Frag' FlorenceEvidenz. Klar. Anwendbar.
Uhr 7/8Sources Journal Tree
Easy Demo

Florence Themenbrowser · Alter & Demenz · Seite 67

Was ist neu im Gesundheitswesen?

Entdecken Sie tatsächlich neu veröffentlichte Arbeiten aus Medizin, Pflege, Therapie, Public Health und Life Sciences. Sortiert nach Publikationsdatum, nicht nach Zitierhäufigkeit.

Themen erkunden

Aktuelle Forschung nach Fachgebiet

24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
13.08.2026journal-article

Clinics and Practice

Calcaneal Insufficiency Fracture: An Underrecognized Cause of Atraumatic Heel Pain in Older Adults

Koji Nozaka, Naohisa Miyakoshi

Background/Objectives: Calcaneal insufficiency fractures may be overlooked in older adults presenting with atraumatic heel-region pain because early radiographic findings can be absent or inconclusive. Evidence regarding how often these fractures are identified in routine outpatient practice remains limited. This study aimed to describe the observed frequency, diagnostic pathway, clinical characteristics, treatment, and documented clinical course of calcaneal insufficiency fractures in an orthopaedic outpatient coh …

13.08.2026journal-article

Sexes

Transcendent Lobbying: Jewish Prayer for Trans People as Resilience, Embodiment, and Sacred Alignment

Elazar Ben-Lulu

In recent years, scholarship has increasingly explored the intersections of theology, liturgy, and transgender identities. At the same time, transgender individuals continue to encounter resistance, exclusion, and stigmatization within many religious settings, where gender diversity is frequently framed as incompatible with established theological norms. Against this backdrop, this study examines the emergence of contemporary non-Orthodox Jewish prayers written by and for transgender and non-binary individuals. Dra …

13.08.2026journal-article

Advanced Electromagnetics

Analysis of Cost Control and Quality Improvement Paths for Geriatric Elderly Care Services under Long-term Care Insurance

Q. Yuan, Y. W. Long, W. Y. Xie

Efficient management of large-scale service systems requires robust information integration, intelligent resource allocation, and data-driven decision support. This study proposes a cost-control and quality-optimization framework based on multimodal data fusion, efficiency evaluation, and simulation-driven decision analysis. Heterogeneous information from administrative records, clinical indicators, caregiver surveys, and policy datasets is integrated through a unified data-processing architecture to support compre …

13.08.2026journal-article

npj Aging

Interpretable epigenetic clock links aging pathways and disease-specific methylation profiles

Rajarshi Mandal, Ning Xie, Gil Alterovitz

Abstract We developed an interpretable blood-based epigenetic clock to estimate DNA methylation age and identify disease-specific DNA methylation alterations. Using 8233 Illumina methylomes from healthy controls and nine age-associated diseases, we used ridge selection to retain 4855 CpG sites and benchmarked 20 regression architectures with Bayesian hyperparameter optimization. Tree-based boosting models performed best, and a weighted ensemble achieved a mean absolute error of 2.54 years on held-out test data, out …

13.08.2026journal-article

BMC Pulmonary Medicine

Age-related effects of comprehensive in-patient physiotherapy after lung cancer surgery across age groups: an ambispective observational cohort study in middle-aged and older patients

Ayse Sena Manzak Dursun, Betul Cinar, Fuat Gökdemir, Omer Soysal, Alis Kostanoğlu

Abstract Background Postoperative recovery after lung cancer surgery may be influenced by age, comorbidity burden, and perioperative rehabilitation strategies. However, evidence regarding the age-related effects of structured early inpatient physiotherapy programs remains limited. This study aimed to evaluate the age-related effects of a comprehensive in patient physiotherapy (CIPT) program on hospital length of stay (LoS), clinical parameters, symptom-related outcomes, and inflammatory biomarkers in patients under …

13.08.2026journal-article

Frontiers in Aging

Age-related differences in BMD response during three years of denosumab treatment

Koji Ishikawa, Tomoyuki Asada, William Richardson, Choiselle Marius, Mahoko Ishikawa, Tuyet Nguyen, Philip Varnadore, Soji Tani, Peter Passias, Benjamin Aaron Alman

Introduction Denosumab increases bone mineral density and reduces fracture risk in patients with osteoporosis. However, whether BMD response to denosumab differs by age, particularly during longer term treatment, remains unclear. This study investigated the association between baseline age and BMD gain during 3 years of denosumab treatment in patients with osteoporosis. Methods This retrospective study included patients with osteoporosis who were treated with denosumab. DXA-based BMD and bone turnover markers were …

13.08.2026journal-article

European Journal of Sport Science

Effects of Fast Rhythmic Auditory Pacing on the Exercise Intensity of a Cognitive–Motor Training in Older Adults

Mingyi Ye, Vilma Gómez, Sean Mullen, Jeffer E. Sasaki, Rodrigo Vitório, Gustavo Christofoletti, Emerson Sebastião

ABSTRACT This study examined the objective and perceived exercise intensity and movement volume during an acute session of a cognitive‐motor training, namely, square‐stepping exercise (SSE), in older adults under two pacing conditions and three step‐pattern complexities. Thirty older adults (73.6 ± 7.4 years) completed SSE under normal pace (Normal) and externally paced (Paced; 150% of normal walking speed) conditions in randomized order. For each condition, participants performed three different step patterns for …

13.08.2026journal-article

Cells

Potential Roles of Cellular Senescence and Inflammaging in Prostate Cancer: Aging Microenvironment, Immune Remodeling, and Therapeutic Implications

Qiuyang Zhang, Keyi Shen, Sen Liu

Prostate cancer is common in older men, yet mechanisms linking aging to tumor progression remain incompletely defined. Beyond genetic alterations, aging reshapes the prostate microenvironment through cellular senescence, chronic low-grade inflammation, immune dysfunction, stromal remodeling, metabolic stress, and impaired tissue repair, collectively promoting inflammaging. This persistent inflammatory state may create a permissive niche for tumor initiation, progression, immune evasion, and treatment resistance. Se …

13.08.2026journal-article

Neuropsychopharmacology

The effect of theta-gamma coupling on response to cognitive remediation combined with transcranial direct current stimulation in older adults at high risk for dementia: a PACt-MD secondary analysis

Heather Brooks, Mina Mirjalili, Clement Ma, Daniel M. Blumberger, Christopher R. Bowie, Corinne E. Fischer, Alastair J. Flint, Nathan Herrmann, Sanjeev Kumar, Krista Lanctôt, Linda Mah, Benoit Mulsant, Bruce G. Pollock, Nicole Schoer, Reza Zomorrodi, Tarek K. Rajji

Abstract The PACt-MD study demonstrated that combined cognitive remediation (CR) and transcranial direct current stimulation (tDCS) slows global cognitive decline in individuals with mild cognitive impairment (MCI) or remitted major depressive disorder (rMDD) over a median follow-up of four years. Prefrontal theta-gamma coupling (TGC), measured via electroencephalography (EEG), is a marker of prefrontal cortical function and may index cognitive compensation, the mechanism thought to underlie CR+tDCS effects. This s …

13.08.2026journal-article

Transactions of the Royal Society of Tropical Medicine and Hygiene

Molecular detection of pulmonary tuberculosis and Candida albicans co-infection in people living with HIV/AIDS in Nigeria

Fatima Muhammad Sani, Ahmad Adamu Yarma, Lawal Garba, Shuaibu Isa, Muhammad Tukur Adamu, Taofiq Abdullahi Umar, Salawaudeen Adamu, Idris Nasir Abdullahi

Abstract Objectives Concurrent pulmonary tuberculosis (PTB) and antifungal-resistant candidiasis pose significant clinical and public challenges in resource-limited settings. This study determined the prevalence of PTB and antifungal-resistant Candida albicans co-infection among people living with HIV/AIDS (PLWHA) in Gombe State, Nigeria. Methods Sputum samples from 348 PLWHA were processed and tested for Mycobacterium tuberculosis using GeneXpert equipment. Moreover, C. albicans was isolated and identified using C …

13.08.2026journal-article

Nursing Reports

Healthcare Access for Older Indigenous Women in Latin America: A Scoping Review of Barriers, Facilitators, and Knowledge Gaps

Francisco Javier Arroyo-Cruz, Karina Isabel Casco-Gallardo, Edith Araceli Cano-Estrada, Benjamín López-Nolasco, Abigahid Vianey Morales-Ortiz, Claudia Atala Trejo-García, José Antonio Guerrero-Solano

Background: Over recent decades, Latin America has undergone significant population aging, accompanied by persistent inequalities that adversely affect healthcare access, particularly among Indigenous populations. This scoping review aimed to map and synthesize the available evidence on healthcare access for older Indigenous women in the region, identifying relevant dimensions, barriers, facilitators, and existing knowledge gaps. Methods: A systematic search was performed in scientific databases and gray literature …

13.08.2026journal-article

Journal of Electrochemical Energy Conversion and Storage

Electrode Architecture Effects on Lithium-Ion Battery Aging: A Pseudo-Two-Dimensional Modeling Approach

Irene Giusti, Marella De Santis, Federico Poli, Luca Piancastelli, Alfredo Liverani

Abstract This study investigates the electrochemical performance and aging behavior of lithium-ion batteries (LIBs), focusing on the architectural effects of electrode and separator geometries alongside active material particle sizes. A pseudo-two-dimensional (P2D) model is employed to simulate lithium intercalation, solid diffusion, and coupled thermal behavior across a full-factorial design space. Despite its one-dimensional formulation, the model provides an optimal balance between computational efficiency and c …

13.08.2026journal-article

Journal of Functional Morphology and Kinesiology

Efficacy and Cost-Effective Treatment of Isometric Resistance Training for Blood Pressure Control: A Narrative Review in Healthy Individuals and People with Cardiovascular Diseases

Matteo Vitarelli, Domenico Mario Giamundo, Alberto Grossi, Giuseppe Caminiti, Gabriele Morganti, Francesca Strassoldo di Villanova, Bruno Ruscello, Elvira Padua, Maurizio Volterrani, Valentina Morsella, Marco Alfonso Perrone, Vincenzo Manzi, Gennaro De Rosa, Lorenzo Loffredo, Enrico Maggio

Isometric resistance training (IRT) has emerged as a promising non-pharmacological intervention for blood pressure (BP) management. Although current hypertension guidelines primarily recommend aerobic and dynamic resistance exercise, growing evidence indicates that IRT is an effective, feasible, and time-efficient alternative. This narrative review summarizes the current evidence on the efficacy, physiological mechanisms, and clinical applications of IRT. We reviewed randomized controlled trials, systematic reviews …

13.08.2026journal-article

Journal of Clinical Medicine

Comparative Analysis of the ASA-PS Score and Clinical Frailty Scale in Predicting Postoperative Intensive Care Unit Requirement in Geriatric Hip Fracture Surgery: A Retrospective Evaluation

Dilek Kalaycı, Tuğba Aşkın

Background/Objectives: Identifying geriatric hip fracture patients who will require postoperative intensive care unit (ICU) admission remains a clinical challenge. The American Society of Anesthesiologists Physical Status (ASA-PS) classification and the Clinical Frailty Scale (CFS) are both used in preoperative risk stratification, yet their comparative utility for this purpose has not been well characterized. Methods: This single-center, retrospectively designed study included 243 patients aged 65 years or older w …

13.08.2026journal-article

Innovation in Aging

An assessment of data and code sharing in research funded by the Nathan Shock Centers, 2017-2022: A meta-research study

Colby J Vorland, Simon Chung, Aidan S Kramer, John R Hultquist, David B Allison, Andrew W Brown

Abstract Background and Objectives Data and code sharing facilitate reproducibility, trust, and efficient reuse of research resources. Growing recognition of their importance among researchers, journals, and funders led the Nathan Shock Centers (NSC) Coordinating Center to propose documenting and supporting data and code sharing in aging research. As a baseline, we characterized data and code sharing practices in NSC-funded research. Research Design and Methods We surveyed articles citing NSC grants published 2017- …

13.08.2026journal-article

Metals

Effect of Aging Time on Tensile Properties of 7075 Aluminum Alloy

Yong Wang, Sawei Qiu, Tuo Ye, Qinghang Cui, Jiajun Han, Pengcheng Guo

A solid solution treatment (SST) followed by single-stage aging (0–30 h, 140 °C) was performed on 7075 aluminum alloy specimens with longitudinal axes oriented at 0°, 45° and 90° to the rolling direction. The mechanical properties and microstructure were analyzed by tensile testing, optical microscope (OM), electron backscatter diffraction (EBSD), scanning electron microscope (SEM) and transmission electron microscope (TEM). The results show that the average tensile strengths of the as-received 7075 aluminum alloy …

13.08.2026journal-article

JAMA Network Open

Plasma Alzheimer Biomarkers and Diagnostic Decision-Making in Memory Clinics

Sinthujah Vigneswaran, Inge M. W. Verberk, Lynn Boonkamp, Lisanne in ‘t Veld, Marleen J. A. Koel-Simmelink, Daniel Antwi-Berko, Luuk van Unen, Rebecca Rousset, Thomas Claessen, Marissa D. Zwan, Rik Ossenkoppele, David Wilson, Afina W. Lemstra, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Majon Muller, Francesco Mattace-Raso, Janne M. Papma, Harro Seelaar, Charlotte E. Teunissen, Argonde C. van Harten

Importance Blood-based biomarkers (BBM) provide minimally invasive, scalable, lower-cost tools for identifying neurodegenerative diseases, but prospective data on their clinical validity in memory clinic settings are limited. Objective To evaluate how a tailored plasma BBM panel (phosphorylated tau 181 [pTau181], glial fibrillary acidic protein [GFAP], and neurofilament light chain [NfL]) during multidisciplinary diagnostic meetings is associated with syndrome diagnosis, suspected etiology, and clinician confidence …

13.08.2026journal-article

Transplant Infectious Disease

Attrition and Delays in Kidney Transplant Evaluation Among People Living With HIV and End‐Stage Renal Disease

Kyle M. Crawford, Jillian Catalano, Dhriti Shah, Scott Curry, Alexandra G. Mills, Yosra Alkabab, Drew Charles, Courtney E. Harris, Ruth O. Adekunle

ABSTRACT Introduction People living with HIV (PLWH) have a higher incidence of end‐stage renal disease (ESRD) than HIV‐negative individuals and are less likely to receive a kidney transplant. We described attrition and delays across the transplant care continuum for PLWH with ESRD at the Medical University of South Carolina (MUSC) and explored factors associated with waitlisting. Methods Retrospective review of electronic health records of PLWH with ESRD who received care at MUSC or were referred for kidney transpl …

13.08.2026journal-article

Frontiers in Sports and Active Living

Physical environment as a catalyst for healthy aging: servicescape, motivation, and well-being in older adult park golf

Jaepil Seo, Kisun Hwang, Joonha Shin, Seung-Hwan Woo, Young-Kyun Sim

Background/objective Active leisure activities like park golf are crucial for older adults' successful aging. Grounded in the Stimulus-Organism-Response (S-O-R) paradigm and Self-Determination Theory (SDT), this study investigated the structural relationships among perceived servicescape, facility image, satisfaction, motivation, and subjective well-being. Methods A quantitative cross-sectional design was employed. Data from 264 older adult park golf participants in South Korea were analyzed using structural equati …

13.08.2026journal-article

Frontiers in Aging Neuroscience

Sex- and age-dependent associations between waist-to-hip ratio and cognitive impairment: a cross-sectional study of rural adults aged 40 years and older in northwestern China

Simeng Cui, Yu Zhang, Qiqi Qiang, Ziyu Liu, Peijie Liu, Liangjun Dang, Jin Wang, Wenhui Lu, Kang Huo, Yu Jiang, Chen Chen, Ling Gao, Shan Wei, Junlong Feng, Suixia Cao, Suhang Shang, Qiumin Qu, Meng Zhang

Background Obesity is a modifiable risk factor for cognitive impairment; however, body mass index fails to capture fat distribution. Waist-to-hip ratio (WHR), reflecting central adiposity, may better characterize obesity-related differences in cognitive impairment. Nevertheless, whether the association between WHR and cognitive impairment varies by sex and age remains unclear. Methods This cross-sectional study included 1,792 adults aged ≥40 years from rural China. Cognitive impairment was defined using education-a …

13.08.2026journal-article

HIV Medicine

Psychosocial vulnerabilities and loss to follow‐up in people living with HIV in France

Charlène Mafuta, Sophie Grabar, Laurence Lievre, Cécile Goujard, Jean‐Paul Viard, Olivier Bouchaud, Laurence Meyer, Rémonie Seng, Sophie Abgrall

Abstract Background Migration status is consistently associated with a higher risk of loss to follow‐up (LTFU). We investigated how sex, sexual orientation and social vulnerabilities affect the association between migration status and LTFU for hospital care in people living with HIV, using data from the ANRS CO9‐COPANA cohort linked to the nationwide French hospital database on HIV (ANRS CO4‐FHDH). Methods The COPANA prospective cohort enrolled antiretroviral drug‐naïve adults newly diagnosed with HIV‐1 between 200 …

13.08.2026journal-article

Revista de Geopolítica

RECONHECIMENTO DE SABERES E COMPETÊNCIAS NO PCCTAE: ENTRE A VALORIZAÇÃO DO TRABALHO REAL E A GESTÃO ESTRATÉGICA DE PESSOAS

Fernando Carlos Braga do Nascimento

O capítulo analisa o Reconhecimento de Saberes e Competências do Plano de Carreira dos Cargos Técnico-Administrativos em Educação (RSC-PCCTAE) como mecanismo de valorização remuneratória e como fonte potencial de conhecimento para a gestão estratégica de pessoas nas Instituições Federais de Ensino. Argumenta-se que o RSC amplia as formas de acesso ao Incentivo à Qualificação ao reconhecer saberes construídos no exercício profissional, sem romper com a estrutura remuneratória referenciada pela titulação formal. A pe …

13.08.2026journal-article

Antioxidants

Reduced Serum PON1 Lactonase Activity Is Associated with Mild Cognitive Impairment and Mixed Dementia

Raffaella Riccetti, Alessandro Trentini, Gianmarco Mola, Gloria Brombo, Dario Francesco di Paola, Massimiliano Castellazzi, Raffaella Candeloro, Maria Cristina Manfrinato, Giovanni Zuliani, Carlo Cervellati

High-density lipoprotein (HDL)-associated paraoxonase-1 (PON1) contributes substantially to the antioxidant and anti-inflammatory functions of HDL. Impairment of these protective properties has been associated with Alzheimer’s disease (AD) and other forms of dementia, particularly those involving neurovascular dysregulation. In the present study, we investigated for the first time the potential involvement of the putative physiological lactonase activity of PON1 in serum samples from a large cohort of older adults …

13.08.2026journal-article

Spinal Cord

Impact of respiratory muscle training on sleep disordered breathing in people with tetraplegia: a sub-analysis of a randomised controlled trial

Claire L. Boswell-Ruys, R. H. Chaminda Lewis, Rachel A. McBain, Nirupama S. Wijesuriya, Danny J. Eckert, Bonsan Bonne Lee, Simon C. Gandevia, Jane E. Butler

Abstract Study design Sub-analysis of a randomised controlled trial. Objectives Respiratory muscle training (RMT) in people with tetraplegia yields marked improvements in inspiratory muscle strength. The present study investigated whether RMT also modifies sleep disordered breathing (SDB) and daytime sleepiness. Setting Independent research institute in Sydney, Australia. Methods Sixty-two adults with tetraplegia underwent six weeks of supervised RMT. The active-RMT group trained the respiratory muscles through pro …