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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
18.08.2026journal-article

Frontiers in Immunology

A protracted diagnostic journey of pediatric PAPA syndrome and subsequent response to tofacitinib therapy: a case report and literature review

Shuien He, Hao Deng, Jinghua Yang, Wenwen Jiang

PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) is a rare autosomal dominant autoinflammatory disorder caused by mutations in the PSTPIP1 gene. In pediatric patients, arthritis often precedes cutaneous manifestations by several years, leading to frequent misdiagnosis as septic arthritis. Treatment is challenging, with IL-1 inhibitors being the most pathophysiology-based first-line therapy, but their accessibility is limited by high costs. We reported an 11-year-old Chinese boy with a 7-ye …

18.08.2026journal-article

Frontiers in Immunology

Association between gut microbiota characteristics and therapeutic efficacy of multimodal combination therapy in hepatocellular carcinoma with portal vein tumor thrombus: a secondary analysis of a prospective phase II trial

Xinwen Liang, Ye Li, Minhui Liang, Zhiming Zeng, Kai Hu, Lihua Yang, Hui Yan, Muyun Li, Jie Zeng, Jing Tang, Yufeng Lv, Li Liang, Jiali Meng, Huabin Su, Jie Ma, Ning Mo

Background Hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) carries a poor prognosis. Although SBRT combined with cadonilimab and lenvatinib has shown encouraging antitumor activity in a prior prospective phase II trial, marked interpatient heterogeneity remains. Gut microbiota may influence antitumor immunity and could help identify patients more or less likely to benefit from this regimen. Objective To characterize baseline and longitudinal gut microbiota features in treatment-naïve HCC patie …

18.08.2026journal-article

Mind & Language

Non‐assertoric Moorean speech acts

Maciej Tarnowski

This paper offers a unified account of Moorean speech acts beyond assertion. While the knowledge norm of assertion provides a familiar explanation of Moorean assertions, it does not generalize easily to non‐assertoric cases. I argue that Stalnaker's model of common ground provides a suitable framework for explaining these phenomena. Speech acts propose updates to the common ground, understood as targeting common knowledge, involving both their satisfaction and sincerity conditions, and Moorean speech acts universal …

18.08.2026journal-article

Journal of Clinical Medicine

Effectiveness of Single-Use Negative Pressure Wound Therapy (Pico 7) in Chronic Lower Limb Wounds: A Randomized Clinical Trial

Celia Villalba-Aguilar, José Alberto Laredo-Aguilera, Lucía Villalba-Aguilar, Esperanza Barroso-Corroto, Cristina Del Viso-Cudero, Víctor Serrano-Fernández, Juan Manuel Carmona-Torres

Background: Chronic lower limb wounds, such as diabetic and vascular ulcers, affect up to 2% of the global population, imposing high healthcare costs and a significant risk of amputation. Although nursing care and traditional treatments are fundamental, single-use portable Negative Pressure Wound Therapy PICO 7 system, has emerged as a cost-effective alternative. The objective of this study was to evaluate the effectiveness of PICO 7, compared to the usual treatment in chronic lower limb wounds or their dehiscence …

18.08.2026journal-article

Journal of Clinical Medicine

Optimizing Vestibular Rehabilitation: From Neuroplastic Mechanisms to Multimodal Therapeutic Strategies

Brahim Tighilet, Emna Marouane, Frédéric Xavier, Christian Chabbert

Peripheral vestibulopathy (PV) is a common disorder that causes dizziness and balance impairment, substantially affecting patients’ quality of life. When symptoms persist, they frequently lead to anxiety, depression, and an increased risk of social isolation. Although central vestibular compensation (CVC) often promotes functional recovery, current pharmacological options remain limited and are primarily aimed at symptom control. Consequently, they should be considered adjuncts rather than alternatives to rehabilit …

18.08.2026journal-article

Journal of Clinical Nursing

Building a Competency Framework for Primary Hospital Nurses in ‘Internet + Nursing’ Based Home IV Therapy

Lingyan Chen, Yimao Sang, Ya Wang, Jie Yang

ABSTRACT Objective To establish a core competency item system for home‐based intravenous therapy nurses in primary hospitals under the ‘Internet + Nursing Services’ framework. Methods Based on the ‘Iceberg Model’ theoretical framework, a preliminary framework for the core competency item system of home‐based intravenous therapy nurses in primary hospitals under the ‘Internet + Nursing Services’ framework was constructed from December 2024 to May 2025 through literature review and semi‐structured interviews. The con …

18.08.2026journal-article

Brain Circulation

Effects of remote ischemic conditioning on sleep function in patients during stroke rehabilitation: A multicenter randomized controlled pilot study

Yunqian Luo, Liang Chu, Yiyi Li, Li Xiong, Wenyu Lu, Jiamin Chen, Alexander Weiss, Sydni Rosenfeld, Xintong Wu, Zhen Chen

Abstract: BACKGROUND: Remote ischemic conditioning (RIC) is a simple, low-cost, and safe intervention. Clinical evidence regarding its effects on sleep disturbances and related psychological symptoms during the poststroke rehabilitation phase remains limited. This pilot study evaluated the feasibility and clinical effects of RIC in this population. METHODS: In this multicenter, randomized, double-blind, sham-controlled pilot trial, patients undergoing poststroke rehabilitation with comorbid sleep disturbances were …

18.08.2026journal-article

Revista Ibero-Americana de Humanidades, Ciências e Educação

SAÚDE MENTAL DOS PROFISSIONAIS DA SAÚDE: FATORES DE RISCO, ESGOTAMENTO PROFISSIONAL E ESTRATÉGIAS DE PREVENÇÃO

Ana Carla do Espirito Santo, Flávio Eduardo Fernandes Alves, Washington Luiz Moreira Brum, Diogo Vicente de Oliveira, Rozenila da Silva Dolzane, Márcia Silva Conceição

Este artigo analisa a saúde mental dos profissionais da saúde, com ênfase nos fatores psicossociais de risco, no esgotamento profissional e nas estratégias de prevenção aplicáveis aos serviços de saúde. Realizou-se revisão narrativa com busca estruturada, atualizada até agosto de 2026, em PubMed/MEDLINE e SciELO, complementada por documentos da Organização Mundial da Saúde e de órgãos oficiais brasileiros. As evidências mostram que sobrecarga, jornadas prolongadas, trabalho em turnos, baixa autonomia, insuficiência …

18.08.2026journal-article

JMIR Research Protocols

Mental Readiness of Clients and Families Before Discharge From Drug Rehabilitation: Protocol for a Qualitative Study

Eny Purwandari, Aad Satria Permadi, Rini Lestari

Background Relapse following drug rehabilitation remains a major mental health challenge in Indonesia. Although rehabilitation programs emphasize individual recovery, postdischarge outcomes are strongly influenced by the family as the primary microsocial environment. However, family mental readiness before discharge from rehabilitation has not been systematically explored, particularly in ways that support structured and scalable postrehabilitation care. Objective This study aims to explore the mental readiness of …

18.08.2026journal-article

TAMSAAL

AI-Based Speech and Language Therapy for Children with Autism in Pakistan: Parents’ and Speech-Language Therapists’ Perspectives

Iqra Shaheen, Sahrish Nazir, Toqeer Zahra, Syed Tariq Shah

Autism Spectrum Disorder (ASD) is associated with significant communication difficulties that affect children’s social interaction, learning, and daily functioning. Speech and language therapy plays an important role in improving communication skills; however, limited access to specialized services remains a major challenge in Pakistan. This study explored the perspectives of parents and speech-language therapists regarding AI-based speech and language therapy for children with autism. A qualitative phenomenologica …

18.08.2026journal-article

American Journal of Physical Medicine & Rehabilitation

Ventral Column Spinal Cord Stimulation for Pain Management

Behnum A. Habibi, Chong H. Kim, Gustaf M. Van Acker

Spinal cord stimulation (SCS) is a form of neuromodulation that delivers electrical impulses to the spinal cord, altering pain signals to provide relief from chronic pain. Since its introduction in the 1960s, SCS has primarily targeted the dorsal columns of the spinal cord. While SCS has proven effective for many neuropathic pain conditions, its limitations have driven exploration of alternative anatomical targets for electrical stimulation. Work in the 1970’s suggested that ventral column spinal cord stimulation ( …

18.08.2026journal-article

International Journal of Molecular Sciences

Fucoidan-Based Combination Strategies in Cancer Therapy: Biological Basis, Current Evidence, and Future Perspectives

Yumi Jang

Combination therapy has emerged as an effective strategy to enhance anticancer efficacy while overcoming the limitations of conventional cancer treatment, including systemic toxicity and therapeutic resistance. Among marine-derived bioactive compounds, fucoidan, a sulfated polysaccharide isolated from brown seaweeds, has attracted considerable attention because of its multitarget biological activities, favorable safety profile, and ability to enhance therapeutic responses. Increasing evidence suggests that fucoidan …

18.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Facial Emotion Recognition Difficulties in Children With Developmental Language Disorder: A Predominantly Linguistic Issue

Raúl López-Penadés, Àngels Esteller-Cano, Victor Sanchez-Azanza, Eva Aguilar-Mediavilla, Daniel Adrover-Roig

Purpose: Developmental language disorder (DLD) has been associated with difficulties in several cognitive and emotional domains, including emotion recognition (ER). However, the literature remains inconclusive on whether the ER difficulties extend to emotion discrimination—limited to perceptual processing—or affect more advanced stages of emotional identification, which are necessary for labeling emotions. The primary aim of this study was to explore potential impairments in facial ER in children with DLD. Method: …

18.08.2026journal-article

JNCI: Journal of the National Cancer Institute

Endocrine therapy in early-stage estrogen Receptor-Low breast cancer: a systematic review and Meta-Analysis

Davide Massa, Edoardo Chiappe, Virginia Delucchi, Fabio Girardi, Eva Blondeaux, Marina La Commare, Valentina Guarneri, Matteo Lambertini, Maria Vittoria Dieci

Abstract Background Tumors with ≥1% estrogen receptor (ER) expression by immunohistochemistry (IHC) are classified as hormone receptor-positive. While this definition includes ER-low tumors (ER 1-9%), the clinical benefit of endocrine therapy (ET) in ER-low early-stage breast cancer (BC) remains uncertain. Methods This is a systematic review and meta-analysis of studies in early-stage ER-positive, HER2-negative BC reporting (i) ET efficacy within ER-low tumors and/or (ii) outcomes comparing ER-low versus ER-rich di …

18.08.2026journal-article

Medical Physics

Impact of millimeter‐scale target motion on the precision of spatially fractionated radiation therapy using proton minibeams

Oxana Actis, Cristian Fernandez‐Palomo, Verdiana Trappetti, Michele Togno, Paolo Pellicioli, Dominic Leiser, David Meer, Valentin Djonov

Abstract Background While pencil beam scanning (PBS) with motion mitigation such as re‐scanning, breath hold, or gating is well established for treating moving targets in clinical practice, the precision for Spatially Fractionated Radiation Therapy (SFRT) using proton minibeams introduces presents a unique challenge. The sub‐millimeter precision required for SFRT cannot be achieved with typical PBS spot sizes (millimeters), necessitating multi‐slit beam collimation, which reduces the dose rate and reintroduces moti …

18.08.2026journal-article

Military Medicine

Enhancing Rural Veteran Access to Specialty Pelvic Health Rehabilitation Through Mentorship and a Novel Model of Care Coordination

Allison M Gustavson, Melanie Pomasko, Nicole Khaldy, Jordan Mamkhezri, Tejal Patel, Ashley C Mog, Caroline Merkel, Jaimie Frazier, Jessica Jungman, Mark Havran, Kristen E Gray

Abstract Introduction Pelvic health rehabilitation (PHR) treats pelvic floor disorders that result in pain, incontinence, and sexual dysfunction. Within the Veterans Health Administration (VHA), few clinicians are trained to provide PHR, particularly in rural areas. We developed and implemented 2 programs: a mentorship program to increase the PHR workforce and a virtual Care Navigator program to increase direct PHR access. Our aims were to describe the PHR project and initial program evaluation. Materials and Metho …

18.08.2026journal-article

ACS Sensors

Removable SERS Microneedles with In Situ Thermal Feedback for Precise Photothermal Therapy of Infected Wounds

Rongchao Mei, Yunqing Wang, Haijing Zhu, Qishuo Wang, Yujing Huang, Lili Dong, Yixuan Wu, Qian Yang, Ping Liu, Xiaoyan Wang, Lingxin Chen

Abstract The lack of precise thermal feedback from local treatment sites and potential safety risks caused by the shedding of sensing materials remain critical bottlenecks, limiting the clinical translation of in vivo implantable sensors and therapeutic platforms. Herein, we report removable, near-infrared (NIR)-responsive surface-enhanced Raman scattering (SERS) microneedles with actual subcutaneous temperature feedback (RTF-SEMNs). Constructed on rigid polymethyl methacrylate (PMMA) arrays, the microneedle tips a …

18.08.2026journal-article

BMC Sports Science, Medicine and Rehabilitation

Rehabilitative game-based exercise integrated into conservative treatment for adolescent idiopathic scoliosis: a pilot randomized controlled trial

Hande Tunc, Devrim Tarakcı, Yasemin Koc, Eylul Pınar Kısa, Deniz Oke

Abstract Background The incorporation of game-based exercise into conservative treatment for adolescent idiopathic scoliosis (AIS) has the potential to increase patient engagement, yet the evidence supporting its efficacy remains sparse. This study aimed to evaluate the effects and usability of game-based rehabilitative exercises in conservative treatment for AIS. Methods This assessor- and statistician-blinded pilot randomized controlled trial involved female participants aged 10–14 years with AIS, Cobb angles of …

18.08.2026journal-article

Diabetology & Metabolic Syndrome

Effects of carbohydrate counting training versus standard nutritional and medical therapy on glycemic control and sarcopenia in type 2 diabetes: an open-label randomized controlled trial

Funda Gargaci Tuncer, Indrani Kalkan, Ozden Ezgi Uner, Serkan Elarslan

Abstract Introduction Carbohydrate counting training is recommended for patients with type 1 diabetes as it has been proved to be effective in providing glycemic control. However, there is limited evidence of this training on glycemic control in patients with type 2 diabetes. Furthermore, there is limited knowledge on presence of sarcopenia in this group. Objective To examine sarcopenia in patients with type 2 diabetes receiving intensive insulin therapy and evaluate the effect of carbohydrate counting training on …

18.08.2026journal-article

BMC Complementary Medicine and Therapies

Ginger in supportive therapy against side effects of oncological treatment: a systematic review

Sarah Christina Burg, Jennifer Dörfler, Jens Büntzel, Judith Büntzel, Jutta Huebner

Abstract Background Oncology patients experience many side effects of their cancer treatment, which can affect their daily life. Phytotherapy is commonly used to reduce side effects or to support the treatment. Especially ginger plays a key role in the treatment of nausea and vomiting. The aim of this systematic review is to summarize the current scientific status of ginger in supportive therapy against side effects of oncological treatment. Methods In January 2025 a systematic search was conducted searching five e …

18.08.2026journal-article

International Journal of Advanced Research in Science Communication and Technology

Integrative Role of Ayurveda as an Adjunct in Modern Oncology: Rasayana Therapy and Supportive Care

Uday Lawate

Objective: To review the role of Ayurvedic Rasayana therapy as an adjunct to modern oncology and to evaluate its supportive, preventive, and palliative applications in cancer care. Data Source: Classical Ayurvedic texts including Charaka Samhita, Sushruta Samhita, and Ashtanga Hridaya, along with electronic databases such as PubMed, Scopus, Google Scholar, AYUSH portals, and reports from CCRAS and NIA were reviewed. Review Methods: A comprehensive literature review of publications from 2000 to 2025 was conducted, i …

18.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Dimensions of discomfort: Exploring smartphone dimensions and its impact on upper extremity musculoskeletal health

Ramya Ramasamy Sanjeevi, Kamalakannan Mohanan, Karthick Balasubramanian, Mohammed M Alshehri, Mohammad Zaino, Salma J Abudayah, Salma Omar Naseeb, Shazia Malik, Marissa Javier Bautista, Ramzi Abdu Alajam, Ahmad Sahely, Bsmah Husein Alfaifi, Shaima A Alothman

Background Smartphones have become essential tools in modern daily life, with usage intensifying in the post-pandemic era. Prolonged and addictive smartphone use has been increasingly associated with Musculoskeletal disorders (MSD) in the upper extremity. Beyond usage duration, device characteristics may also influence musculoskeletal strain. Objectives This study examined the relationships between smartphone usage patterns, addiction levels, device dimensions, pain severity, and the 12-month prevalence of MSD in t …

18.08.2026journal-article

Frontiers in Immunology

Real-world efficacy and safety profile of low-dose cadonilimab in recurrent or metastatic cervical cancer as first-line therapy

Xiaoshi Liu, Jing Zheng, Can Zhang, Xunwei Shi, Liping Peng, Dengfeng Wang, Guonan Zhang

Background Cadonilimab, a bispecific PD-1/CTLA-4 antibody, has activity in recurrent/metastatic cervical cancer (R/M CC), but high costs limit accessibility, especially in low- and middle-income countries. Hence, we aimed to assess whether lower dose of cadonilimab may achieve comparable clinical outcomes with improved tolerability. Methods This retrospective real-world study evaluated 137 R/M CC patients treated with cadonilimab 6mg/kg every three weeks as first-line therapy at Sichuan Cancer center from January 1 …

18.08.2026journal-article

Frontiers in Rehabilitation Sciences

Evaluation of AI-generated exercise prescriptions for diverse cardiac conditions in rehabilitation: a simulation study using the DeepSeek model

Luca Perrero, Menada Gardalini, Tatiana Bolgeo, Patrizia Valorio, Calogero Malfitano, Valter De Michelis

Background Cardiac rehabilitation (CR) significantly improves outcomes for patients with cardiovascular disease, but delivering consistently personalized exercise prescriptions remains challenging due to resource limitations and practice variability. Artificial intelligence (AI), particularly large language models (LLMs), may support the generation of guideline-adherent baseline exercise programs. Objective This study aimed to assess the adherence to guidelines, expert-evaluated safety, and clinical plausibility of …