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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

Journal of Neuro-Oncology

Subperineural ‘onion-peeling’ dissection for maximizing extent of resection and facial nerve preservation for onco-functional balance in vestibular schwannoma surgery

James K. Liu, Ahmed Sabra, Yaxel Levin-Carrion, Caryn J. Ha, Sraavya Anne, Arevik Abramyan, Vicente Rojas-Navas, Kevin Wong, Yu-Lan Mary Ying, Robert W. Jyung

Abstract Introduction Planned subtotal resection (STR) of vestibular schwannomas (VS) followed by stereotactic radiosurgery (SRS) has gained popularity for minimizing facial nerve injury. However, recurrence risk correlates with residual tumor volume, and long-term outcomes remain unknown. The authors report their facial nerve outcomes with planned maximal safe resection using a facial nerve-sparing subperineural “onion-peeling” technique, and compare their outcomes to those of the hybrid STR-SRS approach. Methods …

25.08.2026journal-article

Current Oncology Reports

Head and Neck Rhabdomyosarcoma in Children: An Otolaryngological Perspective on Diagnostic and Therapeutic Approaches

Agata Wojno, Milena Chmielewska, Sara Shefa, Oliwia Cichy, Paulina Lenkiewicz, Karolina Dorobisz

Abstract Purpose of Review Head and neck rhabdomyosarcoma (HNRMS) is the most common soft-tissue sarcoma in children, with approximately 30–40% of cases arising in the head and neck region. Due to its anatomical complexity, histopathological diversity, and molecular heterogeneity, HNRMS remains a major diagnostic and therapeutic challenge in pediatric otolaryngology. This review aims to summarize current evidence regarding the epidemiology, clinical presentation, diagnostic strategies, contemporary treatment modali …

25.08.2026journal-article

The Laryngoscope

MDADI as a Screening Tool for VFSS ‐Graded Swallowing Impairment in Head and Neck Cancer Patients

Zachary G. Brumm, Eric A. Anyimadu, Meera Kohli, Jennifer Silver, Beatrice Manduchi, Katherine Hutcheson, Arushi Gulati, G. Elisabeta Marai, Tyler W. Crosby, Clark A. Rosen, VyVy N. Young, Guadalupe Canahuate, Yue Ma

ABSTRACT Objectives To determine clinically useful MD Anderson Dysphagia Inventory (MDADI) thresholds associated with Videofluoroscopic swallow study (VFSS)‐graded swallowing impairment in head and neck cancer (HNC) patients and to explore whether a reduced‐item MDADI could preserve discrimination while minimizing patient burden. Methods This retrospective cross‐sectional study analyzed HNC patients from a prospectively maintained dysphagia surveillance program who completed the MDADI within 120 days of VFSS. Assoc …

25.08.2026journal-article

Frontiers in Oncology

MicroRNA-phytochemical interactome targeting thioredoxin-interacting protein: a narrative review at the nexus of RNA therapeutics, cancer biology, and metabolic regulation

Peter Chinedu Agu, Patrick Maduabuchi Aja, Cecilia Ogechi Ofor, Kehinde Ross, Jun Lu

MicroRNAs (miRNAs) are increasingly recognized as central regulators of gene expression, cellular adaptation, and disease progression. This is fundamentally reshaping current understanding of disease molecular pathogenesis and therapeutic intervention. Beyond their established roles in development and metabolism, miRNAs actively participate in oncogenesis, metabolic dysfunction, inflammation, and redox homeostasis. Emerging evidence shows that phytochemicals can modulate miRNA-mediated regulatory networks by influe …

25.08.2026journal-article

BMC Cancer

Photon irradiation prompts autophagy in anaplastic thyroid cancer

Sabine Wächter, Franziska Knauff, Silvia Roth, Norman Krasser-Gercke, Katrin Roth, Ali Ebrahimifard, Detlef K. Bartsch, Pietro Di Fazio

Abstract Although promising results have been obtained for anaplastic thyroid cancer (ATC) therapy, this therapy still needs to be improved. In addition to the currently approved therapies, radiotherapy alone or combined with adjuvant immunotherapy could be beneficial for patients affected by ATC. The patients affected by this aggressive solid malignancy could benefit from the modulation of autophagy in cancer cells. This study focused on detecting autophagy players in ATCs and bursting autophagy process via photon …

25.08.2026journal-article

Small

Nanomessenger‐Mediated Signal Crosstalk Encodes Multithreading Death Program Against Tumor Metastasis

Mengyang Wang, Yijing Zhang, Liqiang Wang, Yajing Han, Linghui Lv, Ziqing Xu, Henan Zhao, You‐Nian Liu

ABSTRACT The regulation of death programs is central to malignant behaviors and immune evasion of tumor cells and represents a promising therapeutic target in cancer therapy. The main challenge lies in how to utilize associated signaling among different cell death processes for amplifying antitumor effect. This study proposes an effective “signal crosstalk” strategy driven by the disruption of intracellular messenger homeostasis, which triggers concurrent death pathways and immune activation to suppress metastasis. …

25.08.2026journal-article

Psycho-Oncologie

Psychological health challenges and supportive care considerations for gynecological cancer patients during radiotherapy: a narrative review

Jun Ma, Xu Li, Xiu Yang, Muyi Zhang, Songbo Wu, Li Liu, Xueqian Ma, Panfeng Wang

Background: Gynecological cancer patients frequently experience anxiety, depression, and social isolation, particularly regarding body image, sexual health, fertility, and family roles. Radiotherapy is a central treatment modality and provides a clinically important window for psycho-oncological support. Objective: To synthesize evidence on psychological health challenges and supportive care considerations, including psychosocial interventions, for gynecological cancer patients during radiotherapy. Methods: We cond …

25.08.2026journal-article

Clinical Psychological Science

Extending Temperament-Based, Data-Driven Profiles of Attention-Deficit/Hyperactivity Disorder to Dual-Treatment-Seeking Hispanic/Latine Youths

Katherine M. Schmarder, Cameron Riopelle, Min Zhu, Stephanie S. J. Morris, Kathleen E. Feeney, Jessica N. Smith, Erica D. Musser

Attention-deficit/hyperactivity disorder (ADHD) nosology lacks biological and predictive validity, temporal stability, and ability to capture heterogeneity in emotional functioning, executive function, and/or reward sensitivity. Prior work has addressed limitations in current practice by data-driven temperament profiles (mild, surgent, irritable) in a largely White, non-Hispanic/Latine (88%), community-recruited sample. In the present study, we extend this work to a predominantly Hispanic/Latine (80%), clinically r …

25.08.2026journal-article

Recent Patents on Anti-Cancer Drug Discovery

Multi-target Drug Discovery for Cancer Therapy: A Contemporary Review

Thirumalaikumaran Rathinam, S. Pradeep Kumar Reddy, Yella Sirisha, Voleti Vijaya Kumar, Byran Gowramma, Dipen Purohit, Kaviarasan Lakshmanan

Introduction: Cancer remains one of the leading causes of mortality worldwide, with conventional therapies often limited by systemic toxicity, therapeutic resistance, and tumor heterogeneity. Multi-target drug discovery has emerged as a contemporary strategy to overcome these challenges, particularly through multi-kinase inhibitors and bispecific antibodies that simultaneously modulate multiple oncogenic pathways. Methods: This review integrates evidence from preclinical investigations, pivotal clinical trials, reg …

25.08.2026journal-article

Clinical Case Studies

A Clinical Case Study of Cognitive Behavior Therapy for Young Adult Cancer Survivors’ Psychological Distress: Utilizing the Generic Cognitive Model

Anao Zhang, Meiyan Chen, Vincent Luong

Adolescents and young adults (AYAs) diagnosed with cancer often experience psychological distress that reflects the interaction of medical uncertainty, developmental disruption, and pre-existing cognitive and coping patterns. This clinical case study illustrates the use of cognitive behavior therapy (CBT), informed by the Generic Cognitive Model, with a 23-year-old young adult survivor of Hodgkin lymphoma experiencing anxiety, depressive symptoms, fear of cancer recurrence, avoidance, and difficulty re-engaging wit …

25.08.2026journal-article

Annals of Surgical Oncology

Prognostic Factors in Patients with Peritoneal Mesothelioma Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Systematic Review and Meta-Analysis

Jan Philipp Ramspott, Anna Kolmhofer, Ibrahim Büdeyri, Michael Weitzendorfer, Stephan Regenbogen, Lukas Schabl-Cayron, Philipp Schredl, Alexander D. Bungert, Klaus Emmanuel, Dino Bekric, Jaroslav Presl, Andreas Pascher, Daniel Neureiter, Tarkan Jäger

Abstract Background Diffuse malignant peritoneal mesothelioma (DMPM) is a rare and aggressive disease in which cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has improved survival. However, recurrence rates remain high, highlighting the need for reliable prognostic factors to guide patient selection. This systematic review and meta-analysis aimed to evaluate prognostic factors in patients with DMPM undergoing CRS and HIPEC. Materials and Methods A systematic literature s …

25.08.2026journal-article

Current Oncology

Initial Experience with MR-Guided or CT-Guided Stereotactic Body Radiotherapy for Prostate Cancer

Marc Vincent N. Barcelona, Noelia Sanmamed Salgado, Enrique Gutierrez Valencia, Alejandro Berlin, Rachel Glicksman, Charles Catton, Andrew McPartlin, Jeff D. Winter, Jennifer Dang, Vickie Kong, Yangqing Deng, Peter Chung

We report early toxicity outcomes after institutional implementation of prostate SBRT using 42.7 Gy in seven fractions delivered with either MR-guided adaptive SBRT (MRgSBRT) or CT-guided non-adaptive SBRT (CTgSBRT). Between July 2019 and May 2023, 216 patients received this regimen. Genitourinary (GU) and gastrointestinal (GI) toxicities were retrospectively assessed using the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. Most patients had intermediate-risk disease (86%), and 14% had high-ris …

25.08.2026journal-article

Current Treatment Options in Pediatrics

Strategies to Improve Neurologic Outcomes in Neonatal Cardiac Surgery

Jill Hsia, Elizabeth A. Herrup, Alisa A. Burnham, Lyla Hampton, Jennifer M. Lynch, Shavonne L. Massey, Maryam Y. Naim

Abstract Purpose of Review Neonates with congenital heart disease (CHD) necessitating repair during infancy are at risk for adverse neurodevelopmental outcomes throughout their lifespan. The etiology of brain injury in this population is multifactorial and includes both modifiable and non-modifiable risk factors. We aim to review modifiable risk factors and evidence-based interventions aimed at improving short- and long- term neurodevelopmental outcomes. Recent Findings Despite increasing focus in recent years on i …

25.08.2026journal-article

Frontiers in Artificial Intelligence

Multi-modal digital twin model outperforms conventional biomarker stratification in pancreatic cancer

Matthew Griffiths, Jennifer J. Knox, Grainne M. O’Kane, Trevor J. Pugh, Julie M. Wilson, Anna Dodd, Sandra E. Fischer, Robert C. Grant, Faiyaz Notta, Steven Gallinger, Irina Babina, Andrew V. Biankin

Better patient selection for treatment is critical to improving both cancer care and therapeutic development in oncology. The ability to predict individual patient responses to cancer treatment ahead of time would transform cancer care with substantial impact on outcomes, quality of life and cost. We generated molecular digital twins of individual participants using a Bayesian foundation model of cancer (FarrSight®) in the COMPASS clinical trial (a non-randomized study of mFOLFIRINOX and gemcitabine + nab-paclitaxe …

25.08.2026journal-article

Journal of Chittagong Medical College Teachers' Association

Factors Associated With Good Outcomes Following Conservative Treatment of Cervical Spondylosis

Sakhawat Ahmed Nasir, Selina Nazir, S M Iftea Kharul Islam, Sansannu, A N M Manzurul Kader

Background: Cervical Spondylosis (CS) is a common degenerative condition that contributes substantially to chronic neck pain and functional disability. Although conservative treatment is routinely used, clinical outcomes vary widely among patients. This study aims to determine the factors associated with good outcomes following conservative management of cervical spondylosis in adults attending a tertiary-care hospital. Materials and methods: A prospective observational study was conducted among adults aged 35–70 y …

25.08.2026journal-article

Frontiers in Immunology

Microbiome-host interactions in locally advanced cervical cancer: the impact on chemoradiotherapy treatment outcomes and toxicity

Helena C. J. Schellekens, Bob J. R. Bindels, Irene Regueiro Zapico, Servaas A. Morré, Evert J. van Limbergen, Edith M. G. van Esch, John Penders, Peggy J. de Vos van Steenwijk

Cervical cancer remains one of the most common malignancies among women worldwide, and treatment of locally advanced disease is often associated with substantial toxicity that negatively affects the quality of life. Therefore, strategies aimed at improving survival while minimizing treatment-related side effects are essential. Emerging evidence suggests that the gut and vaginal microbiomes influence cervical carcinogenesis, treatment response, and treatment-related adverse effects. This narrative review aims to sum …

25.08.2026journal-article

Journal of Fatima Jinnah Medical University

Experience of Pediatric Brain Tumor Surgery at the Punjab Institute of Neurosciences, Lahore, Pakistan: A Retrospective Analysis of Outcomes and Challenges

Hassaan Zahid, Ahtesham Khizar, Asad Iftikhar, Maryem Tanweer, Zia Ul Rehman Najeeb, Haseeb Mehmood Qadri

Background: Brain tumours are the most prevalent solid cancers in children and are a significant cause of cancer morbidity. However, there is limited information on surgical outcomes in Pakistan, particularly in newly established paediatric neurosurgery units. This study aimed to determine the incidence, clinical features, imaging findings, surgical treatment and prognosis of supratentorial and infratentorial brain tumours in children.Methodology: This was a descriptive retrospective study conducted at the Punjab I …

25.08.2026journal-article

Obstetrics & Gynecology

Salpingectomy for the Prevention of Epithelial Ovarian Cancer

American College of Obstetricians & Gynecologists Committee on Clinical Consensus—Gynecology

This Clinical Practice Update provides updated information further supporting the benefit of complete, bilateral salpingectomy at the time of obstetric and gynecologic surgery and to expand the availability of salpingectomy during nongynecologic abdominopelvic surgery for the primary prevention of epithelial ovarian cancer. This document updates Committee Opinion No. 774, Opportunistic Salpingectomy as a Strategy for Epithelial Ovarian Cancer Prevention (Obstet Gynecol 2019;133:e279–84).

25.08.2026journal-article

Tikrit Journal of Pure Science

Oxidative Stress Biomarker, Protein Carbonyl, Malondialdehyde and Antioxidants Superoxide Dismutase, Catalase on Prostate Cancer in Kurdistan Region of Iraq

Gulala Abdulsalam Hamad, Musher Ismael Salih

Prostate cancer (PCa) has notably ascended to the position of the second most commonly diagnosed cancer among men. It constitutes a considerable public health issue on a global scale; typically, prostate cancer causes urological issues in aging men. This study aimed to investigate biomarkers of oxidative stress and antioxidants associated with PCa pathogenesis and their potential implications for diagnosis and treatment. The study included 100 PCa patients and 50 healthy controls and used ELISA (Enzyme-Linked Immun …

25.08.2026journal-article

Chemistry – A European Journal

Targeting Cancer Cells With Self‐Assembled Ru‐Polysaccharide Photocatalyst for Visible‐Light‐Induced Activation of Prodrugs

Jianghua Liu, Dinghao Wu, Alexander Kros, Joost N. H. Reek

ABSTRACT Chemotherapy stands out as an effective cancer treatment, although typically accompanied by side effects arising from systemic toxicity of anticancer drugs due to the limited specific targeting of tumor cells. In this study, we present a self‐assembled Ru‐based polysaccharide photocatalyst that selectively targets cancer cells and catalyzes the prodrug‐to‐drug conversion upon exposure to visible light. The self‐assembled photocatalyst forms via supramolecular interactions between β‐cyclodextrins attached t …

25.08.2026journal-article

Journal of Bone and Joint Infection

Periprosthetic fractures around chronically infected total hip arthroplasties: a case series and pragmatic two-stage treatment framework

Georges F. Vles, Willem-Jan Metsemakers, Laurens Aerden, Jan Geurts, Oliver Borens, Stijn Ghijselings

Abstract. Three periprosthetic femoral fractures around chronically infected total hip arthroplasties (THAs) were treated according to a pragmatic two-stage treatment framework. Infection control and fracture healing were achieved. This may serve as a reference for surgeons confronted with these complex and technically demanding situations.

25.08.2026journal-article

International Health Sciences Review

Hereditary ovarian cancer: BRCA-Associated risk, screening limitations, and risk-reduction strategies

Flavia Drozdz, Mateus Souza Cardoso, Natacha Carmona Cordeiro Alves, Luana Lorenski, Fernanda Tobar Lo Ré Chambray, Livia Azevedo Leonardi

Hereditary susceptibility accounts for a clinically meaningful proportion of epithelial ovarian, fallopian tube, and primary peritoneal cancers, with pathogenic variants in BRCA1 and BRCA2 producing the largest and best-characterized risks. This narrative and critical review examines how BRCA-associated risk should influence genetic identification, ovarian cancer surveillance, and preventive decision-making. Literature searches conducted in August 2026 prioritized clinical guidelines, systematic reviews, prospectiv …

25.08.2026journal-article

Academic Journal of Health

Epidemiological Characteristics and Mortality of Primary Lung Cancer Patients Admitted to the Intensive Care Unit and Undergoing Invasive Mechanical Ventilation

Hamide Gül Özdemir, Melda Türkoğlu, Şahender Gülbin Aygencel, Nazlıhan Boyacı, Kamil İnci, Sinan Özdemir

Background and Aim: Lung cancer is a leading cause of cancer-related mortality globally. Patients frequently require intensive care unit (ICU) admission and invasive mechanical ventilation (IMV) due to disease progression, organ failure, or complications. This study aimed to characterize the demographic and clinical features, survival outcomes, and prognostic factors in patients with primary lung cancer receiving IMV. Materials and Methods: This retrospective, descriptive, cross-sectional study evaluated 84 primary …