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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

European Journal of Pain

Preventive Treatment With Ceftriaxone Attenuates Neuropathic Pain and Anxiety‐Like Behaviour in a Mouse Model of Partial Sciatic Nerve Ligation

Pauline Braconnier, Mathilde Charlier, Alessia Romanin, Nicolas Gilbert, Nathalie Desmet, Emmanuel Hermans

ABSTRACT Background Neuropathic pain is associated with anxiety‐like disorders, suggesting shared neurobiological mechanisms. Glutamatergic dysregulation and impaired astrocytic glutamate uptake, particularly via the astrocytic transporter GLT‐1, have been implicated in central sensitization and associated affective disorders. Ceftriaxone, a β‐lactam antibiotic known to enhance GLT‐1 expression, may represent a potential strategy to alleviate pain‐related anxiety. Methods Neuropathic pain was induced in mice using …

27.08.2026journal-article

Saudi Journal of Otorhinolaryngology Head and Neck Surgery

Objective Assessment of Nasal Tip Projection and Rotation after Lateral Crural Overlay in Primary Open Rhinoplasty: A Prospective Study

Muaid Ismaiel Aziz Baban, Rand Aras Najeeb, Akeel Alhelfy, Haval A. Hama, Mariwan L. Fatah, Shang Qaraman Qadir, Aros Bestun Saeed, Ahmed Muayad, Chiya A. Qadir, Karnas A. Qadir, Sahar Jaffar Hadi, Omed H. Ali

Abstract Background: The lateral crural overlay technique is used in rhinoplasty to correct nasal tip over-projection and ptosis by modifying tip projection and rotation. The study aims to evaluate the effect of the lateral crural overlay technique on nasal tip projection and rotation using objective preoperative and postoperative measurements. Materials and Methods: This prospective interventional clinical study included 50 patients undergoing primary open rhinoplasty using the LCO technique. Patients were followe …

27.08.2026journal-article

Healthcare

Perceptions and Acceptability of Artemisia annua Herbal Tea for Malaria Treatment: A Qualitative Study in Kalima Health Zone, Maniema, Democratic Republic of the Congo

Jerome Munyangi wa Nkola, Pierre Akilimali Zalagile, Hendrick Lukuke Mbutshu, Spartacus Kabala Munyemo, Imani Ramazani Bin Eradi, Alioune Camara

Background: Malaria is a significant public health challenge in the Democratic Republic of the Congo. In conflict-affected areas, access to quality-assured ACTs is restricted by chronic stockouts and circulation of substandard and falsified antimalarials. This study investigates perceptions and social acceptability of Artemisia annua herbal tea in the Kalima Health Zone. Methods: Distinct from the prior provider-arm cross-sectional survey of the same program in the Kalima Health Zone which sampled only biomedical h …

27.08.2026journal-article

Frontiers in Medicine

RBPMS::NTRK3-rearranged sacral malignant spindle cell tumor in neurofibromatosis diagnosed by RNA sequencing: a case report and literature review

Chaopeng Chen, Bin Qi, Yuanyuan Miao, Zhujiang Zhuang, Chaowen Wang, Weiping Dai

Malignant spindle cell tumors arising in patients with neurofibromatosis are diagnostically challenging because malignant peripheral nerve sheath tumor (MPNST) and emerging NTRK-rearranged mesenchymal neoplasms may show overlapping clinical, histological, and immunophenotypic features. We report a 31-year-old man with a more than 20-year history of neurofibromatosis who presented with progressive lumbosacral pain and left lower-limb numbness. Imaging revealed a large cystic-solid sacral mass involving the S1–S2 reg …

27.08.2026journal-article

Information

Stage-Oriented Text Classification for Russian-Language Clinical and Genetic Documents: Pre-Genetic Triage and Post-Genetic Report Interpretation

Assem Shayakhmetova, Madina Sambetbayeva, Vladimir Barakhnin, Anar Sultangaziyeva, Nurzhan Mukazhanov, Ardak Batyrkhanov, Sandugash Serikbayeva, Raushan Begim

The growing volume of unstructured clinical and genetic text calls for automated processing methods that can meaningfully support clinical decision-making. Most existing work, however, treats the analysis of patient clinical descriptions and the interpretation of genetic reports as unrelated tasks, disregarding the sequence in which real diagnostic decisions unfold. We study two stage-specific families of classification tasks corresponding to the two points at which such decisions are taken—pre-genetic triage from …

27.08.2026journal-article

EMBO Molecular Medicine

A synthetic NKG2A engager enables long-term persistence of HLA-deficient allogeneic engineered Tregs

Tingxi Guo, Kaya R Epstein, Maegan E Hoover, Nathan W Zammit, Jennifer Y Yam, Scott Hussell, Sophia Hernandez, Abigail Doherty, Payam Zarin, Martina Sassone-Corsi, Lindsay Webb, Gene I Uenishi, Thomas Wickham, Christopher L Moore

Abstract Allogeneic cell therapies offer a scalable and off-the-shelf alternative to the autologous approach, but immune rejection, particularly by natural killer (NK) cells following human leukocyte antigen (HLA) ablation, remains a major barrier to their persistence. Here, we report an improved synthetic NKG2A engager to selectively inhibit NKG2A⁺ NK cells while avoiding activation of NKG2C⁺ subsets, thereby overcoming a key limitation of the natural ligand HLA-E. Engineered regulatory T cells (EngTregs) lacking …

27.08.2026journal-article

Journal of Clinical Medicine

Why Hysterectomy Algorithms Diverge from Clinical Practice: A Romanian Cohort Study

Nicoleta Alina Mareș, Alexandru Iordache, Niculae Iordache, Andrei Răzvan Stoica, Iulia Bistriceanu, Iuliana Ceausu, Cristian Viorel Poalelungi

Background: Hysterectomy is a prevalent gynecological procedure and ensuring appropriate use of minimally invasive approaches is essential to enhance the value and quality of care. The aim of this study was to investigate the gap between algorithm-guided recommendations and routine surgical practice in a Romanian real-world cohort by identifying non-clinical factors associated with deviation from the algorithm, and assessing its impact on postoperative hospitalization. Methods: This is a retrospective analytical ob …

27.08.2026journal-article

Archives of Orthopaedic and Trauma Surgery

Pre- and postoperative 4D CT analysis of thumb CMC joint kinematics after first metacarpal extension osteotomy

Alissa Guebeli, Philipp Honigmann, Johannes G. G. Dobbe, Marco Keller

Abstract Introduction First metacarpal extension (Wilson) osteotomy combined with modified Brunelli ligamentoplasty is performed for early thumb carpometacarpal (CMC1) osteoarthritis to improve pain and function. The purpose of this study was to quantify in vivo changes in CMC1 joint contact distribution and kinematics after this combined procedure and to determine whether postoperative patterns resemble those of healthy volunteers. We hypothesized that the procedure would reduce cumulative palmar contact during op …

27.08.2026journal-article

Annals of Gastroenterological Surgery

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

Atsushi Hamabe, Masaaki Ito, Shigeo Toda, Yusuke Suwa, Suguru Hasegawa, Masanori Kotake, Masafumi Inomata, Kazuki Ueda, Atsushi Ogura, Kiichi Sugimoto, Kei Kimura, Koki Otsuka, Tatsuki Noguchi, Koya Hida, Yasumitsu Hirano, Kazushige Kawai, Shigeru Yamagishi, Takeshi Naitoh, Ichiro Takemasa, Japan Society of Laparoscopic Colorectal Surgery

ABSTRACT Aim Circumferential resection margin (CRM) status is a well‐established prognostic factor in rectal cancer surgery; however, its long‐term oncological relevance has not been prospectively validated in Japan, where upfront surgery has long been widely used. This study assessed the prognostic impact of CRM in patients with locally advanced rectal cancer treated with minimally invasive surgery. Methods The PRODUCT trial was a multicenter, prospective, observational study conducted at 18 institutions in Japan. …

27.08.2026journal-article

Molecular Genetics & Genomic Medicine

Biallelic VPS41 Variants in Autosomal Recessive Spinocerebellar Ataxia 29 Resolved by Long‐Read Sequencing and RNA Analysis

Natsuki Nakamura, Yosuke Nishio, Hiromi Nyuzuki, Ai Fukushima, Masaki Miura, Yu Kobayashi, Risako Ishioka, Kotaro Tsukada, Yasuyoshi Oka, Koyo Tsujikawa, Hironobu Morinaga, Mie Inaba, Jun Tohyama, Yuka Nakazawa, Takeshi Ikeuchi, Takeshi Ono, Shinji Saitoh, Tomoo Ogi

ABSTRACT Background Biallelic variants in VPS41 , encoding a subunit of the HOPS complex, cause autosomal recessive spinocerebellar ataxia 29 (SCAR29), a rare neurodevelopmental disorder with an incompletely defined phenotypic and molecular spectrum. Methods We investigated a 24‐year‐old man with cerebellar ataxia, hypotonia, and intellectual disability. Exome sequencing identified four candidate VPS41 variants. Because maternal DNA was unavailable, long‐read genome sequencing was performed to determine allelic con …

27.08.2026journal-article

Med Phoenix

Impact of Patient Counselling on Knowledge, Attitude and Practice in Management of Diabetes Mellitus among Patients Visiting National Medical College & Teaching Hospital, Birgunj, Nepal

Anil Kumar Shah, Amrullah Shidiki, Sanjay Kumar Sah

Introduction: Type 2 diabetes mellitus (T2DM) is a major metabolic disease. Counselling of a patient uplifts the patient’s ability to cope with disease and make decisions on its management and medication. The aim of counselling is to provide information about KAP needed for disease management thereby enhancing therapeutic outcomes. Materials and Methods: A case control study was conducted among 113 T2DM patients. The fasting blood sugar (FBS), Post prandial (PP); KAP and medical adherence (MA) scores were obtained …

27.08.2026journal-article

ANZ Journal of Surgery

How to Do a Refined Rotational Flap

Ho Yin Kam, Ashavri Sharma, Sam Hamilton, Nitin Sharma

ABSTRACT Rotation flaps are a reliable reconstructive option for moderate to large cutaneous defects, particularly in areas of limited tissue laxity. However, flap planning can be challenging for trainees or surgeons who perform these reconstructions infrequently. We describe a simplified and reproducible modification of Ahuja's rotation flap technique, using triangulation of the defect and proportional geometric landmarks to guide flap design. Key principles include a broad‐based flap, generous rotational arc, pre …

27.08.2026journal-article

International Journal of Biology and Life Sciences

Progress on Molecular Mechanism of Disulfide Death in Gastric Cancer and its Clinical Targeted Treatment Strategy

Yujie Liu

Disulfide death is a newly discovered regulatory cell death mode in 2023, which is driven by the high expression of SLC7A11 and glucose starvation, and is characterized by the collapse of actin skeleton. It shows great potential in the targeted treatment of gastric cancer. This paper systematically reviewed the molecular mechanism of disulfide death, summarized the research progress of disulfide death related genes (DRGs) in the prognosis evaluation, molecular typing and immune microenvironment regulation of gastri …

27.08.2026journal-article

Cells

Endothelial Cells Offer a Better Option than Smooth Muscle Cells for the Treatment of Ischemic Limb Disease

Akazha Green, Hanyu Zhang, Bing Bo, Bijay Guragain, Yalin Wu, Yuhua Wei, Jianyi Zhang, Lei Ye

Peripheral arterial disease (PAD) is estimated to affect at least 10 million people in the United States and over 200 million individuals worldwide. The clinical manifestations of PAD range from impaired mobility and pain with activity to chronic limb-threatening ischemia with risk of eventual tissue loss. Despite the significant global prevalence and debilitating consequences of the disease, non-option patients remain largely undertreated. Recognizing that ECs are well-known for their therapeutic role in enhancing …

27.08.2026journal-article

Cells

The Chronic Wound Microbiome: Dynamics and Treatment Response

Ilaria Cavallo, Francesca Sivori, Massimo Francalancia, Alessandro Greco, Mauro Truglio, Fulvia Pimpinelli, Enea Gino Di Domenico

Chronic ulcers require prolonged care and carry an increased risk of infection and limb loss. Sequencing studies of diabetic foot ulcers, venous leg ulcers, and pressure ulcers have revealed dynamic, patient-specific microbial communities whose composition varies with local tissue conditions and treatment exposure. This review examines changes in microbial burden and community structure during wound-bed and antimicrobial interventions and their relationships with healing. Observed shifts may contribute to therapeut …

27.08.2026journal-article

Anesthesiology

Development of an Arterial Carbon Dioxide Estimation Model Using End-tidal Carbon Dioxide Levels during Surgery in the Pediatric Population

Ju Hyoun Park, Chaeeun Cho, Hee-Soo Kim, Boohwi Hong, Chang-Hoon Koo, Kwangsoo Kim, Hyun Ho Kim

Background: Intraoperative arterial carbon dioxide partial pressure monitoring is essential for pediatric ventilatory management but requires invasive arterial sampling. While end-tidal carbon dioxide offers a noninvasive alternative, its reliability is limited by individual physiologic gradients. This study developed a machine learning model to estimate arterial carbon dioxide partial pressure using end-tidal carbon dioxide and intraoperative clinical features in children. Methods: The authors retrospectively anal …

27.08.2026journal-article

The Journal of Clinical Endocrinology & Metabolism

Arginine Vasopressin Deficiency in Children - A Practical Guide to Etiological Diagnosis and Long-Term Surveillance

Chiara Morreale, Angelica Pisati, Marta Panciroli, Flavia Napoli, Giuseppa Patti, Andrea Rossi, Natascia Di Iorgi, Mohamad Maghnie

Abstract Arginine vasopressin deficiency (AVP-D) is an uncommon but clinically important cause of the polyuria-polydipsia syndrome. Establishing the diagnosis extends beyond confirming hypotonic polyuria and requires differentiation from primary polydipsia and arginine vasopressin resistance, together with identification of the underlying etiology. Unlike adults, children and adolescents with AVP-D frequently present with the earliest manifestation of an evolving neoplastic, infiltrative, inflammatory, congenital, …

27.08.2026journal-article

Visualization in Medicine

Роль визуализирующих и функциональных методик в диагностике компрессионного стеноза трахеи у больных шейно загрудинным зобом

Игорь Владимирович Карпатский, Екатерина Олеговна Жучкина, Олег Игоревич Карпатский

Введение. Шейно загрудинный зоб приводит к постепенной компрессии трахеи, которая нередко протекает субклинически, что затрудняет своевременную диагностику. Диссоциация между клиническими проявлениями и степенью стеноза обусловливает необходимость комплексного применения визуализирующих и функциональных методов, однако их роль и сравнительная ценность остаются недостаточно систематизированными. Цель — на основе анализа современной литературы оценить диагностическую ценность лучевых и функциональных методик в выявле …

27.08.2026journal-article

Minerals

Enhanced Slag–Metal Separation for Preparation of Al-Si Alloys from Crystalline Silicon Cutting Waste by a CaO-Al2O3-CaF2 Slag Treatment

Donghui Wei, Kai Li, Tianding Li, Shan Ren, Haiyu Li, Hongbin Du, Xiangdong Xing

Crystalline silicon cutting waste (SCW) is a promising secondary silicon resource for Al-Si alloy production, but high-melting Al2O3 generated during aluminothermic reduction hinders alloy droplet coalescence and slag–metal separation. In this study, a CaO-Al2O3-CaF2 slag treatment strategy was developed to regulate in situ formed Al2O3 and improve Al-Si alloy recovery from SCW. The effects of slag composition, smelting temperature, and holding time on separation behavior, massive alloy yield, and Si recovery were …

27.08.2026journal-article

Frontiers in Immunology

Research advances on postbiotics in promoting skin wound healing: mechanisms, formulations, and clinical translation

Yu Xing, Jinyu Song, Bingbing Shang, Guangdi Yang, Ye Zhao, Ming Li, Binbin Hou

Wound healing is a complex process involving different cell types, molecules and stages in the dermis, epidermis and associated microbiome. Chronic wounds caused by pressure, diabetes, or immunodeficiency often have huge economic and therapeutic costs. Postbiotics, in particular inactivated bacteria, cell components and metabolites, are emerging as novel treatments targeting the skin microbiome and provide precise treatment options for wound healing, inflammation, angiogenesis and re-epithelialization. We review th …

27.08.2026journal-article

TEM Journal

Machine Learning-Driven IoT System for Patient Monitoring

Adham Mohsen Saeed, Yasamin Hamza Alagrash, Meriam Noureddine Jemel, Lamjed Ben Said

In this paper, a healthcare monitoring system is introduced under IoT based on WiFi enabled Arduino boards to deliver patient data to the cloud through the ThingSpeak platform. It checks abnormalities in health, such as body temperature, level of oxygen, heart rate and vibration, which are checked by the system. A Long Short-Term Memory (LSTM) model is used to generate a synthetic dataset consisting of 14,664 samples, each labeled as either normal or abnormal based on expert assessment. A comparative approach betwe …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

A composite model incorporating systemic inflammatory burden and GRACE score for enhanced identification of elevated myocardial stress in acute myocardial infarction: an exploratory analysis

Peng Libao, Lin Wenji, Wang Mengjiao, Zou Jiali

Introduction Acute myocardial infarction (AMI) remains a leading cause of mortality and heart failure worldwide. Early identification of patients with elevated myocardial stress, a key driver of adverse outcomes, is clinically important. However, the utility of a composite inflammatory burden score for this purpose remains unclear. Methods This retrospective study enrolled 302 consecutive patients hospitalized for AMI at Shenzhen Qianhai Shekou Hospital between January 2023 and December 2024, with 50 healthy contro …

27.08.2026journal-article

Clinical Oral Investigations

Visual distractions for pediatric patients in a dental environment using eye-tracking technology: a cross-sectional study

Alhowra A. Alshaikh, Ghalia Y. Bhadila, Osama M. Felemban, Heba M. Elkhodary, Amani A. Al Tuwirqi

Abstract Objective To evaluate visual attention patterns in anxious versus non-anxious children toward various environmental distractions in a dental clinic using eye-tracking technology and assess the impact of visual distractors on gaze behavior. Materials and methods This cross-sectional study, including 121 children 6–12 years of age. Anxiety levels were determined using the Children’s Fear Survey Schedule–Dental Subscale. Standardized operatory images, with and without distractors, were presented while eye-tra …

27.08.2026journal-article

Journal of Ophthalmic Inflammation and Infection

Clinical course of multiple sclerosis-associated uveitis: a retrospective series of 49 cases

William Gil, Sabine Mainbourg, Robin Jacquot, Ludovic Trefond, Louis Olagne, Pierre Clavelou, Sébastien Trouillier, Antoine Bardy, Marc Andre, Géraldine Androdias-Condemine, Caroline Vasseneix, Laurent Kodjikian, Thomas El-Jammal, Sandra Vukusic, Pascal Sève

Abstract Background The temporal relationship between uveitis and neurological relapses in multiple sclerosis (MS)–associated uveitis is poorly documented; and MS-targeted disease-modifying therapies (DMTs) may influence the ocular course. Objective To evaluate the temporal relationship between uveitis and neurological relapses in MS-associated uveitis, and to assess the impact of MS treatments on uveitis outcomes. Methods This is a retrospective multicenter study. Uveitis cases were identified from the “Lyon Uvéit …