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Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
19.08.2026journal-article

JAMA Surgery

Incisional Negative Pressure Wound Therapy for Prevention of Surgical Site Infection

Shaan Patel, Shiva A. Nischal, Kush M. Kale, Akash Dubb, Srinivas K. Prasad, Daniel Refai

Importance Incisional negative pressure wound therapy (iNPWT) has been proposed as a nonantibiotic adjunct to standard dressings for preventing surgical site infection (SSI), but uncertainty remains regarding consistency across SSI subtypes and dressing-related harms. Objective To evaluate the efficacy and safety of iNPWT vs standard dressing in adults undergoing surgery. Data Sources PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched from inception through March 7, 2026. Stu …

19.08.2026journal-article

Frontiers in Neurology

Glycosylation disorders in pediatric epilepsy: pathophysiology, imaging and precision therapy

Lijuan Fan, Yajun Shen, Jianjun Wang, Jing Gan

Epilepsy is a common neurological disorder in children and about 30% of children with epilepsy develop drug-resistant epilepsy. Epilepsy resulting from genetic variations and structural brain abnormalities has been extensively studied. Based on the current evidence, however, glycosylation, a major post-translational modification on over 70% of human brain proteins, is necessary for the stability of neural networks. This article delves into the many aspects of glycosylation abnormalities in epilepsy, including impai …

19.08.2026journal-article

International Journal of Advanced Multidisciplinary Research and Studies

The Influence of Occupational Stress on Police Officers’ Accountability in Service Delivery in Nairobi City County, Kenya

Ziphorah Mulimi King’oo, Dr. Merecia Ann Sirera, John Ndikaru Wa Teresia

Occupational stress is a significant concern in policing because of the demanding nature of police work and its potential implications for professional conduct and service delivery. This study examined the perceived influence of occupational stress on police officers’ accountability in service delivery in Nairobi City County, Kenya. The study was guided by the Job Demand-Control Theory and Cognitive Behaviour Theory and employed a cross-sectional descriptive survey design. Data were collected from police officers u …

19.08.2026journal-article

Journal of Parkinson’s Disease

Rehabilitation strategies for atypical parkinsonian syndromes: A scoping review of progressive supranuclear palsy, multiple system atrophy, corticobasal syndrome, and dementia with Lewy bodies

Hikaru Kamo, Satoru Amano, Isabelle K Gerzenshtein, Dinesh K Vuddandam, Koichi Nagaki, Mai Shimizu, My-Vy Tran, Arunmozhimaran Elavarasi, Nikolaus R McFarland, Aparna Wagle Shukla

Background Rehabilitation plays a crucial role in maintaining function and independence in neurodegenerative disorders. However, evidence on its effectiveness in atypical parkinsonian syndromes including progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal syndrome (CBS), and dementia with Lewy bodies (DLB) remains fragmented. Objective This scoping review aimed to comprehensively map the literature on rehabilitation interventions for PSP, MSA, CBS, and DLB, summarize intervention types …

19.08.2026journal-article

International Journal of Molecular Sciences

The Evolution of FAP-Targeted CAR T-Cell Therapy in Solid Tumors: From Immunotherapy to Immunotheranostic Applications

Hugo Boutier, Anja Feldmann, Michael Bachmann

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment landscape of hematologic malignancies but has demonstrated limited efficacy in solid tumors, mainly due to the complex and immunosuppressive tumor microenvironment (TME). Among the strategies to overcome this challenge, targeting the tumor stroma rather than the tumor cells themselves has gained increasing interest. In this context, fibroblast activation protein alpha (FAP), a cell surface protease overexpressed by cancer-associated fib …

19.08.2026journal-article

Frontiers in Psychology

Bidirectional effects of speech and gesture: evidence from a novel levels-of-congruence paradigm

Laura Pissani, Vera Demberg

Introduction Previous research has shown that speech and gesture are integrated during comprehension, with differences in response times and electrophysiological activity observed between incongruent and congruent gesture—speech pairings. Beyond these incongruency effects, it remains unclear whether comprehenders use gestures to adapt or extend conventional interpretations for novel communicative purposes. Method The current study examined the bidirectional influence of speech and gesture by employing a novel level …

19.08.2026journal-article

International Journal of Health Sciences and Research

Retrospective Analysis of the Effectiveness and Safety of Pregabalin and Duloxetine Fixed-Dose Combination Therapy in the Management of Neuropathic Pain (RESET Study)

Nitin Kapure, Mayur Mayabhate, Akhilesh Sharma

Background: Neuropathic pain is a complex, chronic pain condition arising from somatosensory nervous system lesions or disease. Pregabalin and duloxetine are individually established pharmacological agents for neuropathic pain management; however, their combined efficacy as a fixed-dose combination (FDC) remains underexplored in real-world clinical settings. Objective: To retrospectively evaluate the effectiveness and safety of pregabalin–duloxetine FDC therapy in patients with neuropathic pain over a 3-month treat …

19.08.2026journal-article

Renal Replacement Therapy

Early serum creatinine trajectory phenotypes during the first 72 h after ICU admission and 1-year mortality in PCI-treated acute myocardial infarction: a retrospective cohort study

Hasan Burak Isleyen, Sevil Tugrul Yavuz, Sercan Bulut, Fatih Kizkapan, Cevahir Alioglu, Ali Arda Sozen, Mahsa Khanmohammadi

Abstract Background Static creatinine thresholds after percutaneous coronary intervention may miss early renal dynamics. We examined whether serum creatinine trajectory phenotypes during the first 72 h after intensive care unit admission were associated with mortality and renal outcomes in PCI-treated acute myocardial infarction. Methods We performed a retrospective cohort study using MIMIC-IV version 3.1. Adults with acute myocardial infarction who underwent percutaneous coronary intervention, had an intensive car …

19.08.2026journal-article

Cancers

First-Line Maintenance Therapy Patterns in BRCA Wild-Type, HRD-Negative or Biomarker-Unknown Advanced Epithelial Ovarian Cancer: A Five-Country European Real-World Study by APLUSA

Mario Uccello, Stergios Boussios, Christine Maï, Hilary Worton, Arthur Bazire, Bertrand de Buhren

Background/Objectives: First-line maintenance is established in advanced epithelial ovarian cancer (AEOC), but management remains uncertain for patients without a BRCA mutation or homologous recombination deficiency (HRD)-positive disease. We assessed real-world use of bevacizumab, poly(ADP-ribose) polymerase (PARP) inhibitors and active surveillance in France (FR), Germany (DE), Italy (IT), Spain (ES) and the United Kingdom (UK). Methods: Anonymised physician-reported charts were analysed from a retrospective, non …

19.08.2026journal-article

Science Translational Medicine

Carboxyl-terminal blockade of sortilin binding enhances progranulin gene therapy in a mouse model of frontotemporal dementia

Shreya N. Kashyap, Stephanie N. Fox, Vivianna R. DeNittis, Katherine I. Wilson, Nicholas R. Boyle, Mary Bullock, Aniketh S. Tadepalli, Stephanie R. Miller, Jorge J. Palop, Yohannes A. Ambaw, Tobias C. Walther, Robert V. Farese, Charles F. Murchison, Andrew E. Arrant, Erik D. Roberson

Frontotemporal dementia is commonly caused by loss-of-function mutations in the progranulin gene. Potential therapies for this disorder have entered clinical trials, including progranulin gene therapy and drugs that reduce progranulin interactions with sortilin. Both approaches ameliorate functional and pathological abnormalities in mouse models of progranulin insufficiency. Here, we investigated whether modifying the progranulin carboxyl terminus to block sortilin interactions would improve the efficacy of progran …

19.08.2026journal-article

International Journal of Language & Communication Disorders

Phonological Awareness and Nonword Repetition in Children With and Without Speech Sound Disorders: A Comparative Analysis

Özlem Icoz, Esra Özcebe

ABSTRACT Objective This study aimed to compare phonological awareness and verbal working memory skills, as measured by a nonword repetition task, in children with speech sound disorders (SSD) and typically developing peers. It also examined the relationship between these two cognitive‐linguistic abilities within each group. Methods The study included 30 children aged 4 to 6 years diagnosed with SSD and 30 age‐matched typically developing children. Participants were recruited from a clinical population and their typ …

19.08.2026journal-article

Exercise Science

Nutritional Strategies to Mitigate Muscle Loss During Rehabilitation After Sports Injuries: A Narrative Review

Kihyuk Lee, Jooyoung Kim

Sports injuries frequently involve periods of reduced activity, immobilization, or unloading that accelerate skeletal muscle loss and delay functional recovery. This narrative review synthesizes current evidence on nutritional strategies to attenuate muscle loss during sports injury rehabilitation using a muscle-centered, phase-informed, and evidence-hierarchical perspective. Current evidence regarding energy availability, protein and amino acid strategies, creatine, and omega-3 fatty acids was qualitatively synthe …

19.08.2026journal-article

World Journal of Psychiatry

Effects of cognitive behavioral therapy-based group intervention on burnout and anxiety symptoms in operating room nurses

Chun-Ling Chen, Wen-Mei Liu, Rui-Ping Cai, You-Xian Zhong, Min Liang

BACKGROUND Operating room nurses are vulnerable to burnout and mental health issues related to high-intensity workloads, the complexity of technical operations, and the immense pressure of responsibility. Although cognitive behavioral therapy (CBT) has proven effective in the treatment of burnout and anxiety, there is a dearth of systematic research on option B, CBT-based group interventions targeting operating room nurses, as well as insufficient evidence for its long-term effects. AIM To evaluate the effects of C …

19.08.2026journal-article

Journal of Medical Imaging and Radiation Oncology

Effects of Music Therapy on Physiological Indicators and Subjective Comfort in Patients Undergoing Large Medical Imaging Examinations: A Systematic Review and Meta‐Analysis

Zefang Li, Tiexiong Wu, Haina Fu

ABSTRACT Objective To systematically evaluate the effects of music therapy on physiological indicators and psychological states in patients undergoing large medical imaging examinations, providing evidence‐based support for clinical auxiliary interventions. Methods A comprehensive literature search was conducted across English and Chinese databases, including PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang Database, and VIP Database, from inception to May 2026. RCTs investigating music therapy inter …

19.08.2026journal-article

Musculoskeletal Care

Rehabilitation Experiences and Support Needs of Patients With Hemiplegic Shoulder Pain Based on the ICF Framework: A Qualitative Study

Xingyu Li, Hualu Yang, Minghong Sui, Jiaqing Liu, Xin Wang, Xiaotian Liu, Guangfa Xiang, Rui Luo, Yanhong Chen, Beirong Mo

ABSTRACT Background Hemiplegic shoulder pain (HSP) multi‐dimensionally affects the rehabilitation process of stroke survivors. Although previous literature has explored post‐stroke functional recovery, empirical qualitative investigations into the authentic rehabilitation experiences and deep care needs of this specific population during hospitalisation remain to be further elucidated. Objective Guided by the International Classification of Functioning, Disability and Health (ICF) framework, this study aimed to exp …

19.08.2026journal-article

Frontiers in Endocrinology

Elevated IGF-1 levels are associated with accelerated bone age advancement during growth hormone therapy in children: a multicenter cohort study

Jungmin Ahn, Hwalrim Jeong, Junghwan Suh, Hyun Wook Chae

Background Elevated insulin-like growth factor-1 (IGF-1) levels are associated with earlier pubertal onset and accelerated bone maturation. However, the effect of IGF-1 increases during growth hormone (GH) therapy on bone age (BA) advancement across different etiologies of short stature remains unclear. Methods This multicenter observational study included 1,944 children with idiopathic growth hormone deficiency (IGHD), idiopathic short stature (ISS), or small for gestational age (SGA) enrolled in the LG Growth Stu …

19.08.2026journal-article

Borderline Personality Disorder and Emotion Dysregulation

Understanding stakeholder views on dialectical behavior therapy for post-traumatic stress disorder: a qualitative analysis of clinician and patient experiences

Laurie Nadeau, Émiliane Larrivée, Anne-Sophie Paré, Christine Therriault, Alain Taillefer, Florence Charest, Alexandre Hudon, Félix-Antoine Bérubé, Lionel Cailhol

Abstract Background Individuals with Borderline Personality Disorder (BPD) and Complex Post-Traumatic Stress Disorder (C-PTSD) often face significant challenges in treatment due to the severity and complexity of their symptoms. Dialectical Behavior Therapy for PTSD (DBT-PTSD) is a phase-based, multicomponent psychotherapy developed to address the needs of this population. While its efficacy has been demonstrated in clinical trials, little is known about how patients and clinicians experience this treatment. Methods …

19.08.2026journal-article

American Journal for Young Scientists

Artificial Intelligence for Early Detection of Alzheimer's Disease: A Comparative Review of Speech, Neuroimaging, and EEG Biomarkers

Hudson Barber

Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia globally. Accurate and early diagnosis of AD is essential to enhance patient care and management, facilitate recruitment for clinical trials, and provide access to novel treatments at a stage when intervention may have greater potential benefit. However, the early detection of AD before obvious clinical symptoms have emerged is challenging. Firstly, there is no unique, widely available screening test for early dia …

19.08.2026journal-article

Cancers

B Cell Aplasia Following CAR T Cell Therapy: Incidence, Kinetics, Prognostic Implications, and Clinical Management

Malak Khalifeh, Malini Surapaneni, Huda Salman

B cell aplasia (BCA), the sustained depletion of circulating CD19-positive B cells, is the defining on-target, off-tumor consequence of anti-CD19 chimeric antigen receptor (CAR) T cell therapy. Despite its occurrence across all approved CAR T cell products and all responding patients, BCA has not been systematically reviewed as a standalone clinical and biological phenomenon. This review synthesizes data from landmark trials and real-world cohorts across B cell-acute lymphoblastic leukemia (B-ALL), large B cell lym …

19.08.2026journal-article

International Journal of Veterinary Medicine

Rationale for the use of testicular hyaluronidase in the therapy of bovine mastitis

S. V. Nikolaev, A. A. Zalevskiy

The study evaluated the effectiveness of testicular hyaluronidase in the treatment of mastitis in cows. The research was conducted on Holstein animals with recurrent catarrhal inflammation of one udder quarter (more than twice per lactation). All animals (n=20) underwent therapy, which included a supramammary novocaine block and an injection of an anti-inflammatory agent on the first day of treatment, as well as intracisternal administration of the drug «Mastiet Forte» until clinical recovery. The experimental grou …

19.08.2026journal-article

Radiation Protection Dosimetry

Occupational effective doses for regional and university hospitals in Albania (2021–2025): optimization and statistical analysis

Ervis Gega, Elida Bylyku, Elda Spahiu, Brunilda Daci, Klaudia Kaçori

Abstract The Institute of Applied Nuclear Physics conducts periodic monitoring of doses for occupationally exposed workers in Albania. This is the first study in Albania that includes all regional and university hospitals in the country. Measurements are carried out in 2-month periods using thermoluminescent dosemeters composed of LiF:Mg,Ti crystals which are measured with the Harshaw 6600 and Harshaw 4500 reader. The results indicate that the average dose for the years 2021 to 2025 is 0.62 mSv y−1 and collective a …

19.08.2026journal-article

Advanced Materials

Machine Learning‐Based Screening of Optimal miRNA Targets Enabled by a Cytosolic Delivery Carrier for Augmenting Cancer Therapy

Hang Xu, Pengxiang Min, Yanbin Fu, Ge Sun, Hui Wu, Mengqiao Pan, Chaoxian Zhao, Jiatong Li, Ying Wu, Ying Xu, Bin Gu, Jiahua Pan, Lin Zhang, Peifeng Liu

ABSTRACT Nucleic acid therapeutics offer promise for precision cancer treatment, but are limited by inaccurate target selection and inefficient delivery. This work presents a therapeutic platform combining dual machine learning models (LASSO and RSF)‐based miRNA target screening with a modular biomimetic nanocarrier system. Systematic screening and experimental validation identify miR‐873 as a previously uncharacterized tumor‐suppressive miRNA in prostate cancer, and miR‐20a as oncogenic. Mechanistic studies reveal …

19.08.2026journal-article

Antibiotics

Does a Loading Dose Improve Outcomes? Colistin Therapy for Urinary Tract Infections Caused by Multidrug-Resistant Gram-Negative Bacteria

Wasan Katip, Puntapong Taruangsri, Siriporn Okonogi, Shaun Wen Huey Lee, Ajaree Rayanakorn

Background: Colistin remains an important therapeutic option for complicated urinary tract infections (cUTIs) caused by multidrug-resistant Gram-negative bacteria. A loading dose is often recommended to rapidly achieve steady-state plasma concentrations, but its clinical benefit specifically for cUTIs, where local urinary drug concentrations markedly exceed plasma levels, remains unclear. Methods: We conducted a retrospective cohort study of adult patients treated with intravenous colistin for cUTIs at Nakornping H …