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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
19.08.2026journal-article

Journal of Translational Medicine

Epitranscriptomic RNA modifications in cancer DNA damage response: mechanistic links between RNA fate, genome maintenance, and therapy resistance

Xiaoning Yang, Hongxiu Wang, Jiawei He, Shuqiang Yang, Meijia Zhao, Luqian Zhao, Jingjing Wang, Xiaowen Chen, Xin Xu, Hongran Qin

Abstract Epitranscriptomic RNA modifications have emerged as a fundamental regulatory layer linking RNA metabolism with genome maintenance, DNA damage response (DDR), and therapeutic resistance during cancer evolution. Throughout tumorigenesis, persistent oncogenic signaling, replication stress, oxidative stress, metabolic reprogramming, chronic inflammation, and anticancer treatments continuously generate DNA lesions that challenge genome integrity. Although the DDR network normally safeguards genomic stability by …

19.08.2026journal-article

Egyptian Rheumatology and Rehabilitation

Effect of peripheral neuropathy on Achilles tendon: ultrasonographic study

Youssy Saeed Eshak Gergius, Mona Mansour Hassab Elnaby, Alshymaa Mohamed Farouk Mohamed Motaher, Salwa Galal Moussa

Abstract Introduction Type 2 diabetes mellitus (T2DM) is frequently associated with diabetic peripheral neuropathy (DPN) and musculoskeletal complications, including Achilles tendon abnormalities. Limited evidence exists regarding if tendon abnormalities progress with increasing neuropathy severity or not. Therefore this study aimed to compare ultrasonographic Achilles tendon abnormalities between patients with T2DM with and without DPN, to investigate the relationship between neuropathy severity and tendon structu …

19.08.2026journal-article

Current Opinion in Otolaryngology & Head & Neck Surgery

A translational framework for early-phase inner-ear gene therapy: clinical trial design, regulatory strategy, and ethical considerations

Emma C. Dunn, Spencer H. Short, Ravi N. Samy

Purpose of review Hereditary hearing loss has historically been approached as a diagnostic category rather than a therapeutically modifiable disease. Recent advances in molecular genetics, cochlear gene delivery, and first-in-human clinical trials are changing that. This review summarizes contemporary progress in the genetics of hearing loss, with emphasis on emerging gene-based therapies, clinical trial design, regulatory and ethical considerations, and practical implications for otolaryngologists as biologic trea …

19.08.2026journal-article

SEISENSE Journal of Management

The Double-Edged Effects of Hybrid Work on Employee Well-Being

Ryan Basith Fasih Khan

Purpose: This study maps and synthesizes research on hybrid work and employee well-being, explaining its simultaneous resource and demand effects.Design/Methodology: Following PRISMA 2020 and SPAR-4-SLR, 250 Scopus records published from 2020 to 3 June 2026 were screened. After excluding 26 articles in press, 224 articles were bibliometrically mapped and 200 underwent structured title-abstract synthesis using VOSviewer and thematic coding.Findings: Five clusters organize the field. Flexibility and autonomy appeared …

19.08.2026journal-article

Artefactum - revista de estudos interdisciplinares

BEYOND THE BIOMEDICAL MODEL: PHYSICAL THERAPY EXPERT EXAMINATION AS A GUARANTEE OF OBJECTIVITY IN LABOR TECHNICAL EVIDENCE

Rodrigo Moreira Campos, Samantha de Freitas Campos, Andervan Aguiar de Lima

This study analyzes the technical, scientific, legal, and regulatory foundations that support the practice of physical therapists as judicial experts and technical assistants in labor courts. Through a narrative literature review and theoretical-documentary analysis, the study addresses the core role of human functioning evaluation in establishing work capacity, occupational restrictions, and technical evidence. The central problem lies in overcoming the strictly biomedical paradigm in labor litigations, shifting t …

19.08.2026journal-article

Frontiers in Computer Science

Integrating human–computer interaction and real-time thermal imaging: user-centered design of a thermographic system for physical rehabilitation

Margarita Kaplun-Mucharrafille, Alberto Rossa-Sierra, Rita Q. Fuentes-Aguilar, David Vidaña-Zavala

Infrared thermography has emerged as a non-invasive technique for monitoring physiological processes in clinical rehabilitation; however, its adoption remains limited due to challenges in usability, data integration, and measurement reliability. This work presents the design and development of a thermographic medical device with a user-centered graphical user interface (GUI), integrating real-time thermal acquisition, processing, and analysis within a unified clinical workflow. The proposed system is based on a mod …

19.08.2026journal-article

npj Digital Medicine

In silico trials for sex-specific patient inclusion criteria in cardiac resynchronization therapy

Shuang Qian, Devran Ugurlu, Elliot Fairweather, Richard E. Jones, Hassan Zaidi, Sanjay Prasad, Brian P. Halliday, Daniel Hammersley, Gernot Plank, Edward Vigmond, Cristobal Rodero, Abdul Qayyum, Derek Bivona, Kenneth C. Bilchick, Christopher A. Rinaldi, Alistair Young, Pablo Lamata, Martin Bishop, Steven Niederer

Abstract Cardiac resynchronization therapy (CRT) guidelines are based on clinical trials with limited female representation and inconsistent left bundle branch block (LBBB) definitions. Conventional QRS duration (QRSd) criteria show variable diagnostic accuracy between sexes, partly due to differences in heart size and remodelling. We evaluated the influence of sex, heart size, LBBB, and conduction delay on QRSd and assessed the diagnostic performance of conventional and indexed QRSd criteria using a population-bas …

19.08.2026journal-article

Cancer Research Communications

FGFR1 suppresses STING-mediated interferon response in endocrine therapy resistant breast cancer

Torbjørn Amundsen. Lien, Sushil Dhakal, Anne Marthe. Fosdahl Wium, Helga Bergholtz, Serhat Gunesten, Helene Midtun. Flatekvål, Daniel Nebdal, Phuong Vu, Antoni Hurtado, Jens Henrik. Norum, Therese Sorlie

Abstract Fibroblast growth factor receptor 1 (FGFR1) amplification is frequently observed in ER⁺/HER2⁻ breast cancer and has been linked to poor response to endocrine therapy. While FGFR1 has been implicated in therapeutic resistance, its role in regulating interferon (IFN) response in the context of endocrine resistance remains unclear. We investigated whether FGFR1 modulates the IFN response through the GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway in tamoxifen-resistant breast cancer. We …

19.08.2026journal-article

Occupational Health

Mental Health Disclosure and Employability Perceptions: An Evaluation of Trustworthiness, Job Suitability, and Value

Cody Normitta Porter, Bryony Jerome, Daniel Lawrence, Mircea Zloteanu, April Smith

Employment is an important determinant of psychological, social, and economic wellbeing, yet individuals with mental health disorders often face barriers to workforce participation. This study examined the impact of mental health disclosure on perceptions of trustworthiness, job suitability, and value to the company, focusing on Major Depressive Disorder (MDD), Emotionally Unstable Personality Disorder (EUPD), and schizophrenia. Using experimental vignette methodology, 330 participants evaluated a job candidate bef …

19.08.2026journal-article

International Journal of Innovative Science and Research Technology

Therapeutic Architecture and War Trauma: A Literature Review Toward the Design of a Psychosocial Rehabilitation Center

Bucyedusenge Elizabette, Mahamat Talba, Bwemba Charles, Youssoufa S., Ndongo Jean Paul, Mbessa Michel

Architectural design bears a major responsibility in creating health spaces dedicated to the reconstruction of victims of conflict. Rehabilitation centers, conceived for individuals with a fragile psyche, require calm and regenerative environments that foster dignified social reintegration. This article presents a systematic literature review structured around four interconnected axes: the foundations of architectural programming; the historical and spatial principles of therapeutic architecture; the neurobiologica …

19.08.2026journal-article

World Journal of Psychiatry

Post-interventional anxiety and depression in patients undergoing endovascular therapy for acute ischemic stroke: A retrospective cohort study

Chao Yu, Yu-Hao Ding, Yu-Yi Xie, Jun-Jie Shao, Jing-Li Wang

BACKGROUND Endovascular therapy (EVT) has revolutionized the management of acute ischemic stroke (AIS) caused by large-vessel occlusion, significantly improving functional outcomes. However, the psychological sequelae following EVT, particularly anxiety and depression, remain insufficiently characterized. A clearer understanding of the prevalence and predictors of post-interventional anxiety and depression is essential for delivering comprehensive stroke care. AIM To evaluate the prevalence, severity, and risk fact …

19.08.2026journal-article

Acta Ophthalmologica

Proliferative vitreoretinopathy: An integrative, multi‐pathway perspective on pathogenesis and therapy

Koen A. van Overdam, J. Sebag

Abstract Proliferative vitreoretinopathy (PVR) remains the principal biological cause of failed retinal detachment repair. Classical pathogenic models centred on retinal pigment epithelium (RPE) dispersion, retinal injury responses or compartment‐restricted mechanisms do not fully explain the heterogeneity, biomechanical behaviour and clinical variability of PVR. We propose an integrative framework in which PVR is conceptualised as a biological process arising from the interaction of three interdependent pathways: …

19.08.2026journal-article

Ear & Hearing

Spectro-Temporal Modulation Sensitivity Prospectively Predicts Speech-in-Noise Recognition in Cochlear Implant Users

Julia Erb, Malte Wöstmann, Jens Kreitewolf, Jan Peter Thomas, Christiane Völter, Jonas Obleser

Objectives: For cochlear implant (CI) patients, reliable predictors of speech outcome are desirable. In this longitudinal study, we examined the contributions of spectro-temporal sensitivity to successful speech recognition following cochlear implantation. Design: We assessed N = 46 recently implanted adult patients shortly after CI activation (T1) and 6 months later (T2) with an adaptive ripple discrimination paradigm where dynamic ripples varied around the temporal rate of 4 Hz and spectral scale of 0.5 cyc/oct. …

19.08.2026journal-article

Current Treatment Options in Neurology

Prism Therapy and Surgical Intervention for Oscillopsia

Elizabeth M. Bolton, Nicholas J. Volpe

Abstract Purpose of Review The purpose of this article is to present a critical appraisal of current therapeutic and surgical strategies for patients with nystagmus and associated oscillopsia. Different forms of nystagmus and associated oscillopsia as well as evidence supporting successful use of prism and surgical treatment of these patients are considered. Recent Findings Low power yoked prisms are effective and under-utilized in the treatment of infantile nystagmus syndrome (INS). Surgical treatments for INS and …

19.08.2026journal-article

Exploration of Targeted Anti-tumor Therapy

Mitochondrial checkpoint for interferon responses in macrophages

Andreas O. Mieland, Oliver H. Krämer

A functional immune system is a key antagonist of cancer cell growth. Cytokines such as interferons (IFNs) promote the onset of inflammation, turn cells into an anti-viral state, and shape the dynamic tumor-immune cell interactome. Recent work illustrates how type I IFNs contribute to the resolution of inflammatory conditions. This involves macrophage-mediated efferocytosis for the clearance of apoptotic cells and the intrinsic capacity of type I IFNs to restrict their own autocrine signaling loops via the IFN-stim …

19.08.2026journal-article

JAMA

HIV Status Exclusion in Sickle Cell Gene Therapy

Daniel Prior, Lakshmanan Krishnamurti

This Perspective discusses the ethical, scientific, clinical, and manufacturing implications of excluding patients living with HIV from gene therapies for sickle cell disease.

19.08.2026journal-article

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

Antihyperglycemic Drugs and Risk of Asthma Exacerbation in Patients With Asthma and Type 2 Diabetes: A Multinational Retrospective Cohort Study

Chun‐Tse Hung, Chen‐Yen An, Yao‐Cheng Tsai, Chi‐Won Suk, Chung‐Hsuen Wu

ABSTRACT Background Antihyperglycemic drugs have shown benefits in asthma control. However, evidence regarding the comparative effectiveness of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2is) in reducing asthma exacerbations remains inconsistent. Objective We aimed to evaluate the association of GLP‐1 RAs versus SGLT‐2is with risk of asthma exacerbation among patients with asthma and type 2 diabetes. Methods This retrospective cohort study used electron …

19.08.2026journal-article

Egyptian Rheumatology and Rehabilitation

Diagnostic value of nailfold capillaroscopy in suspected secondary Raynaud phenomenon: a cross-sectional analytical study

Yimy Medina, José S. Cortés, Manuel Pérez

Abstract Background Nailfold capillaroscopy (NFC) is a widely used rheumatology tool for assessing Raynaud phenomenon (RP). Nonspecific abnormal findings observed through NFC may appear in patients with primary RP, suspected secondary RP, secondary RP, and healthy individuals. Differentiating between these findings remains a subject of ongoing research. This study aimed to describe capillaroscopic alterations in patients with suspected secondary RP and compare them with healthy subjects. Methodology This was a cros …

19.08.2026journal-article

Journal of Marital and Family Therapy

Multi‐Family Therapy in East and Southeast Asia—A Systematic Review and Meta‐Synthesis

Ouyang Hanlai, Sufang Peng, Jue Chen, See Heng Yim

ABSTRACT This systematic review examined the characteristics, cultural adaptations, and effectiveness of multi‐family therapy in studies conducted in the Chinese Mainland, Hong Kong, and Singapore. Eighteen reports from 17 studies were included, covering quantitative, qualitative, and mixed‐methods designs. Quantitative findings showed that multi‐family therapy was more consistently associated with improvements in individual‐level outcomes (e.g., symptom severity, psychological distress, functioning), whereas effec …

19.08.2026journal-article

CHIMIA

Light-Induced Cancer Therapy

Lukas Schneider

Photodynamic therapy (PDT) and photothermal therapy (PTT) are promising light-induced approaches for cancer treatment. This article outlines the historical development of PDT and summarizes the underlying photophysical and photochemical mechanisms responsible for reactive oxygen species (ROS) generation and tumour destruction. Major classes of clinically approved and emerging photosensitizers (PSs) are discussed together with important design criteria and current limitations. In addition, the principles of PTT, inc …

19.08.2026journal-article

Общество: социология, психология, педагогика

Scientific Substantiation of Emotion-Image Therapy: A Theoretical Review

Ekaterina Yu. Prokopenkova

The article presents a systematic theoretical review of the scientific foundations of Emotion-Image Therapy (EIT) – a Russian psychodynamic method developed by N.D. Linde. Unlike previous works, which have been predominantly descriptive, this study integrates the conceptual framework of EIT into the broader context of fundamental psychological and neurophysiological theories. The central thesis of the article is that the key con-structs of EIT (the energetic metaphor of emotions, the image as a representation of co …

19.08.2026journal-article

Frontiers in Psychiatry

Network analysis of social isolation, loneliness, depression and anxiety among post-discharge rehabilitation patients

Yonglan Li, Dongsheng Wang, Shuangting Xu, Jing Xu

Background Patients undergoing inpatient or outpatient rehabilitation frequently experience substantial changes in physical functioning, social roles, and daily routines, which may increase vulnerability to social disconnection and psychological distress. This study applied network analysis to explore the interrelationships among social isolation, loneliness, anxiety, and depression in post-discharge rehabilitation patients. Aims This study aimed to characterize two network models of social isolation, loneliness, d …

19.08.2026journal-article

Journal of Cancer Research and Clinical Oncology

Profiling the tumor microenvironment of a hepatocellular carcinoma patient with primary resistance to immunotherapy plus anti-angiogenic therapy but exceptional response to chemotherapy plus bevacizumab

Qin Xu, Rui Zhu, Zirui Wang, Chengjian Zhao, Xiaofen Li, Nuerye Tuerhong, Wanting Hou, Yu Yang

Abstract Background Hepatocellular carcinoma (HCC) with extrahepatic metastasis (EHM) carries a poor prognosis, and treatment options after failure of anti-angiogenic targeted agents combined with immune checkpoint inhibitor (ICI) remain limited. Case Presentation An adult patient with advanced HCC exhibited primary resistance to three sequential immunotherapy-based regimens: first-line lenvatinib plus camrelizumab (progressive lung metastases), second-line atezolizumab plus bevacizumab (rapid tumor marker surge), …