Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Onkologie · Seite 65

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
24.08.2026journal-article

Vigilância Sanitária em Debate

Gerenciamento de riscos nas compras públicas de medicamentos oncológicos: estratégia e métodos para mitigação de falhas

Virginia Luiz de Sousa, Jorge Carlos Santos da Costa, Elezer Monte Blanco Lemes

Introduction: Public procurement of oncology medicines represents a significant share of healthcare expenditures and plays a crucial role in ensuring universal access to essential therapies. However, the bidding process is subject to failures that compromise efficiency, transparency, and patient safety. Objectives: To develop and apply a risk management (RM) model adapted to the reality of public procurement of oncology medicines, based on nationally and internationally recognized methodologies. Method: Case study …

24.08.2026journal-article

Melanoma Research

Treatment discontinuation after complete response to BRAF/MEK inhibition in metastatic melanoma: long-term clinical outcomes from a single institution

Maja Ivanova, Igor Stojkovski, Violeta Klisarovska

The optimal duration of BRAF/MEK inhibitor therapy in patients with metastatic melanoma who achieve complete response remains uncertain. Although targeted therapy is commonly continued until disease progression or unacceptable toxicity, prolonged treatment may be associated with chronic adverse events, impaired quality of life, and treatment fatigue. We performed a retrospective single-center analysis of patients with BRAF -mutated metastatic melanoma who achieved radiologically confirmed complete response during c …

24.08.2026journal-article

Journal for Person-Oriented Research

Treatment of anxiety in athletes using cognitive behavioral therapy: A single-case experimental design with multiple baselines.

Rebecka Ekelund, Stefan Holmström, Andreas Stenling

Anxiety is one of the most prevalent mental health problems in athletes, yet the inclusion of athletes with clinical mental health problems in intervention studies remains limited. Furthermore, no studies to date have investigated the mechanisms of cognitive behavioral therapy (CBT) on anxiety and positive affect in athletes. Hence, the aim of the current study was to examine the effect of CBT on moderate to severe symptoms of anxiety and positive affect in athletes, as well as to investigate the mediated effects o …

24.08.2026journal-article

Techniques in Hand & Upper Extremity Surgery

Pyrocarbon Hemiarthroplasty Via Lateral Approach for the Treatment of PIP Osteoarthritis

Istvan Zoltan Rigo, Preben Olsson Dovland, Asgeir Amundsen

Hemiarthroplasty of the proximal interphalangeal (PIP) joint using a pyrocarbon implant was initially described for the salvage of nonreconstructable fractures with loss of 1 joint surface. Later, this method was used to treat osteoarthritis. PIP hemiarthroplasty is less invasive than total arthroplasty. The lateral approach to the PIP joint has been described in combination with silicone arthroplasty, offering the advantages of a less demanding surgical preparation and avoiding violation of the extensor mechanism. …

24.08.2026journal-article

Scientific Reports

Seasonal assessment of groundwater quality and irrigation suitability using a solar-powered AgNP/activated carbon treatment system in a coastal aquifer

Mohamed Y. Omar, Rania A. Ibrahim, Ebtesam El Bestawy, Kareem M. Tonbol, Ragaa A. Ahmed

Abstract The increasing water scarcity, groundwater degradation, and climate variability have increased the demand for sustainable groundwater management strategies in arid and semiarid regions. This work presents an integrated framework for groundwater monitoring and irrigation suitability assessment of groundwater from 13 borehole at a university campus in Alexandria, Egypt, under climate change conditions. The developed system was implemented via a field-scale, solar-powered fixed-bed column packed with a green- …

24.08.2026journal-article

BMC Medicine

Boosting ovarian cancer immunotherapy via discoidin domain receptor 2 blockade and CD28 x mucin 1 bispecific antibodies

Martina Kunkl, Silvia Malatesta, Flavia Ottavi, Ilenia Masi, Manolo Sambucci, Virginia Vigiano Benedetti, Maria Egle De Stefano, Martina Leopizzi, Maria Teresa Fiorillo, Marco Rossi, Francesco Mura, Anacleto Proietti, Enrica Martinelli, Camilla Nero, Anna Fagotti, Giovanna Borsellino, Luca Battistini, Valerio Licursi, Francesco Spallotta, Laura Rosanò, Loretta Tuosto

Abstract Background Serous ovarian carcinoma (SOC) is a highly aggressive gynaecological malignancy with frequent relapse and the development of chemoresistance. A major feature of SOC tumour microenvironment is the accumulation of dense collagen fibres, which promote tumour progression and immune evasion. Discoidin domain receptor 2 (DDR2), a collagen-binding receptor tyrosine kinase activated by fibrillar collagens, mediates extracellular matrix-associated signalling involved in tumour progression and immune excl …

24.08.2026journal-article

PLOS One

Development and psychometric evaluation of an assessment tool assessing Pharmacists’ knowledge and practice on antimicrobial prophylaxis among cancer patients

Lee Jia Hui, Nicole Lam Koh Yie, Justine Yap, Muhamad Nasrul, Ali Haider Mohammed, Bassam Abdul Rasool Hassan, Lee Jia Jia, Dinesh Sangarran Ramachandram, Ruth Sim, Angelina Lim, Juman Dujaili, Ali Blebil

Background Despite advancements in cancer therapy, opportunistic infections remain a significant obstacle to successful patient outcomes. This highlights the necessity for research into the role of antimicrobial prophylaxis in preventing opportunistic infections within oncology care. Therefore, this study aims to develop and validate a questionnaire that assesses pharmacists’ knowledge and practices regarding antimicrobial prophylaxis in cancer patients. Method The research was conducted in 2 phases. Phase I focuse …

24.08.2026journal-article

International Journal of Basic & Clinical Pharmacology

Triple-negative breast cancer: unmet needs and emerging targeted and immunotherapeutic approaches

Diya Agarwal, Ammana Sathwika Reddy, Balasani Ashwitha, Muppasani Thanvitha, Mamidala Ravalika

Triple-negative breast cancer (TNBC) is a tough type of breast cancer. It does not have estrogen, progesterone, or HER2 receptors. This makes it hard to treat because common hormone and HER2 therapies do not work, often leading to poor results. To look at new treatments for TNBC, focusing on new molecular targets, antibody-drug conjugates (ADCs), immunotherapy, resistance issues, and future personalized medicine. A detailed review was done, combining information from molecular biology, clinical trials, immuno-oncol …

24.08.2026journal-article

Cancer Research Communications

CRB-701: a Second-Generation Nectin-4 Targeted Antibody–Drug Conjugate with Optimized Stability and Pharmacokinetics for the Treatment of Solid Tumors

Zhaopeng Sun, Mo Dan, Lu Lv, Mingyue Shen, Can Yuan, Congcong Niu, Yang Zhang, Xixin Hu, Xiwu Hui, Andrew Kolodziej

Abstract The adhesion protein nectin-4 is a clinically validated tumor-selective antigen that is overexpressed across multiple cancer types and has been successfully exploited as a target for antibody–drug conjugates (ADCs), most notably enfortumab vedotin (EV), which is approved for treatment of urothelial carcinoma. Here, we report the design and preclinical characterization of a second-generation nectin-4 targeted ADC, CRB-701 (also identified as SYS6002). CRB-701 was synthesized using microbial transglutaminase …

24.08.2026journal-article

International Journal of Molecular Sciences

Coumarin and Curcumin-Metal Complexes as Next-Generation Photosensitizers in Cancer Photodynamic Therapy

Siu Kan Law, Albert Wing Nang Leung, Chuanshan Xu

To explore the emerging role of natural ligands, specifically coumarin and curcumin, and their coordination with the transition metals ruthenium (Ru) and iridium (Ir) as photosensitizers (PSs) in photodynamic therapy (PDT) for cancer. This highlights the integration of natural compounds and transition metals to overcome limitations in photophysical properties, hypoxia tolerance, and clinical translation. Regarding PDT oncology, this examines an immunological effect on Ru/Ir complexes and natural ligand-metal hybrid …

24.08.2026journal-article

Pharmacognosy Magazine

Identification of Potential Active Ingredients and Mechanisms of Scleromitrion diffusum for Lung Cancer Based on Network Pharmacology and Molecular Docking Technology

Yue Lu, Li Chunyan

Background Lung cancer is known as the primary cause of cancer-related deaths worldwide. Scleromitrion diffusum is a classic traditional Chinese medicine for the treatment of lung cancer. However, the active ingredients and mechanisms are not yet clear. Purpose To study the ingredients and mechanisms of S. diffusum based on network pharmacology and molecular docking technology. Methods The major chemical ingredients of S. diffusum were screened, and the corresponding targets were obtained through the Batman-TCM dat …

24.08.2026journal-article

Frontiers in Public Health

Prevalence and influencing factors of oral frailty in cancer patients: a systematic review and meta-analysis

Wenxiao Liu, Meng Fang, Yukai Luo, Tianshu Mei, Ping Huang

Introduction This study systematically evaluated the prevalence of oral frailty and its associated influencing factors among patients with cancer through a comprehensive systematic review and meta-analysis. Methods A systematic search was conducted across nine electronic databases up to January 13, 2026, and 13 studies involving 3,524 participants were ultimately included. Results The pooled analysis demonstrated that the prevalence of oral frailty in patients with cancer was 52% (95% CI: 46%–59%), indicating a sub …

24.08.2026journal-article

Frontiers in Oncology

Comparable outcomes after McKeown and Ivor-Lewis minimally invasive esophagectomy with standardized two-field lymphadenectomy: a propensity score-matched study

Siyu Quan, Yun Li, Xianyun Cai, Fengqi Guo, Ya Wang, Hounai Xie

Background Minimally invasive esophagectomy (MIE) is widely used for esophageal cancer, but the optimal choice between McKeown and Ivor-Lewis MIE remains controversial. This study compared perioperative outcomes and 5-year overall survival (OS) between the two approaches under a standardized two-field lymphadenectomy framework. Methods We retrospectively reviewed a cohort of 1,011 patients who underwent MIE for esophageal cancer between May 2017 and May 2020. To minimize selection bias, 1:1 propensity score matchin …

24.08.2026journal-article

Frontiers in Psychiatry

Identifying core symptoms of anxiety and depression in colorectal cancer patients: network analysis

Yu Chen, Jing Chen, Dandan Wu

Background Negative emotions, particularly anxiety and depression, are highly prevalent among cancer patients. Due to the unique disease characteristics of colorectal cancer, the coexistence of depression and anxiety is even more common, warranting close attention from clinical practitioners. This study aims to elucidate the characteristics of anxiety and depression symptom networks in patients with colorectal cancer. Methods A cross-sectional study was conducted among 364 colorectal cancer patients recruited via c …

24.08.2026journal-article

Frontiers in Oncology

Artificial intelligence for bone metastases: a systematic review and meta-analysis of diagnostic and prognostic performance

Luisana Sisca, Mariam Grazia Polito, Emy Sisca, Giuseppe Francesco Papalia, Francesco Vilardi, Fabio Venuti, Alessio Cortellini, Marianna Silletta, Roberta Scafetta, Silvia Calagna, Michele Iuliani, Silvia Cavaliere, Sonia Simonetti, Bruno Vincenzi, Giuseppe Tonini, Francesco Pantano

Bone metastases are a major complication of advanced solid tumors and are associated with substantial morbidity and reduced survival. Imaging plays a central role in detection and monitoring, yet conventional modalities and qualitative risk scores remain limited by suboptimal specificity and inter-reader variability. Artificial intelligence (AI) has emerged as a potential tool to improve diagnostic accuracy and prognostic assessment. We performed a systematic review and meta-analysis of studies published between Ja …

24.08.2026journal-article

Uludağ Üniversitesi Tıp Fakültesi Dergisi

Effects of Chemotherapy and Chemoradiotherapy on Survival and Toxicity in Locally Advanced Unresectable Pancreatic Cancer

Gülen Doğan, Ender Kurt

The optimal treatment for locally advanced, unresectable pancreatic cancer remains controversial. This study aimed to compare the effects of chemotherapy and chemoradiotherapy on survival and toxicity in patients with locally advanced, unresectable pancreatic cancer. A total of 59 patients were retrospectively analyzed. Overall survival (OS), progression-free survival (PFS), and treatment-related toxicities were evaluated. Twenty-five patients received chemotherapy followed by concurrent radiotherapy with gemcitabi …

24.08.2026journal-article

Veterinary Evidence

Efficacy of vincristine-ivermectin combination therapy in the treatment of canine transmissible venereal tumour (CTVT)

Athulya Prakash

PICO Question In dogs diagnosed with canine transmissible venereal tumour (CTVT), does treatment with vincristine combined with ivermectin, compared to treatment with vincristine alone, lead to improved clinical outcomes? Clinical bottom line Category of research Treatment. Number and type of study designs reviewed Two randomised controlled trials. Strength of evidence Weak. Outcomes reported The studies collectively indicate that the combination of vincristine and ivermectin may be an effective and well-tolerated …

24.08.2026journal-article

Advanced Science

A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Yan Zhao, Yufei Lan, Min‐Goo Lee, Jinjun He, Yueran Pan, Eunji Kim, Xin Fu, Sungwook Jung, Wanxia Lu, Jinyue Fan, Haoxiang Chen, Yuanbo Zhao, Yuling Xu, Jong Seung Kim, Chao Zhang

ABSTRACT Precision control over nucleic acid delivery remains a critical challenge in cancer therapy, particularly for siRNA‐based gene silencing, where off‐target effects limit clinical translation. Herein, we report a programmably engineered DNA nanocircuit with cascaded dual‐AND logic gates, which enables the development of a spatiotemporally controlled siRNA delivery strategy for precision cancer therapy. The DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extrac …

24.08.2026journal-article

International Journal of Surgery Open

Initial diagnosis of extraparatoid Warthin’s tumor in a 64-year-old Syrian patient: a challenging diagnosis

Peter Simon, Rima Alabbas, Hosam Salman, Sara Nezam, Nezam Nezam, Nour Abbas, Ali Mohammad Yousof, Ali Ahmad Solaiman, Sawsan Ismail

Warthin tumor (WT) is the second most prevalent benign neoplasm of the salivary glands. WT is mainly detected near the mandibular angle in the parotid gland, accounting for 2–15% of parotid gland neoplasms. Extraparotid presentations, on the other hand, occur in less than 1% of cases and are mainly detected in the submandibular gland, the minor salivary glands, and the parapharyngeal region. These presentations usually trigger a diagnostic dilemma because they mimic the presentation of metastatic tumors. Herein, we …

24.08.2026journal-article

Microorganisms

Toward AI-Driven Detection of Asymptomatic Chronic Conditions from Stool Metagenomics and Dietary Data: A Multimodal Deep Learning Framework for T1DM, T2DM, MOS/PCOS, Cancer, and Autoimmune Disease

Károly Szili, Csilla Dézsi, Viktor Gulyás-Oldal, Dániel Sallai, Gábor Patay, Ekaterine Paschali, Sándor Nagy

Chronic non-communicable conditions—type 1 and type 2 diabetes mellitus (T1DM, T2DM), metabolic obesity syndrome (MOS), polycystic ovary syndrome (PCOS), colorectal and extra-intestinal cancers, and systemic autoimmune disease—share a prolonged asymptomatic phase during which conventional screening is invasive, insensitive, or resource-intensive. This review synthesizes the 2021–2026 literature on fecal microbiome-based artificial intelligence (AI) diagnostics across these conditions, extracting reported discrimina …

24.08.2026journal-article

PLOS One

Exome-based cancer driver gene comprehensive testing can provide a genetic diagnosis for individuals with triple-negative breast cancer

Daniel Alzate, Angel Yobany Sánchez, Yovana Pacheco, Mario Isaza Ruget, Ramiro Sánchez, Carolina Castillo, Carlos A. Parra-López

Triple-negative breast cancer (TNBC) is characterized by aggressive behaviour, high tumor heterogeneity, and an increased likelihood of recurrence and early metastasis. These factors hinder successful treatment. Genetic diagnosis enables personalized clinical recommendations and treatment options. The objective of this study was to validate whole-exome sequencing (WES) and variant prioritization in cancer susceptibility genes (CSG) associated with hereditary cancer (HC) predisposition in TNBC patients (n = 24). We …

24.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Randomized trial of adjuvant 5-FU-platinum vs paclitaxel-platinum for high-risk penile cancer

Vanita Noronha, Nandini Menon, Minit Shah, Vijay Patil, Aditya Dhanawat, Gagan Prakash, Mahendra Pal, Amandeep Arora, Ankit Misra, Supriya Goud, Sucheta More, Akanksha Yadav, Vedang Murthy, Priyamvada Maitre, Santosh Menon, Palak Popat, Nilesh Sable, Archi Agarwal, Venkatesh Rangarajan, Ankush Shetake, Rajendra Badwe, Kumar Prabhash

Abstract Background Adjuvant chemotherapy is recommended for high-risk penile squamous cell carcinoma (SCC) metastatic to lymph nodes based on retrospective data, but no randomized trials have been conducted. We compared 5-fluorouracil (5-FU)-platinum with paclitaxel-platinum in this setting. Methods In this open-label, randomized trial at an Indian tertiary cancer center, men <70 years with resected node-positive penile SCC and ≥1 high-risk feature (perinodal extension, pelvic node involvement, >1 inguinal n …

24.08.2026journal-article

International Journal of Clinical Oncology and Cancer Research

Comparative Study Between Concurrent Chemoradiation and Radiation Alone in the Treatment of Advanced Head and Neck Cancer

Md. Habib, Sadia Rezvi, Julekha Khatun, Md. Karim

Concurrent chemoradiotherapy is an established option for suitable patients with non-metastatic head and neck squamous cell carcinoma, but evidence from resource-limited settings remains important for real-world treatment decisions. This single-centre prospective comparative study was conducted at the Department of Radiotherapy, Rajshahi Medical College Hospital, Bangladesh, from January to December 2014, comparing early treatment response and acute toxicity between concurrent chemoradiation and radiation alone. 66 …

24.08.2026journal-article

Molecular Cancer Therapeutics

New Therapeutic Cancer Vaccine with Lenalidomide Induces Potent T-cell Immunity and Inhibits HPV E6/E7–Expressing Tumor Growth in Mice

Yohannes Gemechu, Sonia Mukherjee, Jeffrey A. Gelfand, Timothy A. Brauns, Ann E. Sluder, Pierre R. Leblanc, Yuki Agarwala, James Adeosun, Abigail Colley, Daiki Sugita, Jacob J. Smith, George Steinfels, Paul Korner, Ishan Capila, Patrick M. Reeves, Mark C. Poznansky

Abstract Current prophylactic human papillomavirus (HPV) vaccines prevent infection but have limited therapeutic benefit in established HPV-driven malignancies. To address this unmet need, we developed VTX-067, a modular self-assembling therapeutic cancer vaccine consisting of a recombinant Mycobacterium tuberculosis heat shock protein 70–avidin fusion (MAV) noncovalently bound to biotinylated HPV E6/E7 MHC class I– and II–restricted peptide concatemers. MAV is produced in Chinese hamster ovary cells with minimal e …