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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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22 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

American Journal of Health-System Pharmacy

Vancomycin pharmacokinetics and dosing in critically ill adult patients on continuous renal replacement therapy: A scoping review

Maha S Assadoon, Jeffrey C Pearson, Shayma H Alzaidi

Abstract Purpose Acute kidney injury is common in critically ill patients, frequently requiring the use of continuous renal replacement therapy (CRRT). Both critical illness and CRRT significantly alter vancomycin pharmacokinetics, affecting dosing and therapeutic drug monitoring. This scoping review aimed to evaluate vancomycin pharmacokinetics and dosing in critically ill adults receiving CRRT. Summary A systematic scoping review was conducted using PRISMA-ScR guidelines. Studies published through April 2026 were …

27.08.2026journal-article

Critical Care Explorations

Immunomodulation Therapy to Treat Severe Malaria With Multiple Organ Failure

Saige Camara, Amy Buck, Mikayla Burrell, H. David Humes, Stuart L. Goldstein, Carlie N. Myers, Michael Humes

BACKGROUND: Malaria causes more than 600,000 deaths annually. Severe malaria is frequently complicated by acute kidney injury (AKI) and multiple organ failure driven by dysregulated host hyperinflammation. Elevated cytokines, including interleukin-6 and tumor necrosis factor alpha, are associated with disease severity and mortality, yet effective adjunctive immunomodulatory therapies are lacking. We report the first clinical use of the selective cytopheretic device (SCD), an extracorporeal immunomodulatory therapy, …

27.08.2026journal-article

Scientific Journal of Dermatology and Venereology

Multiple Giant Molluscum Contagiosum Arising on Antiretroviral Therapy: A Visible Marker of Unrecognized Immunological Failure in Advanced HIV Disease

Aulia Yasmin, Endra Yustin Ellistasari, Ammarilis Murastami, Prasetyadi Mawardi

Introduction: Molluscum contagiosum is ordinarily self-limiting, but in profound immunosuppression it becomes extensive, giant and atypical. Published reports almost uniformly describe such lesions as revealing previously undiagnosed HIV. Giant lesions arising in a patient already established on antiretroviral therapy are far less often described, and carry a different and more urgent meaning. Case Presentation: A 39-year-old man presented with one year of enlarging papules and nodules on the eyelids, face, neck, r …

27.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Comparing four training modalities on body composition, cardiorespiratory fitness and cardiovascular responses in sedentary young men: a randomized trial

Weihua Zheng, Shuai Han, Shunzhe Piao, Runrong Tang, Hansen Li, Weipeng Liu, Yang Cao

Abstract Background Although high-intensity interval training (HIIT), high-intensity continuous training (HICT), moderate-intensity interval training (MIIT), and moderate-intensity continuous training (MICT) have all been shown to improve health outcomes, few studies have compared these four modalities within the same framework. Therefore, this study aimed to compare the effects of 8 weeks of HIIT, HICT, MIIT, and MICT on body composition, cardiorespiratory fitness, and cardiovascular responses in sedentary young m …

27.08.2026journal-article

JAMA Network Open

Cognitive Behavior vs Bright Light Therapy for Insomnia in Women Undergoing Chemotherapy for Breast Cancer

Trang Thuy Do, Jordan Maccora, Rebecca Wallace, Veronica Aedo-Lopez, Marliese Alexander, Sonia Ancoli-Israel, Bei Bei, Robert Blum, Frances Boyle, Daphne Day, Justine Diggens, Prudence A. Francis, Maria Ftanou, Sheila N. Garland, Alysia Kepert, Duncan Mortimer, Andrew J. K. Phillips, Sharad Sharma, Lesley Stafford, Michelle White, Joshua F. Wiley

Importance Women receiving chemotherapy for breast cancer experience insomnia and fatigue, which impair quality of life. To date, no randomized clinical trial (RCT) has evaluated the use of cognitive behavior therapy for insomnia (CBT-I) and bright light therapy (BLT) both alone and in combination, and few have evaluated the use of either during chemotherapy. Objective To determine the main effects of CBT-I and BLT on insomnia and fatigue symptoms in women undergoing chemotherapy for breast cancer. Design, Setting, …

27.08.2026journal-article

PLOS One

Efficacy and safety of 15 mA transcranial alternating current stimulation (tACS) in the therapy of treatment-resistant depression with increased inflammatory activity: Study protocol for a randomized, double-blind, sham-controlled trial

Xuguang An, Jin Zhang, Xiaofei Hou, Chenghao Yang

Background and Objectives Treatment-resistant depression (TRD) poses a significant clinical challenge, with traditional antidepressant therapies often ineffective. Elevated peripheral inflammation has emerged as a potential biological subtype of TRD, highlighting the need for novel treatments. Transcranial alternating current stimulation (tACS) has garnered attention for its potential antidepressant effects, particularly through its impact on glial cells, which are involved in neuroinflammation and neuronal interac …

27.08.2026journal-article

Clinical Rehabilitation

Effects of short-term compression in people with knee osteoarthritis: A sham-controlled randomised trial

Angelica Viana Ferrari, Hugo Jario Almeida Silva, Glauko A.F. Dantas, Julya P.M. Perea, Gabriel M. Ferretti, Tarcísio F. De Campos, Francisco Alburquerque-Sendín, Tania F. Salvini

Objective To evaluate the effects of knee compression using elastic bandages on pain intensity and physical function in individuals with knee osteoarthritis in the short term. Design Three-arm, randomised controlled trial. Setting Individuals with knee osteoarthritis received compression, sham compression, or no bandaging. Main measures Ninety participants were assessed at baseline (Day 1), Day 6 after intervention, and 12 and 24 weeks post-intervention. The primary outcomes were pain intensity assessed using the V …

27.08.2026journal-article

Frontiers in Global Women's Health

Alcohol use, vision therapy, children, mood … what predicts post-traumatic growth after concussion in women?

Martina Anto-Ocrah, Katherine Kenyon, Celestin Niyomugabo, Michael Chen, Jane Liebschutz, Katherine Snedaker

Background Post-traumatic growth (PTG) refers to positive psychological change following a traumatic or life-altering event. Concussion, also known as mild traumatic brain injury(mTBI), results from a physical trauma that can lead to psychological outcomes such as post-traumatic stress disorder (PTSD) as well as PTG. Research indicates that PTG and PTSD occur at similar rates among individuals who have experienced concussion, consistent with findings across other trauma-exposed populations. While women often experi …

27.08.2026journal-article

JAMA Oncology

Systemic Therapy Considerations in Older Adults With Early-Stage Breast Cancer

Claire E. Smith, Sarah L. Sammons, Christina A. Minami, Mina S. Sedrak, Allison Magnuson, Tracey O’Connor, Tammy T. Hshieh, Sydney Smith, Karen Ruderman, Kate Bak, Nancy U. Lin, Rachel A. Freedman

Importance The treatment of older adults with chemotherapy for early-stage breast cancer involves a complex decision-making process that weighs the competing risks of disease recurrence against the potential harms of treatment. While older adults continue to be underrepresented in therapeutic clinical trials, there is a growing body of evidence to support optimal management of each subtype of early-stage breast cancer, including novel strategies like adjuvant cyclin-dependent kinase 4/6 inhibitors in hormone recept …

27.08.2026journal-article

Applied Sciences

Occupational Hazards, Injuries, and Health Outcomes Among Water and Wastewater Workers: A Systematic Review

Diana Artuso, Francesco Giacobbe, Genoveffa Giaquinta, Placido Brancato, Cinzia Lombardo, Viviana Cafiso, Caterina Ledda

Water and wastewater workers encounter complex occupational exposures, but evidence on related injuries and adverse health outcomes remains fragmented. We systematically searched PubMed/MEDLINE, Scopus, Web of Science Core Collection, and Embase on 23 April 2026 and synthesized evidence using a Population–Exposure–Outcome framework and PRISMA 2020. Two reviewers independently screened and extracted data. Methodological quality was evaluated with design-specific Joanna Briggs Institute tools, and certainty for preve …

27.08.2026journal-article

Neuro-Oncology

26 Investigating boron neutron capture therapy for the treatment of glioblastoma

Bethany Mackinnon

Abstract Introduction With an average survival of 12-18 months, glioblastoma is the most commonly diagnosed malignant brain tumour in adults. Despite treatment advances, survival outcomes have shown minimal improvements over the past decades. Persistent treatment resistance, and disease recurrence, highlight the need for alternative, more effective, therapies to be explored. Driven by advances in accelerator-based neutron sources and next-generation boron compounds, boron neutron capture therapy (BNCT) has re-emerg …

27.08.2026journal-article

BMC Women's Health

Randomized controlled trial of adjunctive zinc-containing vaginal hydrogel following fluconazole therapy for vulvovaginal candidiasis

Dávid Rátonyi, Barbara Kozma, Bence Kozma, Attila G. Sipos, Peter Takacs

Abstract Background Recurrent and persistent vulvovaginal candidiasis remain clinically challenging, and supportive strategies that improve post-treatment microbiological stability are needed. Zinc-containing vaginal hydrogel may influence local host–pathogen interactions, but clinical data on its adjunctive use after fluconazole are limited. Methods This single-center, two-arm, parallel-group randomized clinical trial compared standard oral fluconazole therapy alone with fluconazole followed by adjunctive zinc-con …

27.08.2026journal-article

Allergy

Targeting Airway Remodeling in Severe Asthma: Is There a Window of Opportunity for Biologic Therapy Predicting Effects Using Causal Artificial Intelligence?

Sebastiano Gangemi, Sara Manti, Johann Christian Virchow, Giorgio Walter Canonica

ABSTRACT Airway remodeling is increasingly recognized as a major determinant of asthma progression, fixed airflow limitation, and long‐term morbidity, particularly in severe disease. Although biologic therapies have transformed outcomes by reducing exacerbations and systemic corticosteroid exposure, their potential to modify structural airway trajectories—and whether a time‐sensitive “window of opportunity” exists—remains uncertain. Here, we provide a progressive landscape integrating mechanistic remodeling pathway …

27.08.2026journal-article

Colorectal Disease

Threshold association analysis between residual tumour size and distant metastasis risk after neoadjuvant therapy for rectal cancer: A multicentre retrospective study

Hao Zeng, Xueyi Xue, Dongbo Chen, Xiaojie Wang, Kun Lan, Zhilong Yuan, Wenchang Gan, Baodong Liao, Bozhang Wu, Dongbo Xu, Bing Zeng, Pan Chi, Shuangming Lin, Ying Huang

Abstract Purpose This study aimed to perform a threshold analysis of residual tumour size (RTS) to identify the critical threshold influencing distant metastasis (DM), thereby enabling more precise risk stratification. Methods This multicentre retrospective cohort study included patients with locally advanced rectal cancer who underwent radical surgery following neoadjuvant chemoradiotherapy (nCRT). Kaplan–Meier survival curves were plotted and compared using the log‐rank test. Multivariable Cox proportional hazard …

27.08.2026journal-article

Journal of Cardiovascular Development and Disease

Long-Term Attrition in a 12-Month Adapted Physical Activity Program After Cardiac Rehabilitation: A Real-World Longitudinal Study

Francesca Coppi, Gianluca Pagnoni, Aurora Vicenzi, Susan Darroudi, Gustavo Savino, Cecilia Zurlo, Laura Bernaroli, Francesco Marangi, Milena Nasi, Marcello Pinti, Alessio Baccarani, Anna Vittoria Mattioli, Francesco Fedele, Gilda Sandri

Background: Exercise-based cardiac rehabilitation (CR) is a cornerstone of secondary cardiovascular prevention and improves functional capacity, quality of life, and clinical outcomes. However, maintaining long-term participation remains a major challenge in routine clinical practice. Adapted Physical Activity (APA) programs represent a community-based strategy to promote continued exercise after outpatient cardiac disease, although evidence regarding long-term retention and functional outcomes in real-world settin …

27.08.2026journal-article

The Anatolian Journal of Cardiology

Association Between Different Vericiguat Dose Exposures, Concomitant Quadruple Heart Failure Therapy, and Myocardial Fibrosis Burden in Older Adults with Worsening Heart Failure with Reduced Ejection Fraction

Liyong Ge, Guoqiu Wang, Anning Zeng, Wei Li

Background: Older adults with worsening heart failure with reduced ejection fraction (HFrEF) remain high risk despite quadruple guideline-directed medical therapy (GDMT-4). Whether vericiguat exposure relates to change in myocardial fibrosis is unknown. Methods: A single-center, prospective cohort of patients ≥65 years with HFrEF [left ventricular ejection fraction (LVEF) ≤40%] after a recent worsening event (enrollment from January 2022 to December 2023 with 12-month follow-up) was conducted. Vericiguat exposure w …

27.08.2026journal-article

Clinical Journal of Health Sciences

EMDR Therapy: Theoretical Foundations, Clinical Effectiveness, and a Comparative Review with Trauma-Focused Cognitive Behavioral Therapy

Deniz Erdoğan, Reşat Güven, Demet Karakartal

This study is a systematic review examining the theoretical foundations, historical development, neuropsychological mechanisms, and clinical effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) therapy within the framework of psychiatry, clinical psychology, and trauma literature. Developed by Francine Shapiro in the 1980s, EMDR is a structured and integrative psychotherapy method that combines elements of psychodynamic, cognitive, behavioral, and client-centered approaches and is based on the repr …

27.08.2026journal-article

Frontiers in Audiology and Otology

A review of the applied behavioral neuroscience research used to develop the QCore™ tinnitus therapy platform

Grant D. Searchfield

Background Tinnitus is a heterogeneous disorder of hearing with a complex biopsychosocial basis. This paper reviews the research used in the development of the QCore™ Tinnitus Therapy Platform. Methods A narrative review based on a non-systematic literature search. The review describes the research underpinning the development of 3 QCore™ therapy modes (Relief, Relax, and Retrain) and compares them with major tinnitus guidelines. Results Based on an ecological model of tinnitus and adaptation-level theory, the ther …

27.08.2026journal-article

The International Journal of Artificial Organs

Toward a conceptual framework for systemic effects of continuous renal replacement therapy in critical illness

Yusuke Nishimura

Continuous renal replacement therapy (CRRT) is traditionally used for solute and fluid removal in critically ill patients with acute kidney injury. Emerging evidence suggests that CRRT may also influence systemic biological networks, including inflammation, vascular function, immunity, and metabolism. In sepsis and critical illness, these systems are dynamically dysregulated, involving fluctuating inflammatory mediators, endothelial alterations, immune dysfunction ranging from hyperinflammation to immunoparalysis, …

27.08.2026journal-article

physioscience

Balance between evidence, norms and discourse

Slavko Rogan

Abstract Balance training is a core component of physiotherapy. Despite extensive research, education, practice, and guidelines continue to be dominated by the assumption of a general balance ability that can be improved through non-specific training and measured using standardized assessments. The empirical evidence consistently shows that training effects are largely task‑specific and concentrate on the trained demands, while transfer to other tasks remains limited. Building on this evidence, the present paper ad …

27.08.2026journal-article

Frontiers in Immunology

Radiation-induced lung injury in the era of combination anticancer therapy: a narrative review

Xiuqiong Chen, Yi Duan, He Xiao, Zhengbo Wang, Xiao Yang, Chuan Chen, Mengxia Li

Radiation-induced lung injury (RILI) remains a major dose-limiting toxicity of thoracic radiotherapy. In the era of combination anticancer therapy, its recognition and management have become more difficult. Systemic treatments can cause pneumonitis or interstitial lung disease on their own, but they can also change how radiation injury evolves. By sustaining inflammation or delaying repair of the irradiated lung, these agents may convert a typical radiation-related injury into a more complex pulmonary event. For th …

27.08.2026journal-article

Teras Jurnal : Jurnal Teknik Sipil

Participatory Cost Estimation for the Rehabilitation of Uninhabitable Houses for Stimulant Assistance Recipients in Agam Regency, Indonesia

Yulcherlina, Edwina Zainal, Elfida Agus

Abstract This study identifies the physical conditions and cost requirements for housing stimulant assistance for uninhabitable houses (RTLH) in Agam Regency, West Sumatra. A mixed-methods approach was employed, combining surveys, observations, and cost analysis of 76 BSPS recipient units across 15 villages. The findings reveal that 35–45% of assisted houses remain substandard, with sanitation, ventilation, and flooring as the most deficient components. Actual rehabilitation costs range from IDR 35–50 million per u …