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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Journal of Palliative Medicine

Cost Implication of a Community-Based Pediatric Palliative Care Program

Ying (Elaine) Wang, Wenyun Yang, Megan Young, Kerri Padgett, Elaine Gabovitch, Ning Zhang, Jianying Zhang, Scot T. Bateman

Background: Massachusetts’ Pediatric Palliative Care Network (PPCN) program provides community-based pediatric palliative care (CBPPC) to children with life-limiting conditions and their families. PPCN offers comprehensive clinical services, integrative therapies, and case management. Objectives: This study explores whether PPCN can maintain or reduce health care utilization and costs. Design: PPCN children were compared with a propensity score matched group. Bivariate and regression analyses were conducted to comp …

27.08.2026journal-article

International Journal of Reproduction, Contraception, Obstetrics and Gynecology

Polycystic ovarian syndrome: an updated review of pathophysiology, clinical features, biomarkers, and management

Blessy S. Joseph, Dineshkumar B., K. Krishna Kumar

Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine and metabolic disorders affecting women of reproductive age and represents a major global public health challenge. PCOS is a heterogeneous condition characterized by reproductive dysfunction, hyperandrogenism, insulin resistance (IR), and metabolic abnormalities, frequently accompanied by psychological distress that significantly reduces quality of life. Despite its high prevalence, diagnosis, treatment, and long-term management remain challeng …

27.08.2026journal-article

Journal of Internal Medicine

Hypocholesterolemia in liver and cardiovascular disease: Friend or foe?

Valentina Flagiello, Emelie Barreby, Umberto Vespasiani‐Gentilucci, Stefano Romeo

Abstract Hypocholesterolemia is perceived as benign given its association with lower cardiovascular risk. However, genetic and epidemiological evidence indicates that persistently low levels of low‐density lipoprotein cholesterol (LDL‐C) and apolipoprotein B (ApoB) arise from distinct biological mechanisms with different hepatic implications. Hypocholesterolemia may reflect either impaired hepatic assembly and secretion of ApoB‐containing lipoproteins or enhanced peripheral clearance of circulating lipoproteins, wi …

27.08.2026journal-article

Clinical Cancer Research

A Phase 1 First-Time-in-Human, Open-Label Study of Nelistotug Administered to Patients with Advanced Solid Tumors

Lillian L. Siu, Omid Hamid, Reva Schneider, Jordi Rodon. Ahnert, Scott A. Laurie, Frank Stephen. Hodi, Dong-Wan Kim, Myung-Ju Ahn, Gary Carlson, Hussein Assi, Hamza Khan, Patrick Hanafin, Emily Moore, Madhu Ramaswamy, Reza Mozaffari, Stefan Zajic, Arindam Dhar, Ivan Diaz Padilla, Noboru Yamamoto

Abstract Purpose: This first-in-human, nonrandomized, multicenter study investigated nelistotug (anti-CD96 monoclonal antibody [mAb]) as monotherapy (Arm A) and in combination with dostarlimab (anti-PD-1 mAb) (Arm B), and dostarlimab plus belrestotug (anti-TIGIT mAb) (Arm F) in patients with recurrent or advanced solid tumors. Patients and Methods: Patients received intravenous doses every 3 weeks of nelistotug 2.1–1400 mg, nelistotug 70–1400 mg plus dostarlimab 500 mg, or nelistotug 1400 mg plus dostarlimab 500 mg …

27.08.2026journal-article

Vascular Medicine

Impaired acute metabolic responses to submaximal exercise in peripheral artery disease (PAD)

Lei Wang, Qian Zhu, Hongping Han, Huan Liu, Jin Wang

Background: Peripheral artery disease (PAD) is a prevalent manifestation of systemic atherosclerosis and is associated with substantial morbidity, impaired functional capacity, and adverse cardiovascular outcomes. Although reduced walking performance is a defining clinical feature of PAD, the underlying biological responses to acute physiological stress remain poorly understood. Methods: We conducted a prospective observational study including 35 patients with PAD and 36 control participants. All participants’ seru …

27.08.2026journal-article

Visualization in Medicine

Оценка эффективности алгоритмов глубокого обучения для выявления признаков spina bifida occulta на рентгенограммах позвоночника

Вероника Евгеньевна Казаринова, Андрей Сергеевич Гацук, Кирилл Михайлович Арзамасов, Юрий Александрович Васильев

Введение. Spina bifida occulta — скрытый порок развития позвоночника, часто остающийся недиагностированным до появления неврологических симптомов. Разработка системы автоматизированного выявления данной патологии на рентгенограммах с использованием нейросетей требует обоснованного выбора архитектуры, обеспечивающей оптимальную диагностическую точность. Цель исследования — оценить эффективность алгоритмов глубокого обучения (Res Net50, Efficient Net-B7, RT-DETR-L, YOLO версий 8–12) для выявления признаков spina bifi …

27.08.2026journal-article

Journal of Oncology Pharmacy Practice

Pharmaceutical care in patients with gastric cancer treated with capecitabine: A randomized clinical trial

Patrícia Kaiser Pedroso Cava, Camille Nigri Cursino, Larissa Dos Santos Sebould Marinho, Ana Clara Duarte Dos Santos, Ariela Dutra Norberto De Oliveira, Larissa Rodrigues Nascimento, Vanessa Cristiane Da Silva Ferreira, Dulce Helena Nunes Couto, Jessica Pronestino De Lima Moreira, Thaísa Amorim Nogueira, Selma Rodrigues De Castilho, Sabrina Calil-Elias

Introduction Cancer poses a major challenge to global health, impacting individuals, communities and societies worldwide. A significant proportion of global morbidity and mortality from neoplasms is accounted for by gastrointestinal tumors, due to their high incidence and lethality. Capecitabine, an oral antineoplastic agent, has brought advances in treatment, but requires caution regarding adherence and adverse events. In this context, it is believed that pharmaceutical care can significantly contribute to optimiz …

27.08.2026journal-article

JAMA Otolaryngology–Head & Neck Surgery

Necrotic Nasal Lesion in a Woman Without a History of Immunodeficiency

Jun Yun, Alice C. Yu, Chau T. Nguyen

A 51-year-old woman presented with a 2-month progressively enlarging right nasal lesion and 1 week of painful oral lesions limiting her oral intake. She also noted painful, erythematous nodules on her arms and hands. What is your diagnosis?

27.08.2026journal-article

Military Medicine

Upper Limb Disability in Men with Combat-Related Upper Limb Injury, 8 Years Post-Injury: The ADVANCE Cohort Study

Helena Macdonald, Fraje Watson, Susie Schofield, Alexander N Bennett, Christopher J Boos, Paul Cullinan, Harriet Kemp, Nicola T Fear, Anthony M J Bull

Abstract Introduction Upper limb (UL) injuries place a considerable economic and readiness burden on the military. Long-term outcomes of UL combat-related injuries have not been examined to the same extent as those of lower limb injuries. Specifically, a better understanding of long-term outcomes following non-amputation UL injuries is essential given the crucial role of the ULs in daily activities and quality of life. This study will compare UL disability in (1) participants with UL combat injury, non-UL combat in …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Double-chambered left ventricle with advanced biventricular failure: a case report

Guiping Peng, Xiang Wang, Cailing Chen, Miao Dai

Background Double-chambered left ventricle (DCLV) is an extremely rare congenital anomaly characterized by an aberrant muscular or fibromuscular septum dividing the left ventricular cavity. Most cases present in childhood or adolescence. Adult presentations are exceptional, particularly when complicated by severe valvular dysfunction and advanced heart failure. Case summary A 50-year-old male with longstanding atrial fibrillation presented with one month of exertional chest tightness and progressive dyspnea, includ …

27.08.2026journal-article

Frontiers in Medicine

Efficacy evaluation of acupuncture combined with manipulation for lateral epicondylitis: a meta-analysis

Jing Yin, Guangjun Tang, Baoli Zhao, Yuyang Zhang, Gang Bai, Liyong Liu, Chunli Chi, Wang Hongdong

Objective To systematically evaluate the efficacy of acupuncture combined with manipulation for relieving pain and improving function in patients with lateral epicondylitis (LE). Methods Randomized controlled trials (RCTs) involving patients with LE were retrieved from eight Chinese and English databases from inception to January 1, 2026. The risk of bias of the included studies was assessed using the Cochrane Risk of Bias tool. Meta-analysis was performed using RevMan 5.4.1 software. The main outcomes included cli …

27.08.2026journal-article

Frontiers in Endocrinology

Case Report: Pasireotide treatment in neonatal congenital hyperinsulinism due to a homozygous ABCC8 mutation

Calvin Kurz, Marcia Roeper, Lisa Friesl, Ertan Mayatepek, Thomas Meissner, Sebastian Kummer, Henrike Hoermann, Alena Welters

Mutations in ABCC8 and KCNJ11 are associated with the most severe and diazoxide-resistant forms of congenital hyperinsulinism (CHI). Somatostatin analogues are commonly used off-label as second-line treatment. While octreotide and lanreotide are the most established options, pasireotide—a second-generation somatostatin analogue with higher affinity for somatostatin receptor subtype 5—has been hypothesized to offer improved suppression of insulin secretion. We report the off-label use of subcutaneous pasireotide in …

27.08.2026journal-article

Frontiers in Cellular and Infection Microbiology

A multidimensional nomogram for clinical risk stratification of bloodstream infection and mortality in hematologic malignancies

Lingqiong Lan, Shaozhen Chen, Haojie Zhu, Jixin Fan, Hui Kong, Jinhua Ren, Jianda Hu, Ting Yang

Background Bloodstream infections (BSIs) are serious complications in patients with hematologic malignancies (HMs) and are associated with substantial morbidity and mortality. Effective risk stratification is crucial for optimizing empirical antimicrobial decisions. This study aimed to develop and internally validate nomograms for predicting BSI occurrence and post-BSI mortality among HM patients. Methods This retrospective cohort study enrolled 3,014 HM patients, including 725 with BSI. The cohort was randomly div …

27.08.2026journal-article

Clinical Transplantation

Antithymocyte Globulin Induction Dosed on Ideal Body Weight: Absolute Lymphocyte Count (ALC) Depletion in Kidney Transplant Recipients with and without Obesity

Richard Ramos, Scott T. Benken, Jamie J. Benken

ABSTRACT Objective This study evaluated weight‐based dosing of antithymocyte globulin, or ATG, using ideal body weight (IBW) in kidney transplant patients with and without obesity. Methods This was a single‐center, retrospective cohort study of adult kidney transplant recipients who received ATG for induction from 8/2022 to 8/2023. Patients were divided into groups based on obesity status (i.e., body mass index [BMI] ≥ 30). The primary comparative endpoint was the average absolute lymphocyte count (ALC) across post …

27.08.2026journal-article

Cancers

Personalized Oncology: Organizing Cancer Treatment Around Patient Biology

Julianna Lisziewicz, Oliver Wueseke, Franco Lori

Clinical guidelines remain the foundation of evidence-based oncology, translating population-derived evidence into treatment recommendations for defined patient groups. However, patients with rare cancers, complex tumor biology, or treatment-refractory disease may reach a point at which applicable evidence is limited, or guideline-recommended treatment options have been exhausted. We propose Personalized Oncology as a complementary framework for treatment selection in these situations. Rather than asking only which …

27.08.2026journal-article

Journal of Clinical Medicine

MRI-Derived Scapular Superomedial Angle and Acromial Morphology: A Retrospective Cross-Sectional Reliability and Morphometric Association Study

Sami Kandefer, Volkan Gür, Mehmet Burak Gökgöz, Muhammet Ali Can, Metin Taş, Kemal Buğra Memiş, Mecit Kantarcı, Nizamettin Koçkara, Furkan Yapıcı

Background/Objectives: The magnetic resonance imaging (MRI)-derived scapular superomedial angle (SMA) may serve as a continuous descriptor of scapular geometry. We evaluated whether SMA is associated with acromial morphology, examined SMA and subacromial space (SAS) across acromial categories, and quantified measurement reliability. Methods: In this retrospective cross-sectional study, 306 shoulders from 279 patients (27 bilateral) were analyzed after screening 353 examinations. SMA and SAS were measured independen …

27.08.2026journal-article

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

Personalized ECG-based artificial intelligence models for early seizure prediction

Harilal Parasuram, Mridul Sharma, Gowtham Smitha, Harisankar R. Menon, Siby Gopinath, Akshaya Raman, Sonu Ravindran, Arjun Ramakrishnan, Garima Chauhan, Priya Bhasimon, Anand Kumar

Seizure prediction is critically important, as it can help prevent serious injuries, improve quality of life, and potentially reduce the risk of SUDEP. Autonomic fluctuations are known to occur during the preictal and early ictal phases; however, the pattern and magnitude of these changes vary considerably across patients and seizure types. This highlights the need for developing patient-specific ECG-based seizure prediction models. In this study, ECG data from 30 patients who had at least six recorded seizures dur …

27.08.2026journal-article

American Journal of Health-System Pharmacy

Improving patient safety with triple-scan technology for insulin pen administration

Courtney K Wulffson, Melissa M Babin, Merissa T Andersen Pinotti

Abstract Purpose High-alert medications such as insulin pose serious risks to patients when used in error. In response to vulnerabilities identified in existing insulin administration workflows, we implemented a comprehensive approach to mitigate the risk of errors in the hospital setting. Summary A new electronic health record capability, referred to as the “triple-scan system,” was introduced to enhance insulin pen administration safety. This system requires nurses to scan the patient’s wristband barcode, the ins …

27.08.2026journal-article

Magnetic Resonance in Medicine

Clinical Soma and Neurite Density Imaging ( SANDI ): Translational Microstructure Mapping on Clinical 3T MRI Scanners

Hansol Lee, Kwok‐Shing Chan, Yixin Ma, Dongsuk Sung, Sohyun Han, DongKyu Lee, Eva A. Krijnen, Laleh Eskandarian, Aneri Bhatt, Julianna Gerold, HyungJoon Cho, Susie Y. Huang, Hong‐Hsi Lee

ABSTRACT Purpose The Soma and Neurite Density Imaging (SANDI) model enables characterization of gray matter (GM) microstructure by estimating soma and neurite signal fractions, but its clinical applicability is limited by the need for multi‐shell acquisitions (at least five b ‐values up to 6000 s/mm 2 ), requiring high‐gradient MRI systems. We developed a clinically feasible SANDI model that reduces data requirements and model complexity while preserving sensitivity to cellular‐level microstructural features. Metho …

27.08.2026journal-article

Journal of Clinical Medicine

Mid to Long-Term Outcomes of Low-Energy Selective Laser Trabeculoplasty for Primary Open Angle Glaucoma

Hinako Ohtani, Yuri Fujino, Keigo Takagi, Yuto Yoshida, Chisako Ida, Kana Murakami, Mizuki Koike, Masaki Tanito

Background/Objectives: To evaluate the mid- to long-term outcomes of selective laser trabeculoplasty (SLT) performed with lower energy (≤0.5 millijoules (mJ)) than conventional settings (0.6–1.2 mJ). Methods: This retrospective chart-review study included patients who underwent low-energy SLT (0.34 ± 0.06 mJ) at Shimane University Hospital from April 2018 onward. A total of 54 patients (99 eyes) were analyzed, with a mean follow-up period of 57.5 months and a maximum follow-up period of 114 months. Treatment failur …

27.08.2026journal-article

The Clinical Journal of Pain

The Role of Stress-related Biomarkers, Immune-inflammatory Pathways, and Genetic Polymorphisms in Cognitive-behavioral Therapies for Chronic Low Back Pain and Depression

Adrián Pérez-Aranda, Carla Rodríguez-Freire, Juan P. Sanabria-Mazo, Albert Feliu-Soler, Mar Grasa, Albert Carrillo, Montserrat Esteve, Oriana Filluelo, Araceli Rosa, Ariadna Colomer-Carbonell, Patricia Mas-Bermejo, Lance M. McCracken, Xavier Borràs, Juan V. Luciano

Objectives: This study aimed to (a) evaluate the effects of Acceptance and Commitment Therapy (ACT) and Behavioral Activation Therapy for Depression (BATD) on immune-inflammatory biomarkers in patients with chronic low back pain and comorbid depression, and (b) explore whether these biomarkers and genetic polymorphisms in BDNF and FKBP5 predict treatment response. Methods: A total of 114 female participants (mean age=57.5 y) were randomized to a group-based therapy delivered via videoconference (ACT or BATD, both a …

27.08.2026journal-article

International Journal of Clinical Oncology

Proteinuria as the cause of early dose modification in Japanese patients with metastatic colorectal cancer treated with fruquintinib: a multicenter real-world study

Shohei Udagawa, Chihiro Ishizuka, Hiroki Osumi, Toshiharu Hirose, Natsuko Okita, Hidekazu Hirano, Hirokazu Shoji, Ken Kato, Koichiro Yoshino, Keitaro Shimozaki, Shota Fukuoka, Takeru Wakatsuki, Mariko Ogura, Akira Ooki, Keisho Chin, Kensei Yamaguchi, Atsuo Takashima, Eiji Shinozaki

Abstract Background Fruquintinib has demonstrated survival benefits in patients with previously treated metastatic colorectal cancer (mCRC) in phase III trials. However, real-world data in Japanese patients remain limited. This study evaluated the effectiveness and safety of fruquintinib in routine clinical practice. Methods We conducted a retrospective observational study at two cancer centers. Patients treated with fruquintinib for mCRC between November 2024 and December 2025 were included. Clinical outcomes and …

27.08.2026journal-article

British Journal of Clinical Pharmacology

Acute effects of THC and a CBD+THC combination on cardiovascular haemodynamics and respiratory muscle activity during loaded breathing in healthy adults: A randomized placebo‐controlled crossover study

Edna Karla Ferreira Laurentino, Marina Lyra L. C. Fagundes, Bruno Lobão Soares, Rodrigo Torres‐Castro, Matias Otto‐Yañez, Emerson Arcoverde Nunes, Matheus Freitas Fernandes Pedrosa, Jéssica Danielle Medeiros da Fonsêca, Vanessa R. Resqueti, Guilherme Augusto de Freitas Fregonezi

Aims This study aimed to evaluate the acute effects of cannabidiol plus tetrahydrocannabinol (CBD+THC) and tetrahydrocannabinol (THC) oils on cardiovascular haemodynamics, respiratory muscle activity and peripheral tissue perfusion in healthy adults. Methods In this randomized, double‐blind, crossover trial, participants received orally administered CBD+THC oil (12.5 mg + 12.5 mg), THC oil (12.5 mg) or placebo. Cardiovascular haemodynamics, respiratory muscle electromyography and peripheral tissue perfusion were ev …