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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
13.08.2026journal-article

International Journal of Molecular Sciences

Duration of Caloric Restriction Modulates Brain Redox Adaptation and Frailty During Aging

Desanka Milanovic, Sladjan Pavlović, Milica Prvulovic, Slavica Borković Mitić, Srdjan Sokanovic, Smilja Pracer, Aleksandra Mladenovic

Caloric restriction (CR) is among the most effective nutritional interventions for promoting healthy aging, yet the influence of intervention duration and age at initiation on its efficacy remains incompletely understood. This study investigated the effects of short-term caloric restriction (STCR) and long-term caloric restriction (LTCR) on frailty and brain redox homeostasis in male Wistar rats. Animals were maintained under ad libitum (AL) feeding, or subjected to LTCR initiated at 6 months of age or STCR initiat …

13.08.2026journal-article

JMIR Formative Research

Understanding the Prospective Acceptability of a Fall Prevention Exercise App Among Canadians Aged 50 Years and Older Living in the Community: Mixed Methods Study

Maria Fernanda Fuentes Diaz, Kathryn May Sibley, Chinasa Obiageri Trinitta Ugwuegbulem, Kim Delbaere, Danielle R Bouchard

Abstract Background Falls are a major public health concern due to their impact on individuals and the health system. StandingTall (Ylva Health Pty Ltd) is a digital balance exercise app that has demonstrated strong adherence and fall-reduction effects in Australia. Before considering implementation in Canada, its acceptability must be assessed. Objective This study aimed to explore the prospective acceptability of the StandingTall app among Canadian community-dwelling adults aged 50 years and older with varying le …

13.08.2026journal-article

Physiological Measurement

Comparison of activPAL and ActiGraph measured moderate to vigorous physical activity in people with COPD

Jung Yoen Son, Katelyn Webster-Dekker, Deanna J Marriot, She’Lon Tucker, Janet L Larson

Abstract Objective. ActiGraph accelerometers are commonly used to assess moderate-to-vigorous physical activity (MVPA), but there are concerns about missing data due to compliance issues with hip-worn devices. ActivPAL devices are worn 24 h d −1 on the anterior thigh, minimizing missing data, but activPAL software does not directly estimate MVPA. This study aimed to evaluate the agreement between MVPA derived from activPAL (using five methods) and ActiGraph data (using two methods) among individuals with chronic ob …

13.08.2026journal-article

Frontiers in Psychiatry

Study on multi-modal feature fusion machine learning classification model of Chinese and Western medicine for depressive symptoms in middle-aged and older patients with chronic low back pain

Bo Jin, Juan Gao, Chenying He, Xiaohong Lei

Objective To construct a machine learning classification model integrating multi-modal features of Chinese and Western medicine for screening the risk of depressive symptoms in middle-aged and older patients with chronic low back pain (CLBP). Methods A cross-sectional design included 370 CLBP patients aged ≥45 years admitted to our hospital from January 2022 to June 2024. Based on PHQ-9 scores, they were classified into depression (≥10) and non-depression (<10) groups. Chinese and Western medicine characteristic …

13.08.2026journal-article

Journal of Applied Gerontology

Social and Physical Activity Participation Among Older Adults With Disability: The Interplay of Senior Housing and Perceived Social Cohesion

Byeongju Ryu, BoRin Kim, Sojung Park, Jihye Baek

Residential environments are critical factors influencing activity participation among older adults with disabilities. We examined whether living in senior housing (i.e., retirement communities or independent living) is associated with participation in social and physical activities and whether this association varies by perceived social cohesion. Data came from 3317 respondents in the 2019 National Health and Aging Trends Study who reported difficulty with self-care, mobility, or household tasks. Weighted logistic …

13.08.2026journal-article

Jurnal Ekonomi & Keuangan Islam

What drives people to invest in cash waqf linked sukuk with trust mediation?

Erny Arianty, Syanni Yustiani, Iin Indrawati, Muhammad Iqbal Balative

Purpose – This study aims to examine the factors influencing Indonesians’ investment intentions toward cash waqf-linked sukuk (CWLS).Methodology – This study adopted a quantitative research design using structural equation modeling (SEM). Data were collected from Indonesian respondents who met the predetermined eligibility criteria, resulting in 106 valid response. The proposed model examines the determinants of investment intention toward cash waqf-linked sukuk (CWLS), with religiosity incorporated as a moderating …

13.08.2026journal-article

Jurnal Biologi Tropis

Vascular Cognitive Impairment and Vascular Dementia: A Literature Review

Azka Fadila Latifa, Annisa Fitria Zahra AS, Muhammad Fatih Ma'ruf, Novad Sawelly, Dini Suryani, Herpan Syafii Harahap

Vascular Cognitive Impairment and Dementia (VCID) is a spectrum of cognitive disorders associated with cerebrovascular disease and is a major cause of cognitive decline and dementia in older adults. This study aimed to review the etiology, risk factors, pathophysiology, diagnostic evaluation, and management of VCID to support early detection and appropriate intervention. A literature review was conducted using relevant scientific publications and clinical guidelines addressing VCID. The findings indicate that VCID …

13.08.2026journal-article

Diabetes Care

Housing Instability Associated With Cost-Related Nonadherence and Financial Toxicity in People With Uncontrolled Diabetes

Victoria H. Davis, Roshanak Mehdipanah, Minal R. Patel

OBJECTIVE To assess the prevalence of housing instability and its associations with cost-related nonadherence and financial toxicity among adults with uncontrolled diabetes. RESEARCH DESIGN AND METHODS We analyzed baseline randomized controlled trial data from 600 adults with uncontrolled diabetes and cost-related barriers to care. Logistic and linear regression assessed associations of housing instability with cost-related nonadherence and financial toxicity. RESULTS Half (n = 298) reported housing instability, wh …

13.08.2026journal-article

The Milbank Quarterly

Public Policies in Historical Context and the Association Between Education and US Older Adults’ Health

MARK D. HAYWARD, MATEO P. FARINA

Policy Points Improving population health while reducing inequality is possible, but it depends on broad institutional investments whose benefits extend across the socioeconomic distribution rather than accruing primarily to the advantaged. The education–health gradient is sensitive to the race between technology and education. Recent advances have disproportionately benefitted college‐educated persons, and differential automation risk and unequal access to therapeutics, such as GLP‐1 agonists, may widen these gaps …

13.08.2026journal-article

Materials Research Express

Moisture, aging, and interfacial microstructure of dry-process modified stone mastic asphalt: MA-CK and MA-123 benchmarked against SBS

Ali Almusawi, Ceren Keleş

Abstract Stone mastic asphalt (SMA) conventionally relies on wet-process Styrene–Butadiene–Styrene (SBS) modification to meet demanding rheological requirements, yet the specialized blending infrastructure this entails has sustained interest in dry-process alternatives. This study presents an independent, standards-based comparative evaluation of SMA mixtures modified with two commercially available dry-process polymer composites, MA-CK and MA-123 (PROpolymer, Ruschemicals Group), benchmarked against SBS at their m …

13.08.2026journal-article

European Journal of Ageing

Determinants of life expectancy with unmet needs in the Chinese older population (revision 1)

Hui Wang, Bo Hu

Abstract This study investigates the determinants of and disparities in life expectancy (LE) with unmet long-term care needs among older people in China. The data come from four waves of the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative survey conducted between 2013 and 2020 (N = 42,480). Continuous time multi-state Markov modelling is combined with the life table approach to estimate the total life expectancy and life expectancy with met and unmet needs. Chinese older people …

13.08.2026journal-article

LATAM Revista Latinoamericana de Ciencias Sociales y Humanidades

Efectividad de la terapia dialéctico-conductual en reducción de conductas autolesivas en personas con trastorno límite de la personalidad y muestras clínicas mixtas

Paúl Fernando Calle Cadme, Odalia Llerena Companioni

El presente estudio tuvo como objetivo analizar la efectividad de la terapia dialéctico-conductual (DBT) en la reducción de conductas autolesivas en adolescentes y adultos, tanto en personas con trastorno límite de la personalidad como en muestras clínicas mixtas. Se realizó una revisión sistemática siguiendo los lineamientos PRISMA, mediante la búsqueda en las bases de datos Scopus y Web of Science durante los últimos diez años, incluyendo estudios en español e inglés. Se seleccionaron 25 estudios empíricos que cu …

13.08.2026journal-article

Sociological Perspectives

Toward an Afrolatin Critical Theory of Race: A Critical Approach to Doing Research with Afrolatinx People

Celine Maria Ayala

The politics of language has the potential to “wipe out an entire generation of people.” Like language, the theories, methods and modes of analyses we use have the ability to erase entire groups of people. Using theories that do not center diasporic Blackness to explain Afrolatinx racialized experiences, can lead to the treatment of Blackness as an additive to Latinidad. To combat this treatment, I propose an Afrolatin Critical Framework which is a qualitative methodological frame that centers Blackness throughout …

13.08.2026journal-article

Diabetic Medicine

Conventional adherence assessment methods are low‐sensitivity diagnostic tests in people with type 2 diabetes: The TARGET study

Hanad Osman, Sian Jenkins, Prashanth Patel, Kamlesh Khunti, Samuel Seidu, Pankaj Gupta

Abstract Aims To evaluate the performance of conventional adherence assessment methods against objective chemical adherence testing (CAT) in people with type 2 diabetes. Methods In this prospective cohort study, 90 participants with type 2 diabetes attending primary care were assessed using CAT ( n = 49), medication possession ratio (MPR; n = 60) and Hill‐Bone Medication Adherence Scale (HBMAS; n = 58). Associations with HbA 1c and blood pressure (BP) were assessed, and within‐person diagnostic performance was eval …

13.08.2026journal-article

Frontiers in Cellular and Infection Microbiology

Application of artificial intelligence in geriatric infection: recent advances and prospects

Puyu Liang, Zhaoyi Tan, Beibei Liang, Yuxi Xu, Tianlin Wang, Zhijian Zhang, Yun Cai

Background As global population aging accelerates, infectious diseases in older adults have emerged as a growing public health burden with substantial clinical, economic, and societal implications. The rapid advancement of artificial intelligence (AI) offers a transformative opportunity to enhance the management of infections in this vulnerable population. Methods This review delineates key determinants specific to geriatrics that influence infection susceptibility and atypical presentation, including age-related o …

13.08.2026journal-article

Cosmetics

Pilot Investigations of Sodium Acetylated Hyaluronate on Telomeres and Inclusive Anti-Aging Skincare

Yuhua Jiang, Jason Wu, Aline Delobelle, Luyan Wang, Thibaut Saguet, Junjie Jiang

The telomere is one of the biological hallmarks of skin aging. Sodium acetylated hyaluronate (SAH) is an acetylated derivative of sodium hyaluronate, produced by a grafting technology that confers higher resistance to hyaluronidase. This study aimed to explore whether SAH is associated with telomere-related endpoints and with clinical signs of skin aging. Two vitro studies were performed, assessing telomerase activity in human adult keratinocytes and telomere length in human normal fibroblasts by quantitative PCR ( …

13.08.2026journal-article

Probiotics and Antimicrobial Proteins

Oral Co-supplementation with Pediococcus pentosaceus Probiotic and Enteric Polymeric Phycocyanin Nanoparticles Mitigates Aging-Related Biomarkers in Male Wistar Rats: A Preclinical Investigation

Nasser S. Flefil, Asmaa Ezzat, Marwa A. Abd El-Fattah, Hanan Farouk Aly, Eman A. Younis, Tarek N. Soliman, Asmaa Negm El-Dein

Abstract C-phycocyanin (C-PC) is a promising anti-aging nutraceutical due to its antioxidant and anti-inflammatory properties; however, its instability under acidic conditions limits its efficacy, necessitating advanced formulation strategies. This study evaluated the anti-aging potential of novel enteric C-PC nanoparticles (NPs) co-delivered with Pediococcus pentosaceus in a D-galactose-induced aging model in male Wistar rats. C-PC was extracted from microalgal biomass and encapsulated into Eudragit ® S100 nanopar …

13.08.2026journal-article

AGING MEDICINE

Expert Consensus on Influenza Vaccine and Pneumococcal Vaccination in Elderly People With Chronic Respiratory Diseases (2024)

Lijing Wang, Qiao Yu, Qiong Chen, Pulin Yu, Expert Committee of Consensus Opinion on Influenza Vaccine and Pneumococcal Vaccine Vaccination for Elderly People with Chronic Respiratory Diseases, Respiratory Group of Chinese Geriatrics Society

ABSTRACT Chronic respiratory diseases pose a serious threat to the health of the population due to their high incidence, high disability rate, and poor prognosis. It is necessary to improve the prevention and treatment status of chronic respiratory diseases. Vaccination against influenza and pneumococcal infections can reduce the risk of respiratory infections, lower hospitalization and mortality rates, and alleviate disease burden in individuals with chronic respiratory diseases. However, insufficient public aware …

13.08.2026journal-article

PLOS One

Altered kinematics and muscle activities during half squats in people with ankle sprain history

Umi Matsumura, Rena Ogusu, Shimpei Yamamoto, Toshiya Tsurusaki, Yeonghee Lee, Shinya Sunagawa, Hironobu Koseki

Copers are individuals with a history of ankle sprain who return to daily and sports activities without recurrent instability. However, it is unclear whether copers can use movement strategies comparable to those of healthy individuals without a history of ankle sprain. Understanding these movement strategies may be important for designing effective training programs and avoiding unintended biomechanical adaptations. Therefore, we aimed to compare the kinematics and muscular activities of the lower limbs during hal …

13.08.2026journal-article

Journal of Bone and Mineral Research

Large scale proteomic analyses of HR-pQCT-derived bone loss at the radius and tibia in older men

Eric Orwoll, Jack Wiedrick, Charles Ginsberg, Nancy E Lane, Lisa Langsetmo, Nicola Napoli, Andrew J Burghardt, Jodi Lapidus, Osteoporotic Fractures in Men (MrOS) Study Research Group

Abstract Although bone loss progresses rapidly in older adults, its biological drivers are poorly understood, and effective biomarkers are not available. We used large-scale discovery proteomics to identify serum proteins associated with bone loss, and to develop predictive signatures, in older men (mean age 84 yr). Rates of distal radial and tibial bone loss were assessed with high-resolution peripheral quantitative computed tomography (HR-pQCT) over ~6 yr, and ~ 7 K serum proteins were measured with aptamer-based …

13.08.2026journal-article

Aging Clinical and Experimental Research

Multimorbidity burden and frailty profile in older outpatients with diabetes: a cross-sectional study

Lorenzo Luppi, Marco Bertolotti, Giulia Lancellotti, Chiara Mussi

Abstract Background Type 2 diabetes mellitus is extremely frequent in older patients. The coexistence of multimorbidity and frailty may bear a significant impact on the management of this condition. Aim Aim of this study was to describe the clinical profile, including the frailty status, in an outpatient population of elderly subjects with respect to diabetes. Patients and methods Data were collected within a cross-sectional retrospective design from the Cardiogeriatrics Clinic of the University Hospital of Baggiov …

13.08.2026journal-article

Cell Death & Disease

Decay of the Lef1-Srsf3-microRNA axis impairs DNA damage response and underlies stem cell aging

Yasuaki Ikuno, Koichiro Watanabe, Yukie Kande, Yumi Kakeya, Shinsuke Ikeno, Ayano Narumoto, Tomoki Hayashi, Kahori Minami, Kasumi Nobuhiro, Dai Ihara, Yo Mabuchi, Shiho Nakamura, Noriki Fujimoto, Hideyuki Okano, Hayato Naka-Kaneda

Abstract Stem cell (SC) aging is implicated in tissue dysfunction and organismal aging. However, the molecular basis of aging shared across diverse adult SC types remains unclear. Here, we identify the transcription factor Lef1 , the splicing regulator Srsf3 , and a subset of DNA damage response microRNAs (DDR-miRs) as a common molecular axis underlying SC aging. Lef1 was the most consistently downregulated transcription factor during aging, common to mesenchymal stem/stromal cells (MSCs) and hematopoietic stem/pro …

13.08.2026journal-article

Journal of the American Geriatrics Society

Comparison of Claims‐Based Algorithms for Dementia Identification: A Cross‐Sectional Analysis of the National Health and Aging Trends Study ( NHATS )

Ravi Gupta, Hanna Charankevich, Emmanuel F. Drabo, Teneil Brown, Alden L. Gross, Daniel Polsky, Jodi B. Segal, Katherine A. Ornstein

ABSTRACT Background Accurate identification of Alzheimer's disease and related dementias (ADRD) in administrative data is increasingly important for research, care delivery innovation, and policy applications such as risk adjustment. Despite the widespread use of existing claims‐based algorithms to identify ADRD, few studies have compared their use to ongoing longitudinal aging studies. Methods In this cross‐sectional study, we included 2204 NHATS respondents aged 65 years or older classified as having dementia and …

13.08.2026journal-article

European Journal of Criminology

Functional and dysfunctional fear in cyberspace: A qualitative analysis of users and non-users of digital tools aged 65 and older

Nieves Erades-Pérez, Steven Kemp, Esther Sitges-Maciá

Population ageing and accelerated digitalization pose significant challenges for the digital inclusion of older adults, particularly from a criminological perspective. This study examines how fear of cybercrime and insecurity in the use of information and communication technologies (ICT) affect their participation in the digital society and expose them to the risk of online victimization. Through semi-structured interviews, it was identified that dysfunctional fear of cybercrime, prevalent among non-users of ICT, l …