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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

Surgery Today

Long-term prognosis and postoperative liver atrophy after gastrectomy in patients with gastric cancer and liver cirrhosis

Atsushi Yasuda, Masuhiro Terada, Naoko Konami, Atsushi Yamada, Masashi Koda, Tomohiro Nakanishi, Yoko Hiraki, Hiroaki Kato, Osamu Shiraishi, Masayuki Shinkai, Motohiro Imano, Yutaka Kimura, Takushi Yasuda

Abstract Purpose Gastrectomy in patients with liver cirrhosis is associated with an increased postoperative risk and poor prognosis; however, the long-term outcomes remain unclear. This study evaluated the survival of patients with cirrhosis after gastrectomy, focusing on postoperative nutritional deterioration and time-dependent survival effects. Methods This retrospective study included 847 patients who underwent gastrectomy for gastric cancer. Patients were categorized into liver cirrhosis (LC) and non-LC groups …

25.08.2026journal-article

Frontiers in Oncology

Radiofrequency ablation for early breast cancer: from local technique to system-based surgical therapy

Shinichiro Kashiwagi

Radiofrequency ablation (RFA) is a minimally invasive local treatment option for selected patients with early breast cancer, with potential advantages in cosmetic preservation and reduced physical burden. Breast RFA nevertheless requires organ-specific adaptation because abundant adipose tissue, superficial tumor location, and proximity to the skin and chest wall influence electrical impedance, heat conduction, ablation geometry, and safety. A meta-analysis of 17 studies involving 399 patients and 401 lesions small …

25.08.2026journal-article

Journal of Medical Genetics

Rapid minigene workflow for functional reclassification of splicing variants in hereditary cancer diagnostics

Noemi Calandra, Elisabetta Mereu, Paola Ogliara, Guido Casalis Cavalchini, Daniela Francesca Giachino, Mirko Parasiliti Caprino, Giorgia Gai, Alessandro Mussa, Stefano Vallero, Enrico Grosso, Andrea Zonta, Franca Fagioli, Matteo Ruggiu, Barbara Pasini, Roberto Piva

Background Next-generation sequencing of cancer predisposition genes is routinely used in hereditary cancer diagnostics. However, a substantial fraction of detected variants remains clinically unresolved. Using a customised 77-gene panel, we analysed 2142 individuals and identified 384 pathogenic or likely pathogenic variants across 54 genes, corresponding to a diagnostic yield of approximately 18%. Despite this, 17% of cases carried variants of uncertain significance, many of which were suspected to affect pre-mRN …

25.08.2026journal-article

JEADV Clinical Practice

A Practical Guide for Incorporating Emollients in the Treatment of Mild‐to‐Moderate Atopic Dermatitis

Mette Deleuran, Wioletta Barańska‐Rybak, Michael J. Cork, Stamatis Gregoriou, Angela Hernandez‐Martin, Giuseppe Micali, Andaç Salman, Petra Staubach‐Renz, Antonio Torrelo, Charles Velter, Anneke Andriessen, Vanja Adzovic, Liselot Vink

ABSTRACT Emollients and cleansers are essential components in managing atopic dermatitis (AD). While international evidence‐based guidelines recommend using gentle cleansers and emollients daily as a foundational therapy for AD, implementation in practice remains suboptimal. Clinicians may require guidance in selecting the most appropriate options for their patients. This paper, tailored for non‐dermatologist healthcare providers, examines how to choose and integrate emollients into treating mild‐to‐moderate AD, pr …

25.08.2026journal-article

Frontiers in Pediatrics

Clinical research on secure multi-party computation technology for auxiliary respiratory pathogen diagnosis and treatment design in preschool-aged children

Xi Zhai, Pengqian Zhang

Background Privacy-preserving integration of respiratory pathogen, host and treatment data remains difficult in preschool-aged children. We evaluated secure multi-party computation (SMC) as clinician-reviewed decision support for respiratory pathogen diagnosis and treatment planning, while distinguishing technical validation from clinical efficacy. Methods This prospective observational study with a parallel in silico comparator was conducted at a tertiary paediatric centre in 2023 among children aged 3–6 years und …

25.08.2026journal-article

Neurourology and Urodynamics

The Benefits of Adding Non‐Antimuscarinic Pharmaceuticals in Combination With Beta‐3 Agonists for Overactive Bladder Treatment: A Systematic Review

Felicity Smith, Charlotte Phelps, Christian Moro

ABSTRACT Introduction Antimuscarinics, as the current first‐line pharmacologic therapies for overactive bladder, exhibit low patient adherence and high rates of reported side effects. As a modern alternative pharmaceutical treatment, beta‐3 agonists, which relax the urinary bladder, may be more tolerable for patients, increasing adherence and prescription compliance. Of interest is the growing potential for non‐antimuscarinics to be incorporated in combination therapies alongside these beta‐3 agonists. Methods Foll …

25.08.2026journal-article

Frontiers in Oncology

Posterior airway space following mandibular reconstruction using microvascular free flaps in oral cancer patients in relation to radiotherapy: a single-center study

Stefan Heene, Leonard Simon Brandenburg, Klara Klöble, Wiebke Semper-Hogg, Rainer Schmelzeisen, Marc Christian Metzger, Jonas Wüster

Introduction The posterior airway space (PAS) is of considerable clinical relevance, as airway obstruction in this region may compromise patient well-being, manifesting as symptoms ranging from acute dyspnea to chronic obstructive sleep apnea. Although previous studies have demonstrated significant alterations in the PAS following oral and maxillofacial surgical procedures, changes in the PAS among patients with oral cancer undergoing microvascular reconstruction remain insufficiently investigated. This study aimed …

25.08.2026journal-article

Computational and Systems Oncology

Single‐Cell Transcriptomic Identification of Drug‐Tolerant Persister Mechanisms in Capecitabine‐Treated Triple‐Negative Breast Cancer

Md Naiyem Islam, Md Kaziul Islam Sarkar Suja, Alif Al Takbir, Md. Kaderi Kibria

ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and HER2 expression. This lack of receptors limits targeted therapies and contributes to high rates of recurrence. A subset of tumor cells survives even intensive chemotherapy, and growing evidence suggests that drug‐tolerant persister cells (DTPs) play a central role in this survival, evading treatment and later driving relapse. However, the molecular programs that su …

25.08.2026journal-article

Discover Public Health

HIV epidemiology and challenges in prevention, testing and treatment in Eastern Europe and Central Asia from a mixed-method review

Machiko Otani, Soudeh Ehsani, Viatcheslav Grankov, Stela Bivol, Giorgi Kuchukhidze

Abstract Objective Eastern Europe and Central Asia (EECA) is experiencing a rise in the number of new HIV infections and is lagging in reaching the testing and treatment cascade targets. We aimed to identify gaps in prevention, testing, and treatment services, with a focus on key populations (KPs), and propose key actions for the EECA region to achieve the goal of ending AIDS by 2030. Methods A mixed-method review was conducted. Quantitative data, covering 15 EECA countries, were extracted from the standardised glo …

25.08.2026journal-article

Journal of Intelligent & Fuzzy Systems: Applications in Engineering and Technology

Real amply soft sets and parameter-dependent mean operators with an application to prostate cancer risk assessment

Orhan Göçür

This study develops a real amply soft set framework for prostate cancer risk assessment with explicit emphasis on parameter-dependent modelling. Real amply soft sets are formulated as two-layer full-domain mappings: a value layer assigns real subsets or intervals to active parameters, while an endpoint-preference layer assigns criterion-specific positive real intervals that make the proposed parameter-dependent average (mean) operator sensitive to the lower and upper endpoints of clinical intervals. This constructi …

25.08.2026journal-article

Frontiers in Oncology

Economic burden of cancer care in Lebanon’s privately insured population: a seven-year retrospective cohort analysis (2018–2024)

Shadi Saleh, Paul Makhoul, Rawad Chamandi, Zahi Abdul-Sater

Background Cancer imposes a growing economic burden on health systems globally, yet longitudinal, population-level data on cancer care costs within private insurance remain scarce in low- and middle-income countries. Lebanon’s private insurance sector, administered through third-party administrators (TPAs), covers a substantial share of the economically active population, yet no published study has characterized its cancer-related economic burden, including during the country’s economic contraction since 2019. Meth …

25.08.2026journal-article

Cancers

Age Limits of Breast Cancer Screening with Mammography—A Decision-Analytic Benefit–Harm Evaluation to Inform DecisionMaking for the German Context

Gaby Sroczynski, Lára R. Hallsson, Nikolai Mühlberger, Felicitas Kühne, Beate Jahn, Christin Henning, Heike Kölsch, Stefan Sauerland, Konstanze Angelescu, Uwe Siebert

Background/Objectives: To inform policy making for the German breast cancer (BC) screening program, we systematically evaluated the long-term benefits and harms of extended age limits compared to the current standard of biennial mammography at ages 50–69 years using a decision-analytic approach. Methods: We developed and applied a Markov state-transition model for mammography screening in Germany to systematically assess the benefit–harm trade-offs of various screening strategies varying in age at start and end of …

25.08.2026journal-article

Sağlık Bilimleri Dergisi

Investigation of Symptoms and Independence in Activities of Daily Living Among Cancer Patients

Şeyda Karasu, Gamze Özyel, Emine Artan, Elanur Yılmaz Karabulutlu

This study aimed to examine the symptoms experienced by cancer patients and their levels of independence in daily living activities. This descriptive and correlational study was conducted with 421 cancer patients at a city hospital in eastern Türkiye. Data were collected using a Patient Information Form, the Edmonton Symptom Assessment Scale, and the Katz Index of Independence in Activities of Daily Living. The patients’ mean Edmonton Symptom Assessment Scale score was 4.17 ± 1.72, while the mean Katz Index of Inde …

25.08.2026journal-article

Journal of Applied Clinical Medical Physics

Dosimetric and radiobiological evaluations as well as technical aspects of left breast treatment employing DIBH with SGRT in radiotherapy with IMRT step and shoot, IMRT Dynamic MLC and VMAT

Julien Rolland, Stéphane Payan, Pierre Fau, Hugues Mailleux, Agnès Tallet

Abstract Background Treatment of the left breast using deep inspiration breath hold (DIBH), combined with surface guided radiotherapy (SGRT), has emerged as the standard for reducing the dose to the heart, the left anterior descending coronary artery (LAD), and the ipsilateral lung. Since this treatment is administered during breath hold (BH) phases, it is beneficial to limit the duration of delivery to improve patient comfort. Furthermore, the SGRT signal can be disrupted when the gantry passes in front of the lef …

25.08.2026journal-article

Frontiers in Immunology

Multicellular immunosuppressive networks in microsatellite-stable colorectal cancer: CD8+ T cell exclusion, dysfunction, exhaustion, and therapeutic implications

Zhiyuan Xia, Haining Chen, Yefu Shen, Minghui Lin, Xihua Xie, Hao Shu, Shen Pang, Dongchao Liu, Yunfei Cao, Sen Zhang

Microsatellite-stable (MSS) colorectal cancer (CRC), comprising ~85–90% of cases, remains almost universally refractory to PD-1/PD-L1 monotherapy (objective response rate 5–10%), in stark contrast to the marked efficacy of immune checkpoint inhibitors (ICIs) in microsatellite-instability-high (MSI-H) disease. Here we synthesize evidence that CD8 + T cell exclusion, dysfunction, and exhaustion in MSS CRC are orchestrated not by cell-autonomous failures but by a multicellular immunosuppressive network in which tumor- …

25.08.2026journal-article

Advanced Materials Technologies

A U‐shaped Microfluidic Platform for Culturing Vascularized Colorectal Cancer Spheroids Reveals Tumor–Endothelial Crosstalk and Invasion‐Associated Remodeling

G. Cretti, M. Ballerini, A. Mantegazza, P. Occhetta, M. Rasponi

ABSTRACT Current tumor‐on‐chip platforms force trade‐offs between reproducible single‐spheroid positioning, size control, and symmetric full‐surface vascularization. To bridge this gap, we developed a closed U‐shaped microfluidic device that traps a single pre‐formed colorectal cancer (CRC) spheroid at a defined position, uniformly embedded in a fibrin matrix containing GFP‐HUVECs to enable volumetric tumor–endothelial interactions and longitudinal imaging. Optimized HT29 spheroids generated a measurable pro‐angiog …

25.08.2026journal-article

Current Oncology

Tumor Characteristics and Event Free Survival in Older and Younger Women with Early Breast Cancer

Samantha Kodikara, Alexis C. Wardell, Allison M. Deal, Annie Page, Hyman B. Muss, Kirsten A. Nyrop

Background: Age, race, body mass index (BMI), breast density, parity, smoking and alcohol use are associated with increased risk for breast cancer. These factors, as well as tumor characteristics, treatment regimens and comorbidities, are analyzed for associations with five-year event free survival (EFS) in a sample of women with Stage I-III breast cancer who received chemotherapy with curative intent. Methods: EFS was defined in terms of breast cancer recurrence, second primary, metastasis, and overall survival. A …

25.08.2026journal-article

Cancer Science

The Role of IGF2BP3 ‐Mediated Immune Response Activation in Enhancing Immunotherapy of Koumine for Gastric Cancer

Qiu Hongqiang, Lin Hailing, Lou Luqi, Wang Linyao, Lin Tian, Shengjie Zhu, Zhang Dongmei, Chen Rong, Mao Yunyi, Wancai Que, Yu Cheng

ABSTRACT Resistance to immune checkpoint blockade in gastric cancer often arises from defective antigen presentation due to MHC‐I downregulation, yet strategies to restore MHC‐I expression remain limited. Here, using the natural alkaloid koumine as a chemical probe, we identified IGF2BP3 as a druggable regulator of MHC‐I antigen presentation. Network pharmacology, proteomics, surface plasmon resonance, and cellular thermal shift assays were used to identify and validate koumine's target. Genetic rescue experiments, …

25.08.2026journal-article

Bladder Cancer

Difficult conversations in bladder cancer survivorship: Integrating mental health and intimacy into routine urologic care

Armine K. Smith, Daniela Wittmann, Krisztina Emodi, Gail Dykstra, Brian Billings, Mary Sullivan, Mary W. Dunn, Glenn J. Treisman

Introduction Bladder cancer survivorship extends beyond oncologic control and includes significant psychological distress, demoralization, sexual dysfunction, and identity disruption. Despite their clinical relevance, structured approaches to difficult conversations in bladder cancer care remain inconsistent. Objective To develop interdisciplinary consensus recommendations for integrating structured communication regarding mental health and intimacy into routine bladder cancer care. Methods A multidisciplinary brea …

25.08.2026journal-article

Frontiers in Immunology

Prognostic superiority of volumetric PET parameters (MTV and TLG) over SUV in advanced non-small-cell lung cancer: a systematic review and meta-analysis of univariate and multivariate evidence

Jinwen Han, Hanxiang Zhang, Xianhong He, Zhimin Wang

Purpose To systematically assess the prognostic significance of baseline 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ([ 18 F] FDG PET/CT) metabolic parameters in patients with non-small cell lung cancer (NSCLC) undergoing immune checkpoint inhibitor (ICI) therapy. Methods A systematic search of five core databases was conducted up to March 2026. Relevant data concerning NSCLC patient characteristics, metabolic [ 18 F] FDG PET/CT parameters, and survival outcomes were extracted. Hazard r …

25.08.2026journal-article

Journal of Neuro-Oncology

Subperineural ‘onion-peeling’ dissection for maximizing extent of resection and facial nerve preservation for onco-functional balance in vestibular schwannoma surgery

James K. Liu, Ahmed Sabra, Yaxel Levin-Carrion, Caryn J. Ha, Sraavya Anne, Arevik Abramyan, Vicente Rojas-Navas, Kevin Wong, Yu-Lan Mary Ying, Robert W. Jyung

Abstract Introduction Planned subtotal resection (STR) of vestibular schwannomas (VS) followed by stereotactic radiosurgery (SRS) has gained popularity for minimizing facial nerve injury. However, recurrence risk correlates with residual tumor volume, and long-term outcomes remain unknown. The authors report their facial nerve outcomes with planned maximal safe resection using a facial nerve-sparing subperineural “onion-peeling” technique, and compare their outcomes to those of the hybrid STR-SRS approach. Methods …

25.08.2026journal-article

Current Oncology Reports

Head and Neck Rhabdomyosarcoma in Children: An Otolaryngological Perspective on Diagnostic and Therapeutic Approaches

Agata Wojno, Milena Chmielewska, Sara Shefa, Oliwia Cichy, Paulina Lenkiewicz, Karolina Dorobisz

Abstract Purpose of Review Head and neck rhabdomyosarcoma (HNRMS) is the most common soft-tissue sarcoma in children, with approximately 30–40% of cases arising in the head and neck region. Due to its anatomical complexity, histopathological diversity, and molecular heterogeneity, HNRMS remains a major diagnostic and therapeutic challenge in pediatric otolaryngology. This review aims to summarize current evidence regarding the epidemiology, clinical presentation, diagnostic strategies, contemporary treatment modali …

25.08.2026journal-article

The Laryngoscope

MDADI as a Screening Tool for VFSS ‐Graded Swallowing Impairment in Head and Neck Cancer Patients

Zachary G. Brumm, Eric A. Anyimadu, Meera Kohli, Jennifer Silver, Beatrice Manduchi, Katherine Hutcheson, Arushi Gulati, G. Elisabeta Marai, Tyler W. Crosby, Clark A. Rosen, VyVy N. Young, Guadalupe Canahuate, Yue Ma

ABSTRACT Objectives To determine clinically useful MD Anderson Dysphagia Inventory (MDADI) thresholds associated with Videofluoroscopic swallow study (VFSS)‐graded swallowing impairment in head and neck cancer (HNC) patients and to explore whether a reduced‐item MDADI could preserve discrimination while minimizing patient burden. Methods This retrospective cross‐sectional study analyzed HNC patients from a prospectively maintained dysphagia surveillance program who completed the MDADI within 120 days of VFSS. Assoc …

25.08.2026journal-article

Frontiers in Oncology

MicroRNA-phytochemical interactome targeting thioredoxin-interacting protein: a narrative review at the nexus of RNA therapeutics, cancer biology, and metabolic regulation

Peter Chinedu Agu, Patrick Maduabuchi Aja, Cecilia Ogechi Ofor, Kehinde Ross, Jun Lu

MicroRNAs (miRNAs) are increasingly recognized as central regulators of gene expression, cellular adaptation, and disease progression. This is fundamentally reshaping current understanding of disease molecular pathogenesis and therapeutic intervention. Beyond their established roles in development and metabolism, miRNAs actively participate in oncogenesis, metabolic dysfunction, inflammation, and redox homeostasis. Emerging evidence shows that phytochemicals can modulate miRNA-mediated regulatory networks by influe …