Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Alter & Demenz · Seite 6

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
26.08.2026journal-article

The Journal of Cardiovascular Aging

Machine learning model predicting new-onset acute kidney injury in fulminant myocarditis

Yongsheng Qu, Xin Zheng, Jing Zhang, Famin Ye, Jingjing Zhang

Aim: To develop and validate a SHapley additive exPlanations (SHAP)-interpretable machine learning (ML) model for predicting new-onset Acute kidney injury (AKI) after coronary care unit (CCU) admission in patients with Fulminant myocarditis (FM). Methods: This retrospective cohort study included 157 consecutive patients with FM admitted to the CCU of Fuwai Central China Cardiovascular Hospital between January 2018 and January 2026. Admission clinical data were used for model development and internal validation. ML …

26.08.2026journal-article

Longevity Horizon

The Centriole as a Candidate Division Counter in Stem-Cell Aging

Jaba Tqemaladze

Background. Replicative aging of stem cells requires a mechanism counting cell divisions. Centrioles — organelles with mother–daughter asymmetry and no de novo generation in most somatic cells — are candidate division counters: their geometry may accumulate mitotic-age information. Hypothesis. The centriole acts as a division counter in stem-cell aging: structural parameters (length, cartwheel integrity, daughter-relative positioning) change predictably with each division and contribute to senescence entry. Propose …

26.08.2026journal-article

Working with Older People

Strengthening elder neglect prevention through community-based nursing: stakeholder perspectives from Indonesia

Nurhasanah Nurhasanah, Darmawati Darmawati, Hajjul Kamil, Marthoenis Marthoenis

Purpose Elder neglect is a complex and often hidden form of elder abuse influenced by family relationships, caregiver capacity and weaknesses in health and social service systems. Despite its growing public health significance, evidence on stakeholder perspectives to inform community-based prevention strategies remains limited, particularly in low- and middle-income countries. This study aims to explore stakeholder perspectives on the determinants, manifestations, prevention strategies and health system gaps relate …

26.08.2026journal-article

Microbial Genomics

Genomic diversity of Pseudomonas aeruginosa causing bacteremic pneumonia in an intensive care unit, with emergence of an OXA-796-producing NDM-1 ST773 isolate

Kihyun Lee, Hyemin Chung, Kuenyoul Park, Sang-Ho Choi, Heungsup Sung

Pseudomonas aeruginosa bacteremic pneumonia carries exceptionally high mortality, yet there is a paucity of genomic characterization of the strains causing this infection. We performed hybrid sequencing (Illumina and Oxford Nanopore) of 12 non-redundant P. aeruginosa isolates from patients with severe bacteremic pneumonia admitted to the intensive care unit of a tertiary hospital between 2015 and 2023. The 12 isolates were assigned to nine distinct sequence types, suggesting that severe bacteremic pneumonia can ari …

26.08.2026journal-article

Frontiers in Aging Neuroscience

Association of the hsCRP- triglyceride-glucose index (CTI) with early infarct growth rate in acute ischemic stroke due to large artery occlusion

Haiping Tang, Guojun He, Lei Li, Shuangfei You, Deming Li, Songjie Chen, Yan Guo, Yongqing Cheng, Shifu Sun

Background Rapid infarct growth in acute ischemic stroke (AIS) due to large artery occlusion (LAO) is associated with poor clinical outcomes despite successful recanalization. The hypersensitive C-reactive protein (hsCRP)-triglyceride-glucose (TyG) index (CTI), a novel biomarker integrating insulin resistance and systemic inflammation, may reflect a meta-inflammatory state that exacerbates ischemic injury. However, its relationship with early infarct growth rate (IGR) remains unexplored. This study aimed to investi …

26.08.2026journal-article

Revista da Associação Brasileira de Pesquisadores/as Negros/as (ABPN)

QUALIDADE DE VIDA EM PESSOAS IDOSAS NEGRAS COM DOENÇAS CRÔNICAS: UMA REVISÃO SISTEMÁTICA

Eusiene Furtado Mota Silva, Ana Hélia de Lima Sardinha, Patrícia Lima Queiroz, Rômulo Luiz Neves Bogéa

Este artigo analisa os fatores que influenciam a qualidade de vida de pessoas idosas negras com doenças crônicas, com foco nas desigualdades sociais e no impacto do racismo estrutural sobre a saúde física e o envelhecimento digno. A revisão sistemática, realizada conforme as diretrizes PRISMA, incluiu 30 estudos das bases Scopus, SciELO e BVS. Os achados revelam alta prevalência de doenças crônicas agravadas por barreiras de acesso, baixa renda e discriminação racial. Identifica-se uma lacuna científica sobre os ef …

26.08.2026journal-article

JAMA Network Open

Dementia Diagnosis Underreporting and Care Engagement and Planning Among Older Adults

Yuting Qian, Kyle A. Gavulic, Xi Chen

Importance Inadequate disclosure and stigma often leave patients with a documented dementia diagnosis unaware of their condition. Resultant patient underreporting creates a major barrier to the benefits of detection; however, the extent of underreporting, its associated factors, and care implications remain understudied. Objective To compare underreporting of dementia diagnosis with that of other diagnosed conditions among persons with probable dementia (PWPD), identify associated patient and care delivery factors, …

26.08.2026journal-article

Frontiers in Public Health

Effects of exercise interventions on fall-related injuries in community-dwelling older adults: an updated systematic review and meta-analysis

Beihai Ge, Jinsong Luo, Xiaofeng Cheng, Deng Wang, Renming Liu, Xianhui Liao

Background Exercise interventions are widely recommended for preventing falls in older adults in the community; however, existing evidence regarding their effectiveness in reducing fall-related injuries remains inconsistent. This updated systematic review and meta-analysis aimed to assess the impact of exercise interventions on fall-related injuries in older adults in the community. Methods PubMed, Embase, Cochrane Library, and CINAHL databases were systematically searched from inception to April 2, 2026. Included …

26.08.2026journal-article

Revista da Associação Brasileira de Pesquisadores/as Negros/as (ABPN)

POPULAÇÃO NEGRA E PERDA AUDITIVA; UMA REVISÃO INTEGRATIVA

Fabiane De Barros, Célia Mariana De Souza, Sabrina Gonçalves, Márcia Machado, Adriana Unchalo, Maira Olchik, Adriane Teixeira

Revisão integrativa da literatura, com objetivo de analisar estudos audiológicos com participantes negros. Foi feita com artigos extraídos das bases de dados PubMed, Embase, Lilacs e Web of Science. A pergunta de pesquisa foi: 'Qual a prevalência da perda auditiva na população negra?'. Os descritores utilizados foram: Hearing Loss, Hearing Impairment, Hypoacus, Transitory Hearing Loss AND Black People OR African Continental Ancestry Group OR Black Person OR Negroid Race OR Negro OR Negroes. Foram incluídos estudos …

26.08.2026journal-article

The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences

Factors shaping social participation among community-dwelling older adults in China: A mixed-methods study from the perspectives of older adults and community workers

Yufan Yang, Weihang Xu, Mingyao Sun, Meng Zhao, Huanhuan Luo, Jingyi Liu, Lillian Hung, Zhiwen Wang

Abstract Objectives Guided by the Social Ecological Model (SEM), this study aimed to examine multilevel influences on social participation among community-dwelling older adults from the perspectives of older adults and community workers. Methods A convergent parallel mixed-methods design was used. The quantitative component included 641 community-dwelling older adults from five communities in Beijing, China. The qualitative component involved semi-structured interviews with 18 older adults and 14 community workers. …

26.08.2026journal-article

Diabetology

Limitations of a Recent Study on Insulin Pen Needle Preferences in People with Diabetes. Comment on Gentile et al. Enhancing Insulin Therapy Adherence Through Technology: Which Needles Do People with Diabetes Prefer? Diabetology 2026, 7, 56

David C. Klonoff, Mandy M. Shao, Agatha F. Scheideman

We read with interest a recent article in Diabetology titled “Enhancing Insulin Therapy Adherence Through Technology: Which Needles Do People with Diabetes Prefer [...]

1 Zitationen
26.08.2026journal-article

Journal of the American Geriatrics Society

Driving Navigation in Older Adults Across the Alzheimer's Disease Continuum

Yiqi Zhu, Julie K. Wisch, Ziqiao Jiao, David C. Brown, Noor Al Hammadi, Tammie L. S. Benzinger, John C. Morris, Beau M. Ances, Ganesh M. Babulal

ABSTRACT Background and Objectives To examine whether time from amyloid positivity (amyloid time), a continuous measure of biological Alzheimer's disease (AD) progression, is associated with differences in navigation‐related driving behaviors among older adults. Methods This longitudinal cohort study was drawn from the DRIVES participants who had at least one PET Pittsburgh compound‐B (PiB) scan. AD timeline was assessed using amyloid time, estimated with the Sampled Iterative Local Approximation (SILA) approach. S …

26.08.2026journal-article

Works of the Faculty of Agriculture and Food Sciences University of Sarajevo

CELIAC DISEASE – A CHALLENGE FOR PEOPLE AFFECTED IN THE HERZEGOVINA-NERETVA CANTON

Robert Kepić, Emina Ademović, Mladenka Vukojević, Jasna Avdić

Celiac disease is a chronic disorder of the digestive system caused by the intake of gluten in genetically predisposed individuals. It is characterized by a high prevalence and often delayed diagnosis due to nonspecific symptoms, such as chronic diarrhea, vomiting, loss of appetite, fatigue, and anemia, which are frequently pushed aside, or misattributed to other conditions. The disease often occurs in association with other autoimmune diseases. Having in mind a complex administrative structure of Bosnia and Herzeg …

26.08.2026journal-article

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

Possible osteosarcopenia is associated with floss in intrinsic capacity and early cognitive deficits: a longitudinal study of older adults in Singapore

Vanessa Jean Wen Koh, Khong Thi Minh Thu, Lakkhina Troeung, Rahul Malhotra, Dheeraj Jha, Anitha D Praveen, Yi Xing Liu, Benedikt Helgason, Navrag B Singh, Angelique Wei-Ming Chan

Abstract Background Osteosarcopenia is linked to frailty, falls, fractures, and mortality. It may impair intrinsic capacity (IC), with emerging evidence especially pointing to its relationship with cognition capacity. We determined the prevalence and characteristics of persons with possible osteosarcopenia in older adults and examined its association with IC, with a focus on cognition. Methods 2,291 participants were recruited through a national household survey of older adults in Singapore. Socio-demographic, heal …

26.08.2026journal-article

Psychogeriatrics

Internal Consistency, Construct Validity and Incremental Explanatory Power of the Action Observation Sheet‐B ( AOS ‐B) for Dementia Caregiver Burden and Clinical Severity

Reiko Hashimoto, Daisuke Sumita, Takanori Senoo, Yumeno Furukawa, Eiji Ikeda, Akira Tamai, Takashi Uehara

ABSTRACT Background Although the behavioral Action Observation Sheet‐B (AOS‐B) addresses the clinical limitations, patient anxiety and caregiver biases of traditional dementia assessments, evidence regarding its incremental explanatory power remains insufficient. Using real‐world clinical data, this study evaluated the 47‐item AOS‐B's internal consistency, validity and independent contribution to explaining caregiver burden. Methods We retrospectively analysed data from 107 patients with different dementia subtypes …

26.08.2026journal-article

Sociological Perspectives

Authentically, Yet Situationally ‘Latinx’ and ‘Latine’: How Gender-Expansive People of Latin American Descent Navigate Panethnic Labels

Luis Edward Tenorio, David Munoz, Stephanie Granobles

The present study draws from interviews with 54 U.S.-born gender-expansive people of Latin American descent to examine how they understand, identify with, and use ‘Latinx’ and ‘Latine’ relative to ‘Hispanic’ and ‘Latino/a’. We find many not only identified with ‘Latinx’ and ‘Latine’ among labels like ‘Hispanic’ and ‘Latino/a’, they also described ‘Latinx’ and ‘Latine’ to feel the most authentic. Participants also reported the political and policy climate in the U.S. around gender-expansive individuals contributed t …

26.08.2026journal-article

Nature Communications

Deep learning aging marker from retinal images unveils sex-specific clinical and genetic signatures

Olga Trofimova, Leah Böttger, Sacha Bors, Yating Pan, Bart Liefers, Jose D. Vargas-Quiros, Victor A. de Vries, Michael J. Beyeler, David M. Presby, Dennis Bontempi, Janna Hastings, Caroline C. W. Klaver, VascX Consortium, Ciara Bergin, Bogdan Draganski, Adham Elwakil, Györgyi V. Hamvas, Ilaria Iuliani, Ihor Kuras, Ilenia Meloni, Sofia Ortin Vela, Ian Quintas, Marc Schindewolf, Reinier O. Schlingemann, Mattia Tomasoni, Sven Bergmann

Abstract Retinal fundus images offer a non-invasive window into systemic aging. Here, we fine-tune a foundation model (RETFound) to predict chronological age from color fundus images in 71,343 participants from the UK Biobank, achieving a mean absolute error of 2.85 years. The resulting retinal age gap, i.e. the difference between predicted and chronological age, is associated with cardiometabolic traits, inflammation, cognitive performance, all-cause mortality, dementia, cancer, and incident cardiovascular disease …

26.08.2026journal-article

Corporate and Business Strategy Review

Emotional intelligence in leadership: People-centered practices and cultural transformation. The case of Microsoft strategy

Ioanna Dimitrakaki

Research on emotional intelligence (EI) and leadership has expanded considerably in recent years. However, limited attention has been given to how emotionally intelligent leadership may shape people-centered organizational cultures and adaptive workplace practices (Goleman, 1998; López-Cabarcos et al., 2019). This study examines how EI-informed leadership may contribute to cultural transformation, employee engagement, and organizational adaptability within contemporary organizations. The paper focuses on Microsoft …

26.08.2026journal-article

Frontiers in Sociology

Delayed academic consolidation and active aging in European academia: a collaborative autoethnography of migrant women

Mihaela Vancea, Noemí Duran-Salvadó, Valeria De Ormaechea-Otarola, Carolina Quirós-Domínguez

Introduction Migrant women's opportunities for active aging, understood through the World Health Organization framework of health, participation, and security, are shaped by cumulative inequalities across the life course. In European higher education, migrant women academics often experience delayed academic consolidation through trajectories marked by precarious employment, disrupted institutional and relational ties, constrained recognition, and normative expectations that privilege linear and uninterrupted caree …

26.08.2026journal-article

Exercise Science

Effects of High-Intensity Interval Training Versus High-Intensity Circuit Training on Airflow Limitation in Older Adults with Pre- COPD: A Pilot RCT

Eun-Ah Jo, Soo-Jin Lee, Ki Uk Kim, Myung-Jun Shin, Tae-Sung Park, Jung-Jun Park

PURPOSE: Pre-COPD, characterized by mild airflow limitation, represents a critical window for preventing progression to chronic obstructive pulmonary disease (COPD). This pilot randomized controlled trial examined the effects of high-intensity interval training (HIIT) versus high-intensity circuit training (HICT) on pulmonary function in older adults with pre-COPD.METHODS: Twenty older men aged 60-75 years with pre-COPD, defined as normal or near-normal FEV1 with symptoms, risk factors, and mild airflow limitation …

26.08.2026journal-article

Reproduction

Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate ovarian aging by inhibiting ferroptosis

Chia-Jung Li, Li-Te Lin, Pei-Hsuan Lin, Boyang Wang, Zhi-Hong Wen, Kuan-Hao Tsui

Abstract Ovarian aging is characterized by a decline in oocyte quantity and quality, often driven by oxidative stress and cellular damage. Human umbilical cord mesenchymal stem cell-derived exosomes (hUC-MSC-Exos) have emerged as a potent cell-free therapy for regenerative medicine. In this study, Female mice with early ovarian aging (31-33 weeks; n = 8 per group) received 10 intraperitoneal injections of hUC-MSC-Exos (240 µL/dose, 6.5 × 10¹⁰ particles/mL) over two weeks. Ovarian function, follicular development, D …

26.08.2026journal-article

Frontiers in Public Health

Effects of Health Qigong on quality of life, physical function, and mental health in older adults: a systematic review and meta-analysis of randomized controlled trials

Shi-han Liang, Ming-yuan Zhao, Si-min Huang, Qing-Fa Dou, Ya-kai Zhang

Background Health Qigong is widely used for health promotion in older adults. This study aimed to systematically evaluate its effects on physical function, psychological well-being, and quality of life (QoL), alongside the moderating effects of intervention characteristics. Methods Seven databases were systematically searched (up to May 2025). Twenty-two randomized controlled trials involving 1,791 older adults were included. Risk of bias was assessed using Cochrane RoB, and meta-analyses were performed using RevMa …

26.08.2026journal-article

Nature Aging

Cytotoxic CD4+ T cells induce age-associated myelopoiesis through CCL5–CCR5 signaling

Enrique Gabandé-Rodríguez, Gonzalo Soto-Heredero, Elisa Carrasco, Carlos Anerillas, José Ignacio Escrig-Larena, Jorge Martínez-Cano, Sandra Delgado-Pulido, Isaac Francos-Quijorna, Gabriela Desdín-Micó, Tatiana Smirnova, Manuel M. Gómez de las Heras, Álvaro Fernández-Almeida, Alice Leandri, Andrea Cugurra, Eva María Blanco, Elia Winand-Osete, Pablo Ramírez-Ruiz de Erenchun, Virginia Zorita, Camilla Bean, Valentin Basset, Françoise Solly, Amanda Garrido, Rafael de Cabo, Santos Mañes, Manolis Pasparakis, Matteo Iannacone, César Cobaleda, Olaia Naveiras, Myriam Gorospe, María Mittelbrunn

Abstract Age-associated hematopoietic skewing results in an increase in the neutrophil-to-lymphocyte ratio, which serves as a strong predictor of all-cause mortality in older adults, although its causes are incompletely understood. Here we show that cytotoxic CD4 + T lymphocytes accumulate in the bone marrow of mice during aging and induce myelopoiesis, increasing the neutrophil-to-lymphocyte ratio. T cell receptor-dependent induction of mitochondrial stress and activation of STING upregulates the chemokine CCL5 in …