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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Neuroimaging Abnormalities and Genotype-Phenotype Correlations in Noonan Syndrome: A Multicenter Cohort Study

Giuseppa Patti, Nadia Gabriella Maiorano, Francesca Piccoli, Alice Zucconi, Maria Grazia Calevo, Federica Tamburrino, Emanuela Scarano, Concetta Schiavariello, Cesare Rossi, Laura Mazzanti, Eleonora Orlandini, Gabriella Pozzobon, Martina Finamore, Cristina Baldoli, Anna Grandone, Mario Cirillo, Francesca Aiello, Domenico Corica, Malgorzata Wasniewska, Alessandro Cattoni, Paolo Remida, Donatella Capalbo, Fabio Tortora, Maria Carolina Salerno, Sara Azzolini, Mariam Mansour, Maria Felicia Faienza, Stefano Palladino, Domenico Tortora, Giulia Rosti, Francesca Faravelli, Cristina Venturino, Pasquale Capuozzo, Letizia De Mori, Paola Maietta, Anna Elsa Maria Allegri, Chiara Morreale, Alessia Angelelli, Flavia Napoli, Natascia Di Iorgi

Abstract Context Neuroradiological findings in Noonan syndrome (NS) remain insufficiently characterized Objective To characterize neuroimaging abnormalities in children with genetically confirmed NS and evaluate their associations with clinical phenotype Design, Setting, and Participants In this multicenter retrospective study, brain MRI scans and longitudinal clinical and genetic data were reviewed from children with genetically confirmed NS evaluated between 2008 and 2023 at seven pediatric endocrinology centers …

27.08.2026journal-article

Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi

Microsurgical Aspects of Middle Cerebral Artery Variations: Clinical and Anatomo-radiological Implications

Mustafa Eren Yüncü, Berra Bilgin, Yeliz Pekçevik, Ali Karadag, Necmettin Tanrıöver

The middle cerebral artery is the largest branch of the internal carotid artery and supplies extensive cortical and deep cerebral territories. Variations in its branching pattern are of considerable importance in microsurgical planning and may influence aneurysm development. This study aimed to evaluate the prevalence of middle cerebral artery variations, their microsurgical anatomy, and their relationship with anterior circulation aneurysms. Computed tomography angiography images of 500 patients were retrospective …

27.08.2026journal-article

BMC Oral Health

Parental knowledge, attitude, and practice on oral complications of leukemia treatment: a cross-sectional study

Nosrat Nourbakhsh, Ailar Adib Haji Bagheri, Maryam Torkian, Sheida Bagheri, Sahar Talebi

Abstract Background Leukemia is among the most common childhood cancers, and treatments such as chemotherapy and radiotherapy often lead to oral and dental complications. With rising survival rates, attention to oral health and its impact on quality of life has become increasingly important. Parental knowledge and practice play a vital role in preventing and managing these complications. Therefore, this study assessed the knowledge, attitude, and practice (KAP) of parents of children with leukemia regarding oral sy …

27.08.2026journal-article

Big Data & Society

Commodifying compassion in the digital age: The promise and perils of tech for good

Maha Rafi Atal, Sofie Elbæk Henriksen, Lisa Ann Richey

Digital and data-driven technologies are transforming the humanitarian and development sectors. With the promise of faster, more efficient and accurate aid delivery, these technologies are often designed and implemented in partnerships between aid organizations and private technology firms. Consequently, “Tech for Good” has emerged as a significant humanitarian domain, where Big Tech companies aspire to create innovative technological solutions to humanitarian problems and link their business interests and strategi …

27.08.2026journal-article

Academia Nutrition and Dietetics

Beyond glycemia: clinical nutrition in type 2 diabetes and cardiometabolic risk

Antonio Maria Labate, Provvidenza Villari

Type 2 diabetes (T2D) is a multifactorial cardiometabolic disorder in which dysglycemia coexists with visceral adiposity, insulin resistance, atherogenic dyslipidemia, hypertension, and metabolic dysfunction-associated steatotic liver disease (MASLD). In this setting, clinical nutrition should be considered a therapeutic intervention rather than a generic lifestyle add-on. This mini-review summarizes how nutritional strategies can modify major cardiometabolic domains in adults with T2D, with a practical focus on Me …

27.08.2026journal-article

Diabetes Obesity and Cardiometabolic CARE

Electronic Health Record–Based Algorithms May Improve Identification of Cases of Atypical Diabetes, Including in Groups Underrepresented in Biomedical Research

Victoria Chen, Cristina I. Fernández Hernández, Megan Griff, Julia L. Douvas, Micah Koss, Melton Fan, Will Marshall, Evelyn Greaux, Wyatt Pfau, Marjan Rezaei, Jeremy Graber, Vatsala Singh, Laura K. Wiley, Sridharan Raghavan, Neda Rasouli, Miriam S. Udler, Sara J. Cromer, RADIANT Study Group

OBJECTIVE To determine whether electronic health record (EHR)-based algorithms can identify individuals with atypical diabetes (AD) eligible for the Rare and Atypical Diabetes Network (RADIANT) study and whether these algorithms improve identification and enrollment of individuals from populations underrepresented in biomedical research (UBR). RESEARCH DESIGN AND METHODS Two RADIANT clinical sites independently developed EHR-based algorithms to identify AD phenotypes, including a lean type 2 diabetes–like physiolog …

27.08.2026journal-article

Karya Journal of Health Science

RELATIONSHIPS BETWEEN ORTHOREXIA NERVOSA TENDENCY, MINDFUL EATING, AND BODY MASS INDEX IN YOUNG ADULTS (19-32 AGED): A CROSS-SECTIONAL STUDY BASED ON GENDER DIFFERENCES

Murat Altan, Şemsi Gül Yılmaz Kocaman, Hasan Yıldırım

Objective: This cross-sectional study investigated the associations between Orthorexia Nervosa (ON), mindful eating, and body mass index (BMI) among young adults, and explored gender-based differences in ON tendencies and mindful eating.Method: The research was conducted between October and December 2024 in Elazığ, Türkiye, and included 757 healthy participants. Data were collected using face-to-face questionnaires assessing sociodemographic characteristics, the Orthorexia Nervosa-11 Scale (ORTO-11), and the Mindfu …

27.08.2026journal-article

Sustainability

Assessing the Implementation of Artificial Intelligence-Based Systems for Sustainable Solid Waste Management in Selected Countries in Asia, Europe and North America: A Systematic Review

Lynda Andeobu, Santoso Wibowo, Srimannarayana Grandhi

The efficient management of solid waste remains a persistent challenge worldwide, particularly in developing countries, due to increasing waste generation driven by rapid population growth and urbanisation. Artificial Intelligence (AI) has emerged as a transformative approach to improving solid waste management (SWM) by enhancing waste collection, sorting, recycling, and resource recovery processes. Several countries have integrated AI into their SWM systems; however, the extent of AI-driven automation across the S …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Artificial intelligence-empowered echocardiography: an updated review of clinical management in hypertrophic cardiomyopathy

Miao Zhang, Shanshan Yuan, Hongyan Dai, Guoan Wang

Hypertrophic cardiomyopathy (HCM) is a common and highly heterogeneous inherited cardiomyopathy characterized by complex clinical phenotypes and diverse disease trajectories, posing significant challenges for early diagnosis, precise phenotypic classification, and risk stratification. Owing to its noninvasive nature, repeatability, and wide availability, echocardiography remains the cornerstone imaging modality for the diagnosis and longitudinal management of HCM. However, conventional echocardiographic analysis re …

27.08.2026journal-article

International Journal of Molecular Sciences

Effect of Dupilumab on Allergen-Specific IgE Levels and Clinical Tolerance in Patients with Food Allergy: A Systematic Review

Magdalena Grześk-Kaczyńska, Szymon Kaczyński, Bernadetta Kosztulska, Magdalena Rydzyńska, Tomasz Rosada, Natalia Ukleja-Sokołowska

Food allergy is a growing global health concern associated with significant dietary restrictions, impaired quality of life, and risk of severe allergic reactions. Dupilumab, a monoclonal antibody targeting the interleukin-4 receptor alpha (IL-4Rα), inhibits IL-4 and IL-13 signaling and has demonstrated efficacy across multiple type 2 inflammatory diseases. This systematic review aimed to evaluate the effects of dupilumab on food allergy outcomes in pediatric and adult patients. Across studies, dupilumab treatment w …

27.08.2026journal-article

Frontiers in Public Health

Cost-effectiveness of tremelimumab plus durvalumab versus sorafenib for unresectable hepatocellular carcinoma in China: an economic evaluation based on five-year overall survival data from the HIMALAYA trial

Rui Feng, Ping Liang, Yajing Wang, Dong Li, Huixian Jia, Ying Zheng, Liman Huo, Qi Lv

Objective To assess the cost-effectiveness of tremelimumab plus durvalumab [the Single Tremelimumab Regular Interval Durvalumab (STRIDE) regimen] versus sorafenib as first-line treatment for unresectable hepatocellular carcinoma in China using 5-year follow-up data from the HIMALAYA trial. Methods A three-state partitioned survival model comprising progression-free survival, progressed disease, and death was developed from the perspective of the Chinese healthcare system. Individual patient data were reconstructed …

27.08.2026journal-article

Frontiers in Immunology

Datopotamab deruxtecan in breast cancer treatment: a systematic review of clinical efficacy and safety

Julia Piekarz, Natalia Picheta, Jakub Pobideł, Natalia Gierulska, Krzysztof Kułak, Rafał Tarkowski

Background Breast cancer (BC) remains the most common malignant tumor in women worldwide and a leading cause of cancer-related deaths. Despite therapeutic advances, patients with advanced BC, particularly triple-negative breast cancer (TNBC), still face limited effective treatment options. Antibody-drug conjugates (ADCs) represent a compelling strategy that combines precise tumor targeting with cytotoxic payloads, effectively bridging targeted delivery with microenvironmental disruption. Datopotamab deruxtecan (Dat …

27.08.2026journal-article

F1000Research

How to measure the perimeter from digital images

David Legland

Image analysis aims at extracting quantitative information from digital images. As for any measurement method, the measures obtained from image analysis present some measurement errors that should be better considered during interpretation of results. This work investigates the quality of measures obtained from image analysis based on measurements on synthetic shapes with various geometries, sizes, positions and orientations, by focusing on the methods available in common image analysis software. The perimeter is u …

27.08.2026journal-article

Clinical Psychology & Psychotherapy

Are Metacognitive Beliefs and Cognitive Flexibility Associated With Cannabis Use Disorder In Adolescents? A Case–Control Study

Neval Kızıl, Masum Öztürk, Fatma Subaşı Turgut, Yağmur Soysal, Ayfer Gözü Pirinççioğlu

ABSTRACT Objective Cannabis is among the most commonly used substances by adolescents and is frequently associated with the development of addiction. Various individual, environmental and psychological factors are associated with the onset and maintenance of cannabis use disorder (CUD). Our study aimed to compare levels of depression, anxiety, stress, perceived cognitive flexibility and metacognitive beliefs in adolescents diagnosed with CUD with those in a healthy control (HC) group. Another objective was to inves …

27.08.2026journal-article

Frontiers in Psychology

Artificial intelligence-assisted speaking in Spanish as a foreign language: effects on foreign language emotions and willingness to communicate

Yifan Miao, Pingping Hu

Introduction Although AI-powered conversational tools are increasingly used in foreign language education, little is known about their longitudinal effects on learners’ emotional experiences and willingness to communicate (WTC), particularly among beginner learners of languages other than English. Grounded in Positive Psychology, Control-Value Theory, and the WTC framework, this study examined the effects of AI-assisted speaking practice using TalkPal AI on foreign language enjoyment (FLE), foreign language anxiety …

27.08.2026journal-article

JURPIKAT

Akselerasi Validasi Spasial melalui Plotting Data Digital PTSL di Loket Yuridis Kantor Pertanahan

Toton Fanshurna, Nadia Ludyanti Esya Putri, Calista Putri Fitriana, Rensi Haiziah

Pendaftaran Tanah Sistematis Lengkap (PTSL) tak sekadar menghasilkan dokumen, melainkan membentuk basis data pertanahan yang menuntut ketepatan serta keterhubungan informasi yuridis dan spasial. Masalah timbul saat data digital dalam jumlah besar memerlukan penataan ulang akibat ketidaksesuaian informasi.Kegiatan pengabdian ini bertujuan mendukung percepatan validasi spasial melalui plotting data digital PTSL di Loket Yuridis Kantor Pertanahan Kabupaten Jember. Metode dilakukan secara partisipatif, meliputi identif …

27.08.2026journal-article

Responsible Enterprise Pedagogy

Fair and equitable digital literacy and technology education: addressing the education gap through social entrepreneurship

Amy Abdou, Irene van Driel, Dadi Chen

Purpose This study examines two small social enterprises – a social business and a non-profit – founded by the same entrepreneur that provide digital literacy and technology education in the Netherlands. By comparing two distinct social enterprise models and their approaches to equitable supplemental education, the paper explores the relationships among entrepreneurial logics, organizational practices and external stakeholder involvement, including the role of government. Design/methodology/approach Drawing on thre …

27.08.2026journal-article

Journal of Fish Health

Growth Performance and Pathological Responses of Tissue Culture and Local <i>Kappaphycus alvarezii</i> Seedlings in Marine Waters of Punti Village, Bima Bay, Indonesia

Alis Mukhlis, Nadirah Karimatul Ilmi, Sanca Rahmatullah, Anita Prihatini Ilyas, Ardyen Saputra

Kappaphycus alvarezii is an economically important carrageenan-producing red alga, and tissue culture has been promoted as a means of improving seedling quality and field growth performance in Indonesian seaweed farming; however, field-based evidence comparing tissue-culture and conventional (local) seedlings under commercial cultivation conditions remains limited. This study therefore compared the growth performance and disease susceptibility of tissue-culture-derived and local Kappaphycus alvarezii seedlings cult …

27.08.2026journal-article

Al Qodiri : Jurnal Pendidikan, Sosial dan Keagamaan

Mental Health from the Perspective of Positive Psychology and the Concept of Patience and Gratitude in Islam

Rudi Herianto

Mental health is increasingly understood as a multidimensional condition involving psychological functioning, meaningful relationships, positive emotions, and the ability to respond constructively to life challenges. Positive psychology provides an important framework for understanding these dimensions through human strengths, flourishing, meaning, and well-being. However, psychological perspectives alone may not fully capture the spiritual dimensions of mental health within Muslim communities. This study examines …

27.08.2026journal-article

Pilot and Feasibility Studies

The Mother Nature Programme: a single-arm mixed-methods feasibility study of a group nature-based intervention for mothers experiencing postnatal mental health difficulties and their infants

Katherine Hall, Rosa Roberts, Katrina Turner, Lucinda Stanton, Sherien Elsheikh, Christopher Barnes, Beverly Shirkey, Lucy Duggan, Paul Moran, Jonathan Evans

Abstract Background Postnatal mental health difficulties are common and often under-treated. Nature-based interventions have potential mental health benefits, but little research has focussed on their applicability postnatally. This study examined the acceptability and feasibility of delivering a co-designed, 5-week group nature-based intervention, The Mother Nature Programme (MNP), for mothers experiencing postnatal mental health difficulties and their infants, in preparation for a future trial. Methods A single-a …

27.08.2026journal-article

BMC Oral Health

Oral findings and antiresorptive therapy exposure duration in postmenopausal women with osteoporosis: a cross-sectional cohort study

Safiyye Süslü, Håvard J Haugen, Tormod Bjartveit Krüger, Bente B. Herlofson, Janne Elin Reseland, Erik Fink Eriksen

Abstract Background Oral findings are common among older adults, but it is unclear whether they vary with the duration of antiresorptive therapy (ART) exposure or relate to the severity of osteoporosis in postmenopausal women. Methods In this cross-sectional cohort ( n = 129), postmenopausal women undergoing osteoporosis assessment/follow-up were stratified by ART exposure duration: no current ART control (G1, n = 50), short ART (G2, 3–5 years; n = 39), and long ART (G3, > 5 years; n = 40). The prespecified primary …

27.08.2026journal-article

Biosensors

Artificial Intelligence in Electrochemical Sensing: A Network Evidence Map of Translational Barriers and Pathways to Point-of-Care Deployment

Muhammad Saqib, Elena I. Korotkova, Kunquan Li, Neda Firoz, Mrinal Vashisth, Amrit L. Hui, Olga I. Lipskikh, Pradip Kumar Kar

The integration of artificial intelligence (AI) and machine learning (ML) with electrochemical sensing has revolutionized analytical diagnostics by overcoming traditional limitations such as signal drift, peak overlapping, and matrix interference. However, despite the exponential growth of this field, a unified framework evaluating translational feasibility remains absent. This review critically analyzes AI/ML architectures applied to electrochemical sensors and biosensors from 2016 to 2025. To the best of our know …

27.08.2026journal-article

Materials

Antibacterial Interventions for Orthodontic Appliances; Surface Modifications, Coatings and Bulk-Incorporated Antibacterial Agents: Materials, Mechanisms and Clinical Application—A Scoping Review

Berta Furió-Alonso, Javier Gil, Danica Nikolic Jovanovic, Andreu Puigdollers-Pérez

Biofilm accumulation on orthodontic appliances is a recognized risk factor for white spot lesion formation and caries during treatment. Antibacterial surface modifications and coating strategies have been proposed as appliance-level preventive approaches. Studied interventions in the literature span true thin-film surface coatings, plasma-based and ion-implantation surface modifications, and bulk-incorporated antibacterial agents in appliance matrix materials. Yet the extent to which in vitro efficacy translates to …

27.08.2026journal-article

Journal of Plastic Surgery and Hand Surgery

Clinical outcomes of a defect-adapted strategy for free fibular great toe flaps in finger reconstruction: a retrospective series of 35 cases

Yangyang Liu, Huajian Zhou, Haoran Jiang, Jun Zhu, Renjie Li, Mingyu Jia

Background: To evaluate the clinical outcomes of a personalized surgical strategy for small-to-medium finger defects, utilizing either free dorsal toe or plantar proper digital artery flaps. Methods: We retrospectively analyzed 35 patients with finger defects (March 2021–January 2025). Patients were assigned by defect characteristics to Group A (pulp defects, n = 21; plantar proper digital artery flap) or Group B (dorsal/lateral defects, n = 14; modified dorsal toe artery flap preserving the plantar proper neurovas …