Medizin: neue Gesundheitspublikationen – Seite 62

27.08.2026journal-article

Energies

Incipient Interturn Short-Circuit Fault Diagnosis of Permanent Magnet Motors Based on Multiscale Entropy and Topological Data Analysis

Zhaoyu Mao, Jien Ma, Shangke Li, Lin Qiu, Youtong Fang

Incipient stator interturn short-circuit faults in permanent magnet synchronous motors produce only weak changes in the terminal currents, which limits the sensitivity of conventional amplitude- and unbalance-based indicators. This paper proposes a phase-wise diagnostic framework that combines multiscale sample entropy (MSE), topological data analysis (TDA), and a Gaussian mixture model (GMM). For each three-period current window, ten scale-dependent sample-entropy components and two persistent-entropy components a …

27.08.2026journal-article

Journal of Occupational & Environmental Medicine

Mismatch Between Exposure Risk and Protection: Occupational Inequities in COVID-19 Prevention Among Field-Based Utility Workers in South Africa

Tanusha Singh, Patrick Zibaya

Objective: Field-based workers faced unique occupational risks during the COVID-19 pandemic. This study assessed occupational disparities in COVID-19 exposure, vaccination uptake, PPE adequacy and implementation of preventive measures among utility workers. Methods: A cross-sectional analytical study was conducted among 154 South African workers in a power distribution company. Data were collected using a questionnaire and analysed using multivariable logistic regression to estimate adjusted odds ratios. Results: T …

27.08.2026journal-article

Frontiers in Medicine

Dynamic analysis of 22 serum biomarkers following pneumothorax

Jirui Chen, Qiang Lyu, Cheng Wang, Qianyu Han, Yuanyuan Wang, Mingwei Jiang, Lei Xue, Yuxiang Jin

Background Pneumothorax is a common respiratory emergency. Current diagnosis primarily relies on imaging examinations, but these have insufficient sensitivity for early or occult cases, and there is a lack of highly specific molecular markers. Investigating the dynamic changes in serum biomarkers is of great significance for the early diagnosis and intervention of pneumothorax. Methods A rat pneumothorax model was established. Serum was collected before modeling and at 1, 2, 6, 12, 24, and 48 h after modeling. Usin …

27.08.2026journal-article

BMC Surgery

Outpatient Total Extraperitoneal (TEP) for inguinal hernia repair following federal German outpatient operation procedure reform: a preliminary single-center descriptive study of same-day discharge, unplanned admission, and patient-reported outcomes

Julia Michel, Krzysztof Nowakowski, Fabian Nimczewski, Jens Hoeppner, Zsolt Madarasz

Abstract Background Outpatient hernia repair is becoming increasingly important, particularly with the adoption of minimally invasive techniques such as total extraperitoneal repair (TEP). Following the 2022 reform of the federal German outpatient operation procedure (AOP) catalog, our institution implemented a planned outpatient TEP pathway for selected patients with unilateral inguinal hernia. Methods This preliminary retrospective single-center study included a core cohort of 108 patients who were successfully d …

27.08.2026journal-article

PLOS Medicine

Adherence to smartphone-delivered antimicrobial prescribing guidelines in hospitals in Lao PDR: A stepped-wedge cluster randomized controlled trial

Vilada Chansamouth, Danoy Chommanam, Sue J. Lee, Susath Vongphachanh, Manivanh Vongsouvath, Sommay Keomany, Viladeth Paphasiri, Chanthala Phamisith, Siho Sengsavang, Phouvieng Douangdala, Khamsay Detleuxay, Sommana Rattana, Bandith Soumphonphakdy, Valy Keoluangkhot, Mavuto Mukaka, Nicholas P. J. Day, H. Rogier van Doorn, Paul Turner, Mayfong Mayxay, Paul N. Newton, Elizabeth A. Ashley

Background Prescribing guidelines are a cornerstone of antimicrobial stewardship programs. Smartphone applications can increase access in low-and middle-income countries (LMICs). Following the release of the Lao national antimicrobial prescribing guidelines in 2021, this trial compared adherence to these guidelines delivered by a smartphone application versus the paper-based version among hospitalized patients and outpatients in six hospitals in Laos. Methods and findings An open cohort stepped-wedge cluster random …

27.08.2026journal-article

Frontiers in Nutrition

Farming as food as medicine in Tanzania: reviving traditional knowledge for health, nutrition, and sustainability

Leonard R. Ndibalema, Joseph Kalonga

Tanzania faces a complex nutrition and public health challenge characterized by persistent undernutrition, micronutrient deficiencies, and an increasing burden of diet-related non-communicable diseases. At the same time, traditional farming systems that historically supplied diverse, nutrient-dense foods are being weakened by urbanization, climate variability, market pressures, and dietary transitions. This narrative review examines farming as food as medicine in Tanzania by synthesizing literature on indigenous cr …

27.08.2026journal-article

Haematologica

Treatment for relapsed pediatric acute myeloid leukemia: variability and comparative effectiveness of current approaches to re-induction

Caitlin W. Elgarten, Lei Wang, Yimei Li, Alix E. Seif, Regina M. Myers, Daniel J. Zheng, Kira Bona, Emi H. Caywood, Taumoha Ghosh, M. Monica Gramatges, Meret Henry, Tamara P. Miller, Arunkumar Modi, Rajen Mody, Caroline Smith, Jamie Stokke, Naomi Winick, Jennifer J. Wilkes, Victor Wong, Brian T. Fisher, Kelly D. Getz, Richard Aplenc

Post-relapse survival of pediatric acute myeloid leukemia (AML) remains poor and there is a paucity of data to inform relapse regimen selection. We sought to describe the treatment landscape for first AML relapse and compare effectiveness of prevalent salvage regimens. To do this, we conducted a retrospective cohort study using the REAL-AML dataset including pediatric patients with first relapse of AML treated at 13 US pediatric institutions from 2011–2023. Primary analyses compared overall survival (OS) by regimen …

27.08.2026journal-article

Archiv Euromedica

IRRITABLE BOWEL SYNDROME IN CHILDREN: PATHOGENESIS, DIAGNOSIS, AND MANAGEMENT

Agata Leszek, Michał Stermach, Zuzanna Lecyk, Małgorzata Lubowiecka, Natalia Moskwa, Iga B. Borejszo, Joanna H. Marczak, Ksenia Kobielak, Katarzyna Marut, Bianka Błaszkiewicz

Background Irritable bowel syndrome (IBS) is a chronic disorder of gut brain interaction in children associated with recurrent abdominal pain, altered bowel habits, psychological comorbidities, impaired daily functioning, and reduced quality of life. Aim This narrative review summarizes current evidence on the pathogenesis, diagnosis, and long term management of pediatric IBS, with emphasis on gut brain interactions, psychosocial factors, recent pediatric guidelines, and pharmacological and non-pharmacological inte …

27.08.2026journal-article

Journal of the American Medical Informatics Association

Evaluation of a clinical decision support design guideline

Selvana Awad, Thomas Loveday, Andrew Baillie, Melissa T Baysari

Abstract Objectives Human Factors (HF) principles are essential for safe and effective clinical decision support (CDS), yet existing guidance is fragmented and rarely evaluated in real world settings. A novel, evidence-based, vendor-agnostic HF-informed guideline was developed to address this gap. This study evaluated its perceived usefulness, usability, and impact on CDS design and optimization. Materials and Methods A 2-phase explanatory sequential mixed methods approach was used. Phase 1 involved a survey of gui …

27.08.2026journal-article

BioMedInformatics

Beyond AT(N): Integrating Neuroimaging, Fluid Biomarkers, and Artificial Intelligence for Alzheimer’s Disease Diagnosis—A Review

Bassam Al-Naami, Lama Almomani, Feras Al-Naimat, Abdel-Razzak M. Al-Hinnawi

This review consists of three parts related to the AT(N) framework, providing a comprehensive overview of biomarker-based diagnosis of Alzheimer’s disease (AD). In recent years, management of AD has shifted from a symptom-based approach toward biological biomarkers targeted at the amyloid (A), tau (T), and neurodegeneration (N) biomarkers, collectively known as the AT(N) framework. This shift has led to the development and investigation of numerous biomarkers with diverse applications and orientations in the litera …

27.08.2026journal-article

European Journal of Pain

Preventive Treatment With Ceftriaxone Attenuates Neuropathic Pain and Anxiety‐Like Behaviour in a Mouse Model of Partial Sciatic Nerve Ligation

Pauline Braconnier, Mathilde Charlier, Alessia Romanin, Nicolas Gilbert, Nathalie Desmet, Emmanuel Hermans

ABSTRACT Background Neuropathic pain is associated with anxiety‐like disorders, suggesting shared neurobiological mechanisms. Glutamatergic dysregulation and impaired astrocytic glutamate uptake, particularly via the astrocytic transporter GLT‐1, have been implicated in central sensitization and associated affective disorders. Ceftriaxone, a β‐lactam antibiotic known to enhance GLT‐1 expression, may represent a potential strategy to alleviate pain‐related anxiety. Methods Neuropathic pain was induced in mice using …

27.08.2026journal-article

Saudi Journal of Otorhinolaryngology Head and Neck Surgery

Objective Assessment of Nasal Tip Projection and Rotation after Lateral Crural Overlay in Primary Open Rhinoplasty: A Prospective Study

Muaid Ismaiel Aziz Baban, Rand Aras Najeeb, Akeel Alhelfy, Haval A. Hama, Mariwan L. Fatah, Shang Qaraman Qadir, Aros Bestun Saeed, Ahmed Muayad, Chiya A. Qadir, Karnas A. Qadir, Sahar Jaffar Hadi, Omed H. Ali

Abstract Background: The lateral crural overlay technique is used in rhinoplasty to correct nasal tip over-projection and ptosis by modifying tip projection and rotation. The study aims to evaluate the effect of the lateral crural overlay technique on nasal tip projection and rotation using objective preoperative and postoperative measurements. Materials and Methods: This prospective interventional clinical study included 50 patients undergoing primary open rhinoplasty using the LCO technique. Patients were followe …

27.08.2026journal-article

Healthcare

Perceptions and Acceptability of Artemisia annua Herbal Tea for Malaria Treatment: A Qualitative Study in Kalima Health Zone, Maniema, Democratic Republic of the Congo

Jerome Munyangi wa Nkola, Pierre Akilimali Zalagile, Hendrick Lukuke Mbutshu, Spartacus Kabala Munyemo, Imani Ramazani Bin Eradi, Alioune Camara

Background: Malaria is a significant public health challenge in the Democratic Republic of the Congo. In conflict-affected areas, access to quality-assured ACTs is restricted by chronic stockouts and circulation of substandard and falsified antimalarials. This study investigates perceptions and social acceptability of Artemisia annua herbal tea in the Kalima Health Zone. Methods: Distinct from the prior provider-arm cross-sectional survey of the same program in the Kalima Health Zone which sampled only biomedical h …

27.08.2026journal-article

Frontiers in Medicine

RBPMS::NTRK3-rearranged sacral malignant spindle cell tumor in neurofibromatosis diagnosed by RNA sequencing: a case report and literature review

Chaopeng Chen, Bin Qi, Yuanyuan Miao, Zhujiang Zhuang, Chaowen Wang, Weiping Dai

Malignant spindle cell tumors arising in patients with neurofibromatosis are diagnostically challenging because malignant peripheral nerve sheath tumor (MPNST) and emerging NTRK-rearranged mesenchymal neoplasms may show overlapping clinical, histological, and immunophenotypic features. We report a 31-year-old man with a more than 20-year history of neurofibromatosis who presented with progressive lumbosacral pain and left lower-limb numbness. Imaging revealed a large cystic-solid sacral mass involving the S1–S2 reg …

27.08.2026journal-article

Information

Stage-Oriented Text Classification for Russian-Language Clinical and Genetic Documents: Pre-Genetic Triage and Post-Genetic Report Interpretation

Assem Shayakhmetova, Madina Sambetbayeva, Vladimir Barakhnin, Anar Sultangaziyeva, Nurzhan Mukazhanov, Ardak Batyrkhanov, Sandugash Serikbayeva, Raushan Begim

The growing volume of unstructured clinical and genetic text calls for automated processing methods that can meaningfully support clinical decision-making. Most existing work, however, treats the analysis of patient clinical descriptions and the interpretation of genetic reports as unrelated tasks, disregarding the sequence in which real diagnostic decisions unfold. We study two stage-specific families of classification tasks corresponding to the two points at which such decisions are taken—pre-genetic triage from …

27.08.2026journal-article

EMBO Molecular Medicine

A synthetic NKG2A engager enables long-term persistence of HLA-deficient allogeneic engineered Tregs

Tingxi Guo, Kaya R Epstein, Maegan E Hoover, Nathan W Zammit, Jennifer Y Yam, Scott Hussell, Sophia Hernandez, Abigail Doherty, Payam Zarin, Martina Sassone-Corsi, Lindsay Webb, Gene I Uenishi, Thomas Wickham, Christopher L Moore

Abstract Allogeneic cell therapies offer a scalable and off-the-shelf alternative to the autologous approach, but immune rejection, particularly by natural killer (NK) cells following human leukocyte antigen (HLA) ablation, remains a major barrier to their persistence. Here, we report an improved synthetic NKG2A engager to selectively inhibit NKG2A⁺ NK cells while avoiding activation of NKG2C⁺ subsets, thereby overcoming a key limitation of the natural ligand HLA-E. Engineered regulatory T cells (EngTregs) lacking …

27.08.2026journal-article

Journal of Clinical Medicine

Why Hysterectomy Algorithms Diverge from Clinical Practice: A Romanian Cohort Study

Nicoleta Alina Mareș, Alexandru Iordache, Niculae Iordache, Andrei Răzvan Stoica, Iulia Bistriceanu, Iuliana Ceausu, Cristian Viorel Poalelungi

Background: Hysterectomy is a prevalent gynecological procedure and ensuring appropriate use of minimally invasive approaches is essential to enhance the value and quality of care. The aim of this study was to investigate the gap between algorithm-guided recommendations and routine surgical practice in a Romanian real-world cohort by identifying non-clinical factors associated with deviation from the algorithm, and assessing its impact on postoperative hospitalization. Methods: This is a retrospective analytical ob …

27.08.2026journal-article

Archives of Orthopaedic and Trauma Surgery

Pre- and postoperative 4D CT analysis of thumb CMC joint kinematics after first metacarpal extension osteotomy

Alissa Guebeli, Philipp Honigmann, Johannes G. G. Dobbe, Marco Keller

Abstract Introduction First metacarpal extension (Wilson) osteotomy combined with modified Brunelli ligamentoplasty is performed for early thumb carpometacarpal (CMC1) osteoarthritis to improve pain and function. The purpose of this study was to quantify in vivo changes in CMC1 joint contact distribution and kinematics after this combined procedure and to determine whether postoperative patterns resemble those of healthy volunteers. We hypothesized that the procedure would reduce cumulative palmar contact during op …

27.08.2026journal-article

Annals of Gastroenterological Surgery

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

Atsushi Hamabe, Masaaki Ito, Shigeo Toda, Yusuke Suwa, Suguru Hasegawa, Masanori Kotake, Masafumi Inomata, Kazuki Ueda, Atsushi Ogura, Kiichi Sugimoto, Kei Kimura, Koki Otsuka, Tatsuki Noguchi, Koya Hida, Yasumitsu Hirano, Kazushige Kawai, Shigeru Yamagishi, Takeshi Naitoh, Ichiro Takemasa, Japan Society of Laparoscopic Colorectal Surgery

ABSTRACT Aim Circumferential resection margin (CRM) status is a well‐established prognostic factor in rectal cancer surgery; however, its long‐term oncological relevance has not been prospectively validated in Japan, where upfront surgery has long been widely used. This study assessed the prognostic impact of CRM in patients with locally advanced rectal cancer treated with minimally invasive surgery. Methods The PRODUCT trial was a multicenter, prospective, observational study conducted at 18 institutions in Japan. …

27.08.2026journal-article

Molecular Genetics & Genomic Medicine

Biallelic VPS41 Variants in Autosomal Recessive Spinocerebellar Ataxia 29 Resolved by Long‐Read Sequencing and RNA Analysis

Natsuki Nakamura, Yosuke Nishio, Hiromi Nyuzuki, Ai Fukushima, Masaki Miura, Yu Kobayashi, Risako Ishioka, Kotaro Tsukada, Yasuyoshi Oka, Koyo Tsujikawa, Hironobu Morinaga, Mie Inaba, Jun Tohyama, Yuka Nakazawa, Takeshi Ikeuchi, Takeshi Ono, Shinji Saitoh, Tomoo Ogi

ABSTRACT Background Biallelic variants in VPS41 , encoding a subunit of the HOPS complex, cause autosomal recessive spinocerebellar ataxia 29 (SCAR29), a rare neurodevelopmental disorder with an incompletely defined phenotypic and molecular spectrum. Methods We investigated a 24‐year‐old man with cerebellar ataxia, hypotonia, and intellectual disability. Exome sequencing identified four candidate VPS41 variants. Because maternal DNA was unavailable, long‐read genome sequencing was performed to determine allelic con …

27.08.2026journal-article

Med Phoenix

Impact of Patient Counselling on Knowledge, Attitude and Practice in Management of Diabetes Mellitus among Patients Visiting National Medical College & Teaching Hospital, Birgunj, Nepal

Anil Kumar Shah, Amrullah Shidiki, Sanjay Kumar Sah

Introduction: Type 2 diabetes mellitus (T2DM) is a major metabolic disease. Counselling of a patient uplifts the patient’s ability to cope with disease and make decisions on its management and medication. The aim of counselling is to provide information about KAP needed for disease management thereby enhancing therapeutic outcomes. Materials and Methods: A case control study was conducted among 113 T2DM patients. The fasting blood sugar (FBS), Post prandial (PP); KAP and medical adherence (MA) scores were obtained …

27.08.2026journal-article

ANZ Journal of Surgery

How to Do a Refined Rotational Flap

Ho Yin Kam, Ashavri Sharma, Sam Hamilton, Nitin Sharma

ABSTRACT Rotation flaps are a reliable reconstructive option for moderate to large cutaneous defects, particularly in areas of limited tissue laxity. However, flap planning can be challenging for trainees or surgeons who perform these reconstructions infrequently. We describe a simplified and reproducible modification of Ahuja's rotation flap technique, using triangulation of the defect and proportional geometric landmarks to guide flap design. Key principles include a broad‐based flap, generous rotational arc, pre …

27.08.2026journal-article

International Journal of Biology and Life Sciences

Progress on Molecular Mechanism of Disulfide Death in Gastric Cancer and its Clinical Targeted Treatment Strategy

Yujie Liu

Disulfide death is a newly discovered regulatory cell death mode in 2023, which is driven by the high expression of SLC7A11 and glucose starvation, and is characterized by the collapse of actin skeleton. It shows great potential in the targeted treatment of gastric cancer. This paper systematically reviewed the molecular mechanism of disulfide death, summarized the research progress of disulfide death related genes (DRGs) in the prognosis evaluation, molecular typing and immune microenvironment regulation of gastri …

27.08.2026journal-article

Cells

Endothelial Cells Offer a Better Option than Smooth Muscle Cells for the Treatment of Ischemic Limb Disease

Akazha Green, Hanyu Zhang, Bing Bo, Bijay Guragain, Yalin Wu, Yuhua Wei, Jianyi Zhang, Lei Ye

Peripheral arterial disease (PAD) is estimated to affect at least 10 million people in the United States and over 200 million individuals worldwide. The clinical manifestations of PAD range from impaired mobility and pain with activity to chronic limb-threatening ischemia with risk of eventual tissue loss. Despite the significant global prevalence and debilitating consequences of the disease, non-option patients remain largely undertreated. Recognizing that ECs are well-known for their therapeutic role in enhancing …

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Aktuelle Forschung nach Fachgebiet

Incipient Interturn Short-Circuit Fault Diagnosis of Permanent Magnet Motors Based on Multiscale Entropy and Topological Data Analysis

Mismatch Between Exposure Risk and Protection: Occupational Inequities in COVID-19 Prevention Among Field-Based Utility Workers in South Africa

Dynamic analysis of 22 serum biomarkers following pneumothorax

Outpatient Total Extraperitoneal (TEP) for inguinal hernia repair following federal German outpatient operation procedure reform: a preliminary single-center descriptive study of same-day discharge, unplanned admission, and patient-reported outcomes

Adherence to smartphone-delivered antimicrobial prescribing guidelines in hospitals in Lao PDR: A stepped-wedge cluster randomized controlled trial

Farming as food as medicine in Tanzania: reviving traditional knowledge for health, nutrition, and sustainability

Treatment for relapsed pediatric acute myeloid leukemia: variability and comparative effectiveness of current approaches to re-induction

IRRITABLE BOWEL SYNDROME IN CHILDREN: PATHOGENESIS, DIAGNOSIS, AND MANAGEMENT

Evaluation of a clinical decision support design guideline

Beyond AT(N): Integrating Neuroimaging, Fluid Biomarkers, and Artificial Intelligence for Alzheimer’s Disease Diagnosis—A Review

Preventive Treatment With Ceftriaxone Attenuates Neuropathic Pain and Anxiety‐Like Behaviour in a Mouse Model of Partial Sciatic Nerve Ligation

Objective Assessment of Nasal Tip Projection and Rotation after Lateral Crural Overlay in Primary Open Rhinoplasty: A Prospective Study

Perceptions and Acceptability of Artemisia annua Herbal Tea for Malaria Treatment: A Qualitative Study in Kalima Health Zone, Maniema, Democratic Republic of the Congo

RBPMS::NTRK3-rearranged sacral malignant spindle cell tumor in neurofibromatosis diagnosed by RNA sequencing: a case report and literature review

Stage-Oriented Text Classification for Russian-Language Clinical and Genetic Documents: Pre-Genetic Triage and Post-Genetic Report Interpretation

A synthetic NKG2A engager enables long-term persistence of HLA-deficient allogeneic engineered Tregs

Why Hysterectomy Algorithms Diverge from Clinical Practice: A Romanian Cohort Study

Pre- and postoperative 4D CT analysis of thumb CMC joint kinematics after first metacarpal extension osteotomy

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

Biallelic VPS41 Variants in Autosomal Recessive Spinocerebellar Ataxia 29 Resolved by Long‐Read Sequencing and RNA Analysis

Impact of Patient Counselling on Knowledge, Attitude and Practice in Management of Diabetes Mellitus among Patients Visiting National Medical College & Teaching Hospital, Birgunj, Nepal

How to Do a Refined Rotational Flap

Progress on Molecular Mechanism of Disulfide Death in Gastric Cancer and its Clinical Targeted Treatment Strategy

Endothelial Cells Offer a Better Option than Smooth Muscle Cells for the Treatment of Ischemic Limb Disease