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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

Asian Journal of Oncology

Managing breast cancer in young women: A survey on challenges and real world scenario

Sabyasachi Parida, Pragyan Roy

Objectives: Breast cancer (BC) is the most common cancer affecting women globally and is the leading cause of cancer death in 103 countries, including India. Recent studies have shown an upsurge in the incidence of breast BC in young Indian women. It is marked by aggressive histological grade, unfavorable hormone status, and higher death rate. The entire process of screening and treatment of young breast cancer (YBC) patients differs from that of postmenopausal BC patients. Relevant issues like fertility preservati …

25.08.2026journal-article

Nutrients

The Gut–Brain Axis and Dietary Patterns in Shaping Long-Term Neurocognitive and Psychosocial Outcomes in Adolescent and Young Adult Survivors of Childhood Cancer: A Systematized Narrative Review

Piotr Pawłowski, Otylia Kościołek, Mikołaj Jeżak, Karol Jakubik, Aneta Kościołek, Marzena Samardakiewicz

Background: The dynamic advancement of pediatric hemato-oncology and intensified therapeutic protocols have significantly increased survival rates while simultaneously highlighting the challenge of long-term treatment complications. Within the cohort of adolescent and young adult (AYA) survivors, delayed neurocognitive deficits, often manifesting as the chemobrain phenotype, and psychosocial disorders constitute a particularly substantial burden. Contemporary neurogastroenterological evidence indicates a fundamenta …

25.08.2026journal-article

Frontiers in Immunology

Perioperative immunochemotherapy for resectable gastric or gastroesophageal junction cancer: a meta-analysis of efficacy and safety from randomized trials

Juan Xu, Xiao-mei Li, Chen Yang, Rui Zhang, Hai-lin Lyu, Li Wang, Jing Xie

Background The efficacy and safety of perioperative immune checkpoint inhibitors (ICIs) combined with chemotherapy for resectable gastric/gastroesophageal junction (GEJ) cancer remain to be definitively established. This meta-analysis aimed to synthesize the latest evidence from randomized controlled trials (RCTs) on this emerging therapeutic strategy. Methods A systematic literature search was conducted in PubMed, Embase, and the Cochrane Library up to June 2026 for RCTs comparing perioperative ICI plus chemothera …

25.08.2026journal-article

Applied Sciences

Longitudinal Evaluation of Gingival Margin Modifications During Treatment with Clear Aligners: A Retrospective Clinical Study in Growing Patients

Marco Clementini, Chiara Pavoni, Francesca Gazzani, Francesca Chiara De Razza, Letizia Lugli, Arianna Malara, Paola Cozza, Roberta Lione

Background: The aim of this study was to evaluate gingival margin modifications during and after orthodontic treatment with Clear Aligners in paediatric patients. Secondary objectives included assessing the relationship between gingival changes and different types of tooth movement and evaluating the stability of these changes after treatment completion. Methods: A total of 50 patients (26 f, 24 m, mean age: 7.6 ± 1.1 years) in mixed dentition were enrolled. Inclusion criteria were good general health, plaque and g …

25.08.2026journal-article

Interdisciplinary CardioVascular and Thoracic Surgery

Association between one-lung ventilation parameters and postoperative pulmonary infection after radical lung cancer surgery: A retrospective cohort study

Qianming Chen, Zhuangwen Hu, Yu Sheng, Zhenlin Jiang

Abstract Objective To investigate the relationship between lung-protective parameters during one-lung ventilation (OLV) and the risk of postoperative pulmonary infection (PPI) after radical lung cancer (LC) surgery. Methods This retrospective study included 319 patients with non-small cell lung cancer who underwent radical LC surgery with OLV during January 1, 2022-December 31, 2025. Patients were divided into PPI (n = 35) and non-PPI (n = 284) groups based on whether PPI occurred during postoperative hospitalizati …

25.08.2026journal-article

Diagnostic Cytopathology

Cytologic Features of Inflammatory Rhabdomyoblastic Tumor Using Conventional and Liquid‐Based Cytology Preparations: A Case Report

Yohei Yamaguchi, Toru Odate, Keito Ogino, Ippei Tahara, Yuka Yokota, Kazuki Kasai, Jiro Ichikawa, Tetsuo Kondo

ABSTRACT Inflammatory rhabdomyoblastic tumor (IRMT) is a recently recognized skeletal muscle neoplasm of uncertain malignant potential, characterized by a prominent inflammatory infiltrate. Although its histologic features are increasingly being defined, reports describing its cytologic characteristics remain extremely limited. Herein, we describe the detailed cytologic findings of a case of IRMT across multiple cytologic preparations. A man in his 60s presented with pharyngeal discomfort and was diagnosed with ton …

25.08.2026journal-article

International Journal of Cancer

Second Breast‐Conserving Treatment for Ipsilateral Breast Tumor Recurrence: A Review of Patient Selection, Reirradiation Techniques, and Clinical Outcomes

Cezara Cheptea, Youlia Kirova, Radu Iulian Mitrica, Mihaela Badea, Pierre Loap

ABSTRACT Local recurrence after primary breast cancer treatment remains a complex clinical scenario in patients previously treated with breast‐conserving therapy and radiotherapy. For decades, salvage mastectomy was considered the standard treatment for ipsilateral breast tumor recurrence, largely because of concerns about local control after repeat lumpectomy and cumulative toxicity after reirradiation. This paradigm has progressively changed. Retrospective comparative series, prospective Phase II data, large mult …

25.08.2026journal-article

Frontiers in Oncology

FDG/PSMA discordance in [177Lu]Lu-PSMA radioligand therapy for mCRPC: a provisional target-sufficiency framework

Jialiang Deng, Guoxiong Ma, Weijin Chen, Songhao Wen, Nanhui Chen

[ 177 Lu]Lu-PSMA radioligand therapy (LuPSMA RLT) has improved outcomes for patients with metastatic castration-resistant prostate cancer (mCRPC), yet clinically meaningful response heterogeneity persists even among patients selected on the basis of PSMA PET positivity. A central limitation of patient-level PSMA eligibility is that it establishes target availability in at least part of the tumor burden, but it does not show whether all metabolically active lesions have sufficient PSMA expression, therapeutic retent …

25.08.2026journal-article

Frontiers in Oncology

Organ preservation after neoadjuvant immunotherapy in mismatch repair-deficient colorectal cancer: response assessment, watch-and-wait, and salvage surgery

Nan Yao, Guoshuai Xu, Ning Duan, Fuzhou Han, Wenqiang Li, Jun Qu

Neoadjuvant immune checkpoint blockade has produced high pathological and clinical response rates in mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H) colorectal cancer, raising the possibility of response-adapted organ preservation. However, the evidence is anatomically uneven and remains immature for routine surgery avoidance. In dMMR colon cancer, neoadjuvant studies primarily establish drug activity through resection-confirmed pathological and nodal response; reliable criteria for nono …

25.08.2026journal-article

Women’s Health and Multidisciplinary Research

Coexistence of Adenomyosis and Its Effect on Survival in Patients with Endometrial Cancer

Ozan Can Polat, Ali Ulvi Hakverdi

Background and Aim: To investigate the impact of coexisting adenomyosis on clinicopathological characteristics and survival outcomes in patients who underwent surgery for endometrial cancer. Materials and Methods: This retrospective, single-center cohort study included 124 patients who underwent surgical treatment for endometrial cancer between January 2015 and May 2022. Patients were categorized according to the presence or absence of adenomyosis based on the final histopathological examination. Demographic charac …

25.08.2026journal-article

Frontiers in Immunology

Therapeutic mRNA vaccines for lung cancer: reshaping the tumor microenvironment to enhance anti-tumor immunity

Hao Wu, Ruiqi Weng, Siyi Gu, Jiyuan Wang, Xiaoyan Ma, Jiaxuan Li, Xiaotian Tie, Chongmin Huang, Keda Chen

Traditional treatments for lung cancer include surgery, radiotherapy, chemotherapy, and targeted therapies (such as Erlotinib, Gefitinib, and Crizotinib), as well as immunotherapy (such as Nivolumab and Pembrolizumab). However, these approaches face challenges such as drug resistance, limited efficacy, and significant side effects, making it difficult to improve long-term prognosis. Therefore, tumor vaccines, as a novel immunotherapy strategy, have become a focus of research, aiming to precisely activate anti-tumor …

25.08.2026journal-article

Advanced Science

Multiplexed Profiling of Individual Extracellular Vesicles Reveals Lung Cancer‐Associated Protein Signatures

Mi Hyeon Cho, Yein Chung, Yoonjeong Choi, Baekdong Cha, Jayeon Song, Nuri Oh, Ala Jo, Thomas S. C. Ng, Hyunho Kim, Hyun‐Kyung Woo, Chang Hyun Kim, Cesar M. Castro, Miles A. Miller, Hakho Lee

ABSTRACT Lung cancer is frequently diagnosed after curative treatment windows have narrowed, creating a need for minimally invasive biomarkers that report tumor development at earlier stages. Extracellular vesicles (EVs) are promising analytical targets because they carry molecular cargo from their originating cells, but tumor‐associated EV signals can be rare in blood and obscured in bulk measurements. Here, we present Cygnus ( Cy clic‐imaging g ateway to n anovesicles u nderlying s ignature), an end‐to‐end workfl …

25.08.2026journal-article

Journal of The Society of Obstetricians and Gynaecologists of Pakistan

The diagnostic accuracy of MRI pelvis in parametrial invasion in patients with cervical cancer keeping histopathology as gold standard

Sualeha, Shafaq Aijaz, Ekta, Sajad, Uroosa Ana, Keenjhar

OBJECTIVE: To determine the diagnostic accuracy of MRI pelvis in parametrialinvasion in patients with cervical cancer keeping histopathology as gold standard.STUDY DESIGN: Cross-sectional studySETTING: Department of Radiology, Liaquat University of Medical and Health Sciences,Hyderabad.STUDY DURATION: 23 rd April 2022 till 23 rd October 2022METHODS: Women aged 30-70 years having suspicion of cervical cancer clinicallywere included. Pregnant patients and patients with already diagnosed with other pelvicmalignancy we …

25.08.2026journal-article

Molecular Cancer Therapeutics

Antitumor Activity of Orally Available Cyclic Peptide LUNA18 through Direct Pan-RAS Inhibition across Diverse RAS Genetic Alterations

Hitoshi Sase, Saki Michisaka, Yukako Tachibana, Masami Hasegawa, Toshihiko Fujii, Kana Takei, Tomoko Kanei, Naoaki Murao, Ryuichi Komatsu, Kentaro Asanuma, Shino Kuramoto, Norihito Shibahara, Atsushi Ohta, Mikimasa Tanada, Takuya Shiraishi, Hitoshi Iikura, Takehisa Kitazawa, Hiroshi Tanaka

Abstract Although recent extensive efforts led to the landmark discovery of clinically effective KRASG12C inhibitors (KRASG12C-i), targeting RAS genetic alterations beyond the G12C mutant remains challenging. In this study, we report on LUNA18 (paluratide), an orally available cyclic peptide that acts as a first-in-class pan–RAS-GDP inhibitor, exhibiting potent inhibitory activity against a wide variety of RAS mutations. LUNA18 demonstrated antitumor effects against cancer cells with various RAS alterations, includ …

25.08.2026journal-article

Monaldi Archives for Chest Disease

Association between early weight variation and treatment outcomes among extensively drug-resistant tuberculosis patients in Pakistan: a multicenter retrospective cohort study

Muhammad Abubakar, Javeria Sehar, Rimsha Mukhtar

Tuberculosis (TB) is commonly associated with significant weight loss, and weight gain during treatment is often considered an indicator of treatment response. However, evidence regarding the association between weight change and treatment outcomes among patients with extensively drug-resistant TB (XDR-TB) remains limited. This study aimed to evaluate the relationship between weight change during treatment and treatment outcomes among XDR-TB patients in Pakistan. A multicenter retrospective cohort study was conduct …

25.08.2026journal-article

Applied Immunohistochemistry & Molecular Morphology

PRAME Expression in Merkel Cell Carcinoma: Correlation With MCPyV Status, PD-L1, and Tumor-Infiltrating Lymphocytes in a Multicenter Cohort

Erdem Comut, Betul Ogut, Arbil Acikalin, Ozlem Erdem, Nese Calli Demirkan

Preferentially expressed antigen in melanoma (PRAME) expression has been described in Merkel cell carcinoma (MCC), but its clinicopathologic and biological significance remains incompletely characterized. We investigated PRAME expression in MCC and its relationship with Merkel cell polyomavirus (MCPyV) status, PD-L1 expression, tumor-infiltrating lymphocytes (TILs), clinicopathologic features, and clinical outcome. Thirty-five MCC cases from 3 centers were retrospectively reviewed. Histopathologic features and immu …

25.08.2026journal-article

Pakistan Journal of Medical Sciences

Clinical study on the combined use of cardiovascular agents and statins in the treatment of coronary heart disease

Zhili Chen, Qianqian Zhang, Yue Zhang, Zhe Xu, Xiaozhe Yang

Objective: To evaluate the clinical efficacy of combining cardiovascular agents with statins in the treatment of coronary heart disease (CHD). Methodology: This was a retrospective study. A total of 110 patients diagnosed with CHD and treated at Shijiazhuang Eighth Hospital between January 2024 to December 2025 were enrolled and randomly divided into two groups, with 55 patients in each group. The control group received conventional therapy, including anticoagulation, coronary vasodilation, antiplatelet therapy, an …

25.08.2026journal-article

SAS Journal of Surgery

Surgical Treatment of a Dorsal Fifth Carpometacarpal Dislocation Associated with a Fourth Metacarpal Base Fracture: A Case Report

MY Mazouzi, A Massri, S Bousselmame, O Assouab, MR Fekhaoui, O Aguenaou, J Mekkaoui, M Boufettal, RA Bassir, M Kharmaz, MO Lamrani

Background: Carpometacarpal dislocations are uncommon, frequently overlooked injuries that may cause substantial functional impairment when diagnosis and stabilisation are delayed. Case presentation: A 19-year-old man sustained a closed injury to the right hand after a heavy metal object fell on it. Radiographs demonstrated a dorsal dislocation of the fifth carpometacarpal joint associated with a fracture of the fourth metacarpal base. The initial closed reduction was unstable. Reduction under regional anaesthesia …

25.08.2026journal-article

Cancers

Health-Related Quality of Life and Mid-Term Oncological Outcomes After Subcostal Uniportal Robot-Assisted Lung Cancer Surgery: A Secondary Analysis of a Clinical Trial

Chuan Cheng, Ya-Chun Hsu, Yin-Kai Chao

Objective: Subcostal uniportal robot-assisted thoracic surgery (URATS) using the da Vinci Single-Port (SP) system avoids intercostal placement of the main robotic access. This prespecified secondary analysis of a prospective trial characterized chronic postsurgical pain and health-related quality of life (HRQOL) as primary patient-reported outcomes after subcostal URATS for early-stage lung cancer, with mid-term oncological outcomes as an exploratory endpoint. Methods: Patients from the parent trial (NCT05535712) u …

25.08.2026journal-article

Laboratory Animal Research

Considerations for selecting immunodeficient mouse strains for cancer xenograft models

Jiwon Lee, Joohee Jung

Abstract Preclinical (in vivo) experiments for efficacy and toxicity are predominantly conducted in mice. Nevertheless, human-derived cells, tissues, and organoids are generally rejected by the immune system of mice. Thus, immunodeficient mice are used as xenograft models to overcome immune rejection in cancer research. Xenograft mouse models are divided into ectopic, orthotopic, and metastatic models based on the transplant sites. Xenograft mouse models are established by transplanting cancer cells, tissues, or or …

25.08.2026journal-article

Cancer Research

ETV6 Rearrangement Suppresses CDKN1B Transcription by Disrupting an Intragenic Super-enhancer in Acute Lymphoblastic Leukemia

Wenqian Xu, Xiaofang Ma, Xue Sun, Gaoxian Song, Shuhan Zhu, Jie Tian, Ruirui Shi, Linlang Guo

Abstract ETV6-rearranged acute lymphoblastic leukemia (ALL) is associated with poor prognosis in adults. Previously, a super-enhancer (SE) located within the ETV6 intragenic region (ETV6-SE) was identified in a rare fusion gene, ETV6::ACSL6; however, further work is needed to determine whether ETV6-SE is broadly present in ALL and how ETV6 rearrangements affect the SE function. In this study, we demonstrated that ETV6 functions as a regulatory element via ETV6-SE in ALL, with CDKN1B as a key target. CRISPR interfer …

25.08.2026journal-article

Frontiers in Oncology

Oncofetal reprogramming and cellular plasticity in colorectal cancer: from mechanisms to clinical translation

Haoyu Wang, Songhao Liu, Mingxuan Zhang, Chunping Deng, Zhenguo Han

Colorectal cancer (CRC) progression and metastasis, as well as tolerance to therapy, are driven not only by genetic alterations but also by cell-state plasticity. Oncofetal reprogramming (OnF) refers to the reactivation of fetal intestinal developmental or injury-repair programs in tumor cells, thereby weakening adult lineage identity and enhancing the capacity for state transitions. Available evidence suggests that, in specific Wnt-dependent or APC-aberrant contexts, YAP/TAZ–TEAD and AP-1 may act cooperatively to …

25.08.2026journal-article

Frontiers in Medicine

Prognostic effect of the preoperative albumin-to-globulin ratio bladder cancer: a meta-analysis

Fangfang Huang, Changyun Chen, Yan Mao, Tingting Lin, Qianqian Hu

Background The preoperative albumin-to-globulin ratio (AGR) has emerged as a potential prognostic indicator in various malignancies. However, its specific prognostic value in bladder cancer remains to be fully elucidated. Thus, the association between preoperative the AGR and the prognosis of bladder cancer should be systematically evaluated through a meta-analysis of the available evidence. Methods A systematic search was performed across major electronic databases (PubMed, Embase, and the Cochrane Library) to ide …

25.08.2026journal-article

Frontiers in Digital Health

Oncologists' knowledge, attitudes and needs about artificial intelligence in clinical oncology in Luxembourg in 2026: a national cross-sectional survey (AICO study)

Dominic Kaddu-Mulindwa, Xianqing Mao, Caroline Duhem, Sigrid de Wilde, Stefan Rauh, Gilles Klein, Frank Jacob, Sophie Servais

Introduction Artificial intelligence (AI) is rapidly entering the field of medical oncology. Clinician literacy, ethical awareness, and governance structures are prerequisites for safe implementation, yet real-world data on adoption, training and ethical perceptions from small European healthcare systems remain scarce. Methods We conducted an anonymous national cross-sectional online survey among all practicing physicians (medical oncologists, radiation oncologists, haematologist-oncologists) and oncology residents …