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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
27.08.2026journal-article

Cancers

Treatment Sequencing of CDK4/6 Inhibitors in Bone-Only Hormone Receptor-Positive Metastatic Breast Cancer: Multi-Center Real-World Data Revealing a Numerical Trend Favoring Later-Line Use

Serkan Yıldırım, Büşra Bülbül, Bekir Ucun, İrem Turgut Yeğen, Cengiz Yılmaz, Atike Pınar Erdoğan, Ece Şahin Hafızoğlu, Erhan Gökmen, Murat Araz, Ahmet Oruç, Orhan Önder Eren

Background: Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy represent the gold standard in the first-line treatment of hormone receptor (HR)-positive, HER2-negative metastatic breast cancer (MBC). However, the optimal timing of CDK4/6i initiation in patients with bone-only disease (BoD) remains a matter of clinical discussion. This multicenter retrospective study evaluated the impact of CDK4/6i treatment line (first-line vs. second-or-later-line) on progression-free survival (PFS) a …

27.08.2026journal-article

Undergraduate Research in Natural and Clinical Science and Technology Journal

The University of Ottawa Healthcare Symposium (UOHS) 2026 Pitch-O-Rama: Undergraduate Elevator Pitch Research Competition

Maryam Al-Zadjali, Donya Sobati

The University of Ottawa Healthcare Symposium (UOHS) is an undergraduate conference that highlights the role of interdisciplinary collaboration in healthcare. Now in its sixteenth year, UOHS brings together students and researchers from fields such as biomedical sciences, engineering, health policy, and digital health to explore current challenges and advancements in healthcare. The conference provides a platform for discussions on emerging technologies, healthcare delivery, and the integration of research into cli …

27.08.2026journal-article

Journal of Wellness

A Language We Built Together: A Physician Assistant’s Reflection on a Renal Transplant

Oviya Mahendran, Sampathkumar Sakthi Selvakumar

This is not just a story of kidney transplantation in a tertiary care hospital in a tier-2 city of South India. It is all about a true clinical journey of resilience, where a young woman with congenital hearing loss, battling chronic kidney disease, discovered hope, understanding, and companionship through a physician assistant's compassionate communication.

27.08.2026journal-article

World Journal of Gastrointestinal Surgery

Prognostic value of acute liver injury in cirrhotic patients after the transjugular intrahepatic portosystemic shunt procedure

Liang Yin, Jing-Qiu Zhang, Yi-Jiang Zhu, Sen-Lin Chu, Kai-Cai Liu, Pan Zhang, Li Dong, Yong-Hui Zhang, Dong Lu, Wei-Fu Lv, Chun-Ze Zhou, De-Lei Cheng

BACKGROUND Acute liver injury (ALI) is a potential complication after transjugular intrahepatic portosystemic shunt (TIPS) in patients with cirrhosis, which may result from hemodynamic shear stress and direct mechanical needle trauma. However, the incidence, risk factors, and prognostic significance of post-TIPS ALI remain poorly defined. Such injury may contribute to postoperative morbidity and adverse outcomes, yet its clinical impact remains underrecognized. AIM To investigate the incidence, risk factors, and pr …

27.08.2026journal-article

Nature Journal of Emerging Sciences Technologies and Innovations

<b>Machine Learning- Based Cardiovascular Disease Risk Prediction in Hypertensive Patients: Explainable insights into Clinical Risk Factors</b>

Chinatu Michael Anyanwu, John Chiedozie Onyianta, Ogechi Gift Onyedi, Onuoha Thomas, Stephen Uche Udeh, Collins Nnalue Udanor

Hypertension is one of the most important modifiable risk factors for Cardiovascular Disease (CVD), yet identifying which hypertensive patients are at higher risk remains challenging in clinical practice. This study developed and evaluated three machine-learning models: logistic regression, random forest, and Gradient Boosting for CVD risk prediction in a cohort of 23,543 hypertensive patients drawn from a 70,000 patient cardiovascular dataset. After preprocessing, feature engineering, SMOTE-based class balancing, …

27.08.2026journal-article

Journal of Clinical Medicine

Closing Europe’s Cardiovascular Implementation Gap: A Critical Review of the Safe Hearts Plan and the Cyprus Test Case

Georgios P. Georghiou, Sotiris Kyriakou, Panos Georghiou, Amalia Georgiou, Nikolas Iosif, Konstantinos Toutouzas, Andrew Xanthopoulos, Konstantinos Lampropoulos, Argyris Kyriakou, Filippos Triposkiadis

Cardiovascular disease remains Europe’s leading cause of death and disability despite mature evidence for prevention, acute and chronic treatment, rehabilitation, and secondary prevention. This structured critical narrative review evaluates whether the European Safe Hearts Plan can convert this evidence into coordinated, measurable, and accountable cardiovascular pathways. We appraise the plan’s ten flagship actions by evidence maturity and implementation readiness; distinguish shared system functions from disease- …

27.08.2026journal-article

Journal of Eye Movement Research

Saccadic Oscillations After Donepezil Administration in Patients with Dementia: Time Course and Clinical Correlates

Ileok Jung, Ji-Soo Kim, Moon-Ho Park

Donepezil, a cholinesterase inhibitor widely used in dementia, can be associated with saccadic oscillations (SO), but their time course and clinical relevance are unclear. In this prospective observational study, 18 patients with dementia underwent video-oculography at baseline (V0), one month (V1), and three months (V2) after initiation or dose escalation of donepezil. SO were counted over a single 30 s recording during visual fixation and in darkness, expressed as events/30 s. Dizziness was assessed with the Dizz …

27.08.2026journal-article

British Journal of Haematology

LTB ‐ TREAT : A validated international prognostic model for time to treatment in low tumour burden follicular lymphoma

Luani Barge, Lachlan Webb, Anita Pelecanos, Niamh Waters, Ross Salvaris, Sam Lai, Tessa Potezny, Helen Cashman, Caitlyn Nguyen‐Ngo, Denise Lee, Costas K. Yannakou, Nada Hamad, Adrien Chauchet, Sylvain Choquet, Cédric Rossi, Adélie Herbin, Lukshe Kanagaratnam, Cyrielle Rodier, Constantine S. Tam, Abir Bhattacharyya, Chan Y. Cheah, Eliza A. Hawkes, Kirk Morris, Eric Durot, Joshua Tobin, Greg Hapgood

Summary Watchful waiting (WW) in low tumour burden follicular lymphoma (LTB FL) defers treatment. There is a need to develop a model to predict time to treatment (TTT). We aimed to develop and externally validate a model for TTT in LTB FL. We conducted a retrospective analysis across eight centres within the Australasian Lymphoma Alliance. Two hundred and twenty‐nine patients were included between 2004 and 2022 with a median follow‐up of 5.0 years (range 0.5–17.8 years) and a median age was 64 years. All patients w …

27.08.2026journal-article

Journal of Cutaneous and Aesthetic Surgery

Quantitative analysis of brow lifting with polydioxanone barbed threads using 3D imaging: A retrospective study

Doo Yeoul Chang, Moon Seop Choi

Objectives: As people age, facial ptosis leads to wrinkles, prompting interest in rejuvenation techniques such as thread lifting. This procedure targets sagging areas such as the jowl, nasolabial folds, brows, and double chin using barbed threads for enhanced tissue grip. The study explores polydioxanone (PDO) MINT threads, featuring 360° helical barbs, for brow lifting, hypothesizing stronger lifting effects due to their unique design. Results suggest barbed threads may effectively improve brow ptosis. Material an …

27.08.2026journal-article

Sports Medicine - Open

Pre-fatigue Direct 1RM Testing vs. Post-fatigue Load–Velocity Profiling: Which Better Predicts Maximal Strength in the Deadlift After Resistance Training?

Danica Janicijevic, Deniz Şentürk, Yaodong Gu, Amador García-Ramos

Abstract Background Resistance training loads are commonly prescribed based on a previously determined 1-repetition maximum (1RM). Whether velocity-based methods better reflect the actual 1RM as fatigue accumulates during the training session than relying on a pre-training 1RM remains unknown. Objectives To determine whether pre-training direct 1RM testing or post-training load–velocity (L–v) profiling more accurately estimates hexagonal barbell deadlift (HBD) 1RM following resistance training-induced fatigue. Meth …

27.08.2026journal-article

Neuro-Oncology

33 Endoscopic Transsphenoidal Surgery for Pituitary Tumors: Experience and Outcome Analysis from a Tertiary Care Center Nepal

Dipendra Kumar Shrestha

Abstract Introduction Pituitary tumors account for 10–15% of brain tumors and frequently cause morbidity through mass effect or hormonal dysfunction. Endoscopic transsphenoidal surgery (ETS) has become the global standard due to superior visualization and reduced risk compared to microscopic techniques. In Nepal, delayed patient presentation and constrained resources limit the widespread adoption of endoscopic surgery. With limited local outcome data, our study provides benchmark evidence to guide practice in resou …

27.08.2026journal-article

The American Journal of Tropical Medicine and Hygiene

Association of Parasite Biomass with Disease Severity in Plasmodium vivax and Plasmodium falciparum Malaria Infections

Prasad H. Babar, Jacob A. Tennessen, Rimi Chakrabarti, Jayashri T. Walke, Usheer Kanjee, Anvily Almeida, Mezia Fernandes, Pooja Gawas, Laura Karschney, John White, Marina Vaz, Edwin Gomes, Pradipsinh K. Rathod, Manoj T. Duraisingh

ABSTRACT. The clinical and parasitological factors underlying severe malaria pathogenesis remain incompletely understood, particularly in Plasmodium vivax ( P. vivax ). To address this issue, clinical and parasitological metrics, including circulating peripheral parasitemia and the parasite biomass (the total number of parasites in the body consisting of both circulating peripheral and noncirculating parasites), were measured in patients with severe and uncomplicated monoinfections of P. vivax and Plasmodium falcip …

27.08.2026journal-article

The American Journal of Tropical Medicine and Hygiene

First Identification of Naturally Infected Paratriatoma hirsuta: A Vector for Trypanosoma cruzi and Implications for Chagas Disease Transmission

Paul A. Lenhart, Walter Roachell, Robert Fathke, Bernardo Delgado, Alexander M. Potter, Ian Copeland, Francisco Sanchez, Mauricio Solis, Amanda Cline, MaeJean Ramnarace, Gena G. Lawrence, Eyal Oren, Penelope J. Quintana, Shannon McBride, Cassandra Kerwin, Isydra G. Lujan, Tolulope Morawo, Riley E. Tedrow, Gerardo Pacheco, Jose Betancourt, Paula E. Stigler Granados

ABSTRACT. The first detection of Trypanosoma cruzi ( T. cruzi ) in wild-caught Paratriatoma hirsuta ( P. hirsuta ) from military installations near the United States/Mexico border in California and Arizona is reported in the present study. As part of a Chagas disease surveillance initiative, 20 adult and 63 immature P. hirsuta were collected from 16 wood rat nests, along with sympatric Triatoma rubida ( T. rubida ). Initial polymerase chain reaction (PCR) screening revealed presumptive T. cruzi -positive samples, w …

27.08.2026journal-article

International Journal for Students as Partners

Belonging and collaboration in clinical education

Courtney Lewis, Alivia English

Effective clinical education depends on strong student–educator partnerships, yet the processes that support or hinder these relationships remain poorly understood. This study examined perspectives of clinical educators (CEs) and students on fostering belonging in clinical education. Members of the Student-Instructor Partnerships in Clinical Education (SIPCE) learning community, representing diverse health professions, participated in focus groups. Discussions explored definitions of belonging, barriers to partners …

27.08.2026journal-article

Frontiers in Medicine

Single-dose dexamethasone increases perioperative glycemic variability in older patients with diabetes undergoing lung surgery: a continuous glucose monitoring-based randomized controlled trial

Xiaoyi Zhang, Cheng Huang, Xiang Wang, Jun Zhang, Xiaomei Ling, Jiahao Xu, Jue Ma, Fei Zhong, Haihua Shu

Objectives To investigate whether a single intraoperative dose of dexamethasone alters perioperative glycemic dynamics in older patients with type 2 diabetes undergoing thoracoscopic lung resection. Glycemic dynamics were captured using continuous glucose monitoring (CGM). Methods 72 patients aged ≥ 60 years with type 2 diabetes who underwent elective thoracoscopic lung resection were randomly assigned to receive either 8 mg of dexamethasone or placebo (0.9% saline) intravenously during anesthesia induction. The pr …

27.08.2026journal-article

Addiction Science Reviews

Positive Psychotherapy in the Treatment of Alcohol Use Disorder: A Systematic Review

Atakan Taşkıran, Reşat Güven, Deniz Ergün

This study is a systematic review examining the effects of positive psychotherapy-based treatment of alcohol dependence on craving and relapse within the framework of psychiatry, clinical psychology, and addiction literature. Alcohol use disorder is a chronic and relapsing mental health problem characterized by impaired control over alcohol use, tolerance development, and continued use despite negative consequences. Positive psychotherapy, developed by Nossrat Peseschkian as a humanistic, psychodynamic, resource-or …

27.08.2026journal-article

The Egyptian Journal of Otolaryngology

Clinical presentation, management and outcomes of differentiated thyroid cancer: a tertiary center experience

Samer Ahmed Ibrahim, Ahmed Adly Mohammed, Mohammed Naguib Mohamed, Reham Mohamed Faheim, Rehab Saeed Hussein, Ahmed Abdelmoneim Teaima

Abstract Introduction Thyroid cancer is considered the most common endocrine tumor worldwide and its incidence is increasing. Objective We conducted this study to analyses demographic, clinicopathological, imaging data, treatment, outcomes, recurrence rate, overall survival and prognosis of differentiated thyroid cancer (DTC) cases. Patients & methods This is a retrospective study done in our tertiary hospital including patients diagnosed with DTC from 2015 to 2020. One hundred seventy-six patients’ data were revie …

27.08.2026journal-article

Frontiers in Cardiovascular Medicine

Zero-fluoroscopy catheter ablation for arrhythmias in pregnancy: validation of a standardized approach with 5-year follow-up

Sebastian Stec, Marek Bronisz, Joanna Kornaszewska, Katarzyna Styczkiewicz, Marcin Nosal, Alicja Hajduk-Hejnar, Anna Kustroń, Szymon Stec, Agata Bielecka-Dąbrowa, Marta Kornaszewska, Janusz Śledź

Background Increasing experience with zero- (ZF) or near-zero fluoroscopy catheter ablation (CA) supports the implementation of an early fluoroless approach for recurrent, symptomatic arrhythmias during pregnancy. Aim This study evaluated the feasibility, efficacy, and safety of CA using a standardized ZF approach during pregnancy. Methods Data were derived from a large, prospective multicenter registry (ELEKTRO-RARE-A-CAREgistry). Between 2012 and 2019, more than 2,655 CA procedures were performed in women using a …

27.08.2026journal-article

Emergency Medicine Journal

Early management of crush injury and crush syndrome: a Faculty of Pre-Hospital Care consensus statement

Felix Wood, Philip Cowburn, Jason Smith, Lauren Weekes, Timothy Godfrey, Sam Wilkins, Elizabeth Freeman, Leo Wood, Jake Gluyas-Harris, Peter Gimson, Oliver Brown, Benjamin Earle-Wright, Hannah Clancy, Rhiannon Wilkinson, Owen Williams

Guidance is required for UK prehospital care providers managing patients with suspected crush injury to minimise preventable morbidity and mortality. This consensus statement gives relevant and practicable recommendations following a structured evidence review and a consensus process. Differences between this and previous guidance reflect, in part, the context for which these recommendations are intended. The role of aggressive fluid administration and concerns regarding hyperkalaemia are de-emphasised. This consen …

27.08.2026journal-article

Journal of Bone and Joint Surgery

Principles of Level Selection for Instrumentation in Adult Cervical Spinal Deformity Surgery

Zeeshan M. Sardar, Josephine R. Coury, Anson G. Bautista, Katherine Dong, K. Daniel Riew, Justin L. Reyes

➢ For isolated cervical deformities in patients with good bone health, the upper instrumented vertebra can be C3 or C4. ➢ For patients with global cervical deformity, poor bone health, planned 3-column osteotomies, or long fusion constructs, C2 may be an appropriate upper instrumented vertebra. ➢ For patients with focal kyphosis, optimal sagittal alignment, and preserved bone stock, a lower instrumented vertebra cranial to the cervicothoracic junction is appropriate. ➢ For patients with poor cervical sagittal align …

27.08.2026journal-article

Scientific Reports

W-AGRU-Net: a dual-stream attention framework for robust brain tumor segmentation in clinical MRI imaging

Marwa Abbas, Hussein Mogahed, Aziza Hussein, Ashraf Khalaf, Mohamed Mourad

Abstract Segmenting brain tumors from MRI scans is a challenging aspect of medical image analysis because of anatomical complexity, ambiguous tumor boundaries, and variability of shape. In this paper, we propose W-AGRU-Net, a new dual-stream U-Net framework that combines W-Attention mechanisms with residual connections for strong and accurate glioma segmentation. Our framework uses two asymmetric streams that have pyramid-shaped dilated convolution schemes (PDCS) for hierarchical multi-scale context capturing. The …

27.08.2026journal-article

Clinical Journal of Health Sciences

EMDR Therapy: Theoretical Foundations, Clinical Effectiveness, and a Comparative Review with Trauma-Focused Cognitive Behavioral Therapy

Deniz Erdoğan, Reşat Güven, Demet Karakartal

This study is a systematic review examining the theoretical foundations, historical development, neuropsychological mechanisms, and clinical effectiveness of Eye Movement Desensitization and Reprocessing (EMDR) therapy within the framework of psychiatry, clinical psychology, and trauma literature. Developed by Francine Shapiro in the 1980s, EMDR is a structured and integrative psychotherapy method that combines elements of psychodynamic, cognitive, behavioral, and client-centered approaches and is based on the repr …

27.08.2026journal-article

Microbiology Spectrum

Performance evaluation of clinical diagnostic kits for Group B Streptococcus available in China

Rong Su, Xiaoli Chen, Shouneng Lu, Yujie Zhou, Yue Liu, Qiongzi Huang, Ying Zhang, Xinyan Zheng, Mengting Li, Wangheng Hou, Kunyu Yang, Huiming Ye, Yunfeng Lv, Zimin Tang, Shengxiang Ge

ABSTRACT Group B Streptococcus (GBS) is a significant pathogen capable of causing postpartum bacteremia in pregnant women and vertical transmission to neonates, which can result in fatal outcomes. Therefore, prenatal screening for vaginal GBS colonization is essential for preventing neonatal transmission. This study conducted an external quality assessment to evaluate the performance of 12 commercially available GBS detection kits in China. A total of 12 GBS detection kits (three antigen-based and nine nucleic acid …

27.08.2026journal-article

International Journal of Teaching and Learning in Higher Education

Contextualizing Second Language Anxiety in Multilingual Higher Education: Classroom Conditions and Clinical Settings

Busayo O Ige

In South African universities, multilingual students whose first language is not English face distinct challenges that impact academic participation and success. This qualitative study examines how second language (L2) anxiety shapes first-year students’ classroom and clinical experiences at the University of Cape Town. Drawing on open-ended survey data, the study reveals that fear of negative evaluation, communicative apprehension, and prevailing language ideologies contribute to students’ reluctance to speak, fee …