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22 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Frontiers in Endocrinology

Pre-treatment serum phosphate as a metabolic correlate of live birth after IVF/ICSI: a retrospective cohort study

Zhilong Wang, Xiaoyue Shen, Qingqing Shi, Yuan Yan, Chuanming Liu, Ruiwei Jiang, Feifei Lu, Lingjuan Wang, Jie Mei, Yue Jiang, Weihong Zhou, Na Kong

Background Oocyte developmental competence is influenced by the systemic metabolic milieu during folliculogenesis. Inorganic phosphate is essential for ATP synthesis, nucleic acid metabolism, and phosphorylation-dependent signalling, but its relationship with assisted reproductive technology outcomes remains unclear. We investigated whether pre-treatment fasting serum phosphate was associated with live birth after first IVF/ICSI fresh embryo transfer. Methods This retrospective cohort study included 2, 226 women ag …

27.08.2026journal-article

Small

A 3D‐Printed Microvascular Surgery Training Platform With High‐Fidelity, Biomimetic Properties

Lin Huang, Krish Narotam, Emma Berman, Alexander Park, Jiaao Guan, Jason Llaneras, Garrison Leach, Lieselot Carrette, Reid Abrams, David B. Berry, Shaochen Chen

ABSTRACT Current vascular grafts face limitations including inadequate mechanical strength, inability to replicate small and complex anatomical structures, ethical concerns with animal‐based training models, and high costs that limit accessibility. We developed a cytocompatible vascular graft fabrication platform combining dual‐network hydrogels with high‐resolution digital light processing (DLP) 3D printing to address these bottlenecks. Through systematic evaluation of hydrogel formulations, we identified a polyac …

27.08.2026journal-article

Healthcare

Knowledge, Attitudes, and Practices of Pulmonary Tuberculosis Patients Regarding Tuberculosis and Home-Based Treatment

Xuwen Fu, Jianjie Jiang, Yuanying Li, Jiajia Duan, Zhaojing Shi, Xiang Li

Objectives: To assess the knowledge, attitudes, and intended practices (KAP) of pulmonary tuberculosis (PTB) patients regarding the disease and home-based treatment. Methods: A cross-sectional study was conducted at the authors’ hospital from 1 September 2024 to 28 February 2025, using a self-designed KAP questionnaire. Differences in KAP scores across demographic subgroups were analyzed, and the associations among knowledge, attitude, and practice were examined. Results: A total of 509 valid responses were include …

27.08.2026journal-article

World Journal of Otorhinolaryngology - Head and Neck Surgery

Current Advances in Spatial Pathology of Nasal Polyps: Challenges, Opportunities for Artificial Intelligence, and Future Directions

Zi‐Xuan Hua, Xin Luo, Ning Kang, Ze‐Zhi Guo, Man‐Hou Chao, Hua‐Mei Yan, Wan‐Xin Zhang, Tong Wu, Zi‐Qi Zhang, Xue‐Kun Huang, Ya‐Na Zhang, Zhao‐Hui Shi, Qin‐Tai Yang

ABSTRACT Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by inflammatory heterogeneity, epithelial hyperplasia, and tissue remodeling, with spatial pathology critical for deciphering pathological mechanisms and guiding clinical practice. Conventional histopathological techniques rely on subjective visual evaluation, limited by inadequate spatial resolution of molecular markers and imprecise quantitative analysis. Recent advances show that spatial transcriptomics reveals nasal polyps (NP) inflamma …

27.08.2026journal-article

Reproductive Medicine

Role of Uterine Fluid-Derived Molecules in Embryo Implantation

Chen Zhou, Xiaoqing Zhu, Lijun Guan, Zhiqian Xu, Xiangbin You, Xiaoxia Li, Youbing Yang

Embryo implantation is a highly selective and hormonally regulated event, critically dependent on endometrial receptivity and the molecular microenvironment of uterine fluid (UF). UF is actively secreted by endometrial glands and epithelial cells and comprises proteins, metabolites, hormones, and extracellular vesicles (EVs) carrying miRNAs, lncRNAs, and regulatory proteins. These components coordinate embryo development, trophoblast invasion, angiogenesis, and maternal–fetal immune tolerance. Dysregulation of UF c …

27.08.2026journal-article

QJM: An International Journal of Medicine

Lytic bone lesions in a patient diagnosed with breast cancer – Sarcoidosis

Ami Schattner, Ina Dubin, Yair Glick, Vladimir Kravtsov

Abstract Sarcoidosis is an inflammatory disease of unknown cause with protean manifestations and presentations which may affect almost any organ. Involvement of intra-thoracic organs (lungs, lymph nodes), reticuloendothelial system, skin, and eyes is predominant. The histological hallmark is non-necrotizing (noncaseating) granulomas. Bone involvement in sarcoidosis is noteworthy. We report a woman who developed crescendo back pain, with multiple lytic bone lesions. Since she had been recently diagnosed with locally …

27.08.2026journal-article

JAMA Otolaryngology–Head & Neck Surgery

Imaging-Detected Extranodal Extension in p16-Positive Oropharyngeal Cancer

Christopher W. Fleming, Chandana A. Reddy, Sarah Stock, Jonathan Lee, Maura Gillison, Jimmy J. Caudell, Jessica L. Geiger, Dukagjin M. Blakaj, Greg A. Krempl, A. Dimitrios Colevas, Christopher U. Jones, Nabil F. Saba, Jack Phan, Thomas J. Galloway, Samantha Seaward, Sharon Spencer, Pedro Torres-Saavedra, Sue S. Yom, Quynh-Thu Le, Shlomo A. Koyfman

Importance Imaging-detected extranodal extension (iENE) has been included in the American Joint Committee on Cancer (AJCC) and Union for International Cancer Control (UICC) protocol tumor-node-metastasis 9th edition staging system (TNM9) for human papillomavirus (HPV)-mediated (p16-positive) oropharyngeal cancer (HPV-positive OPC). Objective To confirm the new TNM9 staging system on a prospective dataset. Design, Setting, and Participants This prognostic study included patients with HPV-positive OPC with clinically …

27.08.2026journal-article

Clinical Case Reports

Biliary Atresia With Situs Inversus Abdominalis Managed by Kasai Portoenterostomy: A Case Report From Muhimbili National Hospital, Tanzania

Rajabu Athumani Bakari, Alfred Chibwae, Brian Kimanthi, Tariq Aziz, Georvin Marco Haule, Novath Ngowi, Ally Hamisi Mwanga, Zaitun M. Bokhary

ABSTRACT Biliary atresia associated with situs inversus abdominalis is a rare congenital combination that complicates diagnosis and surgical orientation. Early recognition, meticulous preoperative planning, and timely Kasai portoenterostomy can achieve favorable short‐term outcomes. Surgeons should consider anatomical variations to optimize operative safety and improve biliary drainage and prognosis.

27.08.2026journal-article

Annals of Nuclear Medicine

[18F]FDG PET/CT role in FUO among patients with end-stage renal disease on renal replacement therapy

Domenico Albano, Chong Jiang, Francesco Bertagna

Abstract Objective End-stage renal disease (ESRD) patients undergoing renal replacement therapy (RRT) are at increased risk of infections, inflammatory disorders, and malignancies because of immune dysfunction, repeated vascular access procedures, and immunosuppressive therapy after kidney transplantation. Fever of unknown origin (FUO) is particularly challenging to investigate in this population, and evidence regarding the role of [18 F]FDG PET/CT remains limited. This study evaluated the diagnostic performance, c …

27.08.2026journal-article

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

Comparison of Clinical Outcomes of Single and Double Soft Anchor Fixation in Arthroscopic Treatment of Anterior Bankart Lesions

Fatih İlker Can, Emre Gültaç, Burak Şener, Rodi Ertoğrul

The aim of this study was to compare the clinical, functional, and stability outcomes of arthroscopic Bankart repair performed using either a single or double soft anchor in patients with limited anterior Bankart lesions between the 1 and 5 o’clock positions. Our retrospective cohort included patients underwent arthroscopic Bankart repair for anterior shoulder instability between January 2018 and December 2023. Glenoid defects or other associated shoulder pathologies were excluded, and all patients had a minimum tw …

27.08.2026journal-article

International Journal of Reproduction, Contraception, Obstetrics and Gynecology

Polycystic ovarian syndrome: an updated review of pathophysiology, clinical features, biomarkers, and management

Blessy S. Joseph, Dineshkumar B., K. Krishna Kumar

Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine and metabolic disorders affecting women of reproductive age and represents a major global public health challenge. PCOS is a heterogeneous condition characterized by reproductive dysfunction, hyperandrogenism, insulin resistance (IR), and metabolic abnormalities, frequently accompanied by psychological distress that significantly reduces quality of life. Despite its high prevalence, diagnosis, treatment, and long-term management remain challeng …

27.08.2026journal-article

Frontiers in Medicine

Robot-assisted closed reduction and navigated fixation for pelvic ring injuries: a focused narrative review of a reduction-fixation-audit framework

En Wu, Feng Gu, Wenkai Zhang, Xiaoyu Li, Ye Liang, Zhanxiao Liu, Shen Liu, Yonghui Liang

Pelvic ring injuries combine three-dimensional deformity with narrow osseous corridors and proximity to neurovascular structures. Minimally invasive fixation can reduce exposure-related morbidity, but its success remains constrained by the quality of reduction achieved before fixation. This focused narrative review examined CT-based phenotyping and planning, mirror-template reconstruction, robot-assisted fracture reduction (RAFR), navigated percutaneous fixation, and postoperative audit. English- and Chinese-langua …

27.08.2026journal-article

Lifestyle Medicine

Chronic Liver Disease Self‐Management for Veterans: A Feasibility Trial

Carol Gonzalez, Ann Deioma, Heather M. Patton, Erik J. Groessl

ABSTRACT Background Rates of chronic liver disease (CLD) related to obesity and other cardiometabolic risk factors have increased dramatically and contribute to significant health burden and mortality. Lifestyle modification is commonly recommended, with a focus on nutrition, exercise, medication adherence, screening for CLD complications, and active participation in health care. Self‐management interventions can facilitate lifestyle modification in patients with chronic diseases, including CLD. This study tested t …

27.08.2026journal-article

Lifestyle Medicine

Systematic Review and Descriptive Synthesis of Behaviour Change Techniques in Physical Activity Interventions During and Beyond Breast Cancer

Alejandro Dominguez Garcia, Barbara A. Mullan, Kylie Hill, Lauren J. Breen, Chloe Maxwell‐Smith

ABSTRACT Purpose Many interventions aim to support women with and after a breast cancer diagnosis to increase physical activity; however, the behaviour change components supporting long‐term effectiveness remain unclear. This review examined the behaviour change techniques used in physical activity interventions in breast cancer populations that reported long‐term behavioural outcomes (≥12 weeks post‐intervention). Methods Six databases (CINAHL Ultimate, Medline, ProQuest, PsycINFO, Scopus, Web of Science) were sea …

27.08.2026journal-article

Frontiers in Medicine

Interpretable and explainable predictive machine learning models for gastric retention before gastroscopy

Yun Dai, Huan-Zhong Su, Hong-Bin Zhang, Jin-Hai Chen, Guo-Xing Xu, Hai-Xing Wang

Background Early detection of gastric retention (GR) is challenging in clinical practice. We aimed to develop and validate interpretable machine learning (ML) models for predicting GR risk using routinely available clinical features. Methods This retrospective study enrolled 3,233 consecutive patients (training cohort: n = 2,263; validation cohort: n = 970) who underwent gastroscopy between January 2022 and December 2024. To address class imbalance, the Synthetic Minority Over-sampling Technique (SMOTE) was applied …

27.08.2026journal-article

Frontiers in Medicine

Upper border of anal transitional zone: a new landmark for endoscopic internal hemorrhoid therapy

Jingyao Li, Huiyan Li, Hao Xu, Jing Dong, Tiantian Guo, Hongjiao Yao, Qi Yang

Background and aim Endoscopic therapies are important approaches for managing internal hemorrhoids. This study assessed the feasibility of endoscopic examination of the upper border of anal transitional zone (ATZ) and its clinical utility and underlying anatomical basis as a landmark for internal hemorrhoid. Methods Mucosal demarcation line (MDL) and the dentate line were identified and measured in 207 adults using white-light and narrow band imaging (NBI) endoscopy, with three biopsies for histologic confirmation. …

27.08.2026journal-article

Journal of Palliative Medicine

Cost Implication of a Community-Based Pediatric Palliative Care Program

Ying (Elaine) Wang, Wenyun Yang, Megan Young, Kerri Padgett, Elaine Gabovitch, Ning Zhang, Jianying Zhang, Scot T. Bateman

Background: Massachusetts’ Pediatric Palliative Care Network (PPCN) program provides community-based pediatric palliative care (CBPPC) to children with life-limiting conditions and their families. PPCN offers comprehensive clinical services, integrative therapies, and case management. Objectives: This study explores whether PPCN can maintain or reduce health care utilization and costs. Design: PPCN children were compared with a propensity score matched group. Bivariate and regression analyses were conducted to comp …

27.08.2026journal-article

Military Medicine

Artificial Intelligence Answering Patient Questions About Developmental Dysplasia of the Hip: Accuracy, Readability, and Clinical Utility

Michael G Johnston, William Ferris, Harrison Diaz, Andrew Rosso, Mark S Katsma

Abstract Introduction Artificial intelligence (AI) tools are increasingly used by patients and caregivers seeking medical information. Developmental dysplasia of the hip (DDH) is a common pediatric condition that frequently prompts parental questions regarding screening, diagnosis, and treatment. The purpose of this study was to evaluate the accuracy, completeness, and clarity of responses generated by a Department of Defense–approved AI chatbot (NIPR-GPT) when answering commonly asked DDH-related questions. Method …

27.08.2026journal-article

PLOS One

CLIN-LLM: A safety-constrained hybrid framework for clinical diagnosis and treatment generation

Md. Mehedi Hasan, Md. Abir Hossain, Farman Hossain Sayem, Bikash Kumar Paul, Ziaur Rahman, Mohammad Shorif Uddin, Rafid Mostafiz

Accurate symptom-to-disease classification and clinically-grounded treatment recommendations remain challenging, particularly in heterogeneous patient settings with high diagnostic risk. Existing large language model (LLM)-based systems often lack medical grounding and fail to quantify uncertainty, resulting in unsafe outputs. We propose CLIN-LLM, a safety-constrained hybrid pipeline that integrates multimodal patient encoding, uncertainty-calibrated disease classification, and retrieval-augmented treatment generat …

27.08.2026journal-article

Frontiers in Medicine

Intranodal palisaded myofibroblastoma of the supraclavicular region in an adolescent with an HDAC2 variant: a case report

Yiyang Yu, Yiming Zhao, Lili Cao

Intranodal palisaded myofibroblastoma (IPM) is a rare benign mesenchymal tumor of lymph nodes that most often arises in the inguinal region. We report an 18-year-old woman with an incidentally detected left supraclavicular mass. Imaging showed a well-circumscribed hypervascular lesion, and core biopsy demonstrated a spindle-cell neoplasm for which low-grade malignancy could not be excluded. Complete excision revealed an intranodal spindle-cell proliferation with nuclear palisading, hemorrhage, compressed peripheral …

27.08.2026journal-article

Journal of Internal Medicine

Hypocholesterolemia in liver and cardiovascular disease: Friend or foe?

Valentina Flagiello, Emelie Barreby, Umberto Vespasiani‐Gentilucci, Stefano Romeo

Abstract Hypocholesterolemia is perceived as benign given its association with lower cardiovascular risk. However, genetic and epidemiological evidence indicates that persistently low levels of low‐density lipoprotein cholesterol (LDL‐C) and apolipoprotein B (ApoB) arise from distinct biological mechanisms with different hepatic implications. Hypocholesterolemia may reflect either impaired hepatic assembly and secretion of ApoB‐containing lipoproteins or enhanced peripheral clearance of circulating lipoproteins, wi …

27.08.2026journal-article

Clinical Cancer Research

A Phase 1 First-Time-in-Human, Open-Label Study of Nelistotug Administered to Patients with Advanced Solid Tumors

Lillian L. Siu, Omid Hamid, Reva Schneider, Jordi Rodon. Ahnert, Scott A. Laurie, Frank Stephen. Hodi, Dong-Wan Kim, Myung-Ju Ahn, Gary Carlson, Hussein Assi, Hamza Khan, Patrick Hanafin, Emily Moore, Madhu Ramaswamy, Reza Mozaffari, Stefan Zajic, Arindam Dhar, Ivan Diaz Padilla, Noboru Yamamoto

Abstract Purpose: This first-in-human, nonrandomized, multicenter study investigated nelistotug (anti-CD96 monoclonal antibody [mAb]) as monotherapy (Arm A) and in combination with dostarlimab (anti-PD-1 mAb) (Arm B), and dostarlimab plus belrestotug (anti-TIGIT mAb) (Arm F) in patients with recurrent or advanced solid tumors. Patients and Methods: Patients received intravenous doses every 3 weeks of nelistotug 2.1–1400 mg, nelistotug 70–1400 mg plus dostarlimab 500 mg, or nelistotug 1400 mg plus dostarlimab 500 mg …