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Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
13.08.2026journal-article

Frontiers in Cellular and Infection Microbiology

Application of artificial intelligence in geriatric infection: recent advances and prospects

Puyu Liang, Zhaoyi Tan, Beibei Liang, Yuxi Xu, Tianlin Wang, Zhijian Zhang, Yun Cai

Background As global population aging accelerates, infectious diseases in older adults have emerged as a growing public health burden with substantial clinical, economic, and societal implications. The rapid advancement of artificial intelligence (AI) offers a transformative opportunity to enhance the management of infections in this vulnerable population. Methods This review delineates key determinants specific to geriatrics that influence infection susceptibility and atypical presentation, including age-related o …

13.08.2026journal-article

Cosmetics

Pilot Investigations of Sodium Acetylated Hyaluronate on Telomeres and Inclusive Anti-Aging Skincare

Yuhua Jiang, Jason Wu, Aline Delobelle, Luyan Wang, Thibaut Saguet, Junjie Jiang

The telomere is one of the biological hallmarks of skin aging. Sodium acetylated hyaluronate (SAH) is an acetylated derivative of sodium hyaluronate, produced by a grafting technology that confers higher resistance to hyaluronidase. This study aimed to explore whether SAH is associated with telomere-related endpoints and with clinical signs of skin aging. Two vitro studies were performed, assessing telomerase activity in human adult keratinocytes and telomere length in human normal fibroblasts by quantitative PCR ( …

13.08.2026journal-article

Probiotics and Antimicrobial Proteins

Oral Co-supplementation with Pediococcus pentosaceus Probiotic and Enteric Polymeric Phycocyanin Nanoparticles Mitigates Aging-Related Biomarkers in Male Wistar Rats: A Preclinical Investigation

Nasser S. Flefil, Asmaa Ezzat, Marwa A. Abd El-Fattah, Hanan Farouk Aly, Eman A. Younis, Tarek N. Soliman, Asmaa Negm El-Dein

Abstract C-phycocyanin (C-PC) is a promising anti-aging nutraceutical due to its antioxidant and anti-inflammatory properties; however, its instability under acidic conditions limits its efficacy, necessitating advanced formulation strategies. This study evaluated the anti-aging potential of novel enteric C-PC nanoparticles (NPs) co-delivered with Pediococcus pentosaceus in a D-galactose-induced aging model in male Wistar rats. C-PC was extracted from microalgal biomass and encapsulated into Eudragit ® S100 nanopar …

13.08.2026journal-article

AGING MEDICINE

Expert Consensus on Influenza Vaccine and Pneumococcal Vaccination in Elderly People With Chronic Respiratory Diseases (2024)

Lijing Wang, Qiao Yu, Qiong Chen, Pulin Yu, Expert Committee of Consensus Opinion on Influenza Vaccine and Pneumococcal Vaccine Vaccination for Elderly People with Chronic Respiratory Diseases, Respiratory Group of Chinese Geriatrics Society

ABSTRACT Chronic respiratory diseases pose a serious threat to the health of the population due to their high incidence, high disability rate, and poor prognosis. It is necessary to improve the prevention and treatment status of chronic respiratory diseases. Vaccination against influenza and pneumococcal infections can reduce the risk of respiratory infections, lower hospitalization and mortality rates, and alleviate disease burden in individuals with chronic respiratory diseases. However, insufficient public aware …

13.08.2026journal-article

PLOS One

Altered kinematics and muscle activities during half squats in people with ankle sprain history

Umi Matsumura, Rena Ogusu, Shimpei Yamamoto, Toshiya Tsurusaki, Yeonghee Lee, Shinya Sunagawa, Hironobu Koseki

Copers are individuals with a history of ankle sprain who return to daily and sports activities without recurrent instability. However, it is unclear whether copers can use movement strategies comparable to those of healthy individuals without a history of ankle sprain. Understanding these movement strategies may be important for designing effective training programs and avoiding unintended biomechanical adaptations. Therefore, we aimed to compare the kinematics and muscular activities of the lower limbs during hal …

13.08.2026journal-article

Journal of Bone and Mineral Research

Large scale proteomic analyses of HR-pQCT-derived bone loss at the radius and tibia in older men

Eric Orwoll, Jack Wiedrick, Charles Ginsberg, Nancy E Lane, Lisa Langsetmo, Nicola Napoli, Andrew J Burghardt, Jodi Lapidus, Osteoporotic Fractures in Men (MrOS) Study Research Group

Abstract Although bone loss progresses rapidly in older adults, its biological drivers are poorly understood, and effective biomarkers are not available. We used large-scale discovery proteomics to identify serum proteins associated with bone loss, and to develop predictive signatures, in older men (mean age 84 yr). Rates of distal radial and tibial bone loss were assessed with high-resolution peripheral quantitative computed tomography (HR-pQCT) over ~6 yr, and ~ 7 K serum proteins were measured with aptamer-based …

13.08.2026journal-article

Aging Clinical and Experimental Research

Multimorbidity burden and frailty profile in older outpatients with diabetes: a cross-sectional study

Lorenzo Luppi, Marco Bertolotti, Giulia Lancellotti, Chiara Mussi

Abstract Background Type 2 diabetes mellitus is extremely frequent in older patients. The coexistence of multimorbidity and frailty may bear a significant impact on the management of this condition. Aim Aim of this study was to describe the clinical profile, including the frailty status, in an outpatient population of elderly subjects with respect to diabetes. Patients and methods Data were collected within a cross-sectional retrospective design from the Cardiogeriatrics Clinic of the University Hospital of Baggiov …

13.08.2026journal-article

Cell Death & Disease

Decay of the Lef1-Srsf3-microRNA axis impairs DNA damage response and underlies stem cell aging

Yasuaki Ikuno, Koichiro Watanabe, Yukie Kande, Yumi Kakeya, Shinsuke Ikeno, Ayano Narumoto, Tomoki Hayashi, Kahori Minami, Kasumi Nobuhiro, Dai Ihara, Yo Mabuchi, Shiho Nakamura, Noriki Fujimoto, Hideyuki Okano, Hayato Naka-Kaneda

Abstract Stem cell (SC) aging is implicated in tissue dysfunction and organismal aging. However, the molecular basis of aging shared across diverse adult SC types remains unclear. Here, we identify the transcription factor Lef1 , the splicing regulator Srsf3 , and a subset of DNA damage response microRNAs (DDR-miRs) as a common molecular axis underlying SC aging. Lef1 was the most consistently downregulated transcription factor during aging, common to mesenchymal stem/stromal cells (MSCs) and hematopoietic stem/pro …

13.08.2026journal-article

Journal of the American Geriatrics Society

Comparison of Claims‐Based Algorithms for Dementia Identification: A Cross‐Sectional Analysis of the National Health and Aging Trends Study ( NHATS )

Ravi Gupta, Hanna Charankevich, Emmanuel F. Drabo, Teneil Brown, Alden L. Gross, Daniel Polsky, Jodi B. Segal, Katherine A. Ornstein

ABSTRACT Background Accurate identification of Alzheimer's disease and related dementias (ADRD) in administrative data is increasingly important for research, care delivery innovation, and policy applications such as risk adjustment. Despite the widespread use of existing claims‐based algorithms to identify ADRD, few studies have compared their use to ongoing longitudinal aging studies. Methods In this cross‐sectional study, we included 2204 NHATS respondents aged 65 years or older classified as having dementia and …

13.08.2026journal-article

European Journal of Criminology

Functional and dysfunctional fear in cyberspace: A qualitative analysis of users and non-users of digital tools aged 65 and older

Nieves Erades-Pérez, Steven Kemp, Esther Sitges-Maciá

Population ageing and accelerated digitalization pose significant challenges for the digital inclusion of older adults, particularly from a criminological perspective. This study examines how fear of cybercrime and insecurity in the use of information and communication technologies (ICT) affect their participation in the digital society and expose them to the risk of online victimization. Through semi-structured interviews, it was identified that dysfunctional fear of cybercrime, prevalent among non-users of ICT, l …

13.08.2026journal-article

Frontiers in Public Health

Theme recognition and evolutionary analysis of older adults cognitive disorder prevention and control policies based on the BERTopic model

Wang Zili, Ji Huimin, Song Yulei, Luo Dan, Yin Tingting, Xu Guihua, Bai Yamei

Introduction The early diagnosis and treatment of mild cognitive impairment (MCI) can help decelerate or even reverse the progression of dementia. Therefore, China attaches great importance to the prevention and control of MCI and has introduced a series of policies. Methods Policy themes were identified by pre-processing, vectorizing, and clustering relevant policy texts by using the BERTopic model, and their temporal evolution patterns were revealed through dynamic topic modeling. Results Central-level policies o …

13.08.2026journal-article

WORK: A Journal of Prevention, Assessment & Rehabilitation

Occupational strain and post-retirement rehabilitation among older factory workers

Hema Shangkari Poobalan, Viswanathan Annamalai, Briget Yi Jack Chin, Dina Adam, Pradeep Balakrishnan, Vikram Mohan, Ai Yean Phan

Background Long-term factory work involves repetitive, physically demanding tasks that contribute to musculoskeletal degeneration in later life, particularly affecting the knee and cervical spine among ageing workers. Qualitative evidence on how retired industrial workers perceive occupational strain, arthritis progression and post-retirement rehabilitation remains limited. Objective To explore the lived experiences of retired factory workers with knee and neck arthritis, focusing on perceived occupational causatio …

13.08.2026journal-article

npj Urban Sustainability

Space for people, not cars: a large-scale visual choice experiment on urban street redesigns

Michael Wicki, Claudia Sinatra, Aura Huang, David Kaufmann

Abstract Urban street reallocations and redesigns are central to sustainable mobility transitions, yet public acceptance remains a major challenge. While previous research has examined general attitudes toward transport policy, little is known about how specific design features shape support across diverse user groups. We conducted a large-scale stated choice experiment ( N = 5991) embedded in a nationally representative mobility panel in Switzerland. Respondents evaluated navigable 360° and static visualizations o …

13.08.2026journal-article

Frontiers in Public Health

Openness influences emotion recognition in middle-aged and older adults through hippocampal volume and fluid intelligence: a serial mediation model

Yan Wang, Libin Song, Pang Jin, Bo Zhou

Background Openness to experience is positively associated with emotion recognition ability in middle-aged and older adults, yet the underlying neurocognitive mechanisms remain unclear. Methods Using a serial mediation model, the present study examined the neurocognitive pathways through which openness to experience influences emotion recognition accuracy and processing speed via hippocampal volume and fluid intelligence in 912 middle-aged and older adults aged 36–100 years, with age, sex, intracranial volume, and …

13.08.2026journal-article

Journal of Applied Physics

The effect of aging and charge variability on the detonation performance of a conventional plastic-bonded high explosive

Carlos Chiquete, Eric K. Anderson, Scott I. Jackson

Plastic-bonded explosives (PBXs) are pressed composites of energetic crystals (>90 wt. %), polymeric binder, and an internal porosity structure (1–2 vol. %). The binder ensures material stability, while porosity promotes more reliable reaction initiation. These microstructural features critically influence the bulk mechanical and detonation performance properties of the high explosive (HE), yet the connection between microstructure and bulk behavior remains incompletely understood, complicating both manufacture …

13.08.2026journal-article

PLANTS, PEOPLE, PLANET

Within‐tree spatial heterogeneity of sap flow velocities and wood properties and its effect on the uncertainty of tree level sap flux estimates

Stefan Seeger, Markus Weiler, Martin Maier

Societal Impact Statement As forests are important for biodiversity and recreation and provide vital resources globally, it is essential that their health can be accurately monitored, for example, by using sap flow probes to measure tree water uptake. We investigated whether sap flow measurements might differ at various locations within the same tree due to variation in wood properties. We found high variability in sap flow measurements across one tree, meaning that accurate measurements might require a large numbe …

13.08.2026journal-article

Formosan Journal of Musculoskeletal Disorders

Perioperative Implant-associated Fractures in Geriatric Pertrochanteric Fixation: Incidence, Risk Factors, and the Influence of Proximal Femoral Geometry

Jiun-Jen Yang, Chih-Yang Lai, Ping-Jui Tsai, Chang-Heng Liu, Yi-Hsun Yu

Abstract Background: Perioperative implant-associated fractures (PIAFs) are defined as new cortical or structural disruptions occurring during nail insertion and represent an under-recognized complication associated with cephalomedullary nailing in geriatric pertrochanteric fractures. Objectives: This study aimed to evaluate the incidence, associated factors, and radiographic characteristics of PIAFs in a consecutive cohort. Materials and Methods: A retrospective review was conducted on 258 patients aged ≥60 years …

13.08.2026journal-article

International Journal of Innovative Science and Research Technology

Prediction of Geriatric Patients Readmission Using XGBoost

Aisha Al- Mustapha, Prema Kirubakaran, Ridwan Koladapo, Kosiso Precious Nwajiobi

Hospital readmission among geriatric patients is a critical indicator of healthcare quality, imposing significant burdens on both patients and healthcare systems. This study proposes an Extreme Gradient Boosting (XGBoost)-based predictive framework for identifying 30-day hospital readmission risk in patients aged 65 years and above.

13.08.2026journal-article

Frontiers in Microbiology

High-fructose diet–induced gut dysbiosis as a mechanistic driver of chronic inflammation and accelerated biological aging: a comprehensive review

Xin-zhu Xu, Mo-si Dong, Jian-yu Dai, Qing-yan Wang, Xuan-chi Dong, Ying Jin

High-fructose diet (HFD) has emerged as a critical dietary risk factor for metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease. This review delineates the molecular mechanisms underlying the pathological cascade linking high-fructose intake, gut dysbiosis, chronic inflammation, and accelerated aging. At the metabolic level, excess fructose is rapidly phosphorylated by ketohexokinase (KHK), depleting intracellular ATP while driving overproduction of uric acid and reactive oxygen …

13.08.2026journal-article

Revista Confluencia

Nivel de conocimiento y percepción de sexualidad saludable en personas mayores autovalentes: Estudio descriptivo en Chillán, Chile

Giselle Pérez Salgado, Cristina Pérez Salgado, Carla Sandoval Astudillo, Fernanda Sepúlveda Aravena, Melanie Vásquez Molina, Patricia Rojas Salinas, Guillermina Mora Bustamante

Introduction: The concerns of age-related changes, leaving aside some factors associated with health, this study aims to the level of knowledge about healthy sexuality in self-reliant seniors attending the More Self-sufficient Senior program at four Family Health Centers in the City of Chillán, 2024. Methodology: A quantitative, observational descriptive study was conducted. The population consists of 779 elderly persons over 60 years enrolled in the program. A non-probabilistic sample is calculated for convenience …

13.08.2026journal-article

Sexes

Transcendent Lobbying: Jewish Prayer for Trans People as Resilience, Embodiment, and Sacred Alignment

Elazar Ben-Lulu

In recent years, scholarship has increasingly explored the intersections of theology, liturgy, and transgender identities. At the same time, transgender individuals continue to encounter resistance, exclusion, and stigmatization within many religious settings, where gender diversity is frequently framed as incompatible with established theological norms. Against this backdrop, this study examines the emergence of contemporary non-Orthodox Jewish prayers written by and for transgender and non-binary individuals. Dra …

13.08.2026journal-article

Clinics and Practice

Calcaneal Insufficiency Fracture: An Underrecognized Cause of Atraumatic Heel Pain in Older Adults

Koji Nozaka, Naohisa Miyakoshi

Background/Objectives: Calcaneal insufficiency fractures may be overlooked in older adults presenting with atraumatic heel-region pain because early radiographic findings can be absent or inconclusive. Evidence regarding how often these fractures are identified in routine outpatient practice remains limited. This study aimed to describe the observed frequency, diagnostic pathway, clinical characteristics, treatment, and documented clinical course of calcaneal insufficiency fractures in an orthopaedic outpatient coh …

13.08.2026journal-article

Advanced Electromagnetics

Analysis of Cost Control and Quality Improvement Paths for Geriatric Elderly Care Services under Long-term Care Insurance

Q. Yuan, Y. W. Long, W. Y. Xie

Efficient management of large-scale service systems requires robust information integration, intelligent resource allocation, and data-driven decision support. This study proposes a cost-control and quality-optimization framework based on multimodal data fusion, efficiency evaluation, and simulation-driven decision analysis. Heterogeneous information from administrative records, clinical indicators, caregiver surveys, and policy datasets is integrated through a unified data-processing architecture to support compre …

13.08.2026journal-article

npj Aging

Interpretable epigenetic clock links aging pathways and disease-specific methylation profiles

Rajarshi Mandal, Ning Xie, Gil Alterovitz

Abstract We developed an interpretable blood-based epigenetic clock to estimate DNA methylation age and identify disease-specific DNA methylation alterations. Using 8233 Illumina methylomes from healthy controls and nine age-associated diseases, we used ridge selection to retain 4855 CpG sites and benchmarked 20 regression architectures with Bayesian hyperparameter optimization. Tree-based boosting models performed best, and a weighted ensemble achieved a mean absolute error of 2.54 years on held-out test data, out …