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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

Reports

Rubber Band Ligation for Treatment of Mucoceles: A Potential Minimally Invasive Treatment Approach

Satoru Kusaka, Tatsuya Akitomo, Masashi Ogawa, Yuto Shoji, Jimei Zhao, Ryota Nomura

Mucoceles are benign lesions caused by the accumulation of mucus such as saliva, and are common in children. Surgical intervention is effective but is not well tolerated by children because of its invasiveness, and alternative treatment methods are being explored. A boy aged 2 years and 5 months presented at our hospital with a chief complaint of mucocele. Considering the patient’s age, micro-marsupialization was initially selected to avoid surgical excision; however, the cyst did not resolve. We decided to apply t …

25.08.2026journal-article

Internal Medicine Journal

Improving timeliness of lung cancer care through a rapid assessment clinic

Shakti V. Dabholkar, Shalini Vinod, Zinta Harrington, Benjamin Kolevski, Beth Ivimey, Joseph Descallar, Jonathan P. Williamson

Abstract Background Early diagnosis and treatment of lung cancer improve survival. Guidelines from Australia and worldwide stipulate timeframes of care from referral. The Rapid Lung Assessment Clinic (RLAC) was established to fast‐track the diagnostic and treatment pathway, with a subsequent quality improvement initiative based on the initial analysis of timeliness of care. Aim This study evaluated the performance of RLAC before and after the quality improvement initiative and identified patient and system factors, …

25.08.2026journal-article

Journal of Food Science, Nutrition and Health

Engineering Escherichia coli for targeted biosynthesis of neohesperidin as an adjuvant therapeutic strategy for colorectal cancer

Annabella Dai

Colorectal cancer (CRC) is the third most prevalent cancer and the second most deadly cancer in the world, and current treatments have significant side effects and drug resistance. Citrus plants contain flavonoids glycosides, such as neohesperidin, which has antioxidant, anti-inflammatory, immunomodulatory and antitumor properties, making it a promising CRC adjuvant. However, conventional extraction is limited by low natural abundance, poor consistency and low bioavailability. In this study, E. coli BL21(DE3) were …

25.08.2026journal-article

Diseases

Molecular Pathogenesis, Tumor Microenvironment and Health Disparities in Select Pediatric Solid Tumors: An Integrative Narrative Review

MiaSara Pérez-Salvá, Carolyn M. Ruiz-Pérez, Alondra Veloz-Bonilla, Rocío K. Rivera-Valentín

Background/Objectives: Pediatric solid tumors (PST) are a biologically distinct group of malignancies whose developmental origins and molecular drivers differ substantially from those of adult cancers, with direct implications for therapeutic strategy and clinical outcome. This review synthesizes current evidence on molecular pathogenesis, tumor microenvironment biology, and the structural conditions that shape access to care across select PST. Methods: A narrative review of peer-reviewed literature was conducted p …

25.08.2026journal-article

Current Oncology

Charting the Future of Canadian Adult Acute Myeloid Leukemia (AML) Laboratory Testing: A Canadian Leukemia Study Group Current State Mapping of Diagnostic AML Laboratory Practice

Tina Yu Xuan Luo, Sila Usta, Eric McGinnis, Cheryl A. Mather, Julie Bergeron, Tanya Gillan, Etienne Mahe, José-Mario Capo-Chichi, Philip Berardi, Paul C. Park, Doha Itani, Ashish Rajput, Benjamin Chin-Yee, Fei-Yu Han, Darci T. Butcher, Jennifer Fesser, John DeCoteau, Graeme Quest, Elizabeth McCready, Hubert Tsui

Clinical decision making in Acute Myeloid Leukemia (AML) critically relies on rapid genomic characterization. To better understand the AML diagnostic landscape in Canada, the Canadian Leukemia Study Group (CLSG) conducted a survey of laboratory hematology leadership (n = 18) at 16 laboratories across 10 provinces, administered using Google Forms in September 2024. Nearly all surveyed sites were equipped to deliver a full suite of testing platforms through existing on-site infrastructure or laboratory partnerships. …

25.08.2026journal-article

Clinical Cancer Research

Microsatellite Instability Identifies a Rare but Clinically Relevant Subset of Sarcomas: Insights from the Largest Clinically Sequenced Cohort with Therapeutic Implications

Carla Saoud, Chad Vanderbilt, Jamal Benhamida, Carol D. Morris, Sandra P. D’Angelo, Diana Mandelker, William D. Tap, Zsofia K. Stadler, Marc Ladanyi, Aimee Crago, Jinru Shia, Meera R. Hameed

Abstract Purpose: Microsatellite instability (MSI) has broad biologic and clinical relevance across solid tumors, yet its role in sarcomas remains poorly defined. We delineate the clinicopathologic, molecular, and treatment response landscape of MSI in sarcomas using the largest clinically sequenced cohort to date. Experimental Design: MSI status was assessed in 6,449 bone and soft-tissue tumors, including 5,992 sarcomas from 5,162 patients, using targeted next-generation sequencing and validated bioinformatic pipe …

25.08.2026journal-article

Chest & Heart Journal

Multifocal Giant Cell Tumor of the Ribs Presenting with Chest Pain and Fever: A Rare Case

Towhida Akter Chowdhury, Mohammad Abdullah Al Hasan, Md Zahiduzzaman, Abrar Fayaz Labib, Mirza Md Saief, Muhammad Shakhawath Hossain, Mahmud Rahim, Mohammed Mirazur Rahman

Giant cell tumor of bone (GCTB) is an uncommon, ,usually benign tumor ,which can be locally aggressive. It mostly affects long bone, rib involvement is rare & having multiple rib lesions is very unusual. We report the case of a 47 years old man who presented with chest pain & fever. Initial chest imaging showed opacities along both side of the chest wall. Further tests revealed multifocal GCTB affecting several ribs. Chest Heart J. 2024; 48(2) : 120-123

25.08.2026journal-article

Neuro-Oncology Advances

A novel approach to reverse Warburg metabolism in patients with recurrent glioblastoma: A phase II pharmacodynamic study of dichloroacetate

Carolyn O Dirain, Stuart A Grossman, Xiaobu Ye, Priya Sambasivan, Puranjay Shori, Himashi Liyanarachchi, Thomas D Franklin, Joy Fisher, Trisha Surakus, Michaella Iacoboni, Matthias Holdhoff, Karisa C Schreck, Stephen B Tatter, Richard E Wagner, Roy Strowd, Chetan Bettegowda, Peter W Stacpoole

Abstract Background Glioblastomas are characterized by the Warburg effect, driven by upregulation of pyruvate dehydrogenase kinase (PDK), which inhibits pyruvate dehydrogenase complex (PDC), leading to lactate accumulation. Dichloroacetate (DCA) is a potent and safe PDK inhibitor that crosses the blood-brain barrier, reverses Warburg metabolism, and reduces lactate levels. Methods This trial (RO1FD007271) evaluated the pharmacodynamics and pharmacokinetics of oral DCA in recurrent glioblastoma patients requiring su …

25.08.2026journal-article

Medicinal Research Reviews

Developing the Dopamine D3 Receptor (D3R) Antagonist, ( R )‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman

ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions involved in reward, drug dependence, and impulse control, it has become an attractive target for treating OUD and related substance use disorders. This review first …

25.08.2026journal-article

BMC Palliative Care

Multi-level determinants of comprehensive palliative care delivery for breast and cervical cancer patients in Ethiopia: using the socio-ecological model as an analytical framework

Kalkidan Solomon Deribe, Sarona Shewaye, Nahom Solomon Habtamu, Abigiya Wondimagegnehu, Yoseph Mamo Azmera, Adamu Addissie, Eva J. Kantelhardt, Mirgissa Kaba

Abstract Introduction Comprehensive palliative care is essential for improving the quality of life of women with breast and cervical cancer in Ethiopia, yet services remain poorly organized, largely inaccessible, and concentrated in the capital. While existing studies have quantified service gaps, the multi-level determinants enabling or hindering comprehensive care remain under-explored, particularly how these factors differ between urban and rural settings. Objective To explore the multi-level determinants of imp …

25.08.2026journal-article

Phlebology: The Journal of Venous Disease

Predictors of treatment failure in elderly patients with advanced chronic venous insufficiency

Sahar Ali, Ahmed M. Rashed, Kareem Ayman Shaamash, Ahmed Nageeb, Mohammed Shahat, Hesham Aboloyoun

Objective This study evaluated factors associated with treatment failure in elderly patients with advanced chronic venous insufficiency, focusing on mobility limitation, baseline compression feasibility, CEAP C6 disease, venous anatomy/mechanism, and functional/dependent venous insufficiency. Methods This retrospective cohort study included patients aged ≥65 years with CEAP C3–C6 chronic venous disease managed at a tertiary university hospital between 2022 and 2025. Clinical, functional, social, and duplex ultrasou …

25.08.2026journal-article

International Journal of Molecular Sciences

Exploring the Role of HSD17B2 in Colorectal Cancer Through Bioinformatic Analysis: Preliminary Insights for Prognostic Evaluation

Ana Belen Diaz-Ruano, Eliana Gomez-Jimenez, Alba Hidalgo-Ramirez, Giselle Xavier-Reis, Nieves Casillas-Ruiz, Noelia Garcia-Mascaraque, Alfonso Rubio-Navarro, Maria Paz Zafra, Juan Antonio Marchal, Manuel Picon-Ruiz

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related mortality worldwide. Although screening has reduced CRC in older adults, cases in younger individuals are rising, highlighting the need for early biomarkers. Emerging research highlights the role of estrogen metabolism in CRC progression, with enzymes such as hydroxysteroid (17-beta) dehydrogenase (HSD17B) being increasingly implicated. In this study, we performed a bioinformatics analysis using public …

25.08.2026journal-article

International Migration

Rank, Degrading Treatment, and the Italy‐Albania Agreement

Jamal Barnes, Obed Adonteng‐Kissi

ABSTRACT In November 2023, Italy signed a five‐year agreement with Albania to transfer asylum seekers intercepted in international waters by Italian vessels to Italian‐run detention centres in Albania for asylum processing and deportation. The agreement has been controversial and raises several human rights issues. This article examines these human rights concerns and argues that the agreement is degrading by design. Analysing policy documents, legal cases, speeches, international human rights and refugee law, and …

25.08.2026journal-article

Journal of Breath Research

Diagnosing melioidosis and tracking treatment outcomes using breath

Antao Gao, Mark Mayo, Celeste Woerle, Bart J Currie, Hill E Jane

Abstract Melioidosis is a life-threatening infectious disease caused by Burkholderia pseudomallei ( Bp ). Rapid diagnosis and appropriate antimicrobial treatment are critical to reduce mortality, yet diagnosis is hindered by diverse clinical manifestations, mimicry with other diseases, and reliance on slow culture-based methods. Detecting volatile compounds offers a non-invasive approach for rapid infection detection. In this study, we aim to identify volatile compounds in patients’ breath that can aid in diagnosin …

25.08.2026journal-article

International Journal of Molecular Sciences

DNAM-1-Stimulated NK-92 Cells Exert Preferential Cytotoxic and Apoptosis-Associated Effects on Hormone-Independent Solid Tumor Cell Lines

Mohammadreza Dastouri, Fatima Elmusa

Anti-CD226 antibody-mediated stimulation of NK-92 cells (sNK-92) represents a potential immunotherapeutic approach; however, its cytotoxic and apoptosis-associated effects in hormone-independent solid tumors remain insufficiently characterized. This study investigated the activity of sNK-92 cells against PC3 castration-resistant prostate cancer and SH-SY5Y neuroblastoma cell lines, using PNT1A normal prostate epithelial and BJ normal dermal fibroblast cells as non-malignant controls. Cytotoxicity was assessed by CC …

25.08.2026journal-article

Journal of Cancer Education

Embedding Community Engagement in Underrepresented Student Cancer Research Training Programs: A Preliminary Report

Dennis R. Trinidad, Dahlia I. Sandoval, Kirti Ghei, Tanya E. Penn, Mercedes A. Mendoza, Jill Dumbauld Nery, Valesca Largaespada, Jesse N. Nodora, Noe C. Crespo, Ricardo M. Zayas, Richard M. Cripps, James Murphy, Hala Madanat, Maria Elena Martinez, Corinne McDaniels-Davidson

Abstract Training programs designed to increase participation of underrepresented students in cancer-related careers rarely include structured community engagement components. We describe the design and pilot of the Field Experience in Cancer Outreach and Engagement (FECOE), a program developed as part of the CREATE Partnership (Cancer Research and Education to Advance HealTh Excellence), a National Cancer Institute-funded grant to San Diego State University (SDSU) and University of California San Diego (UCSD). Sch …

25.08.2026journal-article

International Journal of Molecular Sciences

Thiazole-Substituted Benzoylpiperazines with Anti-Cancer and Anti-Inflammatory Activities: Comparative Evaluation with Lercanidipine

Sevde Nur Biltekin Kaleli

Lercanidipine has previously been investigated in our laboratory as a reference compound in cancer-related combination studies, providing a comparative framework for the present evaluation of thiazole-substituted benzoylpiperazines. In the present study, we evaluated the cytotoxic, anti-inflammatory, and p38α MAPK-related activities of thiazole-substituted benzoylpiperazine derivatives. The cytotoxic profiles of the derivatives were evaluated in multiple human cancer cell lines using the MTT assay. Compound 29 show …

25.08.2026journal-article

Biomedicines

Feasibility of Conventional Abdominal Ultrasound for Monitoring Tumor Size After Stereotactic Body Radiotherapy for Hepatocellular Carcinoma

Masayuki Ueno, Yohei Yamanouchi, Hideki Hanazawa, Hiroyuki Takabatake, Takahisa Kayahara, Youichi Morimoto, Satoshi Itasaka, Hirokazu Mouri, Motowo Mizuno

Background/Objectives: Stereotactic body radiotherapy (SBRT) is increasingly used for hepatocellular carcinoma (HCC) that is unsuitable for surgery, radiofrequency ablation (RFA), or transplantation. Although current evidence for imaging assessment after SBRT is largely based on contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI), repeated contrast-enhanced imaging may be difficult to perform at every routine follow-up visit. Thus, we evaluated whether conventional abdominal ultrasound (U …

25.08.2026journal-article

Cancer Science

Psychological Stress Promotes Tumor Growth in Hepatocellular Carcinoma Models Through Myeloid Signaling

Keita Ogawa, Takahiro Aoki, Tatsuya Kaneko, Hongxuan Wang, Daiki Shimizu, Daisuke Katsumi, Iori Kojima, Hidekazu Tanaka, Kiwamu Motoyoshi, Ko Ozaki, Katsuhiro Nishimura, Tomohisa Iinuma, Mariko Takami, Shinichiro Motohashi

ABSTRACT Psychological stress has long been implicated in cancer progression, yet the underlying biological pathways remain incompletely understood. In particular, the influence of stress on myeloid cells remains poorly explored. Here, we demonstrate that restraint stress accelerates hepatocellular carcinoma (HCC) progression through coordinated regulation of macrophages and neutrophils. Across sexes and strains, stressed mice exhibited enhanced tumor growth accompanied by marked neutrophil infiltration and elevate …

25.08.2026journal-article

Cancer Research

Targeting p300 Reverses Acidic Microenvironment–Induced PARP Inhibitor Resistance

Kaixin Cheng, Hao Nie, Wei Zhou, Dajiang Guo, Liping Liao, Xu Zhang, Chen Wang, Rafal J. Zielinski, Janardan N. Gavade, Shruthi Sriramkumar, Yiming Fang, Siyu Xia, Shuai Wu, Hsin-Yao Tang, Andrew V. Kossenkov, Yuan Qi, Jinsong Liu, Kang Le, Dorothea Gruber, Michael J. Soth, Miriam D. Post, Anil K. Sood, Stefanie Flückiger-Mangual, Timothy A. Yap, Benjamin G. Bitler, Rugang Zhang

Abstract Poly (ADP-ribose) polymerase inhibitors (PARPi) are a first-line treatment for patients with epithelial ovarian cancer (EOC), but the development of resistance limits long-term therapeutic efficacy. Tumor acidosis is a hallmark of the tumor microenvironment (TME) that has been shown to promote resistance to cancer therapies, suggesting that it may affect PARPi responses. In this study, we demonstrated that the acidic TME drives a p300-dependent mechanism of PARPi resistance in EOC. Pathologically acidic pH …

25.08.2026journal-article

Journal of Military Science and Technology

Research on the microstructure transformation and mechanical properties of lead alloy layer covering copper electrodes of high-capacity lead-acid batteries upon heat treatment

Doan Minh Cuong, Assoc.Prof.Dr Huong Nguyen Thi, Dinh Van Long, Vu Quang Hung, Nguyen Tien Manh, Vu Minh Thanh

The lead alloy layer on the copper electrodes of high-capacity lead-acid batteries is manufactured by gravity casting. In the cast state, the lead alloy layer exhibits a dendritic, unbalanced crystal structure, a high hardness of 27.9 HV, high residual internal stress, and a high resistance of 0.312 ÷ 0.420 mΩ, making it prone to microcracks and unfavourable for the battery. Through heat treatment, including quenching at 220 °C for 60 minutes followed by aging at 110 °C for 7 hours, the cast microstructure transfor …

25.08.2026journal-article

Mine Water and the Environment

Passive Metalliferous Mine Water Treatment with Recycled Concrete Aggregate

Adrian Brown P.E.

Abstract Metal-impacted water is generated by most metal mine facilities, usually in perpetuity. Responsible and legal mining requires that this water, when discharged, must meet water quality standards that protect human health and the environment. However, active treatment at most mine sites is difficult and expensive to maintain, particularly after the cessation of operations. The project described in this paper has demonstrated a successful method of long-term passive treatment of metalliferous mine water using …

25.08.2026journal-article

Surgery Today

Long-term prognosis and postoperative liver atrophy after gastrectomy in patients with gastric cancer and liver cirrhosis

Atsushi Yasuda, Masuhiro Terada, Naoko Konami, Atsushi Yamada, Masashi Koda, Tomohiro Nakanishi, Yoko Hiraki, Hiroaki Kato, Osamu Shiraishi, Masayuki Shinkai, Motohiro Imano, Yutaka Kimura, Takushi Yasuda

Abstract Purpose Gastrectomy in patients with liver cirrhosis is associated with an increased postoperative risk and poor prognosis; however, the long-term outcomes remain unclear. This study evaluated the survival of patients with cirrhosis after gastrectomy, focusing on postoperative nutritional deterioration and time-dependent survival effects. Methods This retrospective study included 847 patients who underwent gastrectomy for gastric cancer. Patients were categorized into liver cirrhosis (LC) and non-LC groups …

25.08.2026journal-article

Frontiers in Oncology

Radiofrequency ablation for early breast cancer: from local technique to system-based surgical therapy

Shinichiro Kashiwagi

Radiofrequency ablation (RFA) is a minimally invasive local treatment option for selected patients with early breast cancer, with potential advantages in cosmetic preservation and reduced physical burden. Breast RFA nevertheless requires organ-specific adaptation because abundant adipose tissue, superficial tumor location, and proximity to the skin and chest wall influence electrical impedance, heat conduction, ablation geometry, and safety. A meta-analysis of 17 studies involving 399 patients and 401 lesions small …