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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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23 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Cancer Medicine

Adjusted Risk Stratification of Indeterminate Thyroid Nodules Using the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI‐RADS)

Jessica Zhao, Rita Abi‐Raad, Sara I. Pai, Jonathan Langdon, Minhua Wang, Guoping Cai, John Sinard, Adebowale J. Adeniran, Sanhong Yu

ABSTRACT Background The TI‐RADS guides the initial management of thyroid nodules, but the malignancy risk across different categories of cytologically indeterminate thyroid nodules (CITNs), particularly AUS and FN, remains unclear. Methods We reviewed thyroid FNA specimens diagnosed as AUS or FN with TI‐RADS scores of 3, 4, or 5 from 2017 to 2025. Clinical data, molecular results, and surgical outcomes were analyzed. Results A total of 919 CITNs were identified: 304 with TI‐RADS 3, 454 with TI‐RADS 4, and 161 with …

27.08.2026journal-article

EPISTEMUS

Hidrogeles biomédicos y su papel en la medicina del futuro.

Lady Mar Gastélum Rodríguez, Daniel Fernández-Quiroz, Ma. Araceli Correa-Murrieta, Paul Zavala-Rivera, Carmen Sarai Rochín Wong

Los hidrogeles biomédicos son alternativas para mejorar terapias donde los materiales convencionales presentan limitaciones de adaptabilidad, control de liberación y compatibilidad con los tejidos. Este artículo ofrece una visión general de su comportamiento, sus usos principales y los avances recientes que han ampliado su potencial clínico. La evidencia indica que la difusión es el mecanismo dominante en la liberación de fármacos, permitiendo mantener niveles terapéuticos estables. En el tratamiento de heridas, es …

27.08.2026journal-article

Journal of Human Hypertension

Antihypertensive treatment and adverse psychiatric reactions in primary health care

Emina Curic, Henrik Ohlsson, Kenneth Kendler, Jan Sundquist, Kristina Sundquist, Margareta Reis, Bengt Zöller

Abstract Antihypertensive treatment (AHT) has been associated with adverse psychiatric reactions (APRs), but existing data are conflicting. The aim of the present study was to determine the risk for seven different APRs in drug-naive patients with newly diagnosed hypertension in primary health care. This cohort study analyzed registry data of individuals aged 40–70 with a newly diagnosed untreated hypertension without previous psychiatric or cardiovascular comorbidities in Swedish primary healthcare from 2006 and o …

27.08.2026journal-article

Frontiers in Medicine

Endoscopic drainage and one-stage titanium clip closure for appendiceal root abscess mimicking cecal submucosal tumor: a case report

Yanping Dai, Yang Liu, Jun Ye

Periappendiceal abscess stands as a frequent complication stemming from acute appendicitis. One rare variant presents as a submucosal mass at the root of the appendix and cecum. Clinicians often misdiagnose this form at alarmingly high rates. Conventional management brings substantial surgical trauma. It also prolongs patients’ recovery periods. Whether minimally invasive endoscopic intervention works well for this distinct abscess subtype still lacks solid clinical proof. Whether minimally invasive endoscopic inte …

27.08.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Group C Orthobunyavirus Infection in a Patient from the Amazon Putumayo Region of Colombia During an Oropouche Fever Epidemic

Sully Márquez, Lizeth Salazar, John Collins, Victoria Nipaz, Vanessa Dávila Campos, Jacob Van der Ende, J. Kenneth Wickiser, Thomas Briese, Josefina Coloma

ABSTRACT. Orthobunyaviruses, one of the largest and most diverse genera of viruses, include numerous reassortant viruses and present diagnostic challenges due to similar clinical presentations with other arboviral infections. The detection and isolation of a group C orthobunyavirus from a patient with acute febrile illness from Puerto Ospina, Putumayo Department, Colombia during the 2023–2024 Latin American Oropouche fever regional outbreaks are reported in the present study. Using a vertebrate virus-focused metage …

27.08.2026journal-article

BMC Medicine

Healthy lifestyle is associated with lower infection incidence in type 2 diabetes: A prospective cohort study with multi-omics mediation analysis

Mingming Li, Haojun Zhai, Xiaoqiu Dai, Juan Ye, Xiaoqi Ye, Yebei Liang, Siyu Chen

Abstract Background Individuals with type 2 diabetes mellitus (T2DM) are at substantially increased risk of infections, yet effective strategies for infection prevention remain limited. Although adherence to healthy lifestyles has been associated with lower infection risk in the general population, whether these benefits extend to individuals with T2DM remains unclear. Moreover, the association between the American Heart Association’s Life’s Essential 8 (LE8) metrics and infection risk has not been investigated. Th …

27.08.2026journal-article

Communications Medicine

Immune checkpoint molecules as biomarkers of Staphylococcus aureus bone infection and clinical outcome

Motoo Saito, Katya A. McDonald, Alex K. Grier, Himanshu Meghwani, Javier Rangel-Moreno, H. Mark Kenney, Enrique Becerril-Villanueva, Armando Gamboa-Dominguez, Jennifer Bruno, Christopher A. Beck, Richard A. Proctor, Stephen L. Kates, Edward M. Schwarz, Gowrishankar Muthukrishnan

Abstract Background Staphylococcus aureus prosthetic joint infections (PJIs) are broadly considered incurable, and clinical diagnostics that guide conservative vs. aggressive surgical treatments don’t exist. Understanding the human T cell response to chronic S. aureus osteomyelitis may lead to improved patient outcomes and inform new therapeutic strategies. Methods We performed multi-omics studies, including flow cytometry, scRNA-seq, and immunofluorescence in a humanized NSG-SGM3 BLT mouse model and with human cli …

27.08.2026journal-article

Journal of Clinical Oncology

Long-Term Survival Outcomes of Modified-FOLFOXIRI Plus Cetuximab Versus Bevacizumab in RAS / BRAF Wild-Type Metastatic Colorectal Cancer: Final Analysis of the DEEPER Trial

Yu Sunakawa, Manabu Shiozawa, Takanori Watanabe, Hirofumi Ota, Hisateru Yasui, Taichi Yabuno, Mitsuyoshi Tei, Mitsugu Kochi, Dai Manaka, Hisatsugu Ohori, Tatsuro Yamaguchi, Tamotsu Sagawa, Masahito Kotaka, Yutaro Kubota, Takashi Sekikawa, Masato Nakamura, Masahiro Takeuchi, Wataru Ichikawa, Masashi Fujii, Akihito Tsuji

The randomized phase II DEEPER trial (jRCTs061180022) previously reported superior depth of response with modified 5-fluorouracil, leucovorin, oxaliplatin and irinotecan (m-FOLFOXIRI) plus cetuximab versus bevacizumab in patients with RAS wild-type metastatic colorectal cancer (mCRC). Here, we report updated final survival outcomes and exploratory subgroup analyses focusing on RAS / BRAF wild-type and left-sided tumors. Final overall survival (OS) and progression-free survival (PFS) were analyzed in the per-protoco …

27.08.2026journal-article

Energies

Incipient Interturn Short-Circuit Fault Diagnosis of Permanent Magnet Motors Based on Multiscale Entropy and Topological Data Analysis

Zhaoyu Mao, Jien Ma, Shangke Li, Lin Qiu, Youtong Fang

Incipient stator interturn short-circuit faults in permanent magnet synchronous motors produce only weak changes in the terminal currents, which limits the sensitivity of conventional amplitude- and unbalance-based indicators. This paper proposes a phase-wise diagnostic framework that combines multiscale sample entropy (MSE), topological data analysis (TDA), and a Gaussian mixture model (GMM). For each three-period current window, ten scale-dependent sample-entropy components and two persistent-entropy components a …

27.08.2026journal-article

Journal of Occupational & Environmental Medicine

Mismatch Between Exposure Risk and Protection: Occupational Inequities in COVID-19 Prevention Among Field-Based Utility Workers in South Africa

Tanusha Singh, Patrick Zibaya

Objective: Field-based workers faced unique occupational risks during the COVID-19 pandemic. This study assessed occupational disparities in COVID-19 exposure, vaccination uptake, PPE adequacy and implementation of preventive measures among utility workers. Methods: A cross-sectional analytical study was conducted among 154 South African workers in a power distribution company. Data were collected using a questionnaire and analysed using multivariable logistic regression to estimate adjusted odds ratios. Results: T …

27.08.2026journal-article

Frontiers in Medicine

Dynamic analysis of 22 serum biomarkers following pneumothorax

Jirui Chen, Qiang Lyu, Cheng Wang, Qianyu Han, Yuanyuan Wang, Mingwei Jiang, Lei Xue, Yuxiang Jin

Background Pneumothorax is a common respiratory emergency. Current diagnosis primarily relies on imaging examinations, but these have insufficient sensitivity for early or occult cases, and there is a lack of highly specific molecular markers. Investigating the dynamic changes in serum biomarkers is of great significance for the early diagnosis and intervention of pneumothorax. Methods A rat pneumothorax model was established. Serum was collected before modeling and at 1, 2, 6, 12, 24, and 48 h after modeling. Usin …

27.08.2026journal-article

BMC Surgery

Outpatient Total Extraperitoneal (TEP) for inguinal hernia repair following federal German outpatient operation procedure reform: a preliminary single-center descriptive study of same-day discharge, unplanned admission, and patient-reported outcomes

Julia Michel, Krzysztof Nowakowski, Fabian Nimczewski, Jens Hoeppner, Zsolt Madarasz

Abstract Background Outpatient hernia repair is becoming increasingly important, particularly with the adoption of minimally invasive techniques such as total extraperitoneal repair (TEP). Following the 2022 reform of the federal German outpatient operation procedure (AOP) catalog, our institution implemented a planned outpatient TEP pathway for selected patients with unilateral inguinal hernia. Methods This preliminary retrospective single-center study included a core cohort of 108 patients who were successfully d …

27.08.2026journal-article

PLOS Medicine

Adherence to smartphone-delivered antimicrobial prescribing guidelines in hospitals in Lao PDR: A stepped-wedge cluster randomized controlled trial

Vilada Chansamouth, Danoy Chommanam, Sue J. Lee, Susath Vongphachanh, Manivanh Vongsouvath, Sommay Keomany, Viladeth Paphasiri, Chanthala Phamisith, Siho Sengsavang, Phouvieng Douangdala, Khamsay Detleuxay, Sommana Rattana, Bandith Soumphonphakdy, Valy Keoluangkhot, Mavuto Mukaka, Nicholas P. J. Day, H. Rogier van Doorn, Paul Turner, Mayfong Mayxay, Paul N. Newton, Elizabeth A. Ashley

Background Prescribing guidelines are a cornerstone of antimicrobial stewardship programs. Smartphone applications can increase access in low-and middle-income countries (LMICs). Following the release of the Lao national antimicrobial prescribing guidelines in 2021, this trial compared adherence to these guidelines delivered by a smartphone application versus the paper-based version among hospitalized patients and outpatients in six hospitals in Laos. Methods and findings An open cohort stepped-wedge cluster random …

27.08.2026journal-article

Frontiers in Nutrition

Farming as food as medicine in Tanzania: reviving traditional knowledge for health, nutrition, and sustainability

Leonard R. Ndibalema, Joseph Kalonga

Tanzania faces a complex nutrition and public health challenge characterized by persistent undernutrition, micronutrient deficiencies, and an increasing burden of diet-related non-communicable diseases. At the same time, traditional farming systems that historically supplied diverse, nutrient-dense foods are being weakened by urbanization, climate variability, market pressures, and dietary transitions. This narrative review examines farming as food as medicine in Tanzania by synthesizing literature on indigenous cr …

27.08.2026journal-article

Haematologica

Treatment for relapsed pediatric acute myeloid leukemia: variability and comparative effectiveness of current approaches to re-induction

Caitlin W. Elgarten, Lei Wang, Yimei Li, Alix E. Seif, Regina M. Myers, Daniel J. Zheng, Kira Bona, Emi H. Caywood, Taumoha Ghosh, M. Monica Gramatges, Meret Henry, Tamara P. Miller, Arunkumar Modi, Rajen Mody, Caroline Smith, Jamie Stokke, Naomi Winick, Jennifer J. Wilkes, Victor Wong, Brian T. Fisher, Kelly D. Getz, Richard Aplenc

Post-relapse survival of pediatric acute myeloid leukemia (AML) remains poor and there is a paucity of data to inform relapse regimen selection. We sought to describe the treatment landscape for first AML relapse and compare effectiveness of prevalent salvage regimens. To do this, we conducted a retrospective cohort study using the REAL-AML dataset including pediatric patients with first relapse of AML treated at 13 US pediatric institutions from 2011–2023. Primary analyses compared overall survival (OS) by regimen …

27.08.2026journal-article

Archiv Euromedica

IRRITABLE BOWEL SYNDROME IN CHILDREN: PATHOGENESIS, DIAGNOSIS, AND MANAGEMENT

Agata Leszek, Michał Stermach, Zuzanna Lecyk, Małgorzata Lubowiecka, Natalia Moskwa, Iga B. Borejszo, Joanna H. Marczak, Ksenia Kobielak, Katarzyna Marut, Bianka Błaszkiewicz

Background Irritable bowel syndrome (IBS) is a chronic disorder of gut brain interaction in children associated with recurrent abdominal pain, altered bowel habits, psychological comorbidities, impaired daily functioning, and reduced quality of life. Aim This narrative review summarizes current evidence on the pathogenesis, diagnosis, and long term management of pediatric IBS, with emphasis on gut brain interactions, psychosocial factors, recent pediatric guidelines, and pharmacological and non-pharmacological inte …

27.08.2026journal-article

Journal of the American Medical Informatics Association

Evaluation of a clinical decision support design guideline

Selvana Awad, Thomas Loveday, Andrew Baillie, Melissa T Baysari

Abstract Objectives Human Factors (HF) principles are essential for safe and effective clinical decision support (CDS), yet existing guidance is fragmented and rarely evaluated in real world settings. A novel, evidence-based, vendor-agnostic HF-informed guideline was developed to address this gap. This study evaluated its perceived usefulness, usability, and impact on CDS design and optimization. Materials and Methods A 2-phase explanatory sequential mixed methods approach was used. Phase 1 involved a survey of gui …

27.08.2026journal-article

BioMedInformatics

Beyond AT(N): Integrating Neuroimaging, Fluid Biomarkers, and Artificial Intelligence for Alzheimer’s Disease Diagnosis—A Review

Bassam Al-Naami, Lama Almomani, Feras Al-Naimat, Abdel-Razzak M. Al-Hinnawi

This review consists of three parts related to the AT(N) framework, providing a comprehensive overview of biomarker-based diagnosis of Alzheimer’s disease (AD). In recent years, management of AD has shifted from a symptom-based approach toward biological biomarkers targeted at the amyloid (A), tau (T), and neurodegeneration (N) biomarkers, collectively known as the AT(N) framework. This shift has led to the development and investigation of numerous biomarkers with diverse applications and orientations in the litera …

27.08.2026journal-article

European Journal of Pain

Preventive Treatment With Ceftriaxone Attenuates Neuropathic Pain and Anxiety‐Like Behaviour in a Mouse Model of Partial Sciatic Nerve Ligation

Pauline Braconnier, Mathilde Charlier, Alessia Romanin, Nicolas Gilbert, Nathalie Desmet, Emmanuel Hermans

ABSTRACT Background Neuropathic pain is associated with anxiety‐like disorders, suggesting shared neurobiological mechanisms. Glutamatergic dysregulation and impaired astrocytic glutamate uptake, particularly via the astrocytic transporter GLT‐1, have been implicated in central sensitization and associated affective disorders. Ceftriaxone, a β‐lactam antibiotic known to enhance GLT‐1 expression, may represent a potential strategy to alleviate pain‐related anxiety. Methods Neuropathic pain was induced in mice using …

27.08.2026journal-article

Saudi Journal of Otorhinolaryngology Head and Neck Surgery

Objective Assessment of Nasal Tip Projection and Rotation after Lateral Crural Overlay in Primary Open Rhinoplasty: A Prospective Study

Muaid Ismaiel Aziz Baban, Rand Aras Najeeb, Akeel Alhelfy, Haval A. Hama, Mariwan L. Fatah, Shang Qaraman Qadir, Aros Bestun Saeed, Ahmed Muayad, Chiya A. Qadir, Karnas A. Qadir, Sahar Jaffar Hadi, Omed H. Ali

Abstract Background: The lateral crural overlay technique is used in rhinoplasty to correct nasal tip over-projection and ptosis by modifying tip projection and rotation. The study aims to evaluate the effect of the lateral crural overlay technique on nasal tip projection and rotation using objective preoperative and postoperative measurements. Materials and Methods: This prospective interventional clinical study included 50 patients undergoing primary open rhinoplasty using the LCO technique. Patients were followe …

27.08.2026journal-article

Healthcare

Perceptions and Acceptability of Artemisia annua Herbal Tea for Malaria Treatment: A Qualitative Study in Kalima Health Zone, Maniema, Democratic Republic of the Congo

Jerome Munyangi wa Nkola, Pierre Akilimali Zalagile, Hendrick Lukuke Mbutshu, Spartacus Kabala Munyemo, Imani Ramazani Bin Eradi, Alioune Camara

Background: Malaria is a significant public health challenge in the Democratic Republic of the Congo. In conflict-affected areas, access to quality-assured ACTs is restricted by chronic stockouts and circulation of substandard and falsified antimalarials. This study investigates perceptions and social acceptability of Artemisia annua herbal tea in the Kalima Health Zone. Methods: Distinct from the prior provider-arm cross-sectional survey of the same program in the Kalima Health Zone which sampled only biomedical h …

27.08.2026journal-article

Frontiers in Medicine

RBPMS::NTRK3-rearranged sacral malignant spindle cell tumor in neurofibromatosis diagnosed by RNA sequencing: a case report and literature review

Chaopeng Chen, Bin Qi, Yuanyuan Miao, Zhujiang Zhuang, Chaowen Wang, Weiping Dai

Malignant spindle cell tumors arising in patients with neurofibromatosis are diagnostically challenging because malignant peripheral nerve sheath tumor (MPNST) and emerging NTRK-rearranged mesenchymal neoplasms may show overlapping clinical, histological, and immunophenotypic features. We report a 31-year-old man with a more than 20-year history of neurofibromatosis who presented with progressive lumbosacral pain and left lower-limb numbness. Imaging revealed a large cystic-solid sacral mass involving the S1–S2 reg …

27.08.2026journal-article

Information

Stage-Oriented Text Classification for Russian-Language Clinical and Genetic Documents: Pre-Genetic Triage and Post-Genetic Report Interpretation

Assem Shayakhmetova, Madina Sambetbayeva, Vladimir Barakhnin, Anar Sultangaziyeva, Nurzhan Mukazhanov, Ardak Batyrkhanov, Sandugash Serikbayeva, Raushan Begim

The growing volume of unstructured clinical and genetic text calls for automated processing methods that can meaningfully support clinical decision-making. Most existing work, however, treats the analysis of patient clinical descriptions and the interpretation of genetic reports as unrelated tasks, disregarding the sequence in which real diagnostic decisions unfold. We study two stage-specific families of classification tasks corresponding to the two points at which such decisions are taken—pre-genetic triage from …