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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
19.08.2026journal-article

Общество: социология, психология, педагогика

Scientific Substantiation of Emotion-Image Therapy: A Theoretical Review

Ekaterina Yu. Prokopenkova

The article presents a systematic theoretical review of the scientific foundations of Emotion-Image Therapy (EIT) – a Russian psychodynamic method developed by N.D. Linde. Unlike previous works, which have been predominantly descriptive, this study integrates the conceptual framework of EIT into the broader context of fundamental psychological and neurophysiological theories. The central thesis of the article is that the key con-structs of EIT (the energetic metaphor of emotions, the image as a representation of co …

19.08.2026journal-article

Frontiers in Psychiatry

Network analysis of social isolation, loneliness, depression and anxiety among post-discharge rehabilitation patients

Yonglan Li, Dongsheng Wang, Shuangting Xu, Jing Xu

Background Patients undergoing inpatient or outpatient rehabilitation frequently experience substantial changes in physical functioning, social roles, and daily routines, which may increase vulnerability to social disconnection and psychological distress. This study applied network analysis to explore the interrelationships among social isolation, loneliness, anxiety, and depression in post-discharge rehabilitation patients. Aims This study aimed to characterize two network models of social isolation, loneliness, d …

19.08.2026journal-article

Journal of Cancer Research and Clinical Oncology

Profiling the tumor microenvironment of a hepatocellular carcinoma patient with primary resistance to immunotherapy plus anti-angiogenic therapy but exceptional response to chemotherapy plus bevacizumab

Qin Xu, Rui Zhu, Zirui Wang, Chengjian Zhao, Xiaofen Li, Nuerye Tuerhong, Wanting Hou, Yu Yang

Abstract Background Hepatocellular carcinoma (HCC) with extrahepatic metastasis (EHM) carries a poor prognosis, and treatment options after failure of anti-angiogenic targeted agents combined with immune checkpoint inhibitor (ICI) remain limited. Case Presentation An adult patient with advanced HCC exhibited primary resistance to three sequential immunotherapy-based regimens: first-line lenvatinib plus camrelizumab (progressive lung metastases), second-line atezolizumab plus bevacizumab (rapid tumor marker surge), …

19.08.2026journal-article

Nutrients

Resveratrol and Curcumin in Stroke Therapy: From Experimental Evidence to Clinical Perspectives

Mikołaj Grabarczyk, Aleksandra Szychowska, Weronika Szczepańska, Ewa Smolińska, Andrzej Glabinski, Piotr Szpakowski

Stroke remains one of the leading causes of death and long-term neurological disability worldwide, while currently available therapeutic strategies are limited by narrow treatment windows and incomplete neuroprotection. In this context, plant-derived polyphenols have attracted increasing attention as potential adjunctive agents because of their multimodal biological activity. This review focuses on resveratrol and curcumin, two of the most extensively investigated polyphenols, and evaluates their potential role in …

19.08.2026journal-article

Annals of Indian Academy of Neurology

A Retrospective, Single-Arm, Observational Study in Patients with Multiple Sclerosis in India Receiving Ocrelizumab Therapy for 1 Year

MV Padma Srivastava, Joy Dev Mukherji, Anshu Rohatgi, Sameer Arora

Abstract Background and Objectives: Ocrelizumab is an established therapy for multiple sclerosis (MS). However, real-world data from Indian clinical settings remain limited. Hence, the present study was conducted to evaluate the clinical effectiveness, radiological response, and safety profile of ocrelizumab over 12 months of therapy among patients with MS in India. Methods: This retrospective observational study included data from adults diagnosed with multiple sclerosis (MS) who received ocrelizumab for at least …

19.08.2026journal-article

Neurobiology of Language

Neural and Behavioral Predictors of Speech Motor Sequence Learning in Primary Progressive Aphasia

Hilary E. Miller, Michael Brickhouse, Daisy Hochberg, Alfonso Nieto-Castanon, Jason Tourville, Bradford C. Dickerson, Frank H. Guenther

Abstract This study investigated the clinical and neural correlates of speech motor sequence learning in primary progressive aphasia (PPA) to test specific predictions regarding the roles of the left posterior inferior frontal sulcus (pIFS) and left ventral premotor cortex (vPMC). A cohort of 26 participants with PPA completed a 2-day non-native consonant cluster learning paradigm. Participants also completed a battery of clinical speech-language assessments, including tests of phonological and motor programming ab …

19.08.2026journal-article

Earth

Assessing the Functional Suitability of Sewage Sludge-Derived Technosols for the Ecological Rehabilitation of Degraded Areas

Mattia Napoletano, Alessandro Bellino, Alessio Langella, Mariano Mercurio, Vincenzo Baldi, Antonio Ernesto Detta, Daniela Baldantoni

Urban and industrial activities have lasting effects on Earth ecosystems, impairing their functionality. Technosols offer a sustainable solution for restoring degraded urban and industrial ecosystems. In a 30-day microcosm experiment, a mixture of six pioneer plant species was sown in three substrates: a sewage sludge-based Technosol (GF), a zeolite-enriched Technosol (GZ), and a commercial potting mix control (GC). The plant population dynamics, final performance, and substrate biochemical properties were monitore …

19.08.2026journal-article

Frontiers in Psychology

Kinesiophobia and autonomous motivation for cardiac rehabilitation after cardiac surgery: sequential mediation by social support and psychological resilience

Ting Shen, Ting Leng, Qi Peng, Qiuhong Chen, Lin Luo, Xiahong Huang

Objective To examine whether social support and psychological resilience sequentially mediate the relationship between kinesiophobia (fear of movement) and autonomous motivation for cardiac rehabilitation (CR) among patients following cardiac surgery. Methods A cross-sectional survey was conducted with 167 adult patients recruited via convenience sampling from the Department of Cardiac Surgery at a tertiary hospital in China between January 2024 and June 2025. Eligible participants completed validated Chinese versi …

19.08.2026journal-article

Advanced Materials

ROS‐Scavenging Single‐Component Polymeric Nanocarriers for Precision siRNA Delivery in Pulmonary Fibrosis Therapy

Yuxin Yang, Hua Zhang, Jianjun Du, Wen Sun, Xiaojun Peng, Jiangli Fan

ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a progressive refractory lung disorder with limited effective therapies. Although RNA interference (RNAi) holds promise for IPF treatment, current delivery systems are hampered by complex preparation, redundant components, and an inability to modulate oxidative stress, which severely compromises their therapeutic outcomes. Herein, we design a single‐component, lung‐targeted nanosystem, PPN@siIL11, that simplifies formulation while integrating dual functions of efficie …

19.08.2026journal-article

Frontiers in Rehabilitation Sciences

Ethical reflections on the use of the category “children with disabilities” in quantitative research

Christian Møller-Skau

Quantitative research plays a vital role in informing public health policies concerning children with disabilities. However, the categorisation of children as ‘disabled’ in statistical analyses raises complex ethical questions. This perspective article offers a conceptual and normative reflection on the ethical implications of such categorisation, drawing on the frameworks of utilitarianism, deontology, and virtue ethics. It argues that while categorisation may be necessary for policy development and resource alloc …

19.08.2026journal-article

International Journal For Multidisciplinary Research

Telescopic Overdenture as a Conservative Prosthodontic Approach to the Rehabilitation of a Severely Resorbed Mandibular Ridge: A Case Report

Manish Bairwa, Dr Rajesh Kumar -, Dr Sunil Kumar M.V -

Abstract Background: Rehabilitation of a severely resorbed mandibular ridge can be challenging when conventional complete dentures provide inadequate support and stability. Preservation of strategically positioned natural teeth can improve prosthetic support and retention while maintaining proprioceptive feedback. Telescopic overdentures offer a conservative approach by integrating the remaining teeth into a removable prosthesis through primary and secondary coping systems. Case Presentation: A patient with a sever …

19.08.2026journal-article

AIDS

LDL-C target achievement in people living with HIV: impact of combination lipid-lowering therapy. A retrospective cohort analysis

Marcella Manicardi, Jovana Milic, Giuseppe Esposito, Marianna Menozzi, Giuseppe Mancini, Gian Luca Cuomo, Lorenzo Benassi, Elisabetta Delmonte, Severino Ambrosio, Cristina Mussini, Giuseppe Boriani, Giovanni Guaraldi

Background: Real-world low-density lipoprotein cholesterol (LDL-C) target attainment remains low in people with HIV (PWH). Updated ESC/EAS 2025 guidelines underscore the need to reassess treatment patterns in clinical practice. Methods: Retrospective observational longitudinal study including PWH ≥40 years, evaluated twice between 2020 and 2025 at the Modena HIV Metabolic Clinic, with complete laboratory and clinical follow-up data. Objective was to evaluate the real-world use and effectiveness of different lipid-l …

19.08.2026journal-article

Frontiers in Immunology

Impact of IL-6 and ferritin dynamics on clinical outcomes after anti-CD19 CAR-T cell therapy in diffuse large B-cell lymphoma patients

Ling Gao, Yanyan Mao, Cai Sun, Yize Li, Xing Xing, Yuqing Miao, Chunling Wang, Hongfeng Ge, Ziyuan Shen, Wei Sang

Background Interleukin-6 (IL-6) and ferritin are routinely monitored during chimeric antigen receptor T-cell (CAR-T) therapy; however, their temporal dynamics and outcome-specific relevance remain inadequately characterized. This study aimed to evaluate the value of IL-6 and ferritin at multiple time points in patients with diffuse large B-cell lymphoma (DLBCL) receiving anti-CD19 CAR-T therapy. Methods A total of 54 patients (median age 49.0 years; 64.8% male) were retrospectively analyzed. Post-infusion IL-6 and …

19.08.2026journal-article

JMIR Rehabilitation and Assistive Technologies

Impact of Emerging Technologies on Outpatient Care Quality: Mixed Methods Study

Inas Al Khatib, Mahmoud Awad, Abdulrahim Shamayleh

Abstract Background Digital transformation in health care, including telemedicine, wearable devices, robotic process automation (RPA), and electronic medical records (EMRs), is reshaping outpatient care delivery. However, consolidated evidence on how these technologies influence patient care quality (PCQ) remains limited. Objective This study evaluated the impact of emerging digital health technologies on PCQ dimensions in outpatient clinics through a systematic literature review combined with expert perspectives. …

19.08.2026journal-article

Frontiers in Psychology

Exploring the impact of teacher expectations on student behavior and academic performance using cognitive behavioral therapy

Yehui Jin, Qiang Zhou, XinJuan Li

This study evaluated the effectiveness of using a cognitive-behavioral therapy based teacher training program to change teachers’ expectations of students and improve student behavior and academic performance. This paper designs and uses a quasi experimental approach with a non equivalent control group for pre-test/post test. The participants consist of 115 third grade teachers and 356 third grade students from five primary schools. Teachers identified as having low expectations received a 12 week manual CBT traini …

19.08.2026journal-article

Journal of Clinical Medicine

Ultrasound-Based Biofeedback for Pelvic Floor Rehabilitation: A Systematic Review of Randomized Controlled Trials

César Garrido-Fernández, Eva Lantarón-Caeiro, Isabel Escobio-Prieto, Pablo Hernandez-Lucas

Pelvic floor dysfunctions are highly prevalent and can substantially impair quality of life. Physiotherapy is considered a first-line conservative treatment, and the integration of technologies such as ultrasound may enhance outcomes through visual biofeedback. Objectives: To evaluate the effectiveness of ultrasound as a biofeedback tool in physiotherapeutic interventions for pelvic floor dysfunctions across different populations. Methods: A systematic review was conducted following PRISMA guidelines and registered …

19.08.2026journal-article

Nature Cardiovascular Research

Alpha protein kinase 3 gene therapy restores heart function in mouse and human models of cardiomyopathy

James W. McNamara, Ellen B. Keen, Rebecca Sutton, Yinghan She, Hannah Huckstep, Lina H. H. Le, Neda R. Mehdiabadi, Madhavan S. Venkatesh, Brendan Griffen, Richard J. Mills, Christina V. Theodoris, James E. Hudson, Drew M. Titmarsh, Sean J. Humphrey, Enzo R. Porrello, David A. Elliott

Abstract Truncating variants in the ALPK3 gene (encoding alpha protein kinase 3) cause severe cardiomyopathy for which no curative treatment exists 1–3 . Here we establish an adeno-associated virus (AAV)-mediated gene replacement therapy to deliver full-length human ALPK3 . AAV- ALPK3 prevented disease in neonatal Alpk3- mutant mice and reversed established pathology in adults, with proteomic analysis demonstrating reversal of more than 95% of the molecular disease signature. Beyond ALPK3 deficiency, we explored br …

19.08.2026journal-article

Stem Cell Research & Therapy

Efficacy of multi-layered human iPS cell-derived cardiovascular cell sheets in a pacing-induced canine dilated cardiomyopathy model

Yu Shimoyama, Kenji Kakuta, Kiho Araki, Hyoe Komae, Minoru Ono, Jun K. Yamashita

Abstract Background Dilated cardiomyopathy (DCM) is a progressive, intractable disease that leads to heart failure. Heart transplantation is the only curative treatment; however, access is limited by donor scarcity. Induced pluripotent stem cell (iPSC)-based therapies are attracting attention for DCM, but suitable large-animal models and robust preclinical data have been limited. Methods We generated multi-layered cardiovascular cell sheets from human iPSCs by combining cardiomyocytes with endothelial and stromal c …

19.08.2026journal-article

JIKES : Jurnal Ilmu Kesehatan

Penerapan Art Therapy pada Pasien Halusinasi Pendengaran dan Penglihatan di Rumah Sakit Jiwa

Dewi Purwati, Aat Sriati, Indra Maulana, Yofi Purnamagiri

Halusinasi, terutama halusinasi pendengaran yang memiliki prevalensi 70–80% pada pasien dengan gangguan psikotik, merupakan gejala yang sering ditemukan pada pasien skizoafektif dan dapat mengganggu fungsi sosial, perilaku, serta kualitas hidup. Manajemen halusinasi merupakan intervensi keperawatan penting untuk membantu pasien mengontrol gejala yang dialami. Tujuan penelitian ini adalah mendeskripsikan penerapan art therapy sebagai intervensi keperawatan pendukung dalam membantu pasien mengontrol halusinasi penden …

19.08.2026journal-article

Frontiers in Public Health

Workplace violence, occupational burnout, and post-traumatic stress among healthcare workers in Armenia

Meri Mkhitaryan, Armine Chopikyan, Armine Harutyunyan, Tatevik Arakelyan, Armen Muradyan, Artashes Tadevosyan

Background Workplace violence is a significant occupational hazard in healthcare systems worldwide and may have serious psychological consequences for healthcare workers. Exposure to violence can contribute to the development of occupational burnout and post-traumatic stress disorder (PTSD), negatively affecting both staff well-being and the quality of healthcare services. Aim To analyze the types of workplace violence, associated risk factors, and the relationship between exposure to violence, occupational burnout …

19.08.2026journal-article

American Journal of Speech-Language Pathology

Comparing the Community-Identified and Federally Funded Rehabilitation Priorities for Stroke Survivors With Aphasia

Mara L. Goodman, Alyssa N. Kelly, William S. Evans

Purpose: Person-centered rehabilitation for stroke survivors with aphasia (SSwAs) targets meaningful recovery goals using interventions supported by strong scientific evidence. To maximize clinical impact, aphasia research should provide evidence that directly supports person-centered recovery goals. The purpose of this project was to characterize and compare the rehabilitation priorities of SSwAs living in the United States to the research priorities of federally funded aphasia clinical trials. Method: Community-i …

19.08.2026journal-article

ACS Applied Materials & Interfaces

A Near-Infrared-Triggered Mn,Fe-Doped Polyoxometalate Nanozyme Combined with Lactobacillus for the Chemodynamic/Photothermal Therapy of Candida Vaginitis

Xiao Li, Jitao Li, Jing Ge, Liufeng Yang, Haiyan Zhao, Zhou Jie, Chunmeng Liu, Yaling Yang, Xiaomei Wu

Abstract Vulvovaginal candidiasis (VVC) is a common fungal infection that significantly affects women’s health worldwide. Antifungal agent therapies are not particularly effective for VVC and can further promote an imbalance in the vaginal microbiota, increasing recurrence. Nanozymes are currently being evaluated as an alternative therapy owing to their broad-spectrum antibacterial activity and negligible biological toxicity. However, their inherently low catalytic activity limits their antibacterial properties. In …

19.08.2026journal-article

International Journal of Environmental Research and Public Health

The Applicability of Forest Therapy for Socially Isolated Young Adults: Parallel Changes in Psychological Distress and Mindfulness

Yeji Yang, Ji-Eun Pyo, Yongjun Lee, Beom Lee, Chang-Hyou Kim, Jeong-Ho Choi, Jina Yu, Jisoo Lee, Kee-Hong Choi

This study examined the applicability of forest therapy in alleviating psychological distress among socially isolated young adults, with a particular focus on their associations with the mindfulness. A total of 159 socially isolated young adults were recruited from the community and participated in a two-day, one-night forest therapy program. Psychological distress (depression, anxiety, loneliness, and stress) and mindfulness were assessed before and after the program. Multilevel analyses were conducted to examine …

19.08.2026journal-article

Beilstein Journal of Nanotechnology

A redox-responsive viologen–cavitand nanocarrier for dual-function photodynamic therapy

Andrey A Maslennikov, Alexey Yu Usanyov, Amir A Shamsutdinov, Anna P Lyubina, Andrey A Parfenov, Alexandra D Voloshina, Irek R Nizameev, Marsil K Kadirov, Rezeda R Fazleeva, Vitaly V Yanilkin, Kseniya A Zhdanova, Natal’ya A Bragina, Albina Y Ziganshina, Igor S Antipin

Although photodynamic therapy selectively eradicates tumours via light-triggered reactive oxygen species (ROS) generation, conventional photosensitizers suffer from poor solubility and a reliance on short-wavelength light with limited tissue penetration. To address this, we developed a redox-responsive polymeric nanocarrier through free-radical polymerization of a pre-assembled micellar ensemble. This ensemble formed spontaneously in aqueous solution by encapsulating the hydrophobic photosensitizer meso -tetrakis( …