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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Gastric Cancer

Phase II study of mFOLFOX6 in advanced gastric cancer patients with severe peritoneal metastases (WJOG10517G), including an individual patient data comparison with JCOG1108/WJOG7312G

Toshiki Masuishi, Hiroki Hara, Takayuki Ando, Takeshi Kawakami, Yoshiyuki Yamamoto, Naotoshi Sugimoto, Kazuhiro Shiraishi, Taito Esaki, Yuji Negoro, Takao Tsuzuki, Hiroaki Sawai, Masato Nakamura, Takashi Inagaki, Yudai Shinohara, Kentaro Kawakami, Seiichiro Mitani, Kenji Tsuchihashi, Chihiro Kondoh, Hiroo Katsuya, Osamu Maeda, Yuriko Fujita, Kenichi Yoshimura, Masanori Terashima, Takako Eguchi Nakajima, Kei Muro

Abstract Background Advanced gastric cancer patients with severe peritoneal metastases, defined as massive ascites throughout the abdominal cavity and/or inadequate oral intake requiring intravenous infusion support, have been excluded from pivotal clinical trials. Methods This phase II trial evaluated mFOLFOX6 in HER2-negative, chemotherapy-naive advanced gastric cancer patients with severe peritoneal metastases. The primary endpoint was overall survival (OS); secondary endpoints included ascites response rate amo …

27.08.2026journal-article

The Chemical Record

Graphene‐Based Composites for Cancer and Antimicrobial Applications: From Structural Design to Clinical Practice

Jing Xu, Yujia Han, Haixiang Zeng, Hongxia Li, Xiaohui Niu, Xiaoyu Liu, Li Chen, Deyi Zhang, Dongqiang Zhang, Kunjie Wang

Through synergistic interactions with functional components such as metals, metal oxides, polymers, and biomolecules, graphene‐based composites can simultaneously exhibit properties including photothermal conversion, drug delivery, imaging, and molecular recognition, demonstrating significant application potential in cancer diagnosis and treatment as well as antimicrobial therapy. Given that existing research has primarily focused on graphene materials themselves and that a systematic summary of the relationship be …

27.08.2026journal-article

Angewandte Chemie

Harnessing the E3 Ligase KLHL12 for Tumor‐Selective Protein Degradation

Shicheng Xu, Xian Zhang, Shunbo Hu, Xinyi Wang, Yuxin Ge, Ziquan Zhao, Tianbao Zhu, Nan Wang, Limin Du, Qidong You, Xiaoke Guo, Zhengyu Jiang

ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are currently constrained by a reliance on ubiquitously expressed E3 ligases, which compromises tumor selectivity and raises toxicity risks. Here, we identified KLHL12 as a potentially tumor‐selective E3 ligase and reported the development of the first‐in‐class KLHL12‐recruiting PROTACs. Guided by a structure‐based macrocyclization strategy, we obtained a high‑affinity cyclic peptide, cp4 , as a KLHL12‑binding ligand and constructed novel PROTACs against oncogenic B …

27.08.2026journal-article

Neuro-Oncology

24 Human-AI collaboration in brain tumour assessments improves both human and AI agent performance

James Ruffle, Samia Mohinta, Guilherme Pombo, Asthik Biswas, Alan Campbell, Indran Davagnanam, David Doig, Ahmed Hammam, Harpreet Hyare, Farrah Jabeen, Emma Lim, Dermot Mallon, Stephanie Owen, Sophie Wilkinson, Sebastian Brandner, Parashkev Nachev

Abstract Introduction The benefits of artificial intelligence (AI) human partnerships—evaluating how AI agents enhance expert human performance—are increasingly studied. Though rarely evaluated in healthcare, an inverse approach is possible: AI benefiting from the support of an expert human agent. Brain tumour MRI characterisation, a technically challenging and specialist process which often necessitates gadolinium contrast administration, offers an ideal setting to evaluate such partnerships. Methods Here, we inve …

27.08.2026journal-article

Philosophical Transactions of the Royal Society B: Biological Sciences

Piecing together the structure of epidermal growth factor receptor complexes: a journey from crystals to cells and its impact on cancer therapy

Selene Roberts, Dave Clarke, Ioannis Galdadas, Marisa Martin-Fernandez

Abstract The epidermal growth factor receptor (EGFR) was cloned and identified as an oncogene 40 years ago, and since then has become the poster child for receptor tyrosine kinases in physiological and pathophysiological settings. Cell surface EGFRs bind growth factors secreted by adjacent cells and undergo conformational changes that transduce normal or dysregulated growth and division signals across the plasma membrane. It took more than two decades for atomic resolution of partial structures to become available, …

27.08.2026journal-article

Cancers

Beyond Canonical Neoantigens: Emerging Technologies for Identification of Noncanonical Antigens and Implications for Personalized Cancer Vaccines

Yilin Yang, Thomas Kane, Abdurrahman T. Abdelzaher, S. Peter Goedegebuure, William E. Gillanders

Over the past decade, advances in sequencing technologies and computational pipelines enabled the development of personalized cancer vaccines (PCVs). Current PCV strategies primarily target cancer neoantigens generated by non-synonymous DNA mutations, which can result in altered amino acid sequences capable of eliciting tumor-specific immune responses. More recently, a distinct class of tumor-specific antigens (TSA), termed noncanonical or cryptic antigens, has emerged as an additional source of immunogenic targets …

27.08.2026journal-article

Molecular Cancer Therapeutics

Dual-Targeting of EGFR and HER2 by a Bispecific Antibody–Drug Conjugate Demonstrates Broad Antitumor Activity in Multiple Solid Tumors

Xiaojuan Chai, Fu Li, Hongmei Xie, Hanxi Yu, Xiaojing Huang, Yihui Lin, Yuting Lu, Nan Li, Tete Li, Qiangqiang Deng, Weiming He, Wenqiang Zhai, Shu Zhang, Xiaozhen Wang, Haizhou Zhang, Fanglong Yang, Siqin Wang, Lei Jin, John L. Xu

Abstract While HER2-directed antibody–drug conjugates (ADC), such as ENHERTU (DS-8201), represent a major therapeutic advance, treatment options for tumors with low HER2 expression remain limited, and acquired resistance continues to pose a significant clinical challenge. Given the frequent co-expression of EGFR and HER2 across multiple tumor types, we hypothesized that dual-targeting could improve therapeutic efficacy and overcome resistance mechanisms. This approach may achieve broader tumor coverage, synergistic …

27.08.2026journal-article

Neuro-Oncology

21 Adult ependymoma in England: Incidence, treatment, and outcomes from GlioCova

Kerlann Le Calvez, Radvile Mauricaite, Peter Treasure, Thomas C Booth, Stephen J Price, Andrew Brodbelt, Jonathan J Gregory, Seema Dadhania, Lillie Pakzad-Shahabi, Maureen Dumba, Ingela Oberg, Sally Vernon, Jawad Basharat, Matt Williams

Abstract Introduction England has a long-running system for national cancer data collection. In this work we present data on incidence, treatment and survival in all adult ependymoma patients in England diagnosed between 2013 and 2018. Methods Gliocova uses a linked pseudo-anonymised data set of all adult patients in England diagnosed with a primary brain tumour between 2013 and 2018. We identified all adult patients with an ependymoma based on ICD-10 diagnosis and tumour morphology. Results In the 6-year period of …

27.08.2026journal-article

Neuro-Oncology

38 Building Research Capacity: The Impact of The Brain Tumour Charity’s Future Leaders Funding Programme

Lucy Grist, Simon Newman, Emma Thompson

Abstract Introduction Brain tumours remain one of the most challenging cancers, and progress is slowed by a shortage of researchers entering and remaining in the field. To build capacity, ensure research excellence and drive innovation, The Brain Tumour Charity established the Future Leaders Programme to identify talented early‑career researchers and support them to become leaders in brain tumour research. Methods The programme uses a staged funding model. Researchers undertake a three‑year Postdoctoral Fellowship, …

27.08.2026journal-article

Frontiers in Oncology

Feasibility, reliability, and clinical value of genomic assay on pre-therapeutic biopsy for endocrine receptor-positive HER2-negative early breast cancer

Gilles Houvenaeghel, Maxime Souquet Bressand, Valérie Juhan Duguet, Monique Cohen, Catherine Bouteille, Laura Sabiani, Julien Barrou, Loic Juquel, Véronique Brunel, Olivia Quilichini

Endocrine receptor-positive (ER+) and HER2-negative breast cancer (BC) represents approximately 80% of all BCs. Most patients are treated with upfront surgery; however, 15%–30% will develop late recurrences. Genomic assay indication is usually based on postoperative pathological data including histology subtype, tumor size, lymph node status, SBR grade, and Ki67. Performing genomic testing on core needle biopsy specimens prior to surgery may offer several advantages. In this manuscript, we assess the feasibility, r …

27.08.2026journal-article

Frontiers in Oncology

Epigenetic profiling of circulating cell-free DNA for early detection and minimal residual disease assessment in lung cancer: a focus on DNA methylation

Tancredi Didier Bazan Russo, Valerio Gristina, Marco Donatello Delcuratolo, Leonardo Tamburi, Francesco Delli Muti, Filomena Mangiacotti, Clarissa Mujacic, Daniele Fanale, Antonio Galvano, Stefania Gori, Lorena Incorvaia, Antonio Giordano, Francesco Pepe, Umberto Malapelle, Antonio Russo, Lucia Anna Muscarella, Federico Pio Fabrizio

Lung Cancer (LC) continues to be the biggest cause of cancer-related deaths around the world, mostly because of delayed diagnosis. Even if tissue biopsies and circulating tumor DNA (ctDNA) tests have revolutionized clinical management of LC patients, their effectiveness is restricted in settings with lower tumor burden, molecular heterogeneity, and bias in sampling approaches. In this scenario, the epigenetic profiling of cell-free DNA (cfDNA) stands out as a promising, less invasive approach, accurately detect can …

27.08.2026journal-article

Med Research

Organoid Coculture Models for Cancer Research and Immunotherapy

Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen

ABSTRACT Three‐dimensional cancer organoids cultured in vitro closely recapitulate the phenotypic and genetic features of parental tumor tissues, making them powerful tools for cancer research, drug screening, and personalized medicine. However, traditional organoid cultures lack key components of the tumor microenvironment (TME), including cancer‐associated fibroblasts, immune cells, vascular networks, and dynamic physicochemical cues, such as fluid flow and oxygen gradients. These deficiencies limit the ability t …

27.08.2026journal-article

Clinics and Practice

Scientific Clinical Trial Publication Productivity in Medical Oncology: A Comparative Analysis and Data Review of Northern and Southern Italy

Vittorio Gebbia, Sergio Rizzo, Dario Piazza, Daniela Sambataro, Giuseppa Scandurra, Maria Rosaria Valerio

Background: Italy exhibits a socioeconomic divide between its northern and southern regions, which extends into healthcare delivery and biomedical research. Medical oncology is particularly affected by this structural imbalance. This paper examines geographic disparities in clinical trial scientific publication output, citation impact, research funding, and collaboration networks in medical oncology between northern and southern Italy. Methods: A narrative bibliometric analysis was conducted using data from PubMed …

27.08.2026journal-article

Crystals

A Review of Fatigue Performance Research on Aluminum Alloy Forming, Heat Treatment, Additive Manufacturing and Surface Modification Technologies

Baicheng Liu, Hongliang Zhang, Shenghan Li, Yurii Luhovskyi, Zhisheng Nong

Aluminum alloy is a lightweight, high-strength material based on aluminum matrix with the addition of elements such as copper, magnesium, silicon, zinc, manganese, or lithium. Featuring low density, high specific strength, excellent formability, and outstanding corrosion resistance, it is widely applied in the fields of aerospace, rail transit, automotive lightweighting, and additive manufacturing. In the aerospace sector, fatigue failure constitutes the primary failure mode of load-bearing components. This paper r …

27.08.2026journal-article

Discover Oncology

Cellular and transcriptomic responses to a PDE4DIP-directed siRNA in MDA-MB-231 breast cancer cells

Cong Wang, Chunjing Bian, Zhe Wang, Tao Luo

Abstract PDE4DIP/myomegalin is a Golgi- and centrosome-associated scaffold encoded by a complex, alternatively spliced gene. We examined cellular and transcriptomic responses of MDA-MB-231 cells to a PDE4DIP-directed siRNA. Its 21-nt target site occurs in 40 of 49 protein-coding transcripts under the current RefSeq annotation, including transcript variant 34, which encodes MMG8/SMYLE, and is therefore not unique to the MMG8/SMYLE transcript. The principal 443M-reactive species was an approximately 150-kDa band cons …

27.08.2026journal-article

Frontiers in Oncology

Hypothermia and recovery outcomes before and after implementation of a multimodal perioperative temperature-management bundle in minimally invasive radical rectal cancer surgery

Qian Liu, Ling Liu, Chenxi Han, Chunmei Cao, Jiefang Ji, Aihua Zhu

Background Inadvertent perioperative hypothermia is common during minimally invasive rectal cancer surgery. We assessed whether a five-component multimodal temperature-management bundle was associated with improved perioperative outcomes. Methods This single-center retrospective before-and-after study included 247 adults undergoing laparoscopic or robot-assisted radical rectal cancer surgery from 2021 to 2025 (pre-implementation, n = 123; post-implementation, n = 124). The primary outcome was any intraoperative nas …

27.08.2026journal-article

International Journal of Pattern Recognition and Artificial Intelligence

Dense-RBF Grad-CAM: A Clinically Trustworthy AI Framework for early Breast Cancer Detection using mammography images

Rupali Patil, V.V. Dixit

Breast cancer continues to be the most common cause of cancer-related deaths in women globally. The earlier breast cancer is identified, the higher the chance of survival. In screening dense breast tissue, the standard diagnostic approach has essential limitations, including a relatively high false-negative rate and poor interpretability. This research introduces a Dense Radial Bias Functional Gradient-weighted Class Activation Mapping method optimized using the Revolution Optimization Algorithm (DRBF-GradCAM_ROA) …

27.08.2026journal-article

Frontiers in Immunology

Targeting splicing-derived neoantigens for precision cancer immunotherapy

Mutian Tang, H. Leighton Grimes, Nathan Salomonis

Aberrant pre-mRNA splicing in cancer generates protein sequences that are rare or absent in normal tissues, creating a rich source of tumor-specific neoantigens for immunotherapy. These splicing-derived neoantigens arise through diverse mechanisms, including recurrent somatic mutations in core spliceosome components ( SF3B1 , SRSF2 , U2AF1 , and ZRSR2 ), epigenetic derepression of transposable elements that give rise to chimeric exon-TE junctions, and coordinated dysregulation of splicing regulatory networks in can …

27.08.2026journal-article

Frontiers in Oncology

Construction and exploratory validation of a digital pathology prognostic model for stage II–III colorectal cancer based on contrastive learning and attention mechanisms

Yizhan Lu, Zhifeng Qu, Chongbao Sun, Bo Li, Xiaoyang Bai, Qingqing Zhao, Wenxin Zhang, Yandong Zhao, Wuteng Cao, Xuezhi Zhou

Introduction Although TNM staging is the standard framework for prognostic assessment in colorectal cancer (CRC), patients within the same stage can have heterogeneous outcomes. This study aimed to extract tumor-tissue features from whole-slide images (WSIs), develop an image-derived prognostic model for stage II–III CRC, and conduct an exploratory evaluation of its performance. Methods A transfer-learning tissue classifier was used to identify tumor regions in CRC WSIs. Self-supervised contrastive learning was use …

27.08.2026journal-article

Journal of Intensive Care Medicine

Modern Approaches to the Treatment of Respiratory Distress Syndrome in Children: The Role of Surfactant and Antenatal Prophylaxis

Aisuluu Omurzakova, Venera Azhikulova, Mairamkan Sharipova, Nargiza Kurbanova, Gulnura Zhunusbaeva

Background and Objective The aim of the study was to evaluate the multilevel impact of antenatal prophylaxis and modern non-invasive respiratory strategies on the course and outcomes of respiratory distress syndrome in new-borns. Methods A total of 4080 hospitalisations of preterm and full-term infants with confirmed respiratory failure, born between 1 January 2017 and 30 September 2024, who received care at the Osh Regional Clinical Maternity Hospital (Kyrgyzstan), were included in the retrospective cohort registr …

27.08.2026journal-article

International Journal of Molecular Sciences

Paclitaxel Nanomedicines: Molecular Mechanisms of Drug Resistance, Tumor Microenvironment-Responsive Delivery, and Translational Challenges

Dejun Cheng, Guowei Yang, Ruibin Kong, Qin Liu, Li Li, Yunpeng Luan, Qijiang Shu

Paclitaxel (PTX) remains a major component of treatment for solid tumors, but its clinical performance is limited by poor aqueous solubility, solvent-associated toxicity, heterogeneous tumor exposure, and multifactorial drug resistance. This narrative review examines PTX nanomedicines from a molecular pharmacology perspective, focusing on how carrier design interacts with resistance pathways, tumor microenvironment signals, and intracellular drug trafficking. We outline resistance mechanisms involving ATP-binding c …

27.08.2026journal-article

Neuro-Oncology

118 Molecular and Immunological Landscape of the Pleomorphic Xanthoastrocytoma–Epithelioid Glioblastoma Spectrum

Iman Dandapath, Swati Mahajan, Jyotsna Singh, Mehar Chand Sharma, Chitra Sarkar, Vaishali Suri

Abstract Background Pleomorphic xanthoastrocytoma (PXA), especially PXAG3, exhibits considerable morphologic, molecular, and clinical overlap with epithelioid glioblastoma (eGB), raising questions regarding their biological relationship and progression dynamics. Although immune checkpoint pathways have been investigated in glioblastoma, comprehensive integration of immune profiling with transcriptomic signatures across the PXA–eGB spectrum remains inadequately defined. Methods Fifty-three tumors (PXAG2 n = 15, PXAG …

27.08.2026journal-article

Neuro-Oncology

142 Arginine deprivation improves survival and activates the immune system in mouse models of diffuse midline glioma

Molly Brooks, Dani Chattenton, Huan Huang, Zehongru Xu, Richard Perryman, Maria Chatziathanasiadou, Nelofer Syed

Abstract Introduction Diffuse midline glioma (DMG) is a rare but fatal childhood brain tumour with no successful treatments. An inert immune microenvironment is a key factor in the failure to find suitable treatments. Arginine deprivation using ADI-PEG20 has been effective in treating a number of cancers, particularly those which cannot generate their own arginine. Our previous studies demonstrated that ADI-PEG20 combined with radiation eradicated GBM tumours and extended survival of animals indefinitely. ADI-PEG20 …

27.08.2026journal-article

Neuro-Oncology

109 Multi-omic integration reveals intra-tumour heterogeneity and identifies disulfiram and copper as a synergistic therapy in paediatric ependymoma

Alina Pandele, Alison Whitby, Sandra Martinez-Jarquin, Chiara Bastiancich, Donald Macarthur, Ian Kamaly-Asl, David Barrett, Richard Grundy, Dong-Hyun Kim, Ruman Rahman

Abstract Introduction Ependymoma (EPN) is the second most malignant paediatric brain tumour. The PF-A subgroup, associated with a hypoxic microenvironment, has a dismal survival rate of 50%, with clinical trials failing to demonstrate a significant survival advantage from chemotherapy to date. We present a multi-omic integration investigating whether spatially-distinct tumour microenvironments represent targetable metabolic niches in PF-A EPN. Methods Surgical sampling of spatially-distinct regions from eight PF-A …