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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
20.08.2026journal-article

Frontiers in Medicine

Efficacy and safety comparison of hetrombopag and eltrombopag in children with cancer therapy-induced thrombocytopenia: a single-center retrospective study

Li-Ting Yu, Min Zhang, Jia-Xin Zhang, An-An Zhang, Zhuo Wang, Dan He, Hao-Nan Li, Zhi-Ling Li, Yi-Jin Gao

Objective To compare the efficacy and safety of hetrombopag and eltrombopag in children with cancer therapy-induced thrombocytopenia (CTIT), and to explore the clinical value of eltrombopag for this specific pediatric population given the current lack of dedicated literature. Methods This was a single-center retrospective study. A total of 185 pediatric CTIT patients were enrolled, including 114 cases in the hetrombopag group and 71 cases in the eltrombopag group. Baseline characteristics, platelet (PLT) parameters …

20.08.2026journal-article

Journal of Human Immunity

Persistent Hypogammaglobulinemia Following Anti-CD20 Therapy in a Patient with 22q11.2 Deletion Syndrome: A Case Report

Ana Drazic, Srdjan Pasic, Maja Stojanovic, Branka Bonaci-Nikolic, Rada Miskovic

Introduction 22q11.2 deletion syndrome (22q11.2 DS) is one of the most common microdeletion syndromes, characterized by congenital anomalies and variable immune dysfunction secondary to thymic hypoplasia. The resulting immune dysregulation frequently predisposes affected individuals to autoimmune manifestations, including immune thrombocytopenia (ITP). Although rituximab is established therapy for refractory ITP, its B cell–depleting mechanism may carry distinct risk in patients whose B cell compartment already dep …

20.08.2026journal-article

JAMA Network Open

Outpatient Parenteral Antimicrobial Therapy Practice Variability Across Veterans Affairs Hospitals

Elizabeth A. Scruggs-Wodkowski, Lauren Gauntlett, Danielle Helminski, Amanda C. Blok, Nicholas Henry, Sara C. Keller, Ronald E. Kendall, Manon Nitta, Allison Ranusch, Milisa Manojlovich, Molly Harrod, Sarah L. Krein

Importance Challenges providing outpatient parenteral antimicrobial therapy (OPAT) can compromise patient safety and care quality, yet little is known about how OPAT is delivered by health care systems across the US. Objective To understand and compare OPAT delivery at US Department of Veterans Affairs Medical Centers (VAMCs). Design, Setting, and Participants This qualitative study using a mixed-methods approach was performed from February 6, 2024, through April 15, 2025. Six midwestern VAMCs were purposively sele …

20.08.2026journal-article

JOURNAL OF BONE MARROW TRANSPLANTATION AND CELLULAR THERAPY

Hematopoietic cell transplantation for myelodysplastic syndromes

Fernando Barroso Barroso, Yhasmine Delles Oliveira Garcia, Karine Sampaio Nunes Barroso, Roberto Luiz da Silva, Lívia Andrade Gurgel, João Paulo de Vasconcelos Leitão, Beatriz Stela Gomes de Souza Pitombeira, Rodolfo Daniel de Almeida Soares, Gustavo Bettarello

For patients with myelodysplastic syndromes (MDS), allogeneic hematopoietic cell transplantation (HCT) is considered the only treatment with curative potential. However, its use is restricted to a selected group of patients, and transplant outcomes are influenced by a complex interaction of disease related characteristics, patient-specific factors, and the HCT procedure. Since the publication of the previous Brazilian consensus, important advances have been made in the classification and risk stratification of MDS. …

20.08.2026journal-article

Clinical and Experimental Immunology

Peripheral T-Cell Transitions Following Proton Pump Inhibitor Therapy in Eosinophilic Esophagitis

John Plate, Christine Lingblom, Helen Larsson

Abstract Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory condition characterized by eosinophilic infiltration of the esophagus and dysregulated T-cell responses. Proton pump inhibitors (PPIs) are a treatment option for patients with EoE, however, biomarkers for non-invasive monitoring of treatment response are lacking. In this study, we prospectively enrolled twenty patients with EoE who were treated with PPIs, of whom nineteen completed their treatment, and analyzed peripheral blood immune profil …

20.08.2026journal-article

Advanced Healthcare Materials

Dual‐Functional Microreactor Enabling Hydrogen Therapy and Mild Photothermal Therapy for Osteoarthritis Treatment

Zhe Wang, Yuyang Wu, Ze Zhang, Shengyan Yin, Guangbin Wang

ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disorder. Current therapeutic approaches have yielded suboptimal clinical outcomes, primarily due to their inability to effectively eliminate reactive oxygen species (ROS), which are the key drivers of inflammatory pathology. Molecular hydrogen (H 2 ) has emerged as a promising therapeutic agent owing to its selective scavenging of cytotoxic ROS, thereby exerting potent anti‐inflammatory effects. In this study, we propose a spatiotemporally controlled, …

20.08.2026journal-article

Physical Therapy

The Role of Physical Activity in Oral Cancer Recovery:A Systematic Review

Lina Van Lint, Manon Lefever, Yolinne Meert, Lynn Christiaens, Robin Willaert, Kaat Alaerts, Jeroen Van Dessel

Abstract Importance Physical activity (PA) is a cornerstone in cancer rehabilitation, yet evidence in oral cancer remains limited and heterogeneous, despite the significant functional impairments and morbidity associated with treatment. Objective This systematic review synthesizes evidence on PA in people living with or beyond oral cancer (PLWBOC), focusing on its association with recovery-related outcomes across the cancer care continuum. Data Sources A comprehensive systematic search was conducted in 9 databases …

20.08.2026journal-article

Science Journal of Clinical Medicine

Potential for Corneal Recovery During Nonstandard Rehabilitation After LASIK

Galina Semak, Volha Remezava, Yuliya Markava, Gleb Krishtopenko

Laser in situ keratomileusis (LASIK) provides predictable refractive outcomes, but clinically silent epithelial basement membrane dystrophy (EBMD) may become apparent during flap creation and lead to epithelial sloughing, delayed epithelial recovery, and postoperative ocular surface instability. This case report describes the management of a 30-year-old man with bilateral moderate myopia and astigmatism who underwent microkeratome-assisted LASIK after a routine preoperative examination showed no corneal epithelial …

20.08.2026journal-article

Advanced Healthcare Materials

Biphasic Co‐Delivery of Curcumin and 5‐FU using 3D‐Printed Dissolving Microneedles for Skin Cancer Therapy

Rutuja N. Meshram, Dimitrios A. Lamprou

ABSTRACT Dissolving microneedle (MN) arrays are a minimally invasive strategy for localized transdermal chemotherapy; however, their translation is limited by drug loading, reproducible dosing, and the difficulty of incorporating chemically distinct drugs into printable matrices. Although MN‐mediated delivery of curcumin and 5‐fluorouracil (5‐FU) has previously been reported using inkjet/coating‐based approaches, those systems deposit drug formulations onto preformed solid MNs and are therefore constrained by surfa …

20.08.2026journal-article

ACS Applied Materials & Interfaces

Nitroxide Polymer Encapsulating Triptolide for Safe and Effective Small Cell Lung Cancer Therapy by Targeting Energy Metabolism and Pyroptosis

Kuntan Wu, Yixuan Yu, Jiuzhi Xu, Tongxin Zhao, Tingting Hou, Yun Xu, Luyao He, Zhirong Wang, Liansheng Liu, Hai Song, Yu Geng, Qingzhe Wu

Abstract Small cell lung cancer (SCLC) is highly aggressive neuroendocrine tumor with a paucity of effective therapeutic option. Triptolide (TP), a natural diterpenoid triepoxide, exhibits potent antitumor activities, yet its efficacy and underlying mechanisms in SCLC remain largely undefined. Here, we demonstrate that TP effectively inhibits cell viability across all molecular subtypes of SCLC, with greater potency than in nonsmall cell lung cancer. Mechanistically, TP transcriptionally represses hexokinase 1 and …

20.08.2026journal-article

Journal of Clinical Medicine

Prenatal mTOR-Inhibitor Therapy for Fetal Cardiac Rhabdomyomas: Indications, Treatment Duration and Perinatal Outcomes

Ioannis Kyvernitakis, Katharina Schramm, Gert Wiegand, Bernd Feyerabend, Ahmet Alexander Baschat

Background: Fetal cardiac rhabdomyomas are strongly associated with tuberous sclerosis complex (TSC). Although many remain asymptomatic and regress spontaneously, large tumors may cause ventricular inflow or outflow obstruction, arrhythmia, impaired ventricular function, pericardial effusion, hydrops fetalis and fetal demise. Transplacental mammalian target of rapamycin (mTOR) inhibition has emerged as a potential rescue therapy. Methods: We performed a narrative review of published reports on prenatal sirolimus or …

19.08.2026journal-article

Photobiomodulation, Photomedicine, and Laser Surgery

Antimicrobial Photodynamic Therapy Reveals Differential Species Susceptibility and Ecological Shifts in Candida albicans–Pseudomonas aeruginosa Mixed Model

Jiahe Li, Liang Zhou

Background: Candida albicans and Pseudomonas aeruginosa are frequently co-isolated from refractory endodontic infections. Antimicrobial photodynamic therapy (aPDT) is a promising adjunctive disinfection strategy; however, its efficacy against polymicrobial communities containing structurally distinct organisms remains unclear. Objective: To evaluate methylene blue–mediated aPDT at three energy densities (15, 30, and 60 J/cm 2 ) against a dual-species coculture model and to investigate the ecological consequences of …

19.08.2026journal-article

Journal of Back and Musculoskeletal Rehabilitation

Effectiveness of manual therapy on central sensitization in patients with non-specific chronic low back pain: A randomized controlled trial

Serhat Aydoğdu, Naime Uluğ, Zehra Can Karahan, Kamyab Sadeghzadeh, Nagihan Acet

Background Central sensitization (CS), characterized by amplified nociceptive processing within the central nervous system, is considered a key mechanism in chronic nonspecific low back pain (CNLBP). Although manual therapy (MT) is widely used in musculoskeletal rehabilitation, its effectiveness in patients with confirmed CS remains unclear. This study evaluated the effects of MT on CS, pain, disability, and quality of life in individuals with CNLBP. Methods Forty participants with physician-diagnosed CNLBP and CS …

19.08.2026journal-article

Canadian Journal of Physiology and Pharmacology

Cardiotropic Adeno-Associated Virus-Based Gene Therapy via Intracoronary Delivery for Nonischemic Heart Failure

Joseph Abraham, Eugene S Chung, Sitaramesh Emani, Ankit Bhatia, Gregory Egnaczyk, Santosh Sanganalmath, Luke Roberts, Timothy D Henry

Heart failure (HF) remains a leading cause of morbidity and mortality with significant residual risk despite major advances in medical therapies. Development of cardiotropic vectors have allowed gene therapy to be revisited to target the molecular roots of (HF) to potentially improve structural cardiac remodeling and cardiac contractility on top of functional improvement offered by current standard of care therapies. In a first-in-human phase 1 trial, a cardiotropic vector gene AB-1002 targets a phosphorylation pat …

19.08.2026journal-article

Frontiers in Medicine

Application of Home-based extended care based on cloud follow-up in postoperative rehabilitation of lower extremity arteriosclerosis obliterans

Yuandan Huang, Yanjun Zhang, Yang Xu, Peng Wang

Objective To explore the application effect of Home-based extended care based on cloud follow-up in the postoperative rehabilitation of lower limb arteriosclerosis obliterans and provide a reference for postoperative rehabilitation of lower limb arteriosclerosis obliterans. Methods This study employed a prospective cohort study design. 110 patients with lower extremity arteriosclerosis obliterans who underwent interventional treatment were selected and divided into a control group ( n = 52) and an experimental grou …

19.08.2026journal-article

Journal “Ukrainian sense”

«ТРИ ПОБАЖАННЯ» Е.МАКРОНА В НОВОРІЧНІЙ ПРОМОВІ 2025 РОКУ: СЕМІОТИКО-НАРАТИВНИЙ АСПЕКТ

І. Кірковська

Постановка проблеми. Стаття присвячена дослідженню трансформацій у парадигмі політичної комунікації Франції на межі 2025–2026 років. У центрі уваги – феномен «макронізму» як стратегічного наративу, що в умовах глобальної нестабільності еволюціонує від технократичного дискурсу до формату ідеологічного маніфесту. Проблема полягає в дешифруванні прихованих технік переконання, що дозволяють владному суб’єкту мобілізувати суспільство через традиційні ритуальні тексти, зокрема новорічні звернення. Мета дослідження поляга …

19.08.2026journal-article

Blood Advances

American Society of Hematology 2026 Guidelines for Immune Thrombocytopenia (ITP): Initial and Second-Line Therapy in Adults with Primary ITP

Adam Cuker, Deirdra R Terrell, Honieh Sowdagar, Donald M Arnold, Sylvain Audia, James B. Bussel, Tomas Jose Gonzalez-Lopez, Rachael F. Grace, Camila Masias, Keith R. McCrae, Mirjana Mitrovic, Cindy E. Neunert, Sandhya Ramanathan Panch, Surbhi Shah, Brenda G Shy, Jessica VandeVelde, Douglas B. Cines, Sara K Vesely

Background: Since publication of the American Society of Hematology 2019 Guidelines for Immune Thrombocytopenia (ITP), new clinical trials have been completed and new treatments have become available. Objective: These evidence-based guidelines from the American Society of Hematology (ASH) are a focused update of the 2019 ASH ITP guidelines, centering on treatment of adults with primary ITP. Methods: ASH formed a multidisciplinary guideline panel including two patient representatives that was balanced to minimize po …

19.08.2026journal-article

Frontiers in Psychiatry

Effects of visual art therapy on cognitive function in older adults: a systematic review and meta-analysis

Zhenhua Guo, Yingcong Liu, Shan Zhu, Yupeng He

Objective To systematically review the evidence on the effects of visual art therapy on global cognitive function in older adults, and to examine its impact on verbal fluency, naming ability, and activities of daily living. Methods A systematic search was conducted in PubMed, Web of Science, Embase, the Cochrane Library, China National Knowledge Infrastructure (CNKI), the Chinese Biomedical Literature Database, Wanfang Database, and VIP Database for randomized controlled trials (RCTs) published from database incept …

19.08.2026journal-article

JOURNAL OF HUMANITIES AND SOCIAL POLICY

Effectiveness of REBT and CBT in Managing Drug Abuse Among Clients in NDLEA Rehabilitation Centers, Abuja, Nigeria

Fatima Abiola Popoola

This study examined the effectiveness of Rational Emotive Behavior Therapy (REBT) and Cognitive Behavioral Therapy (CBT) in managing drug abuse among clients in the National Drug Law Enforcement Agency (NDLEA) Rehabilitation Centre, Abuja, Federal Capital Territory. The study was guided by three research questions and three hypotheses and adopted a quasi-experimental, non-randomized pretest–posttest research design. The population comprised drug users undergoing rehabilitation at the NDLEA Centre, Abuja. A sample o …

19.08.2026journal-article

JAMA

Arginine Therapy for Sickle Cell Disease Acute Pain Episodes

Claudia R. Morris, Dunia Hatabah, Rawan Korman, Fahd A. Ahmad, Gladstone Airewele, Bolanle Akinsola, Noor Alzraikat, Nitya Bakshi, David C. Brousseau, Kathleen Brown, Andrew D. Campbell, T. Charles Casper, Todd P. Chang, Corrie E. Chumpitazi, Daniel Cohen, Keli D. Coleman, Laura Covelo, Andrea T. Cruz, Christopher Denton, Angela M. Ellison, Melanie Fields, Hailey Jensen, Sara Leibovich, Chris A. Rees, Allison Remiker, Nidhi Singh, Alexis Thompson, Elliott Vichinsky, Anthony Villella, Hagar Wilkinson, Bridget Wynn, Carlton Dampier, Pediatric Emergency Care Applied Research Network (PECARN)

Importance Acute pain episodes are the leading cause of emergency department visits and hospitalizations for patients with sickle cell disease (SCD), yet US Food and Drug Administration–approved drugs for acute pain episodes are lacking. During acute pain episodes, patients develop acute arginine deficiency associated with longer time to crisis resolution and greater total parenteral opioid use. Multiple single-center, phase 2 randomized clinical trials have shown that arginine is safe, is opioid sparing, improves …

19.08.2026journal-article

FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology

Comparative efficacy and safety of prolgolimab and nivolumab in first-line therapy for metastatic or unresectable melanoma: a systematic review, matching-adjusted indirect comparison, and cost-effectiveness analysis

I. A. Utyashev, I. V. Myslevtsev, O. N. Mironenko, V. D. Batorova, K. A. Katilova, K. V. Sapozhnikov, N. A. Sableva, A. A. Lazarev, D. G. Tolkacheva

Background . Metastatic and unresectable cutaneous melanoma (MM/uRCM) is an aggressive malignancy associated with high mortality due to its pronounced metastatic potential. Immune checkpoint inhibitors are used to treat MM/uRCM in the Russian Federation. These inhibitors include nivolumab and prolgolimab, which block the programmed cell death 1 (PD-1) receptor. However, there are no direct comparative data on their clinical and economic efficacy and safety as monotherapy, which complicates optimal therapeutic decis …

19.08.2026journal-article

Occupational Medicine

Occupational anaphylaxis induced by beta-lactam antibiotics exposure in a nurse

M Areia, C Coelho, P Barreira, J Q Gomes

Summary Healthcare workers are exposed to substances that may elicit allergic and irritant reactions, including anaphylaxis, a potentially life-threatening hypersensitivity reaction. We report the case of a nurse with pre-existing hand contact dermatitis who presented anaphylaxis following exposure to ceftriaxone and piperacillin/tazobactam during drug preparation. Diagnostic testing confirmed an allergy to both antibiotics and latex. The absence of prior therapeutic exposure, combined with skin barrier impairment …

19.08.2026journal-article

Frontiers in Psychology

Psychological rehabilitation of women with endometrial cancer: dynamics of quality of life after psychotherapeutic intervention depending on the type of surgical treatment

Ayazhan Janbayeva, Aliya Uteulova, Piko Bettina, Marat Assimov, Fatima Bagiyarova

Endometrial cancer is the most common gynecological malignancy among women, and its incidence has increased considerably over recent decades. Surgical treatment, chemotherapy, radiotherapy, and hormone therapy are frequently associated with psychological distress, impaired social functioning, and reduced quality of life. The present study aimed to examine changes in quality of life among women with endometrial cancer across different stages of treatment and rehabilitation, as well as to assess changes associated wi …