Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Onkologie · Seite 63

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
25.08.2026journal-article

Molecular Biomedicine

Exceptional treatment responses and molecular markers among 103 colorectal cancer cell lines

Anita Sveen, Jakob M. Stenersen, Theophilus Quachie Asenso, Solveig K. Klokkerud, Christian Kranjec, Ina A. Eilertsen, Bjarne Johannessen, Edward Leithe, Kushtrim Kryeziu, Manuela Zucknick, Ragnhild A. Lothe

Abstract Patients with colorectal cancer have few molecularly guided treatment options. Cancers with exceptional treatment response are valuable models for discovery of molecular response mechanisms and might reveal new predictive biomarkers to guide treatment selection. However, the rarity of events is a clinical challenge. We performed integrated high-throughput drug sensitivity testing ( n = 620 drugs) and molecular analyses of 103 colorectal cancer cell lines to build an in vitro foundation for exceptional trea …

25.08.2026journal-article

Journal of Clinical Oncology

Salvage Hypofractionated Accelerated Versus Standard Radiotherapy for Biochemical Recurrence After Radical Prostatectomy: A Phase III Randomized Clinical Trial

Youngju Song, Won Park, Hongryull Pyo, Yeon Joo Kim, Hanjong Ahn, Hwa Jung Kim, Young Seok Kim

PURPOSE To compare hypofractionated radiotherapy (RT) with conventional RT for treating biochemical recurrence following radical prostatectomy. METHODS Between 2019 and 2021, 316 patients with intermediate- to high-risk prostate cancer were randomly assigned to receive salvage RT with either 65 Gy in 26 fractions (hypofractionated RT, HYPO) or 66 Gy in 33 fractions (conventional RT, CONV). RT was delivered to the prostate bed, with elective pelvic nodal irradiation performed at the discretion of radiation oncologis …

25.08.2026journal-article

European Journal of Heart Failure

Heart Failure and Cancer: Incidence and Mortality Patterns, A Systematic Review and Meta-analysis

Luigi Sanasi, Antonio Iaconelli, Danila Azzolina, Pasquale Dolce, Christian Cardile, Lorenzo Cacioli, Alessandro Forni, Matteo Busti, Luca Sensini, Nicola Riccardo Pugliese, Domenico D’Amario, Giovanni Pecorini, Mattia Galli, Giovanna Liuzzo, Francesco Burzotta, Riccardo Rinaldi, Moustafa I Morsy, Pasquale Maffia, Pierpaolo Pellicori, Jocelyn M Friday, Mark Petrie, Bernhard Haring, Michael Böhm, Markus S Anker, Javed Butler, Filippo Crea, John G F Cleland

Abstract Background Cancer and heart failure (HF) frequently coexist due to population ageing and improved survival for both conditions. HF is a well-recognised complication of oncologic therapies and a potential association between HF and subsequent cancer incidence has been recently noticed. We therefore conducted a meta-analysis to quantify cancer incidence and mortality in patients with and without HF. Methods Databases were searched from inception to 15 February 2026. Data from observational studies and random …

25.08.2026journal-article

Manuscript

The decorative treatment of the façades of the ksar of Aït Benhaddou in southern Morocco: material, relief, and light-and-shadow articulation

Alexandra Alekseevna Pallades

The article examines the decorative organisation of three façades in the ksar of Aït Benhaddou in the Ounila Valley in southern Morocco: the northern and western sides of a tower incorporated into the perimeter wall and the façade of a residential building. The aim of the study is to identify the principles governing the decorative organization of the selected façades through an analysis of the relationship between ornament, wall material, architectural mass, and natural light. The analysis focuses on the division …

24.08.2026journal-article

Frontiers in Cell and Developmental Biology

Modulation of the cytoskeleton for cancer therapy

Alexandre Matov

Introduction All degenerative diseases are associated with impairment in intracellular trafficking. The highly dynamic organization and remodeling of the cellular cytoskeleton are dysfunctional in pathology and often lead to drug resistance. Successful analyses of the mechanisms of drug action require statistical analysis of large-scale readouts of molecular interactions at nanometer-scale resolution. The focus of our work is the automated extraction of unbiased information from time-lapse microscopy image series o …

24.08.2026journal-article

Frontiers in Veterinary Science

The microenvironment in canine mast cell tumors: association between tumor-associated tissue eosinophilia and histological grade

María Ezquerra-Durán, Pablo Cardenal-Morales, Luis Javier Ezquerra-Calvo, Raquel Tarazona-Lafarga, Massimo Santella, María Esther Durán-Flórez

Introduction Canine mast cell tumors (MCTs) are common neoplasms with heterogeneous biological behavior, and histological grading alone may not fully reflect their aggressiveness. The tumor microenvironment, particularly tumor-associated tissue eosinophilia (TATE), may provide complementary information on MCT biology. Methods This study evaluated whether intratumoral eosinophil infiltration, expressed as the eosinophil-to-mast cell ratio (EMR), was associated with histological grade in canine MCTs. A secondary obje …

24.08.2026journal-article

Frontiers in Oncology

Unsupervised 20-feature immunohistochemical immune profiling identifies exploratory cervical cancer phenotypes with unfavorable survival signals

Angel Danchev Yordanov, Eva Tsoneva, Polina Damqnova Dimitrova, Stoyan Georgiev Kostov, Ihsan Hasan, Velizar Stefanov Shivarov

Objective To determine whether unsupervised integration of routinely accessible immunohistochemical immune features can identify clinically relevant tumor immune microenvironment phenotypes in cervical cancer. Methods We performed a retrospective exploratory analysis of surgically treated cervical cancer cases with complete scoring for a 20-feature immunohistochemical immune panel. The features were derived from approximately 11 antibody-defined markers, including separate intratumoral (IT) and stromal (ST) scores …

24.08.2026journal-article

Frontiers in Digital Health

Multimodal artificial intelligence and machine learning in oncology: from data integration to precision cancer care

Shruthi Suresh, A. S. Parvathy, Megha Raj, Keziya G. S., M. Lakshmi Priya, Rhitam Biswas, Sudha Ramaiah, Anand Anbarasu

Cancer remains a major global health burden, with approximately 20 million new cases and 9.7 million cancer-related deaths reported globally in 2022. While advances in radiological imaging, molecular profiling, and clinical data have enhanced the interpretation of disease progression, the availability of multiple such modalities still does not meet the needs of a large patient population. This narrative review focuses on the role of multimodal artificial intelligence and machine learning in bridging the gap in inte …

24.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Evaluating longitudinal toxicity and adverse event in cetuximab-treated metastatic colorectal cancer: a pooled analysis from 1,302 patients in ARCAD database

Jun Yin, Katherine E Francis, Guilherme S Lopes, Jane So, Curt L Olswold, Eric Van Cutsem, Carsten Bokemeyer, Richard Adams, Benoist Chibaudel, Axel Grothey, Takayuki Yoshino, Aimery De Gramont, Qian Shi, Christophe Tournigand, Katrin M Sjoquist, John Zalcberg

Abstract Purpose Traditional adverse event (AE) reporting in oncology trials focuses on the single worst CTCAE grade, which may underrepresent chronic or recurrent toxicity burden. We applied a longitudinal toxicity framework to compare toxicity profiles of chemotherapy with or without cetuximab in metastatic colorectal cancer. Patients and Methods We pooled two randomized first-line trials in the ARCAD database. AEs examined were diarrhea, rash, hand-foot syndrome (HFS), fatigue, anorexia, and mucositis. Outcomes …

24.08.2026journal-article

Oncology and Translational Medicine

Cardiac allograft vasculopathy: A comprehensive review of diagnostic strategies and therapeutic approaches

Yuxuan Zhang, Ru Liu, Jie Huang, Lijian Gao, Dong Yin

Cardiac allograft vasculopathy (CAV) is the leading cause of late mortality following heart transplantation. This condition is characterized by diffuse coronary intimal hyperplasia driven by both immune and nonimmune mechanisms. This review summarizes the epidemiology, known and emerging risk factors, and complex pathophysiology of CAV. Regarding diagnosis, we evaluate the clinical utility and integration of various modalities, ranging from invasive coronary angiography and high-resolution intravascular imaging (op …

24.08.2026journal-article

Thyroid®

A Novel Protocol for Pre-Treatment Diagnostic 131 I Scan Within 24 Hours Post-Second rhTSH Administration to Guide Radioiodine Therapy in Differentiated Thyroid Cancer

Rongfang Shen, Huiting Yang, Xiaoting Ye, Ziqing Li, Xuequn Zhu, Rongqin Zhang, Zhanwen Zhang

Background: In the current conventional recombinant human thyrotropin (rhTSH) protocol, radioiodine therapy (RAIT) is given at 24 h post-second injection and diagnostic 131 I whole-body scan (Dx-WBS) at 72 h; hence, Dx-WBS cannot precede RAIT within the same two-injection cycle. This study aimed to evaluate whether Dx-WBS could be performed within 24 hours after the second injection of a novel rhTSH, thereby enabling timely pre-RAIT evaluation without altering the established rhTSH-based RAIT schedule. Methods: Thi …

24.08.2026journal-article

International Journal of Biology and Life Sciences

Fragility and Plasticity of CCR8+Tregs: Providing New Directions for Cancer Treatment

Yuhao He

Regulatory T cells (Tregs) are crucial for maintaining immune homeostasis. However, in the tumor microenvironment, tumor cells induce Tregs to exert immunosuppressive effects, leading to the failure of anti-tumor immunity. Traditional Treg clearance strategies, due to their lack of selectivity, damage peripheral normal Tregs during treatment, causing severe autoimmune side effects. This article analyzes the biological characteristics, fragility, and plasticity of CCR8+Tregs and their molecular mechanisms. The resul …

24.08.2026journal-article

BMC Medical Research Methodology

A simulation-based comparison of Boruta, LASSO, and Elastic Net for variable selection in logistic regression, with an ovarian cancer miRNA application

Reza Arabi Belaghi, Hulya Yurekli, Farzaneh Hamidi, Neda Gilani

Abstract Background Variable selection is a central challenge in logistic regression, particularly in high-dimensional biomedical applications where correlated predictors and limited sample sizes complicate reliable identification of relevant variables. This study aims to systematically compare three widely used variable selection approaches - Boruta, LASSO, and Elastic Net - under a range of data-generating conditions and to illustrate their performance using an ovarian cancer miRNA dataset. Methods We conducted a …

24.08.2026journal-article

Journal of Chemical Technology & Biotechnology

Emerging chemical and biotechnological approaches for sustainable treatment of food industrial wastewater and resource valorization: a review

Misba Khan, Zaryab Shafi, Shumaila Parveen, Vinay Kumar Pandey, Rahul Singh, Sajad Ali

Abstract Food industrial wastewater (FIWW) is a high‐strength and compositionally complex effluent generated from dairy, meat, beverage, fruit and vegetable, and agro‐processing industries. Characterized by high concentrations of organic matter (COD: 1000–6000 mg L −1 ; BOD: 600–4000 mg L −1 ), nutrients, oils, greases, and suspended solids, FIWW poses significant environmental and operational challenges to conventional treatment systems. This review critically evaluates recent advances in sustainable FIWW treatmen …

24.08.2026journal-article

Uludağ Üniversitesi Tıp Fakültesi Dergisi

Assessment of Treatment Response in Patients Diagnosed with Waldenström’s Macroglobulinemia: Single-Center Experience

Şeyma Yavuz, Vildan Ozkocaman, Vildan Gürsoy, Tuba Ersal, İbrahim Ethem Pınar, Fazıl Cagrı Hunutlu, Ezel Elgun, Fahir Özkalemkaş

Waldenström macroglobulinemia (WM) is a rare lymphoplasmacytic lymphoma characterized by the production of monoclonal IgM. It may lead to symptoms such as hyperviscosity syndrome, anemia, and neuropathy. The indication for treatment is not based on a specific IgM level but is determined according to the clinical condition. This study aimed to retrospectively evaluate the treatment responses of patients diagnosed with WM between 2019 and 2024 at the Hematology Outpatient Clinic, Department of Internal Medicine, X Ho …

24.08.2026journal-article

Cancer Research

Cystine Restriction Alleviates T-cell Exhaustion and Enhances CAR T-cell Potency

Xiaoxue Pan, Yuhang Yin, Haopeng Hong, Jichang Li, Jing Zhu, Xin Wang, Yucun Liu, Pengyuan Wang, Shanwen Chen

Abstract Although chimeric antigen receptor (CAR) T-cell therapy has demonstrated significant efficacy in treating hematologic malignancies, its application in solid tumors remains challenging. A major limitation of CAR T-cell efficacy in solid tumors is the functional exhaustion of CD8+ T cells. In this study, we investigated metabolic regulators of CD8+ T-cell exhaustion, identifying that cystine promotes CD8+ T-cell exhaustion. RNA sequencing (RNA-seq) analysis of an in vitro exhaustion model revealed that SLC7A …

24.08.2026journal-article

Diagnostics

Comparison of Radiological and Postoperative Tumor Volume Measurements for SIOP Risk Stratification in Wilms Tumord

Aseel Hamdan, Azza Gharaibeh, Rula Al-Qawabah, Khalil Ghandour, Iyad Sultan, Hadeel Halalsheh

Background: Tumor volume in Wilms tumor (WT) guides risk stratification under the International Society of Pediatric Oncology (SIOP) protocol. While the radiological ellipsoid formula is the current protocol-specified reference method, modalities such as planimetry, intraoperative specimen weight, and pathological volume are often used interchangeably in practice without systematic evaluation. Methods: We reviewed 60 pediatric WT patients. Three measurements were compared against the SIOP-standard radiological elli …

24.08.2026journal-article

Frontiers in Immunology

The aspiration of precision glucocorticoid pharmacotherapy in immune-mediated diseases: where do we stand in integrating pharmacogenomics and biomarkers for individualized treatment?

Matteo Colina, Gabriele Campana

Glucocorticoids remain among the most widely prescribed immunosuppressive and anti-inflammatory agents worldwide, yet their clinical use is complicated by substantial inter-individual variability in both therapeutic response and adverse effects. Despite decades of clinical experience, glucocorticoid prescribing remains largely empirical, with limited integration of precision medicine approaches that could optimize therapeutic outcomes while minimizing toxicity. This review synthesizes current evidence on emerging p …

24.08.2026journal-article

Small

A Biomimetic Breast Tumor‐On‐Chip Platform Reveals Mesenchymal Marker Upregulation Following Gold Nanorod Photothermal Therapy

Camila A. Salvego, Hasti Honari, Anastasiia Dubrova, Stéphanie Descroix, Martha S. Ribeiro, Aurore V. Walle, Claire Wilhelm

ABSTRACT Photothermal therapy (PTT) using plasmonic nanoparticles has emerged as a promising strategy for localized cancer treatment, yet physiologically relevant models for assessing cell‐line model‐dependent responses remain limited. Here, we engineered a breast tumor‐on‐chip platform to investigate gold nanorod (AuNR)‐mediated PTT in a 3D type I collagen microenvironment using luminal‐like MCF7 and triple‐negative breast cancer MDA‐MB‐231 spheroids. A custom microfluidic architecture incorporating sliding‐wall t …

24.08.2026journal-article

Journal of Medical Microbiology

Biofilm sensitization to break Staphylococcus aureus tolerance to cold atmospheric plasma therapy

Abdullah Baz, Jontana Allkja, Muhanna Alshehri, Yao He, Zainab Bilal, Eve Hughes, Olivia Sealy, Craig Williams, Karen Faulds, Gordon Ramage, Jason L. Brown

Introduction. Biofilm-associated infections present a major therapeutic challenge due to their intrinsic tolerance to conventional antimicrobials. Cold atmospheric plasma (CAP) has shown promise as a non-antibiotic antimicrobial modality; however, some bacteria including Staphylococcus aureus can exhibit tolerance to plasma exposure. Gap Statement. Strategies that sensitize CAP-tolerant biofilms to plasma treatment may improve CAP efficacy, but suitable adjunctive compounds and mechanisms remain poorly defined. Aim …

24.08.2026journal-article

Japanese Journal of Clinical Oncology

Prognostic significance of the FAN score in patients with advanced urothelial carcinoma treated with enfortumab vedotin monotherapy

Hiromu Horitani, Atsunari Kawashima, Yu Ishizuya, Yoshiyuki Yamamoto, Takuji Hayashi, Shunsuke Inoguchi, Yuki Horibe, Nesrine Sassi, Yujiro Hayashi, Takeshi Ujike, Koichi Tsutahara, Mototaka Sato, Yosuke Sekii, Koji Yazawa, Fuki Kondo, Yutaka Kurahashi, Wataru Nakata, Toshihisa Asakura, Takahiro Imanaka, Koichi Okada, Masashi Nakayama, Taigo Kato, Koji Hatano, Norio Nonomura

Abstract Objective To evaluate the prognostic significance of the Fib-4 index, ALBI and NLR (FAN) score, a composite score comprising the fibrosis-4 index, albumin-bilirubin score, and neutrophil-to-lymphocyte ratio, in patients with advanced urothelial carcinoma treated with enfortumab vedotin (EV) monotherapy. Methods This multicenter retrospective study included 164 patients with advanced urothelial carcinoma who received EV monotherapy following prior systemic therapy. Patients were classified into three groups …

24.08.2026journal-article

Chinese Medical Journal

Association of serum uric acid with circulating inflammatory proteins and treatment response to ixekizumab in patients with psoriasis: A multicenter prospective cohort study in China

Yuxiong Jiang, Zhuolin Guo, Lingling Yao, Dawei Huang, Rui Ma, Xiaoyuan Zhong, Yu Wang, Jiajing Lu, Ying Li, Yuling Shi

Abstract Background: Serum uric acid (SUA) has been implicated in various inflammatory conditions, yet its association with inflammatory proteins and treatment outcomes in psoriasis remains unclear. This study aimed to investigate the association of SUA levels with specific circulating inflammatory proteins and treatment response to ixekizumab, a monoclonal antibody against interleukin-17A, in patients with moderate-to-severe psoriasis. Methods: Patients attending 26 dermatology centers across China were recruited …

24.08.2026journal-article

Cancer Research Communications

A Phase 2 Study of Berzosertib in Combination with Carboplatin compared to Docetaxel with Carboplatin in Metastatic Castration-Resistant Prostate Cancer

Atish D. Choudhury, Caiwei Zhong, Wanling Xie, Bose S. Kochupurakkal, Peter I-Fan. Wu, Irbaz Bin. Riaz, Ruolin Liu, David D. Yang, Edmund Folefac, Daniel Lee, Mamta Parikh, David J. Einstein, Elizabeth R. Kessler, Tina Mayer, Rana R. McKay, Amanda Pace, Kent W. Mouw, Li Chen, Viktor A. Adalsteinsson, Eliezer M. Van Allen, Charles A. Kunos, Steven D. Gore, Biswajit Das, Alan D'Andrea, Mary-Ellen Taplin, Geoffrey I. Shapiro

Abstract Purpose: Inhibitors of the Ataxia telangiectasia and Rad3-related (ATR) protein kinase, a critical component of the DNA damage repair response, have synergistic anti-cancer activity with platinum compounds in preclinical models. We therefore conducted a Phase 2 study of the ATR inhibitor berzosertib+carboplatin vs. docetaxel+carboplatin in metastatic castration-resistant prostate cancer. Patients and Methods: Patients previously treated with at least one androgen receptor pathway inhibitor and taxane under …

24.08.2026journal-article

Scientific Reports

Re-engineering alum sludge using choline–glycine ionic liquid for enhanced dewatering and dye adsorption in wastewater treatment

Aya M. Rashed, Ibrahim E. T. El-Sayed, Xingmei Lu, Hamed M. Abdel-Bary, Mai K. Fouad, Maha A. Tony

Abstract Large quantities of by-product alum sludge (Al-S) generated from drinking water treatment plants pose significant environmental and disposal challenges due to their high water content and large volume. This study aims to develop a sustainable conditioning and valorization strategy for Al-S using a choline–glycine ionic liquid ([Ch]–[AA]). The ionic liquid was synthesized and applied as a sludge conditioner to enhance dewatering performance. Under optimized conditions, the dewatering efficiency reached 47%, …