Sang Hyoun Choi, Samju Cho

Abstract This study aimed to develop a customized bolus using commercially available transparent gel wax (TGW) without requiring 3D printing technology and to evaluate its applicability in radiotherapy, including its physical and dosimetric characteristics. A dental alginate impression was taken from the curved surface of a mastectomy phantom to replicate the patient’s skin contour. Based on this, a silicone mould was fabricated, into which TGW was poured to form the customized bolus. The fabricated bolus was evalu …

27.08.2026journal-article

Frontiers in Surgery

Trauma-related postoperative redisplacement after tension-band fixation for patellar fracture in Parkinson's disease: a case report and focused literature review

Shaowei Sun, Zhixiang Gao, Longyun Li, Lifu Wang, Cong Xiao

Rationale Patellar fractures in patients with Parkinson's disease (PD) are rarely reported, and evidence regarding optimal fixation and postoperative management remains limited. In this population, recurrent falls, abnormal muscle tone, and impaired bone quality may increase the risk of treatment failure. Patient concerns A 78-year-old man with long-standing PD presented with a patellar fracture after a low-energy fall and subsequently developed trauma-related postoperative redisplacement after a recurrent fall fol …