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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Curative endoscopic closure of a chronic esophagopleural fistula after Boerhaave syndrome using an over-the-scope clip: A case report

Naoto Takahashi, Shigeaki Baba, Yosuke Toya, Haruka Nikai, Ryosuke Fujisawa, Fumitaka Endo, Akira Umemura, Takeshi Iwaya, Hiroyuki Nitta, Akira Sasaki

BACKGROUND Spontaneous esophageal rupture (Boerhaave syndrome) remains a life-threatening condition associated with high mortality rates. In recent years, various treatment strategies for it, including conservative and endoscopic approaches, have been increasingly reported. However, chronic esophagopleural fistula developing after conservative management is often difficult to treat, and no standard therapeutic strategy for it has been established. We report a case of a refractory chronic esophagopleural fistula suc …

27.08.2026journal-article

Clinical and Investigative Medicine

Expression and clinical significance of CA9 and SEC61G in non–small cell lung cancer

Yu Luo, Dehe Chen, Yunxi Wu, Yi Cai, Gaoxiong Xiao, Dinghai He, Yanjun Bai, Li Jiang

Abstract Background: Lung cancer is the malignancy with the highest mortality rate globally. This study aimed to investigate the expression of carbonic anhydrase IX ( CA9 ) and SEC61G in non-small cell lung cancer (NSCLC) tissues and adjacent lung tissues and to analyze the relationships of these genes with clinicopathological features to identify potential biomarkers and therapeutic targets. Methods: Bioinformatic analysis was performed using the TIMER, TCGA, and GTEx databases to evaluate the differential express …

27.08.2026journal-article

npj Parkinson's Disease

Biological heterogeneity in Parkinson’s disease: implications for MRI-based patient stratification

Marta M. Pokotylo, Norbert Brüggemann, Jannik Prasuhn

Abstract Parkinson’s disease is increasingly recognized as a heterogeneous syndrome characterized by diverse pathological processes and clinical manifestations. Here, we propose a multidimensional framework to assess this heterogeneity, with each dimension potentially captured using advanced magnetic resonance imaging techniques. The framework comprises dominant pathological processes, spatial distribution patterns of pathology across brain regions, propagation architecture, temporal dynamics of disease progression …

27.08.2026journal-article

Journal of Hand Surgery (European Volume)

Intraoperative electrodiagnostic testing as a decision-making tool for neonatal brachial plexus palsy: a scoping review

Michael J Albdewi, Martijn JA Malessy, Yamaan S Saadeh

Introduction: Neonatal brachial plexus palsy causes upper extremity paralysis owing to birth-related brachial plexus injury. Although intraoperative electrodiagnostic techniques are routinely used to guide nerve repair in adult brachial plexus surgery, their utility in neonatal cases remains unclear. This scoping review examines whether intraoperative electrodiagnosis aids surgical decision-making, particularly in distinguishing cases amenable to neurolysis, from those that may benefit from nerve reconstruction. Me …

27.08.2026journal-article

Alimentary Pharmacology & Therapeutics

Treatment Patterns in Patients With Eosinophilic Oesophagitis Referred for Expert Consultation

Sydney F. Pomenti, Elina Stoffel, Alexa Choy, Emma Fanuele, Nirmala Gonsalves, Evan S. Dellon, David A. Katzka

ABSTRACT Background & Aims Eosinophilic esophagitis (EoE) patients deemed treatment‐refractory are frequently referred to tertiary centres. We aimed to characterize expert perspectives on patients referred for refractory EoE, including its causes, prevalence, and evaluation. Methods We conducted an anonymous and blinded cross‐sectional survey of international EoE experts ( n = 52) assessing provider characteristics, referral patterns, perceived causes of treatment failure, diagnostic approaches, and prior therapies …

27.08.2026journal-article

Med Research

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong

ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability. Currently, the clinical management of TBI relies primarily on palliative care, whereas complex secondary injury cascades limit the ability of traditional single‐target drugs to achieve consistent clinical benefits. Exosomes, as natural nanoscale extracellular vesicles, offer a highly promising innovative strategy for neuroprotection and repair in TBI due to their inherent abi …

27.08.2026journal-article

Biometrical Journal

Comparison of Methods for Incorporating Related Data When Developing Clinical Prediction Models: A Simulation Study

Haya Elayan, Matthew Sperrin, Glen P. Martin, Frieder Braunschweig, Jonas Faxén, Joakim Alfredsson, David A. Jenkins

ABSTRACT Clinical Prediction Models (CPMs) compute an individual's risk of an outcome, given a set of predictors. Guidance states CPMs should be constructed using data sampled from the target population. However, researchers might have access to ancillary data sets from different time points, countries, or healthcare settings, which could support model development. This study explores in which situations the ancillary data affect CPM performance, given potential heterogeneity. We conducted a simulation study to ass …

27.08.2026journal-article

Biopsychosocial Science and Medicine

Prospective Links between Intraindividual Measures of Negative Affect and Physical Well-being among Couples Coping with Cancer

Shelby L. Langer, Michael Todd, Laura S. Porter, Rachel Koffer

Objective: Research examining associations between intraindividual variability in affective experiences and health stems largely from non-clinical samples and individuals versus within a dyadic context. We sought to examine this linkage in couples coping with cancer. Methods: 233 patients with cancer and their spouses/partners (mean age = 52.5) completed twice-daily ecological momentary assessments for 14 days. Nine negative affect items were used to compute intraindividual negative affect means, standard deviation …

27.08.2026journal-article

PLOS One

First cell-patterning of primary, patient-derived mesenchymal glioblastoma brain cancer cells on parylene-C/SiO2 substrates

Nicholas G. Mellor, Sylvia A. Chung, Pierrette Michaux, Josiah Firth, Scott E. Graham, Bryan W. Day, Charles P. Unsworth

The mesenchymal subtype of the WHO grade IV Glioblastoma (GBM) is the most common and lethal form of adult brain cancer, characterised by its rapid growth, invasiveness and colonisation. Current standard of care includes surgical resection, chemotherapy and radiotherapy. Despite this, mortality remains dismal with median patient survival of less than 15 months after treatment. For these reasons, the World Health Organisation (WHO) classifies GBM as an incurable disease. To address this challenge, the GBM scientific …

27.08.2026journal-article

Journal of Neurology

Long-term patient-reported neurocognitive and functional outcomes after tick-borne encephalitis: a prospective controlled multicenter cohort study

Hilde Skudal, Åslaug Rudjord Lorentzen, Tore Stenstad, Else Quist-Paulsen, Børre Fevang, Keson Jaioun, Malin Veje, Hege Kersten, Randi Eikeland, Jens Egeland

Abstract Objective To characterize cognitive symptoms the first year after tick-borne encephalitis (TBE). Methods We conducted a controlled, multicenter cohort study of 109 hospitalized patients ≥16 years with confirmed TBE in Norway. At 3 and 12 months after admission, patients completed BRIEF-A (Global Executive Composite (GEC) and subscales), Everyday Memory Questionnaire-Revised (EMQ-R), and Rivermead Post-Concussion Symptoms Questionnaire (RPQ), assessing executive functioning, memory, and post-TBE symptoms (h …

27.08.2026journal-article

JMIR Research Protocols

Clinical and Patient-Reported Outcomes Following Multidisciplinary Management of Cancer-Related Pain: Protocol for a Prospective Observational Pre-Post Study

Juan Jose Amate Pena, Laura García Reza, Patricia Concheiro-Moscoso, Betania Groba, Sara Sierra Cardalda, Clara García Lorenzo, Miguel Angel Pereira Loureiro

Background Cancer-related pain remains highly prevalent and frequently undertreated despite advances in oncological therapies and analgesic strategies. Multidisciplinary approaches are recommended to optimize complex cancer pain management and integrate supportive care; however, robust real-world evidence evaluating their measurable clinical and patient-reported impact remains limited. Structured multidisciplinary cancer pain committees may be associated with changes in pain outcomes, quality of life, and patient e …

27.08.2026journal-article

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

Computational biomechanical analysis of medial displacement calcaneal osteotomy placement and orientation

Cecily James Marden, Bo Aletha Pilarczyk, Aaron Bhattachan, Willem Koenders, Bedri Karaismailoglu, Soheil Ashkani-Esfahani, Omer Subasi

Medial displacement calcaneal osteotomy (MDCO) is commonly used to correct valgus hindfoot alignment in progressive collapsing foot deformity, but the biomechanical effects of osteotomy placement and Chevron apex geometry within the surgical safe zone remain unclear. This study evaluated how oblique cut position and Chevron apex orientation affect construct stiffness and stress distribution using patient-specific finite element models. Weight-bearing CT-derived models of the distal tibia, talus, and calcaneus were …

27.08.2026journal-article

Frontiers in Digital Health

Bridging semantics and clinical fidelity: a section-based assessment of a vision–language model (RadVLM) for chest x-ray report generation

Saleh Alzughaibi

Background Artificial intelligence-generated radiology reports may reduce clinician burden, but their factual accuracy remains uncertain. This study evaluated whether surface-level semantic similarity in AI-generated Impression sections reliably reflects structural fidelity in the underlying Findings. Methods RadVLM, a radiology-focused vision–language model, generated Findings and Impression sections for 3,000 public chest radiograph studies. A section-aware evaluation framework assessed Findings-level entity-rela …

27.08.2026journal-article

Aging Clinical and Experimental Research

The association of physical activity with intrinsic capacity: findings from longitudinal analysis in CHARLS and HRS

Xiaoxian Yang, Yan Zhuang, Hui Huang

Abstract Background Physical activity (PA) is a pivotal modifiable determinant of intrinsic capacity (IC), a core component of healthy aging. Aims This study aimed to examine the association between PA and the risk of IC impairment among middle-aged and older adults using nationally representative cohorts from China and the United States. Methods Data from CHARLS (2011–2015) and HRS (2010–2018) were used, including 781 and 2,601 participants, respectively. PA was quantified by metabolic equivalents (MET), and IC im …

27.08.2026journal-article

Eurasian Journal of Medicine and Oncology

Systemic inflammation and risk stratification in pheochromocytoma: Insights from PASS components, TNM stage, and the tumor immune microenvironment

Ümit Çavdar, Tuğçe Tekinaslan, Özlem Eren, Emine Özlem Gür, Serkan Karaıslı, Mehmet Haciyanli, Selda Gücek Haciyanli, Aslı Kahraman, Mehmet Sercan Ertürk, Barış Önder Pamuk, Serkan Yener

Introduction: The Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) and Tumor–Node–Metastasis (TNM) staging capture histopathological and anatomical risk features in adrenal pheochromocytoma, but do not incorporate systemic inflammation. Objectives: To investigate the associations of preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with individual PASS components and American Joint Committee on Cancer TNM stage in adrenal pheochromocytoma. Methods: We retr …

27.08.2026journal-article

Journal of Clinical and Translational Research

Hospital outcomes in Jehovah’s Witness patients with acute gastrointestinal bleeding: A matched cohort study

Taraji 1, Porsha Okiye, Chakravarthy Nulu, Rithvick Kumar, Andrew Bouffler, Ali Mirza, Vishnavi Batchu, Amit Hudgi, Humberto Sifuentes, Raguraj Chandradevan

Background: Acute gastrointestinal bleeding (GIB) may require urgent resuscitation, endoscopy, and red blood cell (RBC) transfusion. Management is particularly challenging in Jehovah’s Witness (JW) patients who decline RBC transfusion. Aim: To compare short-term hospital outcomes between JW patients with acute GIB and individually matched transfusion-eligible comparators. Methods: We conducted a single-center retrospective matched cohort study of adults admitted from 2010 to 2026. Twenty-two JW patients who d …

27.08.2026journal-article

Journal of Clinical Medicine

Therapies for Heart Failure: Clinical Updates and Perspectives

Stela Iurciuc, Dragoș Cozma, Cristina Tudoran

Although signs and symptoms of heart failure (HF) have been described since ancient times, and the term has evolved throughout history, there are still unanswered questions concerning its pathophysiology and best treatment options [...]

27.08.2026journal-article

Breastfeeding Medicine

Psychosocial and Physiological Determinants of Continued Exclusive Breastfeeding at 6 Months’ Corrected Age in Late Preterm Infants

Jinxiu Chen, Qinghua Li, Honghui Wen, Qiuxia Liang, Weiqiang Zhang, Xiujuan Liao, Yanqing Tang

Background and Objective: Exclusive breastfeeding (EBF) is essential for neonatal survival and long-term development; however, late preterm infants (34 +0 –36 +6 weeks of gestation) consistently exhibit lower breastfeeding persistence than term infants. Breastfeeding sustainability in this population is influenced by both psychosocial conditions and physiological readiness. This study aimed to identify modifiable psychosocial and physiological determinants—including prenatal breastfeeding intention, family caregivi …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Colloids in acute pancreatitis: Microcirculatory advantage or inflammatory mirage

Amira Ahmed Abdelrahman Othman

The quest for optimal fluid resuscitation in acute pancreatitis continues to challenge clinicians, balancing perfusion, inflammation, and safety. The recent randomized controlled trial published in World Journal of Gastrointestinal Surgery by Costea et al compared Dextran 40 Plus Ringer’s lactate solution with Ringer’s lactate solution alone in mild-to-moderate acute pancreatitis. While dextran-enhanced therapy significantly reduced C-reactive protein at 72 hours, it did not accelerate systemic inflammatory respons …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Impact of target volume delineation accuracy on locoregional control and survival after postoperative radiotherapy for colorectal cancer

Yao Xing, Min Gu

BACKGROUND Postoperative radiotherapy reduces local recurrence in locally advanced colorectal cancer, but its efficacy depends on accurate target volume delineation. This study assessed the impact of delineation accuracy on treatment outcomes. AIM To investigate the impact of target volume delineation accuracy on treatment outcomes of postoperative radiotherapy for colorectal cancer. METHODS Clinical data of 218 colorectal cancer patients who underwent radical surgery followed by adjuvant radiotherapy at our hospit …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Acute pancreatitis, hypercalcemia, and kidney stones: True incidence or unveiled prevalence?

Selcuk Yuksel

Recent study reported an association between hypercalcemia and nephrolithiasis in acute pancreatitis and proposed a striking rate of de novo stone formation during a 7-day hospitalization. Their work is valuable because it draws attention to the endocrine-metabolic dimension of acute pancreatic injury and to a potentially vulnerable subgroup of patients. However, the reported endpoint raises major biological and methodological concerns. Lithogenesis is a multistep process requiring urinary supersaturation, nucleati …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Metallic clip-associated colonic perforation after peroral endoscopic myotomy: A case report

Geng-Yuan Zhang, Shi-Gong Chen, Zhong-Ti Gao, Zhu-Tang Huang, Sheng-Fu Che, Long Li, Bo Long, Fei-Fei Ding, Ze-Yuan Yu, Hui-Nian Zhou, Zuo-Yi Jiao

BACKGROUND Colonic perforation secondary to a metallic clip following peroral endoscopic myotomy is exceptionally rare, particularly in patients with achalasia and concomitant chronic constipation. CASE SUMMARY We presented a case of a 48-year-old woman with acute abdominal symptoms in which intraoperative exploration revealed a detached metal clip adjacent to the colonic perforation site. A sigmoid colectomy with colostomy was subsequently performed. No discomfort was reported during the 5-month follow-up period. …

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Correction to: “Liuzijue” Qigong training enhances early pulmonary function recovery after esophageal cancer surgery

Yu Bai, Yi-Bin Wu

Correction to: Bai Y, Zhang ZL, Qiao L, Shi LL, Wang J, Nian H, Du QC, Tian ZH, Yao ZL, Wu YB. "Liuzijue" Qigong training enhances early pulmonary function recovery after esophageal cancer surgery. World J Gastrointest Surg 2025; 17(12): 113408 [PMID: 41479713 DOI: 10.4240/wjgs.v17.i12.113408]. In this article, we have identified an error in Tables 3 and 4: The columns labeled “Control group” and “Experimental group” were inadvertently transposed during a post-publication review.

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Magnetic compression anastomosis in gastrointestinal and biliary disease: Techniques and clinical applications

Ravi Teja Reddy, Amit Bagrodia, Kartik Mehta, Venkatesh Vaithiyam, Supraja L Mohan, Nikhil Sirohi, Ashok Dalal, Siddharth Srivastava, Sanjeev Sachdeva

Magnetic compression anastomosis (MCA) is an emerging minimally invasive technique that enables the creation of gastrointestinal anastomoses without surgical suturing or stapling. This technique involves the placement of paired magnets across an obstructed or discontinuous lumen, generating localized compression that induces ischemic necrosis of the intervening tissue, and subsequent formation of a neo-anastomotic tract. Over the past decade, MCA has gained increasing attention in the management of complex gastroin …