Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Medizin · Seite 53

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Neuro-Oncology

129 Electroactive drug delivery for local glioblastoma treatment

Joshua Killilea, Immi Van Der Auweraert, Gary Shaw, Harveena Padda, Holly Briggs, Une Kontrimaite, Leire Landeira Suquia, Rosalie De Ferm, Lucia Moreno Gimeno, Phoebe McCrorie, Estelle Cuttaz, Aaron Lee, Giovanni Carlo Miceli, Stuart Smith, Dong-Hyun Kim, Ruman Rahman, Juanita Lopez, Roberto Portillo Lara, Josef Goding, Heiko Wurdak, Ryan Mathew, Christopher Chapman, Rylie Green

Abstract Introduction Despite recent advances in cancer therapeutics, the prognosis for glioblastoma remains exceptionally poor, stemming from the limited ability of systemically administered chemotherapeutics to cross the blood brain barrier (BBB). Mechanically circumventing the BBB represents a promising avenue. However, biomaterials previously used for local delivery suffer from low control over drug release, further limiting their translation. To address this, an implantable bioelectronic drug delivery device w …

27.08.2026journal-article

Bioengineering

Post-MI Remodeling Mechanics of Left Ventricle: Microstructure-Informed Models, Identifiability, and Uncertainty for Patient-Specific Prediction

Thanyani Pandelani, Fulufhelo Nemavhola

Background: Myocardial infarction (MI) causes spatially heterogeneous loss of contractility and progressive extracellular matrix remodeling, altering left ventricular mechanics from the acute phase through chronic remodeling. This review integrates current understanding of infarct, border-zone, and remote-myocardial microstructure with organ-scale mechanics and patient-specific computational modeling. Methods: A narrative review and perspective were conducted using the literature identified through PubMed/MEDLINE, …

27.08.2026journal-article

Infection Control & Hospital Epidemiology

Impact of a single-set blood culture restriction during the 2024 national blood culture bottle shortage on patient outcomes: an interrupted time series analysis

Joseph B. Ladines-Lim, Bailey Van, Leigh Cressman, Warren B. Bilker, Laurel Glaser, Kathleen Degnan, Michael Z. David

Abstract Objective: To evaluate the clinical and stewardship consequences of a single-set blood culture restriction implemented during the 2024 national blood culture bottle shortage. Design: Interrupted time series analysis of hospitalizations from June 26, 2023, to June 25, 2025. Setting: Two tertiary hospitals in an urban academic health system. Patients: 116,341 inpatient hospitalizations, including 31,034 with ≥1 blood culture obtained. Intervention: A systemwide electronic health record order restriction from …

27.08.2026journal-article

Scientific Reports

Non-invasive detection of obstructive sleep apnea from speech in a limited clinical dataset

Martina Skapova, Pavol Partila, Jaromir Tovarek, Tereza Lubojacka, Jana Slonkova, Ondrej Hruby, Samuel Genzor, Jan Mizera, Petr Mooz

Abstract This study investigates non-invasive detection of obstructive sleep apnea (OSA) from daytime speech in a limited polysomnography-labeled clinical cohort. The objective was to evaluate whether speaker-verification-inspired representations can support robust speech-based OSA screening under constrained clinical data conditions. We compared conventional mel-frequency cepstral coefficient (MFCC)-based classifiers with i-vector systems using cosine-similarity, support vector machine (SVM), and neural-network (N …

27.08.2026journal-article

Frontiers in Immunology

Agonistic anti-CD40 antibodies in patients with solid tumors: a systematic review and evidence map of clinical safety, with exploratory proportional synthesis

Xinrui Yin, Shijia Du

Background Agonistic anti-CD40 antibodies and related CD40 agonist biologics are being developed across multiple solid tumors using diverse biologic formats, delivery routes, and combination regimens. Safety is central to their clinical development but remains difficult to interpret because high-grade adverse events in combination settings may reflect partner therapies, and safety outcomes are reported inconsistently. Methods We conducted a systematic review and evidence map of the clinical safety of CD40 agonists …

27.08.2026journal-article

Journal of Law, Medicine & Ethics

America First Bilateral Health Agreements Threaten to Undermine the Multilateral Global Health Order

Sharifah Sekalala, Shajoe J. Lake, Allan Maleche, Maria Birungi, Frank Ssekamwa

Abstract During the second Trump administration, the United States has signed bilateral health agreements with at least 27 states across Africa and Latin America, reshaping how signatory countries finance, regulate, and monitor their health systems. Grounded in the America First Global Health Strategy, these agreements are being signed as US withdrawal from WHO restructures global health. This column explores how this turn to bilateralism risks weakening multilateral legal obligations on capacity development, acces …

27.08.2026journal-article

Frontiers in Surgery

Clinical characteristics and distinct recovery trajectories of pain and disability after lumbar microdiscectomy in children and adolescents

Muhammed Erkan Emrahoğlu, Mustafa Kavcar, Erdal Reşit Yılmaz, Hüseyin Bozkurt, Mehmet Kalan, Ahmet Günaydın, Hakan Yakupoğlu, Halil Gök, Levent Gürses, Emrah Keskin, Selim Gel, Mehmet Erhan Türkoğlu

Background Pediatric and adolescent lumbar disc herniation (LDH) is uncommon, and recovery after microdiscectomy may differ across pain, disability, and outcome domains. Methods This retrospective single-center case series included patients younger than 18 years of age who underwent microdiscectomy for LDH between 2022 and 2025 and had complete 12-month outcome data. Low back and radicular leg pain were assessed using the visual analog scale (VAS), disability using the Oswestry Disability Index (ODI), and global ou …

27.08.2026journal-article

Frontiers in Pharmacology

Association between a regional reimbursement policy and treatment escalation in pulmonary arterial hypertension: a real-world cohort study with long-term Markov cost-effectiveness analysis

Yilin Xie, Yusi Chen, Jun Luo, Jingyuan Chen, Yingjie Tan, Tianyu Wang, Wenjie Chen, Jiang Li

Background Pulmonary arterial hypertension (PAH) requires long-term treatment with high-cost targeted therapies. However, evidence regarding the associations of reimbursement policies with real-world treatment escalation and long-term economic outcomes remains limited. Objectives To examine the association between implementation of a regional reimbursement policy and real-world treatment patterns and to evaluate the long-term cost-effectiveness of the observed post-policy treatment distribution compared with the pr …

27.08.2026journal-article

Frontiers in Medicine

Gut-derived memory T cells: key mediators of neuroinflammation via the gut-brain axis

Peiyi Liang, Songbai Xu, Xiying Fu, Qianchuang Sun, Yicun Wang

The gut–brain axis constitutes a bidirectional communication network that links the gut microbiota with the central nervous system (CNS) and plays a pivotal role in regulating neuroinflammation. Memory T cells, as central orchestrators of adaptive immunity, undergo differentiation, trafficking, and functional reprogramming within the gut microenvironment. This process establishes a novel framework for understanding the pathogenesis of neuroinflammatory disorders. In this review, we summarize the physiological cross …

27.08.2026journal-article

Frontiers in Medicine

POEMS syndrome presenting as presumed chronic glomerulonephritis with a 1-year delay in diagnosis: a case report

Li Liu, Mingpeng Li, Fugang Li

Background Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes (POEMS) syndrome is a rare paraneoplastic disorder driven by an underlying plasma cell dyscrasia. While renal involvement is common, it typically manifests after neurological or dermatological symptoms. Chronic glomerulonephritis-like manifestations as the sole initial feature for a prolonged period are exceptionally rare and can lead to delayed diagnosis. Case presentation A 38-year-old woman presented with a 1-year history o …

27.08.2026journal-article

Frontiers in Oncology

Case Report: Prostate metastasis from pulmonary sarcomatoid carcinoma: the first reported case and clinical implications of palliative radiotherapy

Xueping Liu, Nai Mu, Guobo Du, Min Hou, Lang He

Pulmonary sarcomatoid carcinoma (PSC) is a highly aggressive lung cancer subtype. Prostate metastasis is extremely rare in lung cancer, and no PSC case with immunohistochemical confirmation has been reported. We report a 68-year-old man diagnosed with left upper lobe carcinosarcoma (myogenic differentiation) on pathological biopsy. He underwent multimodal treatment, including radical resection, adjuvant chemotherapy, anlotinib targeted therapy, and local thoracic radiotherapy. Eight months later, he developed progr …

27.08.2026journal-article

Frontiers in Medicine

Prevalence and associated factors of medical device-related pressure injuries in long-term care facilities: a multicenter cross-sectional study

Suzhen Zhang, Xiuying Zhuo, Mingming Zhang, Jianbing He, Qiuni Cai

Objective To determine the prevalence of medical device-related pressure injuries (MDRPIs) and identify their associated factors among residents in long-term care facilities. Methods A multicenter cross-sectional study was conducted between February and April 2025 across 11 long-term care facilities in Xiamen, China. A total of 380 residents were enrolled. MDRPIs were identified through systematic head-to-toe skin inspection and staged according to the National Pressure Injury Advisory Panel classification. Potenti …

27.08.2026journal-article

Esophagus

Institutional enrollment volume and clinical outcomes after surgery or chemoradiotherapy for clinical stage I esophageal squamous cell carcinoma: a supplementary analysis of JCOG0502

Kazuhiro Shiraishi, Ken Kato, Yuya Ishikawa, Keita Sasaki, Hiroyuki Daiko, Yoshinori Ito, Takeshi Kajiwara, Takashi Kojima, Hiroshi Miyata, Masaki Ueno, Satoru Nakagawa, Shinsuke Sato, Shigeru Tsunoda, Tetsuya Abe, Yoshiaki Nagatani, Yoichi Hamai, Yasue Kimura, Kenro Hirata, Takahiro Tsushima, Hiroya Takeuchi

Abstract Background Surgery and chemoradiotherapy (CRT) are standard options for clinical stage I esophageal squamous cell carcinoma (ESCC). JCOG0502, a multicenter, non-randomized, parallel-group comparison, demonstrated the non-inferiority of definitive CRT compared with surgery for overall survival (OS) in patients with cT1bN0M0 ESCC; however, institutional differences may influence outcomes. This study explored inter-institutional heterogeneity in survival and adverse events (AEs) among patients in JCOG0502. Me …

27.08.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Serology Confirms Near-Absence of Malaria Transmission in Timor-Leste

Elfiana De Fatima Amaral, Isabel Byrne, Helena Brazal Monzo, Raul Sarmento, Maria Do Rosario De Fatima Mota, Gregorio Rangel, Maria Tanesi, Antonio Salles de Sousa, Nelson Martins, Tessa Oakley, Lucsendar Alves, Jennifer Yan, Paul Arkell, Joshua R. Francis, Chris Drakeley

ABSTRACT. Despite malaria remaining a major public health threat, several countries have made significant progress toward elimination. Timor-Leste has reduced the number of malaria cases from more than 200,000 to zero, with no indigenous cases reported since 2022, and has recently been certified as malaria-free by the WHO. At low transmission levels, serological surveys, which detect antibodies to malaria parasites, can augment conventional surveillance by revealing the absence of antibodies and, therefore, of expo …

27.08.2026journal-article

Clinical Pediatrics

Sleep Health in School-Aged Children: A Qualitative Study of Community-Based Pediatric Providers’ Perspectives and Practices

Jessica Page, Grace Wang, Gillian Heckler, Rebecca Robbins, Judith Owens

Despite its importance for general health, sleep health is inconsistently addressed in pediatric primary care, particularly in minority and low-income school-aged children. This study aimed to (1) explore providers’ knowledge, perspectives, and practices related to sleep health in this population and (2) identify opportunities for improving education in clinical settings. Semi-structured interviews were developed and conducted with 12 pediatric providers from 3 community health care centers. Major themes were class …

27.08.2026journal-article

World Journal of Hepatology

Second-line treatment of primary biliary cholangitis: To whom, which molecule, and when

Sylvia Drazilova, Peter Jarcuska, Tomas Koky, Martin Harhovsky, Slavomira Komarova, Jan Vasil, Martin Janicko

Ursodeoxycholic acid (UDCA) is the first-line treatment of primary biliary cholangitis (PBC). Approximately two-thirds of patients have a biochemical response to UDCA, but only one-third of treated patients achieve a complete biochemical response. UDCA nonresponse is associated with hepatic decompensation and higher liver-related mortality; therefore, UDCA nonresponders should be considered for second-line PBC treatment. Nonfibrate peroxisome proliferator-activated receptor (PPAR) agonists elafibranor and seladelpa …

27.08.2026journal-article

Hepatology Research

On‐Treatment Reassessment of Type IV Collagen 7S and M2BPGi‐Qt Improves Long‐Term Hepatocellular Carcinoma Risk Stratification in Chronic Hepatitis B

Kazumi Yamasaki, Hideko Kozuru, Tomoko Sato, Tomoyuki Suehiro, Yasuhide Motoyoshi, Yuki Kugiyama, Akira Saeki, Shinya Nagaoka, Atsumasa Komori, Hiroshi Yatsuhashi

ABSTRACT Aims Hepatocellular carcinoma (HCC) remains a major complication in patients with chronic hepatitis B receiving nucleos(t)ide analogue (NA) therapy despite effective viral suppression. Although on‐treatment assessment of indirect fibrosis indices has been associated with HCC risk, the prognostic value of direct fibrosis markers, particularly type IV collagen 7S (4COL7S), during antiviral therapy remains poorly defined. We investigated whether on‐treatment 4COL7S predicts HCC development, with M2BPGi‐Qt eva …

27.08.2026journal-article

Frontiers in Global Women's Health

Expanding treatment options for syphilis during pregnancy: a review of alternatives to penicillin

Claire L. Townsend, Lynne Mofenson, Sami Gottlieb, Remco P. H. Peters, Oriol Mitjà, Clara Pérez-Mañá, Elaine J. Abrams, Sinead Delany-Moretlwe, Shahin Lockman, Catriona Waitt, Kathryn Miele, Melanie M. Taylor, Françoise Renaud

Syphilis infection during pregnancy leads to around 390,000 adverse birth outcomes each year and is an important cause of preventable stillbirth. Although benzathine penicillin G is safe and effective during pregnancy for treating maternal and fetal infection, there are frequent global shortages and limited options for people with penicillin allergy. We conducted a review of potential alternatives to penicillin for treating syphilis during pregnancy when penicillin is not available or cannot be used, including ceft …

27.08.2026journal-article

World Journal of Otorhinolaryngology - Head and Neck Surgery

Vascular Control‐Focused Surgical Strategy for Pterygopalatine and Infratemporal Fossa Tumors Using Multimodal Image Fusion Reconstruction

Zi‐Cheng He, Nian‐Zhen Zheng, Yong‐Quan Wang, Jia‐Rui Jiang, Chun‐Wei Li, Jian Li

ABSTRACT Objective To classify tumor–internal maxillary artery (IMA) spatial relationships in pterygopalatine and infratemporal fossa (PPF/ITF) tumors, develop a 3D fusion–guided vascular control‐focused surgical strategy, and evaluate its clinical impact. Methods Seventeen patients were prospectively enrolled in the 3D fusion‐guided vascular control‐focused strategy (VCFS) group, while 41 patients were retrospectively enrolled in the conventional strategy group. Multimodal imaging data were used to generate patien …

27.08.2026journal-article

Frontiers in Endocrinology

Pre-treatment serum phosphate as a metabolic correlate of live birth after IVF/ICSI: a retrospective cohort study

Zhilong Wang, Xiaoyue Shen, Qingqing Shi, Yuan Yan, Chuanming Liu, Ruiwei Jiang, Feifei Lu, Lingjuan Wang, Jie Mei, Yue Jiang, Weihong Zhou, Na Kong

Background Oocyte developmental competence is influenced by the systemic metabolic milieu during folliculogenesis. Inorganic phosphate is essential for ATP synthesis, nucleic acid metabolism, and phosphorylation-dependent signalling, but its relationship with assisted reproductive technology outcomes remains unclear. We investigated whether pre-treatment fasting serum phosphate was associated with live birth after first IVF/ICSI fresh embryo transfer. Methods This retrospective cohort study included 2, 226 women ag …

27.08.2026journal-article

Small

A 3D‐Printed Microvascular Surgery Training Platform With High‐Fidelity, Biomimetic Properties

Lin Huang, Krish Narotam, Emma Berman, Alexander Park, Jiaao Guan, Jason Llaneras, Garrison Leach, Lieselot Carrette, Reid Abrams, David B. Berry, Shaochen Chen

ABSTRACT Current vascular grafts face limitations including inadequate mechanical strength, inability to replicate small and complex anatomical structures, ethical concerns with animal‐based training models, and high costs that limit accessibility. We developed a cytocompatible vascular graft fabrication platform combining dual‐network hydrogels with high‐resolution digital light processing (DLP) 3D printing to address these bottlenecks. Through systematic evaluation of hydrogel formulations, we identified a polyac …

27.08.2026journal-article

Healthcare

Knowledge, Attitudes, and Practices of Pulmonary Tuberculosis Patients Regarding Tuberculosis and Home-Based Treatment

Xuwen Fu, Jianjie Jiang, Yuanying Li, Jiajia Duan, Zhaojing Shi, Xiang Li

Objectives: To assess the knowledge, attitudes, and intended practices (KAP) of pulmonary tuberculosis (PTB) patients regarding the disease and home-based treatment. Methods: A cross-sectional study was conducted at the authors’ hospital from 1 September 2024 to 28 February 2025, using a self-designed KAP questionnaire. Differences in KAP scores across demographic subgroups were analyzed, and the associations among knowledge, attitude, and practice were examined. Results: A total of 509 valid responses were include …

27.08.2026journal-article

World Journal of Otorhinolaryngology - Head and Neck Surgery

Current Advances in Spatial Pathology of Nasal Polyps: Challenges, Opportunities for Artificial Intelligence, and Future Directions

Zi‐Xuan Hua, Xin Luo, Ning Kang, Ze‐Zhi Guo, Man‐Hou Chao, Hua‐Mei Yan, Wan‐Xin Zhang, Tong Wu, Zi‐Qi Zhang, Xue‐Kun Huang, Ya‐Na Zhang, Zhao‐Hui Shi, Qin‐Tai Yang

ABSTRACT Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by inflammatory heterogeneity, epithelial hyperplasia, and tissue remodeling, with spatial pathology critical for deciphering pathological mechanisms and guiding clinical practice. Conventional histopathological techniques rely on subjective visual evaluation, limited by inadequate spatial resolution of molecular markers and imprecise quantitative analysis. Recent advances show that spatial transcriptomics reveals nasal polyps (NP) inflamma …