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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
28.08.2026journal-article

The Cardiothoracic Surgeon

Combined radiographic and ultrasonographic assessment of postoperative diaphragmatic dysfunction after cardiac surgery: incidence, predictors, and clinical outcomes — a prospective cohort study

Mohamed Khaled Elnagar, Mohamed Moustafa Abdelaal, Wael Mohamed Elfeky, Mohamed Gamal Shaat, Amr Ahmed Ettish

Abstract Background Reported incidences of postoperative diaphragmatic dysfunction vary widely, largely because diagnostic criteria differ and preoperative imaging is seldom available; whether anatomical elevation, contractile impairment, or their combination carries clinical consequence is undefined, and the reproducibility of any composite definition has not been established. We prospectively studied 169 adults undergoing cardiac surgery, pairing standardised pre- and postoperative chest radiography with quantita …

28.08.2026journal-article

JMIR Nursing

Radar-Based Contactless Monitoring in Different Inpatient Nursing Care Settings: Mixed Methods Feasibility Study

Madeleine Ritter-Herschbach, Sebastian Hofstetter, Dominik Behr, Melina Hager, Burkhard Mueller, Patrick Jahn

Abstract Background Monitoring of vital signs is a critical component of nursing care, facilitating the early detection of complications, enabling the observation of the progression of health status, and providing a foundation for diagnosis and therapeutic decision-making. It is instrumental in ensuring quality of care. Contactless measurement methods, such as radar-based sensors, have the potential to enable continuous monitoring of respiration, heart rate, and bed activity without disturbing or stressing vulnerab …

28.08.2026journal-article

Hacettepe University Faculty of Health Sciences Journal

Classification Profile of Swimmers with Physical Impairments in Turkey

Nazli Busra Cigercioglu, Sercan Yıllı, Büşra Kalkan Balak

Objectives: The purpose of this study was to examine the classification profile of swimmers with physical disabilities in Turkey.Materials and Methods: In this cross-sectional study, 192 physically impaired swimmers (132 males, 60 females; mean age 20.8 ± 4.2 years) were evaluated. Athletes were classified according to the IPC functional classification system (S1–S10) based on standardized medical and technical assessments in line with World Para Swimming Classification Rules. Descriptive statistics and chi-square …

28.08.2026journal-article

International Journal of Social Sciences and Public Administration

A Control-Based Differentiated Framework for the Content Governance Obligations of Generative Artificial Intelligence Service Providers

Shengtao Tai

The content governance obligations of generative artificial intelligence (GAI) service providers constitute a central issue in contemporary AI regulation. Existing legal frameworks, however, impose substantially uniform content governance obligations on GAI service providers without adequately accounting for the significant differences among various service models. Drawing upon risk-control theory, this Article argues that the content governance obligations of GAI service providers should be differentiated accordin …

28.08.2026journal-article

Psychotherapy and Psychosomatics

Back to gut feelings. Latent class analysis of daily perceived health variations identifies later responses to antidepressant treatment

Laura Di Lodovico, Charles Westphalen, Chloé Tezenas du Montcel, Loïck Le Tertre, Philippe Courtet, Philip Gorwood

Major depressive disorder (MDD) is a prevalent and disabling condition, yet predicting individual response to antidepressants remains difficult. Traditional symptom-based assessments, typically conducted weeks apart, may miss early and dynamic changes. Daily self-reported measures of wellbeing dimensions, particularly via simple tools such as visual analog scales (VAS), could provide ecologically valid and patient-centered markers of early treatment response. This study aimed to identify distinct early trajectories …

28.08.2026journal-article

Advanced Healthcare Materials

Biodegradable Biomimetic Nanoplatform Orchestrating an Oxygen–Lactate Cascade to Enhance Photothermal Immunotherapy

Shuo Gao, Yu Chen, Yan‐Xi He, Cong‐Min Huo, Hui‐Yu Cen, Si‐Ye Tong, Rui Huang, Chen Luo, Houjuan Zhu, Wei Xue, Jing‐Yi Zhu

ABSTRACT A biodegradable biomimetic nanoplatform (HMCDL@TK‐M) was constructed by combining hydrogen‐doped H x MoO 3 nanoparticles, dual‐drug loading, and a hybrid spinach–cancer cell membrane coating. The system features pH‐responsive biodegradability, tumor‐homing capability, and high NIR‐II photothermal conversion. An oxygen–lactate cascade, formed via thylakoid membrane‐mediated H 2 O 2 decomposition and lactate oxidase‐driven lactate oxidation, alleviates hypoxia and depletes lactate in the tumor microenvironme …

28.08.2026journal-article

Medicine

Bilateral advancement flaps in the treatment of divided nevus of the eyelid

Yan Yu, Fan Dai, Jie Gao, Tao Liu, Haijuan Sun, Yanrong Li

Divided eyelid nevus can affect facial appearance and is difficult to reconstruct after excision. We conducted a retrospective case series (N = 11) and reported the study according to the STROBE guidelines. Eleven patients aged 1–10 years with congenital divided eyelid nevi underwent single-stage excision followed by bilateral advancement flaps and canthal anchoring. Outcomes were evaluated using the Vancouver Scar Scale (VSS) and parent/guardian satisfaction scores. The median VSS score was 1 (interquartile range, …

28.08.2026journal-article

Medicine

Patterns of non-psychotropic medication use and polypharmacy in patients with psychiatric disorders

Yoriyasu Uju, Tetsuto Kanzaki, Riho Hosoi, Seisuke Mimori, Tsuyoshi Takizawa, Tatsuro Hayakawa

Patients with psychiatric disorders often have various physical diseases that may be associated with an increase in the number of prescribed drugs. Although clinical guidelines addressing antipsychotic polypharmacy are well established, there is limited evidence of non-psychotropic polypharmacy. To elucidate the actual state of inappropriate polypharmacy, this study examined the number and classes of prescribed medicines stratified by age and comorbidities in patients with psychiatric disorders. This cross-sectiona …

28.08.2026journal-article

Journal of Molecular Modeling

Molecular insights and ADMET profiling of iridoids as candidate leads for erectile dysfunction therapy

Marcos Aurélio Carpina de Oliveira Filho, Jacilene Silva, Victor Moreira de Oliveira, Damião Sampaio de Sousa, Matheus Nunes da Rocha, Márcia Machado Marinho, Emmanuel Silva Marinho

Abstract Context Erectile dysfunction (ED) significantly affects male psychosocial health and has an increasing incidence. Although phosphodiesterase 5 (PDEi-5) inhibitors are the first-line therapy, the occurrence of visual side effects resulting from cross-inhibition of the PDE-6 isoform limits their adoption. In this context, the plant Veronica anagallis-aquatica L. emerges as a promising source of bioactive therapeutic compounds. This work investigated the inhibitory potential and selectivity of eight iridoid g …

28.08.2026journal-article

Frontiers in Medicine

Association between blood urea nitrogen-to-creatinine ratio and mortality risk in critically ill patients with ventilator-associated pneumonia: a retrospective study

Lei Liu, Qiuli He, Muhuo Ji, Jun Liu

Background Ventilator-associated pneumonia (VAP) is a frequent complication of mechanical ventilation that increases mortality and strains healthcare resources. The blood urea nitrogen-to-creatinine ratio (UCR) is a readily available marker of renal function and hydration status. We investigated the association between UCR and short-term mortality in critically ill patients with VAP. Methods This retrospective cohort study used data from the MIMIC-IV database and included 2,037 patients with VAP admitted to the int …

28.08.2026journal-article

Frontiers in Public Health

Subnational inequalities and preventable gaps in drowning premature mortality and non-fatal health loss among population younger than 20 years

Gengfeng Su, You Zeng, Wenyi Jin, Queran Lin, Shihao Wang, Pi Guo, Junyan Xi, Lian Liang, Jiajia Wang, Bingying Fan, Min Huang, Jingxuan Jia, Xiaoliang Huang, Xiao Lin

Background Drowning remains a preventable cause of premature mortality among children and adolescents. National estimates can monitor progress, but may not identify subnational locations where risk remains high. We examined drowning burden in the population younger than 20 years in 2023, focusing on age patterns, national differences, subnational variation, and frontier gaps. Methods We analyzed 1990–2023 population health estimates for drowning. Deaths, disability-adjusted life-years (DALYs), death rates, and DALY …

28.08.2026journal-article

Magnetic Resonance in Medicine

SeqEyes : An Open‐Source Toolbox for Synchronized Waveform/Trajectory Visualization in Pulseq

Xingwang Yong, Zheng Liu, Yiyun Dong, Haotian Hong, Yuting Chen, Paul Dubovan, Qiang Liu, Jiye Kim, Unay Dorken Gallastegi, Yohan Jun, Berkin Bilgic

ABSTRACT Pulseq enables vendor‐neutral description of MRI pulse sequences in human‐readable .seq files and is widely used for sequence development and sharing. During design and debugging, rapid evaluation of sequence timing across RF pulses, gradient waveforms, and ADC events is essential. This is particularly challenging for non‐Cartesian acquisitions, where waveform timing does not readily reveal the underlying k ‐space trajectory. Existing tools, however, provide limited interactive capabilities for this task. …

28.08.2026journal-article

BMC Geriatrics

Psychometric properties and age- and gender-specific normative values of the Patient Health Questionnaire-4 among older adults aged 60 years and above

Nikolay Dimitrov, Elmar Brähler, Andreas Hinz, Bjarne Schmalbach, Jörg M. Fegert, Markus Zenger

Abstract Background Mental health problems in older adults are often underrecognized despite their substantial impact on health and well-being. Brief, valid screening tools with age-specific normative data are needed for this growing population. This study examined the psychometric properties of the Patient Health Questionnaire-4 (PHQ-4) and established age- and gender-specific normative values for adults aged 60 years and older in Germany. Methods Data were drawn from four nationally representative face-to-face ho …

28.08.2026journal-article

RSV

Promoção da saúde bucal no ambiente escolar

AYLLA LORENA GOMES LÔBO PALMA

Este estudo analisa estratégias de promoção da saúde bucal no ambiente escolar e sua articulação com a Atenção Primária à Saúde. Realizou-se pesquisa bibliográfica, de abordagem qualitativa, por meio de revisão narrativa de artigos científicos, legislação e documentos institucionais nacionais e internacionais. Os resultados mostram que a escola constitui espaço estratégico para formar hábitos de autocuidado, identificar necessidades e aproximar estudantes dos serviços públicos de saúde. Entretanto, ações educativas …

28.08.2026journal-article

Nursing Reports

Evaluation of the Impact and Satisfaction of Creating a Mother–Child Educational Podcast by University Nursing Students

Sergio Martínez-Vázquez, Rocío Adriana Peinado-Molina, María Antonia Díaz-Ogállar, Antonio Hernández-Martínez, Juan Miguel Martínez-Galiano

Aim: To evaluate the effect of a student-generated podcast intervention focused on maternal–child health topics on nursing students’ self-perceived knowledge, educational satisfaction, and gameful engagement. Introduction: Health education is essential for promoting healthy lifestyles and preventing disease, making the acquisition of effective communication skills vital for nursing undergraduates. While digital audio media and podcasts are increasingly popular pedagogical tools, traditional applications rely on pas …

28.08.2026journal-article

Greenation International Journal of Engineering Science

Design and Development of a Web-Based Informed Consent Information System to Improve the Efficiency and Legal Compliance of Healthcare Administrative Services

Syifa Putri Carissa Candraningtyas, Yuyun Yunengsih, Rina Kurniawati

This study aims to design a web-based Informed Consent Information System to improve administrative efficiency and support the legality of healthcare services. The research method used is the Waterfall method, encompassing the stages of requirements analysis, system design, implementation, testing, and maintenance. The resulting system is a web-based application featuring patient data management, physician data management, medical procedure data, electronic medical procedure consent forms, electronic signatures, as …

28.08.2026journal-article

Oncologie

Gut microbiota-mediated programmed cell death in colorectal cancer: implications for precision medicine

Wei Liu, Wei Zhang

Abstract Colorectal cancer (CRC) remains a major global health burden, with marked interindividual variability in disease progression and therapeutic response. Emerging evidence suggests that the gut microbiota shapes CRC biology not only through inflammation and metabolism, but also by regulating programmed cell death (PCD) pathways that may influence tumor cell fate and treatment sensitivity. This review summarizes recent advances in microbiota-mediated regulation of major PCD modalities relevant to CRC, includin …

28.08.2026journal-article

Archives of Orthopaedic and Trauma Surgery

Patient-reported outcomes after lateral unicompartmental and total knee arthroplasty: a propensity score-matched cohort study

Mustafa Hariri, Reza Sorbi, Babak Moradi, Johannes Weishorn, Raphael Trefzer, Tobias Reiner, Tilman Walker, Timo Albert Nees

Abstract Introduction Comparative evidence on patient-reported outcomes (PROs) after lateral unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) remains limited. We compared PROs between cohorts matched for demographic characteristics and baseline knee function. Materials and methods Prospectively collected single-center data were retrospectively analyzed. Lateral UKA was performed for isolated lateral-compartment osteoarthritis and TKA predominantly for multicompartmental disease. One-to-one …

28.08.2026journal-article

Frontiers in Oncology

Combination therapy with Nifuroxazide and Lenvatinib exerts superior anti-hepatocellular carcinoma effect by enhancing the anti-tumor immune response

Jing Yang, Jiaxin Geng, Yue Yin, Kangle Wang, Leyao Tian, Jingyi Wang, Huijie Jia, Lei Wang, Yongxi Zhang, Tiesuo Zhao

Background Lenvatinib is a first-line multi-target tyrosine kinase inhibitor for hepatocellular carcinoma (HCC) that exerts anti-angiogenic effects by blocking VEGF signaling. However, its clinical efficacy is often compromised by adaptive resistance. Nifuroxazide, an anti-diarrheal agent, has been identified by our group as a potent inhibitor of PD-L1 expression in HCC. Objective This study aimed to evaluate the therapeutic potential and underlying molecular mechanisms of nifuroxazide combined with lenvatinib agai …

28.08.2026journal-article

Frontiers in Neurology

Combined clinical and DWI radiomics model for predicting 90-day functional outcomes after intravenous thrombolysis in acute ischemic stroke patients

Yupeng Bai, Qifeng Liu, Ruonan Zhan, Qiaoqiao Xu, Chunhua Xia, Yinfeng Qian

Objective To develop an interpretable machine learning model based on Diffusion-Weighted Imaging (DWI) radiomics and D-dimer for 90-day outcome prediction after intravenous thrombolysis in acute ischemic stroke (AIS), and to explore candidate upstream transcriptional programs of D-dimer using publicly available rat middle cerebral artery occlusion (MCAO) datasets as an exploratory, hypothesis-generating step. Methods This retrospective study included 115 AIS patients treated with intravenous thrombolysis (January 2 …

28.08.2026journal-article

Social Theory & Health

Public health, trade unions and empowerment: From learning to draft resolutions to addressing the socioeconomic determinants of health

Jane Thomas, Sean Tunney, Adam Cox

Abstract Community empowerment projects aimed at improving health and wellbeing have tended to be ‘place-based’. But they may also be based on ‘communities of interest’. This paper advances an original conception of health-related empowerment by focusing on the work of trade unions, which we treat as being among such communities. Organised labour improves health and reduces inequalities through processes including collective bargaining, even as public health actors have shown resistance to engaging with unions. We …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

The impact of combination therapy for vulvar lichen sclerosus et atrophicus on the quality of life, psychoemotional profile and sexual function of women

N.I. Chernova, M.I. Proskurina, O.V. Dolya, I.S. Zadorozhnaya

Increasing incidence of vulvar lichen sclerosus et atrophicus (VLSA), chronic nature of the disease, severity of itching, and late complications with changes in the anatomy of the external genital organs lead to the development of a number of disorders, including psychoemotional and sexual dysfunctions, and significantly deteriorate the quality of life of patients. Long-term use of topical glucocorticosteroids (tGCSs) has a number of side effects, requires patient compliance, and does not ensure long-lasting diseas …

28.08.2026journal-article

Russian Journal of Clinical Dermatology and Venereology

Nail lesions in a patient with vitiligo

R.V. Saranyuk

Vitiligo is a chronic skin disease of unknown etiology. The appearance of focal depigmentation of various localizations on the skin is its primary clinical manifestation. Vitiligo is considered one of the most common skin diseases. According to various authors, its prevalence ranges from 0.1% to 4%. This dermatosis has a significant impact on the quality of life of patients, especially when the foci of skin depigmentation are localized on visible areas of the body. In addition to the skin, vitiligo can affect hair …

28.08.2026journal-article

Malignant tumours

The mDCF combination as first-line therapy in patients with locally advanced or metastatic esophageal squamous cell carcinoma

V. V. Sokolovskiy, E. A. Dinaeva, A. A. Margusheva, A. A. Tryakin

Introduction. There is no consensus regarding the optimal first-line chemotherapy regimen for locally advanced or metastatic esophageal squamous cell carcinoma. The efficacy of standard chemotherapy combinations is limited and therefore has to be improved. Due to the limited accessibility of modern immunotherapy, chemotherapy remains a valuable commonly used option. We conducted a non-randomized prospective study to evaluate the efficacy and tolerability of the triple combination mDCF. Materials and Methods. The ma …