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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

Cancers

Health-Related Quality of Life and Mid-Term Oncological Outcomes After Subcostal Uniportal Robot-Assisted Lung Cancer Surgery: A Secondary Analysis of a Clinical Trial

Chuan Cheng, Ya-Chun Hsu, Yin-Kai Chao

Objective: Subcostal uniportal robot-assisted thoracic surgery (URATS) using the da Vinci Single-Port (SP) system avoids intercostal placement of the main robotic access. This prespecified secondary analysis of a prospective trial characterized chronic postsurgical pain and health-related quality of life (HRQOL) as primary patient-reported outcomes after subcostal URATS for early-stage lung cancer, with mid-term oncological outcomes as an exploratory endpoint. Methods: Patients from the parent trial (NCT05535712) u …

25.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Epigenetic aging of colorectal mucosa in cancer development

Sheetal Hardikar, Biljana Gigic, Jacob K Kresovich, Victoria Damerell, Caroline Himbert, Jennifer Ose, Adetunji T Toriola, David Shibata, Christopher I Li, Jane C Figueiredo, Doratha A Byrd, Erin M Siegel, Christoph Kahlert, Alexander Brobeil, Peter Schirmacher, Cornelia M Ulrich, Timothy M Barrow

Abstract Background The past decade has seen the development of epigenetic models of aging that accurately estimate chronological age and predict disease incidence and mortality. These estimates are modulated by lifestyle and environmental factors linked to carcinogenesis, but to date this has primarily been studied in blood. Methods We examined epigenetic aging in normal colonic tissue (n = 96), adjacent mucosa (n = 245) and tumors (n = 208), using models trained on age (Horvath, Hannum, Zhang), mortality (PhenoAg …

25.08.2026journal-article

Retina

Incidence and associations of Retinal pigment epithelial (RPE) tear post-loading phase of aflibercept 2mg in Treatment Naïve Neovascular Age-Related Macular Degeneration (nAMD): PRECISE study report 10.

Dimitrios Kazantzis, Sridevi Thottarath, Abhishek Sheemar, Ayse Merve Keskin, Heena Syed Kubravi, Sobha Sivaprasad, for the PRECISE Study Group

Purpose: To report the incidence of retinal pigment epithelial (RPE) tears following three monthly 2-mg aflibercept injections in treatment-naïve neovascular age-related macular degeneration (nAMD) and to identify associated risk factors. Methods: Treatment-naïve patients aged ≥50 years with nAMD and baseline visual acuity (VA) between 24 and 78 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters were included. RPE tears were diagnosed on optical coherence tomography (OCT) as a definite discontinuity of t …

25.08.2026journal-article

Frontiers in Immunology

Cancer-associated fibroblasts as architects of acquired immune-privileged-like niches in gastrointestinal cancers: lessons from ocular immune privilege and barrier biology

Yingjian Wang, Zhe Wang, Fangdi Zhou, Yu Qiao, Zhanyang Luo, Feng Wang, Bingtong Yue, Dao Xin

Gastrointestinal cancers frequently develop immune exclusion and therapeutic resistance, yet these phenotypes are often described separately. Cancer-associated fibroblasts (CAFs) are key stromal architects of immune-excluded tumor microenvironments, and their heterogeneous states can evolve under chemotherapy, radiotherapy, immunotherapy, targeted therapy, and anti-angiogenic pressure. We propose that treatment-induced injury, inflammation, hypoxia, and repair signals reshape CAFs. These therapy-educated CAFs can c …

25.08.2026journal-article

Frontiers in Digital Health

Oncologists' knowledge, attitudes and needs about artificial intelligence in clinical oncology in Luxembourg in 2026: a national cross-sectional survey (AICO study)

Dominic Kaddu-Mulindwa, Xianqing Mao, Caroline Duhem, Sigrid de Wilde, Stefan Rauh, Gilles Klein, Frank Jacob, Sophie Servais

Introduction Artificial intelligence (AI) is rapidly entering the field of medical oncology. Clinician literacy, ethical awareness, and governance structures are prerequisites for safe implementation, yet real-world data on adoption, training and ethical perceptions from small European healthcare systems remain scarce. Methods We conducted an anonymous national cross-sectional online survey among all practicing physicians (medical oncologists, radiation oncologists, haematologist-oncologists) and oncology residents …

25.08.2026journal-article

Frontiers in Medicine

Prognostic effect of the preoperative albumin-to-globulin ratio bladder cancer: a meta-analysis

Fangfang Huang, Changyun Chen, Yan Mao, Tingting Lin, Qianqian Hu

Background The preoperative albumin-to-globulin ratio (AGR) has emerged as a potential prognostic indicator in various malignancies. However, its specific prognostic value in bladder cancer remains to be fully elucidated. Thus, the association between preoperative the AGR and the prognosis of bladder cancer should be systematically evaluated through a meta-analysis of the available evidence. Methods A systematic search was performed across major electronic databases (PubMed, Embase, and the Cochrane Library) to ide …

25.08.2026journal-article

Laws

Corporate Tax Loss Carryforward and Company Regulation Under UAE Law: Rethinking the Tax Accounting Treatment of VirtualAssets—A Comparative Study

Tarek Abdelsalam, Ahmed Moustafa Aldabousi, Haytham Mohamed Sherif, Mohammad Hamdy Alawady, Doaa Mohammad Sayed El Khosht, Abdelrehim Awad

This article re-examines corporate tax loss carryforward and company regulation under United Arab Emirates law as applied to virtual assets. It uses Egypt as one functional benchmark among several, alongside the United States, the United Kingdom, Singapore, the European Union, and OECD reporting standards. The study asks whether the UAE’s general loss architecture—especially Articles 37–40 of Federal Decree-Law No. 47 of 2022—can address transaction-level problems involving classification, realization, valuation, b …

25.08.2026journal-article

Laboratory Animal Research

Considerations for selecting immunodeficient mouse strains for cancer xenograft models

Jiwon Lee, Joohee Jung

Abstract Preclinical (in vivo) experiments for efficacy and toxicity are predominantly conducted in mice. Nevertheless, human-derived cells, tissues, and organoids are generally rejected by the immune system of mice. Thus, immunodeficient mice are used as xenograft models to overcome immune rejection in cancer research. Xenograft mouse models are divided into ectopic, orthotopic, and metastatic models based on the transplant sites. Xenograft mouse models are established by transplanting cancer cells, tissues, or or …

25.08.2026journal-article

Frontiers in Oncology

Oncofetal reprogramming and cellular plasticity in colorectal cancer: from mechanisms to clinical translation

Haoyu Wang, Songhao Liu, Mingxuan Zhang, Chunping Deng, Zhenguo Han

Colorectal cancer (CRC) progression and metastasis, as well as tolerance to therapy, are driven not only by genetic alterations but also by cell-state plasticity. Oncofetal reprogramming (OnF) refers to the reactivation of fetal intestinal developmental or injury-repair programs in tumor cells, thereby weakening adult lineage identity and enhancing the capacity for state transitions. Available evidence suggests that, in specific Wnt-dependent or APC-aberrant contexts, YAP/TAZ–TEAD and AP-1 may act cooperatively to …

25.08.2026journal-article

Cancer Research

ETV6 Rearrangement Suppresses CDKN1B Transcription by Disrupting an Intragenic Super-enhancer in Acute Lymphoblastic Leukemia

Wenqian Xu, Xiaofang Ma, Xue Sun, Gaoxian Song, Shuhan Zhu, Jie Tian, Ruirui Shi, Linlang Guo

Abstract ETV6-rearranged acute lymphoblastic leukemia (ALL) is associated with poor prognosis in adults. Previously, a super-enhancer (SE) located within the ETV6 intragenic region (ETV6-SE) was identified in a rare fusion gene, ETV6::ACSL6; however, further work is needed to determine whether ETV6-SE is broadly present in ALL and how ETV6 rearrangements affect the SE function. In this study, we demonstrated that ETV6 functions as a regulatory element via ETV6-SE in ALL, with CDKN1B as a key target. CRISPR interfer …

25.08.2026journal-article

European Journal of Nuclear Medicine and Molecular Imaging

Clinical impact of routine second‑opinion reading of [¹⁸F]FDG‑PET/CT in newly diagnosed invasive bladder cancer: A multicentre study in a centralised referral network

Renee A. G. Lijnen, Misha L. Vierling, Joanneke B. Ringia, Kees Hendricksen, Gijs H. KleinJan, Arnoud W. Postema, Wouter V. Vogel, Thierry N. Boellaard, Arthur J. A. T. Braat, Linda Heijmen, Bas W. G. van Rhijn, Laura S. Mertens

Abstract Purpose [¹⁸F]FDG‑PET/CT is increasingly used to stage invasive bladder cancer (IBC), resulting in growing demand at tertiary centres for time‑intensive second‑opinion reading of externally acquired scans. However, the incremental clinical value of routine reinterpretation is unclear. We evaluated the clinical impact of second‑opinion [¹⁸F]FDG‑PET/CT reading in a centralised referral network in the Netherlands. Methods In this multicentre retrospective diagnostic cohort study, consecutive patients with hist …

25.08.2026journal-article

Journal Of Babylon Center for Humanities Studies

ضحايا الأسلحة الكيماوية في حلبجة و دور المراكز الطبية الإيرانية والدولية في علاجهم (1988 - 1992)

جوهر عزيز أحمد, هوشمند علي محمود

لم يكن القصف الكيماوي لمدينة حلبجة في 16مارس 1988 مجرد حدث عابر ومميت، بل كان بداية لمرحلة مليئة بالمعاناة لأولئك الذين تعرضوا للغازات الكيماوية وتمكنوا من النجاة. تسلط هذه الدراسة الضوء على حالة المصابين، وتحلل أنواع الغازات السامة التي استخدمتها الحكومة العراقية في هجومها الكيماوي على مدينة حلبجة، مثل غاز الأعصاب وغاز الخردل. وبالإضافة إلى استعراض التداعيات والآثار طويلة الأمد للأسلحة الكيماوية، تركز الدراسة على عمليات علاج الجرحى في مستشفيات كرمانشاه وطهران، وآليات تصنيف المصابين في المراكز الصحية. ويتمثل أحد ال …

25.08.2026journal-article

Food, Nutrition and Health

Breast cancer microenvironment regulation by food and medicine homology substances

Yimao Wu, Ziling Zeng, Yinting Hu, Zichang Chen, Gokhan Zengin, Huijie Miao, Meng-Yao Li

Abstract Breast cancer (BC) represents the primary threat to women’s health worldwide, with its associated disease burden increasing continuously. Although conventional therapies represented by chemotherapy and targeted therapy serve as the cornerstone of current treatment, their accompanying systemic toxic and side effects, as well as insufficient regulation of the tumor microenvironment (TME), have increasingly become bottlenecks restricting the improvement of therapeutic efficacy and patients’ quality of life. A …

25.08.2026journal-article

Current Oncology

Learning Curve and Video-Based Technical Assessment of a Standardized Vesicourethral Anastomosis in Novice Robotic Surgeons

Federico Germinale, Manfredi Bruno Sequi, Antonia Di Domenico, Andrea Benelli, Federico Dotta, Marco Ennas, Giovanni Guano, Claudia Brusasco, Mattia Tosi, Martina Manfredi, Antonio Luigi Pastore, Antonio Carbone, Andrea Fuschi, Carlo Introini

Background/Objectives: Vesicourethral anastomosis (VUA) is one of the most technically demanding steps of robot-assisted radical prostatectomy (RARP) and may influence perioperative outcomes and early urinary continence recovery. Objective assessment of technical performance during the learning curve remains limited. We evaluated the learning curve and technical performance of a standardized VUA technique among novice robotic surgeons using a structured video-based assessment. Methods: In this retrospective single- …

25.08.2026journal-article

Frontiers in Immunology

Syndrome differentiation and treatment of pediatric central precocious puberty: role of the spleen-kidney axis

Yujun Luo, Chaojie Huang, Yanting Lu, Jieying He, Hailing Chen, Jinghua Yang

Pediatric central precocious puberty (CPP) is driven by premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, along with immune-inflammatory imbalance, metabolic dysfunction, obesity, and gut microbiota-derived signals. According to traditional Chinese medicine (TCM) principles, kidney yin deficiency with hyperactive ministerial fire and spleen deficiency with phlegm-dampness form the basis for central pubertal activation and peripheral metabolic-inflammatory burden, thus supporting a combined appr …

25.08.2026journal-article

Dermatology

Long-term disease progression in adult atopic dermatitis: A 6-year observational study of severity and treatment patterns

Lea Krog Nymand, Mia-Louise Nielsen, David Thein, Simon Francis Thomsen, Jacob P. Thyssen, Alexander Egeberg

Background: Atopic dermatitis (AD) is a chronic and heterogeneous skin condition, often with a fluctuating and unpredictable disease course, which can be influenced by treatment patterns and significantly impact patients’ disease burden and mental health. Objective: To characterize disease trajectories stratified by severity and treatment modality, and investigate their association with patient-reported signs, symptoms, and mental health burden. Methods: Patients (≥18 years) with a dermatologist-verified diagnosis …

25.08.2026journal-article

Virtual Reality

Automating EMDR-based mental health treatment in virtual reality

Mu Mu, Olive Chan, Andrew Debus, Murtada Dohan, David Nicholls, Paul Wallang, Kieran Breen

Abstract Eye Movement Desensitisation and Reprocessing (EMDR) is a proven psychotherapy for treating trauma, yet access is severely limited due to a shortage of trained therapists and long waiting times. This paper presents the development of a VR-based EMDR application that automates therapy delivery while maintaining clinical rigour and patient engagement for trauma treatment. The system incorporates therapist-informed designs, naturalistic virtual environments, and game-inspired interaction mechanics to enhance …

25.08.2026journal-article

Blood Coagulation & Fibrinolysis

Describing the clinical outcomes and treatment landscape for male haemophilia A and B patients in a real-world setting across Europe and the United States

Sheena Thakkar, Lisa J. Wilcox, Valeria Merla, Anna Kane, Rabiyah Sahar, Chris Blazos, Sophie Lai, Ella Morton, Kieran Wynne-Cattanach, Nathan Ball

Haemophilia A and haemophilia B are rare bleeding disorders characterized by prolonged bleeding episodes, bruising, and spontaneous bleeds. As the treatment landscape evolves, real-world data are essential to assess disease management practices. This study aimed to describe clinical outcomes for haemophilia A and haemophilia B patients in a real-world setting. Data were drawn from the Adelphi Haemophilia Disease Specific Programme (DSP), a cross-sectional survey of physicians and their patients conducted in France, …

25.08.2026journal-article

Reproduction and Fertility

Transcriptome differences in lesions by color, and cancer mutations in endometriosis

Jeremy Y. Huang, Sona Relovska, Rishi S. Madnani, Li Li, Songlei Liu, Ankrish Milne, Ian N. Waldman, Maya L. Seshan, Anne Lindholm, Emily R. Disler, Rossella M. Gargiulo, Ameya S. Menta, Junyi Chen, Alexandria N. Young, Bradley J. Quade, Antonio R. Gargiulo, Marc R. Laufer, Joshua Ho, Mark D. Hornstein, George M. Church, Michael S. Rogers, Raymond M. Anchan

Abstract Endometriosis is a disease where cells similar to those of the uterine lining grow outside of the uterus, embedding into tissues and organs in the abdominal cavity, forming lesions and causing pain and infertility. Previous studies in patients with endometriosis identified single nucleotide polymorphisms associated with the disease, as well as somatic mutations in cancer-related genes. Here, we use bulk RNA sequencing to determine transcriptome mutation profiling and differentially expressed genes in endom …

25.08.2026journal-article

Journal of Cancer Education

Impact of an Asynchronous E-learning Intervention on Cancer Knowledge and Clinical Practice for Pre-registration Nursing and Allied Health Professions Students and Cancer Support Workers

Julie Armoogum, June Davis, John Gale, Vanessa Taylor

Abstract Pre-registration nursing and allied health professions students and cancer support workers can feel unprepared to care for people affected by cancer and at the end of life. To address this need, nine e-learning modules, collectively called ‘Foundations of Cancer Care’, have been developed aligned to the NHS England ACCEND Framework. The resultant programme is freely available to anyone with a UK email address via the NHS Learning Hub. To evaluate accessibility, structure, relevance, design and style of thi …

25.08.2026journal-article

Frontiers in Oncology

Double heterozygous germline pathogenic variants in patients referred to a tertiary cancer genetics clinic in Singapore

Rachel Su Jen Wong, Pei Yi Ong, Samuel Guan Wei Ow, Robert John Walsh, Gloria Chan, Vanessa Pei Yi Lim, Soo Chin Lee

Background The increasing use of multigene panel testing has led to a rise in the identification of double heterozygous (DH) pathogenic variants in cancer patients, although their frequency and clinical relevance remain poorly characterised, particularly in Asian populations. Methods We conducted a retrospective review of 5,178 patients referred to a tertiary cancer genetics clinic in Singapore. DH pathogenic variants were defined as the presence of two or more distinct pathogenic or likely pathogenic germline vari …

25.08.2026journal-article

Cancers

Can Artificial Intelligence Really Help? A Practicing Radiologist’s Simplified Guide to AI, with a Critical Appraisal of the Use of AI in Cancer-Associated Thromboembolism

Julia H. Miao, Ola A. E. Mohamed, Christopher Straus, Vanessa Peters, Emily Miller, Basant Dawoud, Joshua Brooks, Haidy Megahed, Ahmed Hamimi

Artificial intelligence (AI) has generated considerable excitement in radiology, with claims of transformative improvements in diagnostic accuracy, workflow efficiency, and clinical decision support. However, a critical gap persists between AI’s theoretical promise and its real-world performance, particularly in complex, high-stakes scenarios such as cancer-associated thromboembolism (CAT). CAT is a leading cause of morbidity and mortality in oncology patients, yet it remains underdiagnosed on routine imaging. This …

25.08.2026journal-article

Frontiers in Cell and Developmental Biology

Computational analysis of treatment resistant cancer cells

Alexandre Matov

Introduction Prostate cancer (PC), which is a disease driven by the activity of the androgen receptor (AR), is the most commonly diagnosed malignancy and despite advances in diagnostic and treatment strategies, PC is the second most common cause of cancer mortality in men. Taxane-based chemotherapy is the only chemotherapy that prolongs survival in metastatic PC patients. At the cellular level, taxanes bind to and stabilize microtubules (MTs), inhibiting all MT-dependent intracellular pathways. MTs are highly dynam …

25.08.2026journal-article

Bioinformatics Advances

Leveraging Uncertainty Estimates for Drug Response Prediction in Cancer Cell Lines

Pascal Iversen, Bernhard Y Renard, Katharina Baum

Abstract Motivation Machine learning models for drug response prediction in cancer cell lines could advance precision oncology by tailoring treatments to the molecular tumor profile. Their application is challenged by variability in prediction quality and distribution shifts between training and application. Yet, the most effective uncertainty estimator is domain-specific. We benchmark uncertainty-aware models for drug response prediction. We focus on epistemic uncertainty via ensemble agreement, and aleatoric unce …