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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

Obstetrics & Gynecology

Salpingectomy for the Prevention of Epithelial Ovarian Cancer

American College of Obstetricians & Gynecologists Committee on Clinical Consensus—Gynecology

This Clinical Practice Update provides updated information further supporting the benefit of complete, bilateral salpingectomy at the time of obstetric and gynecologic surgery and to expand the availability of salpingectomy during nongynecologic abdominopelvic surgery for the primary prevention of epithelial ovarian cancer. This document updates Committee Opinion No. 774, Opportunistic Salpingectomy as a Strategy for Epithelial Ovarian Cancer Prevention (Obstet Gynecol 2019;133:e279–84).

25.08.2026journal-article

Frontiers in Immunology

Microbiome-host interactions in locally advanced cervical cancer: the impact on chemoradiotherapy treatment outcomes and toxicity

Helena C. J. Schellekens, Bob J. R. Bindels, Irene Regueiro Zapico, Servaas A. Morré, Evert J. van Limbergen, Edith M. G. van Esch, John Penders, Peggy J. de Vos van Steenwijk

Cervical cancer remains one of the most common malignancies among women worldwide, and treatment of locally advanced disease is often associated with substantial toxicity that negatively affects the quality of life. Therefore, strategies aimed at improving survival while minimizing treatment-related side effects are essential. Emerging evidence suggests that the gut and vaginal microbiomes influence cervical carcinogenesis, treatment response, and treatment-related adverse effects. This narrative review aims to sum …

25.08.2026journal-article

Biosensors

Label-Free Refractive-Index-Based Detection of Breast, Leukemia, and Prostate Cancer Cells Using a Tetra-Core PCF SPR Biosensor

Amit Kumar Shakya, Mantas Grigalavičius

In this research, a high-performance plasmonic refractive index (RI) biosensor based on an external metal deposition (EMD) technique and photonic crystal fiber (PCF) platform for potential cancer detection is presented, investigated, and linked with real-time cancer cells. Variations in the RI of biological fluids are closely associated with pathological conditions, including cancer, due to changes in cellular composition and biomolecular concentration. The proposed tetra-core PCF–SPR biosensor operates within the …

25.08.2026journal-article

Almanac of Clinical Medicine

Diagnostic value of tissue mRNA and microRNA expression profiles for differentiating pancreatic cancer from chronic pancreatitis: A pilot study

Olga A. Freylikhman, Sabina Sh. Seyfedinova, Ivan N. Danilov, Anna A. Kostareva, Evgeny G. Solonitsyn, Olga V. Kalinina

Background: Differential diagnosis of pancreatic ductal adenocarcinoma (PDAC) in patients with chronic pancreatitis (CP) remains challenging because of overlapping morphological and imaging features. Transcripts of tumor-associated genes and microRNAs (miRNAs) are considered promising biomarkers of malignant transformation. Our group previously investigated the expression of 17 tumor-associated messenger RNAs (mRNAs) in pancreatic neoplasms; however, their expression in PDAC compared with CP and their regulatory in …

25.08.2026journal-article

Academic Journal of Health

Epidemiological Characteristics and Mortality of Primary Lung Cancer Patients Admitted to the Intensive Care Unit and Undergoing Invasive Mechanical Ventilation

Hamide Gül Özdemir, Melda Türkoğlu, Şahender Gülbin Aygencel, Nazlıhan Boyacı, Kamil İnci, Sinan Özdemir

Background and Aim: Lung cancer is a leading cause of cancer-related mortality globally. Patients frequently require intensive care unit (ICU) admission and invasive mechanical ventilation (IMV) due to disease progression, organ failure, or complications. This study aimed to characterize the demographic and clinical features, survival outcomes, and prognostic factors in patients with primary lung cancer receiving IMV. Materials and Methods: This retrospective, descriptive, cross-sectional study evaluated 84 primary …

25.08.2026journal-article

Annals of Medicine & Surgery

Asymptomatic bilateral renal granulomas following intravesical BCG immunotherapy for bladder cancer: a case report

Mahnoor Sarfraz, Emmarah Qureshi, Omar Irfan, Ayesha Rashid, Michael Klevay

Introduction and importance: Intravesical Bacillus Calmette–Guérin (BCG) therapy is commonly used as an adjuvant therapy for certain non-invasive bladder cancers following transurethral resection of bladder tumor. Rarely, this treatment can lead to the formation of granulomatous masses in the kidney, with vesicoureteral reflux following BCG being a possible etiology for their development. Case presentation: We report a case of an 82-year-old man with a history of non-muscle-invasive bladder cancer treated with intr …

25.08.2026journal-article

International Journal of Molecular Sciences

Emerging Roles of Cytoneme-Mediated Signaling in Cancer

Sheikh Faisal Asadullah Mahdi, Eric T. Hall

Intercellular communication across cancer cells and the tumor microenvironment (TME) is essential for tumor growth, invasion, metastasis, and therapeutic resistance. Traditionally, these interactions have been viewed through the lens of diffusible signaling molecules and extracellular vesicles. However, growing evidence supports an additional paradigm in which specialized cytoskeleton-based membrane extensions, like tunneling nanotubes (TNTs), tumor microtubes (TMs), and cytonemes, mediate direct, contact-dependent …

25.08.2026journal-article

Global Spine Journal

Nonoperative Management of the Adult Spinal Deformity Patient: A Biopsychosocial Intervention Versus Care-as-usual - A Comparative Treatment-Based Cohort Study With One-Year Follow-Up

Evelien H. W. Hoevenaars, Michiel Beekhuizen, Ahmet Alanay, Yann Philippe Charles, Frank Kleinstueck, Ibrahim Obeid, John O’Dowd, Ferran Pellisé, Javier Pizones, Maarten Spruit, Marinus de Kleuver, Miranda L. van Hooff

Study design Comparative Cohort Study. Objectives The aim of this study was to compare a biopsychosocial intervention for chronic low back pain to unimodal, biomedically focused care-as-usual in symptomatic, conservatively managed adult spinal deformity (ASD) patients. Methods A comparative cohort study of a biopsychosocial intervention cohort ( n =95) and a care-as-usual cohort ( n =95). Inclusion criteria of both cohorts: age ≥18, no surgical indication, Oswestry Disability Index (ODI)>20, coronal Cobb angle ≥20, …

25.08.2026journal-article

European Journal of Ophthalmology

Real-world outcomes after switching to faricimab in treatment-resistant neovascular AMD: Short-term response and 12-month follow-up

Victoria Marechal, Francesca Amoroso, Sorana Pacurariu, Vittorio Capuano, Carl Joe Mehanna, Alexandra Miere, Claudio Xompero, Oudy Semoun, Eric H Souied

Aims To assess the efficacy and safety of faricimab in neovascular age-related macular degeneration (nAMD) resistant to anti-VEGF therapies. Methods This retrospective study evaluated nAMD patients with persistent fluid despite anti-VEGF treatments (aflibercept or ranibizumab; mean injection interval of 4.63 ± 0.78 weeks), switched to faricimab and treated with three monthly injections. Data included demographics, baseline macular characteristics and prior treatments. Outcomes focused on anatomical changes (central …

25.08.2026journal-article

Journal of Bone and Joint Infection

Periprosthetic fractures around chronically infected total hip arthroplasties: a case series and pragmatic two-stage treatment framework

Georges F. Vles, Willem-Jan Metsemakers, Laurens Aerden, Jan Geurts, Oliver Borens, Stijn Ghijselings

Abstract. Three periprosthetic femoral fractures around chronically infected total hip arthroplasties (THAs) were treated according to a pragmatic two-stage treatment framework. Infection control and fracture healing were achieved. This may serve as a reference for surgeons confronted with these complex and technically demanding situations.

25.08.2026journal-article

International Health Sciences Review

Hereditary ovarian cancer: BRCA-Associated risk, screening limitations, and risk-reduction strategies

Flavia Drozdz, Mateus Souza Cardoso, Natacha Carmona Cordeiro Alves, Luana Lorenski, Fernanda Tobar Lo Ré Chambray, Livia Azevedo Leonardi

Hereditary susceptibility accounts for a clinically meaningful proportion of epithelial ovarian, fallopian tube, and primary peritoneal cancers, with pathogenic variants in BRCA1 and BRCA2 producing the largest and best-characterized risks. This narrative and critical review examines how BRCA-associated risk should influence genetic identification, ovarian cancer surveillance, and preventive decision-making. Literature searches conducted in August 2026 prioritized clinical guidelines, systematic reviews, prospectiv …

25.08.2026journal-article

Journal of Viral Hepatitis

ALG ‐020572, an Antisense Oligonucleotide for the Treatment of Chronic Hepatitis B Virus Infection Discontinued for Drug‐Induced Liver Injury

Kosh Agarwal, Dan Forton, Yoh Zen, Min Wu, Tse‐I Lin, Kha Le, Sushmita Chanda, Lawrence Blatt, John Fry, Ed Gane

ABSTRACT Current treatment options for chronic HBV infection are suboptimal in that they fail to suppress HBsAg levels. ALG‐020572 is an antisense oligonucleotide designed to reduce viral protein synthesis through degradation of HBV mRNA. ALG‐020572‐401 was a double‐blind, randomized, placebo‐controlled trial consisting of two parts. Part 1 (single‐ascending doses) evaluated the pharmacokinetics, safety and tolerability of single doses of ALG‐020572 or placebo in healthy participants. In Part 2 (multiple dosing), p …

25.08.2026journal-article

Cancers

Post-VABB Cavity-Targeted Avidin-Pretargeted [90Y]Y-DOTA-Biotin in Nonpalpable Breast Cancer: A Phase I Activity-Escalation Study (ARTHE)

Maddalena Sansovini, Paola Sanna, Paola Possanzini, Emanuela Scarpi, Irene Marini, Silvia Nicolini, Ilaria Grassi, Paola Caroli, Michele Amadori, Annalisa Curcio, Giulia Simoncini, Lucia Fabbri, Oriana Nanni, Manuela Monti, Lilla Vizza, Anna Miserocchi, Valentina Di Iorio, Cristina Cuni, Maria Luisa Belli, Matteo Costantini, Fabio Falcini, Giovanni Paganelli, Federica Matteucci, Anna Sarnelli

Background/Objectives: Vacuum-assisted breast biopsy (VABB) is widely used for the diagnosis of nonpalpable breast cancer but is not considered definitive treatment because microscopic residual disease may persist within or around the biopsy cavity. The ARTHE phase I trial evaluated a cavity-targeted radionuclide strategy based on same-session sequential intralesional administration of avidin followed by [90Y]Y-DOTA-biotin after VABB. Methods: Eighteen women with nonpalpable breast cancer measuring ≤15 mm and a ski …

25.08.2026journal-article

Journal of Chittagong Medical College Teachers' Association

Comparison Between Transverse Skin Crease and Vertical Midline Incision for the Resection of Right Sided Colonic Cancer

Syed Aftub Uddin, Kazi Farhana Ahmed, Tafiqur Nahar, Rumman Khandaker, Kazi Md Asif Hasnan, Sreekanto Chandra Banik, Md Matiar Rahaman Khan

Background: Vertical midline incisions provide good access for right colon resection, but transverse skin crease incisions are increasingly favored for easier operation, reduced postoperative pain, faster recovery, and shorter hospital stays. The aim of this study is to compare the feasibility and short-term outcome of transverse skin crease incision and vertical midline incision for the resection of right sided colonic cancer. Materials and methods: An observational study at CMCH and a private hospital in Chittago …

25.08.2026journal-article

Frontiers in Medical Technology

Bionic vision technologies: progress and perspectives on retinal prostheses and optogenetics for the treatment of advanced retinal degeneration

Na Long, Meng Si, Yin Jiang, Fan Chen, Bei Chen, Fei Jiang, Shangang Pan, Xueqin Chu, Huarong Wu

Advanced degenerative retinal diseases [e.g., retinitis pigmentosa (RP) and age-related macular degeneration (AMD)] are characterized by irreversible photoreceptor loss, and conventional interventions rarely prevent progression to profound vision loss at advanced stages. Retinal prostheses and optogenetic therapies are two leading bionic strategies to bypass absent photoreceptors, yet both are limited by a shared “encoding–biointerface” bottleneck: converting external scenes into interpretable neural activity in su …

25.08.2026journal-article

International Journal of Molecular Sciences

Antitumor Activity of a Synthetic Small RNA Based on a Maytenus hookeri Sequence in Non-Small Cell Lung Cancer

Dengyuan Liu, Xinmeng Yang, Sifen Du, Na Sun, Yexuan Lin, Yixin Dong, Chengyu Jiang

Lung cancer remains the leading cause of cancer-related mortality worldwide, highlighting the urgent need for novel therapeutic strategies. This study aimed to identify bioactive small RNAs derived from Maytenus hookeri Loes. and evaluate their anti-tumor potential against non-small cell lung cancer (NSCLC). The 50 most abundant small RNAs were synthesized and screened in NCI-H460 cells using the MTS assay. Among them, MDM-sRNA-39 significantly inhibited cell viability and was selected for further evaluation of its …

25.08.2026journal-article

Liaquat National Journal of Cancer Care

Adenoid Cystic Carcinoma of the Nasal Septum: A Rare Case Report

Syed Ammad Ali, Raja Muhammad Suleman

Adenoid cystic carcinoma (ACC) is a rare malignant epithelial tumor arising predominantly from salivary glands. Sinonasal involvement is uncommon, and primary ACC originating from the nasal septum is exceedingly rare. Its slow growth and nonspecific symptoms make the diagnosis difficult. A 60-year-old male presented with progressive right-sided nasal obstruction for two years associated with intermittent epistaxis, rhinorrhea, sneezing, and dull aching nasal pain. Clinical examination revealed a pinkish irregular m …

25.08.2026journal-article

Lipids

Dietary Omega‐3 and Omega‐6 Fatty Acid Intake and Breast Cancer Risk: A Systematic Review and Meta‐Analysis of Cohort Studies

Mehdi Karimi, Shirin Maghboulian, Omid Asbaghi, Kimia Kazemi, Amirhossein Goodarzi Olfat, Kosar Omidian, Hossein Rafiei

ABSTRACT Breast cancer remains the most commonly diagnosed malignancy among women worldwide. Although dietary fatty acids have been widely investigated, the relationship between polyunsaturated fatty acids intake and breast cancer risk remains unclear. This study aimed to conduct a systematic review and meta‐analysis of cohort studies to elucidate the association between higher dietary intake of omega‐3 (ω‐3) and omega‐6 (ω‐6) fatty acids and breast cancer risk. A systematic search of major databases was conducted …

25.08.2026journal-article

Hereditas

Subtype-specific ZMYND10 expression as a potential novel prognostic and treatment marker for ER-positive/HER2-negative breast cancer

Mingzhe Jiang, Liang Zhang, Dong Zhao, Dantong Zhu, Jia Li, Zhendong Zheng

Abstract Breast cancer (BC) is a heterogeneous malignant tumor that currently lacks reliable biomarkers. Identifying such biomarkers would enable better risk stratification and present potential treatment options for estrogen receptor positive/human epidermal growth factor receptor 2 negative (ER+/HER2-) disease. This study uses transcriptomic, genomic, and clinical data from the TCGA, METABRIC, GSE96058, GSE25066, and GSE20194 cohorts to investigate the prognostic and therapeutic relevance of ZMYND10 through immun …

25.08.2026journal-article

Egyptian Journal of Neurosurgery

Safety and efficacy of staged radiofrequency bilateral thalamotomy or pallidotomy in the treatment of Parkinson’s disease

Youssef Mohammed El-Gretly, Mohammed Fathy Eisa, Alaa Rashad Ibrahim, Mariam Abd Elrasheed Ghanem

Abstract Background Parkinson’s disease is a progressive neurodegenerative disorder characterized by both motor and non-motor manifestations. Although pharmacological therapies remain the mainstay of treatment, their long-term efficacy is often limited and may be associated with significant adverse effects. Consequently, there is increasing interest in surgical interventions such as radiofrequency pallidotomy and thalamotomy as alternative therapeutic options. This study aimed to assess the safety and efficacy of t …

25.08.2026journal-article

Immunotherapy Advances

Glucocorticoid prophylaxis influences the systemic immune macroenvironment in patients with early stage, treatment naïve, HER2+ breast cancer

Aine O’Reilly, Ioannis Zerdes, Max Backman, Yago Pico de Coana, Ulrika Edbäck, Emmanouil Sifakis, Stina Wickström, Kang Wang, Andreas Lundqvist, John MacSharry, Jonas Bergh, Thomas Hatschek, Theodoros Foukakis, Jana de Boniface, Rolf Kiessling

Abstract Background Glucocorticoid prophylaxis is routinely used in oncology. Glucocorticoids potent immunosuppressive and anti-inflammatory properties raise concerns regarding potential impairment of antitumor immune responses. Preclinical and retrospective studies suggest glucocorticoids may impair antitumor immunity, though these findings are subject to significant bias and confounding factors. Understanding the immunomodulatory effects of prophylactic glucocorticoids, isolated from other therapies, is critical …

25.08.2026journal-article

Diagnostic Cytopathology

Non‐Oncocytic Thyroid Follicular Neoplasm: Cytological Atypia and Development of a Score for Malignancy Risk Stratification

Boris M. Shifman, Nadezhda M. Platonova, Fatima M. Abdulkhabirova, Ekaterina V. Bondarenko, Anastasia M. Lapshina, Liliya S. Urusova, Georgii S. Razmakhaev, Tatyana N. Kamneva, Ekaterina A. Troshina

ABSTRACT Background Cytological diagnosis of follicular neoplasm (FN; Bethesda IV) is associated with intermediate malignancy risk. Further stratification based on cytological features may be particularly relevant for non‐oncocytic FN but requires reliable, reproducible assessment approaches. This study evaluated cytological features of non‐oncocytic FN in terms of interobserver agreement and association with malignancy risk, and developed a cytological atypia scoring system for risk stratification. Methods This cr …

25.08.2026journal-article

Diagnostics

Lung Ultrasound-Guided Non-Fiberobronchoscopic Bronchoalveolar Lavage for Neonatal Atelectatic Pulmonary Disease Treatment: Clinical Practice Guidelines Based on International Expert Consensus

Jing Liu, Ya-Li Guo, Peng Jiang, Xian Zhang, Bi-Ying Deng, Zun-Jie Liu, Xiao-Xiao Wang, Yuan Hong, Xiao-Ling Ren, Meng-Ru Zhao, Ning Li, Cai-Xuan Xie, Qiong Meng, Chu-Ming You, Zhen-Yu Liang, Rui-Yan Shan, Jia-Gen Cen, Shuo Li, Wen-Ping Wang, Li-Li Zang, Ying-Jun Wang, Lu Liu, Wei Fu, Yi-Na Ye, Xiao-Xia Li, Ling-Yun Bao, Zai-Li Feng, Ayinuer Maimaitili, Erich Sorantin, Kai-Sheng Hsieh, Dalibor Kurepa, Jovan Lovrenski, Piotr Kruczek, Stefano Nobile, Tsu F. Yeh, Giovanni Volpicelli, Pradeep Suryawanshi, Abhay Lodha, Yogen Singh, on behalf of the Paediatric Medicine Branch of Asia–Pacific Health Association

Severe pulmonary diseases, including atelectasis, pneumonia, and meconium aspiration syndrome, are major causes of neonatal respiratory distress, weaning difficulties, ventilator or oxygen dependence, prolonged oxygen requirements, extended hospitalization, and poor prognosis. The lack of simple and effective treatment strategies seriously endangers the survival and health of newborns, particularly premature infants. Recent advances in lung ultrasound (LUS) technology have made LUS-guided non-fiberobronchoscopic br …