Therapie & Reha: neue Gesundheitspublikationen – Seite 67

18.08.2026journal-article

ChemistryOpen

Integrated In Silico Discovery of Thymoquinone Analogs Targeting the Keap1–Nrf2 Pathway for Amyotrophic Lateral Sclerosis Therapy

Jabir C. Nalicho, Petro E. Mabeyo, Andrew S. Paluch, Lucas Paul

Oxidative stress drives neuronal vulnerability in amyotrophic lateral sclerosis (ALS), making the Keap1–Nrf2 pathway a vital therapeutic target. While thymoquinone (TQ) modulates this axis, its efficacy is limited by low potency and poor drug‐likeness. We utilized an integrated in silico workflow—including validated QSAR modeling ( R 2 = 0.68, Q 2 ext = 0.66), ADMET profiling, docking, 200 ns molecular dynamics, and MM–PBSA analysis—to identify improved TQ‐derived Keap1 inhibitors. Screening 64 analogs prioritized …

18.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Lexical Bias During Speech Perception Increases Under Signal Degradation but Not Cognitive Load

Zilong Xie

Purpose: Lexical information shapes the interpretation of ambiguous speech sounds, often biasing perception toward real words rather than nonwords—a phenomenon known as lexical bias. This study examined the extent to which signal degradation and cognitive load modulate this bias. Method: Younger adults with normal hearing categorized stimuli along two word–nonword continua (Bap/Gap and Back/Gack), which differed primarily in the formant transitions of the initial consonant. Stimuli were either unprocessed or vocode …

18.08.2026journal-article

Medicina

Adjunctive Hyperbaric Oxygen Therapy for Severe Traumatic Limb Injuries: A Systematic Review and Meta-Analysis

Kang Kook Choi, Youngmin Kim, Dong Keon Yon, Wu Seong Kang

Background and Objectives: Severe traumatic limb injuries, particularly those involving extensive soft tissue damage, present significant challenges in clinical management. Thus, we aimed to critically assess the effectiveness of hyperbaric oxygen therapy (HBOT) as an adjunctive treatment for severe traumatic limb injuries. Materials and Methods: For this systematic review and meta-analysis, we conducted a systematic search of MEDLINE/PubMed, Embase, and the Cochrane Library for studies published up to 7 March 2026 …

18.08.2026journal-article

Journal of Neurologic Physical Therapy

The Effectiveness of Group-based Vestibular Rehabilitation in Adults With Central or Peripheral Vestibular Dysfunction: A Systematic Review

Jia Ying Ang, Sabrina Hernandez, Matthew King, David Snowdon

Background and Purpose: Vestibular dysfunction causes dizziness, vertigo, and balance issues, reducing quality of life. Its high prevalence highlights the need for efficient, equitable management, such as group-based rehabilitation. This systematic review examined the effectiveness of group-based vestibular rehabilitation for adults with central or peripheral vestibular dysfunction. Methods: Databases (MEDLINE, Embase, CINAHL, and Cochrane Central Register of Controlled Trials) were searched for randomized controll …

18.08.2026journal-article

American Journal of Speech-Language Pathology

Innovative Methods for Teaching Health Literacy Concepts in Academic Programs

Shanon Y. Brantley, Amy J. Shollenbarger

Purpose: This clinical focus article describes innovative, evidence-based approaches to teaching health literacy in communication sciences and disorders (CSD) academic programs. Method: A targeted review of the literature on health literacy strategies and instructional methods was conducted to identify comprehensive and relevant approaches for educating health care students. Selected strategies were intentionally aligned with evidence-based, active-learning practices and broader higher education pedagogical framewo …

18.08.2026journal-article

Journal of Clinical Medicine

IDH-Mutant Diffuse Glioma: From Metabolic Origins to Targeted Therapy

Tadeja Urbanic-Purkart

Background/Objectives: Isocitrate Dehydrogenase (IDH)1/2-mutant diffuse gliomas represent a biologically distinct subgroup of adult brain tumors in which eary metabolic reprogramming and accumulation of the oncometabolite D-2-hydroxyglutarate (D-2HG) drive epigenetic, immunologic, and clinical characteristics, including a high burden of glioma-associated epilepsy. This review summarizes the molecular and metabolic consequences of IDH mutations, their role in glioma-associated epilepsy, and the evolving impact of mu …

18.08.2026journal-article

Journal of Endovascular Therapy

Prediction and Progression Stratification of Type II Endoleak After EVAR Using Clinical, Anatomical, and Ultrasound Parameters

Ruchen Li, Xuejun Wu, Xiaofei Mu

Objective: To identify factors associated with type II endoleak (T2EL) after endovascular aneurysm repair (EVAR) and to stratify sac progression risk in patients with established T2EL using clinical, anatomic, and ultrasound-derived parameters. Methods: This ambispective cohort study included patients undergoing postoperative ultrasound surveillance after EVAR. Using the first eligible postoperative ultrasound revisit at the study center as the index time point, perioperative clinical and imaging data up to that re …

18.08.2026journal-article

Bulletin of the National Technical University "KhPI". Series: Actual problems of Ukrainian society development

REHABILITATION AS A MEANS OF RETURNING TO A FULL LIFE

Sergey Khrapov, Olena Khrapova

The article examines the essence of rehabilitation as a comprehensive process of restoring a person’s physical, psychological, and social well-being, defines its role in enabling an individual to return to a fulfilling life, and analyzes modern approaches, methods, and tools of rehabilitation care. The historical aspect of organizing rehabilitation in Ukraine is examined as an effective means of comprehensively restoring the physical health and work capacity of patients, individuals with compromised health, athlete …

18.08.2026journal-article

Frontiers in Medicine

Yifeixiaoji decoction as an adjunct to osimertinib therapy in advanced EGFR-mutated NSCLC: protocol for a randomized, double-blind, placebo-controlled trial

Qiuting Feng, Changchang Sun, Jiangyang He, Yiyang Zhao, Chenbing Sun, Huirong Zhu, Ling Bi

Background Although EGFR-TKIs have substantially improved outcomes in EGFR-mutated advanced NSCLC, acquired resistance ultimately leads to treatment failure in most patients. Yifeixiaoji Decoction (YFXJD), a traditional Chinese herbal formulation, has shown promise as an adjunctive strategy; however, evidence from prospective clinical studies for this specific formula remains limited. We therefore designed this trial to assess whether YFXJD could prolong progression-free survival when added to standard osimertinib …

18.08.2026journal-article

Antibody Therapeutics

Ultrahigh DAR Antibody–Drug Conjugates: Advancing the Next Generation of Targeted Therapy

Haosheng Feng, Bin Liu

Abstract Background Conventional antibody–drug conjugates (ADCs) are typically limited to drug-to-antibody ratios (DARs) of ≤8 because of restricted conjugation sites and unfavorable physicochemical properties at higher DARs, including increased hydrophobicity, aggregation, and rapid systemic clearance. Consequently, most clinically approved ADCs rely on highly potent cytotoxic payloads (e.g., IC₅₀ < 1 nM), which can result in significant off-target toxicities. Methods This mini-review summarizes recent advances …

18.08.2026journal-article

Journal of Neonatology

Neonatal Kawasaki Disease with Progressive Coronary Artery Aneurysms Requiring Infliximab Therapy: A Case Report

Nabagata Roy, Abhishek Nagarajappa, Ajai Kumar Prithvi, Femitha Pournami, Naveen Jain

Kawasaki disease (KD) presents with medium vessel vasculitis. The condition is rare in newborns. We present a previously healthy 4-week-old baby with fever and evolving mucocutaneous involvement. Infectious workup was negative, but inflammatory markers (C-reactive protein, leucocytosis and thrombocytosis) progressively worsened. Serial echocardiography (initially normal) showed a small right coronary artery aneurysm (1.89 mm, z-score +2.77). Treatment was initiated with intravenous immunoglobulin (IVIG), aspirin an …

18.08.2026journal-article

Psycho-Oncologie

A scoping review of high-flow nasal cannula therapy in advanced cancer: implications for quality of life, psychological well-being, and family-centered decision-making

Yating Chuang, Jianyuan Shih, Szuchi Pai, Huayu Lin, Yafung Chang, Yuho Hsieh, Tao’an Chen

High-flow nasal cannula (HFNC) oxygen therapy has received increasing attention as a noninvasive respiratory support modality for patients with advanced cancer. This scoping review examines the clinical application of HFNC in advanced cancer complicated by respiratory failure, with a focus on its potential contributions to symptom relief, quality of life (QoL), psychological well-being, and family-centered decision-making. By synthesizing current clinical evidence, this scoping review suggests that HFNC may reduce …

18.08.2026journal-article

Russian Journal of Skin and Venereal Diseases

Clinical and Pathophysiological Rationale for Topical Therapy in Rosacea.

O. I. Letyaeva, T. V Trapeznikova, A. N. Shafigullina

Background. Rosacea is one of the most common dermatoses and typically manifests during the fifth or sixth decade of life. However, over the past decade, a consistent increase in the incidence of rosacea among individuals younger than 30 years has been observed. The disease follows a chronic, relapsing course and may lead to social maladjustment, anxiety disorders, and depression. Substantial progress has recently been made in understanding the pathogenesis of rosacea. Two principal mechanisms have been identified: …

18.08.2026journal-article

Journal of Midwifery & Women's Health

Association Between Pregnant Women's Risk Perception and Uptake of Antenatal Care Practices

Zozan Duran Aysel, Fatma Koruk, Ibrahim Koruk

Introduction Pregnant women's perceptions of pregnancy‐related risk may influence their engagement with antenatal care practices, yet this relationship has not been sufficiently examined in routine primary care settings. Understanding this association is important for improving the provision of antenatal care. This study aimed to determine pregnant women's uptake of antenatal care practices and to examine the relationship between pregnancy‐related risk perception and the uptake of care. Methods This cross‐sectional …

18.08.2026journal-article

PAIN, JOINTS, SPINE

Assessment of Ozonated Sunflower Seed Oil Gel as an Adjunctive Therapy to Mechanical Debridement in the Treatment of Stage II Periodontitis: A Randomized Clinical Trial

Ahmed Hashem Ahmed Alshareef, Nancy Hussein, Noha F. Ghazi, George Bebawy, Nermin Ali Mohamed Alamer, Mohamed Mahmoud Anees

Objective: To evaluate the clinical and biochemical effects of local drug delivery (LDD) of ozonated sunflower seed oil formulations as adjuncts to mechanical debridement in patients with stage II periodontitis.Materials and methods: In this randomized controlled clinical trial, 75 participants were allocated into five equal groups (n=15): healthy negative control, positive control treated with mechanical debridement only, or combined with LDD of non-ozonated sunflower formulation (S.F.), prepared ozonated sunflowe …

18.08.2026journal-article

EJNMMI Research

Evaluation of the biodistribution of [99mTc]Tc-PSMA-GCK01 SPECT/CT in a prospective, intraindividual comparison with [68Ga]PSMA-11 PET/CT for phenotyping in mCRPC prior to PSMA-targeted radioligand therapy

Emil Novruzov, Eduards Mamlins, Joseph Kabunda, Jens Cardinale, Milani Qebetu, Clemens Kratochwil, Anna Feisthauer, Stefan Martlbauer, Chimbabantu Alexis Kaoma, Sandile Sibiya, Tertia de Bruin, Sipho Mdanda, Mbongeni Shungube, Cindy Davis, Liani Smith, Yonwaba Mzizi, Kgomotso Mokoala, Honest Ndlovu, Keamogetswe Ramonaheng, Frederik L. Giesel, Mike M Sathekge

Abstract Background PSMA-PET/CT became an important means for prostate cancer management. The high-resolution and signal-to-noise ratio of PET is mandatory in primary staging or biochemical relapse that often present with tiny lesions. PSMA-PET is also used to select patients for PSMA-targeted radioligand-therapy, but scanner availability increasingly becomes a bottleneck. The resolution of PSMA-SPECT/CT might be sufficient to tailor PSMA positive vs. negative disease and would help overcome supply limitations. Thi …

18.08.2026journal-article

ESC Heart Failure

Differential Rates of Guideline-Directed Medical Therapy Modification in C-MIC and Control Patients: Results from the C-MIC II Trial

Marat Fudim, Tamara Kovacevic-Preradovic, Dragana N Kosevic, Sasko Jovev, Nermir Granov, Tanja Popov, Igor Rudez, Petar Vukovic, Velibor Ristic, Annette Holtdirk, Miodrag Peric, Faouzi Kallel, Javed Butler, J Eduardo Rame, Stefan D Anker, Marija Zdravkovic

Abstract Background In the C-MIC II trial, C-MIC therapy improved outcomes in patients with heart failure (HF) with reduced ejection fraction (HFrEF). We evaluated whether differences in background HF medication adjustments influenced the observed benefits. Methods Ambulatory patients with chronic non-ischemic HFrEF receiving guideline-directed medical therapy (GDMT) were enrolled. The primary outcome was change in GDMT and diuretic intensity over 6 months. Treatment effects on left ventricular ejection fraction (L …

18.08.2026journal-article

Cell Death & Disease

Reversing KDM6A phosphorylation-driven epigenetic suppression restores pyroptosis and synergizes with anti-PD-1 therapy in HNSCC

Yikang Ji, Xinran Zhao, Cheng Hu, Jun Chen, Zhiyin Li, Xin Hu, Mi Zhang, Qingqing Wan, Xinhua Pan, Yan Wei, Xu Wang

Abstract Immune checkpoint blockade (ICB) has revolutionized head and neck squamous cell carcinoma (HNSCC) treatment. Yet, a major barrier to response is that tumor cells are epigenetically reprogrammed to resist immunogenic cell death, particularly pyroptosis. To elucidate how tumor cells are pre-conFigured for pyroptosis resistance, we investigated the role of post-translational modifications on epigenetic regulators, focusing on the phosphorylation-dependent control of histone demethylase KDM6A. Through integrat …

18.08.2026journal-article

Journal of Occupational & Environmental Medicine

Effects of a worksite health promotion program on cardiometabolic risk factors among healthcare workers in Taiwan

Guo-Li Fabian Chong, Yu-Hsiang Lin, Yi-Chuan Chen, I-Ju Chen, Jau-Yuan Chen

Objective: To evaluate the effects of a 12-week worksite health promotion program on cardiometabolic risk factors among healthcare workers. Methods: A non-randomized controlled trial was conducted in Taoyuan, Taiwan (2019–2021), comparing an intervention group receiving active appointment surveillance and physical training referrals with a control group receiving conventional health education, with measurements taken at baseline and 12 weeks. Results: Among 94 eligible participants, the intervention group showed si …

18.08.2026journal-article

ACS Applied Polymer Materials

Low-Hysteresis Sericin-Based Composite Conductive Hydrogel as a Wearable Sensor for Joint Motion Monitoring in Rehabilitation Training

Fangrong Sun, Ajiao Zhao, Xiang Li, Jingyu Chen, Kunlin Chen

Abstract In flexible sensing applications, the long-term reliability of hydrogels is challenged by sustained and cyclic mechanical deformations. Exposure to forces such as bending and stretching ultimately diminishes sensing fidelity and accelerates material fatigue, shortening the functional lifetime. To improve hydrogel durability and minimize hysteresis, this study develops a composite hydrogel composed of a copolymer matrix of 3-methacrylamidophenylboronic acid and acrylamide integrated with polydopamine-modifi …

18.08.2026journal-article

The Egyptian Journal of Bronchology

Effectiveness of lung flute and acapella devices in pulmonary tuberculosis rehabilitation: a randomized controlled trial

Bhavna Sharma, Bhuvnesh Kumar, Meenakshi Verma, Sumedha Rabra, Mohit Kumar Gangania, Harsh Goyal

Abstract Background Pulmonary tuberculosis (PTB) is a major worldwide health concern, particularly in environments with limited resources, even while pharmaceutical therapies for active tuberculosis have improved outcomes, pulmonary function impairment and a lower quality of life are common post-treatment side effects. Though their relative effectiveness in PTB rehabilitation is yet unknown, devices like the Lung Flute and Acapella have demonstrated potential in enhancing pulmonary rehabilitation, especially in con …

18.08.2026journal-article

Frontiers in Immunology

IgG glycosylation dynamics in active lupus nephritis during the first year of immunosuppressive therapy

Ana Cindrić, Dionysis Nikolopoulos, Natalia Sherina, Frano Vučković, Farah Tamirou, Anne-Marie Patenaude, Maja Pučić-Baković, Barbara Radovani Trbojević, Frédéric A. Houssiau, Gordan Lauc, Ioannis Parodis

Introduction Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) characterized by immune dysregulation and kidney inflammation. Alterations in immunoglobulin G (IgG) glycosylation are known to influence immune responses and have been implicated in autoimmune diseases, including SLE and LN. This study aimed to investigate longitudinal changes in IgG glycosylation in patients with active LN, from before treatment to one year after immunosuppressive therapy initiation. Methods Serum sa …

18.08.2026journal-article

Asian Journal of Oncology

Neoadjuvant, adjuvant, and perioperative systemic therapy in urothelial cancers: Evolving paradigms and future directions

Praloy Basu

Radical surgery is the cornerstone of management for localized muscle-invasive urothelial carcinoma (MIUC), yet surgery alone cures only a proportion of patients because occult micrometastatic disease is common at diagnosis. Over the last two decades, perioperative systemic treatment has evolved from a cisplatin-based chemotherapy paradigm to a more complex framework incorporating immune checkpoint inhibitors, antibody-drug conjugates, biomarker-enriched strategies, and risk-adapted postoperative approaches. Cispla …

18.08.2026journal-article

Journal of Speech, Language, and Hearing Research

Dissociable Effects of Dysarthria Etiology and Severity on the Minimally Detectable Change of Speech Intelligibility

Kelly E. Zdrowak, Antje S. Mefferd, Kaila L. Stipancic

Purpose: The minimally detectable change (MDC) provides a threshold for interpreting changes in outcome measures that are outside of measurement error. There is emerging evidence that dysarthria etiology and speech severity impact the MDC of speech intelligibility; however, an investigation of these factors is needed to determine the unique effects of dysarthria etiology and speech severity. The purpose of the current study was to calculate and compare MDCs of speech intelligibility across five dysarthria etiology …

Was ist neu im Gesundheitswesen?

Aktuelle Forschung nach Fachgebiet

Integrated In Silico Discovery of Thymoquinone Analogs Targeting the Keap1–Nrf2 Pathway for Amyotrophic Lateral Sclerosis Therapy

Lexical Bias During Speech Perception Increases Under Signal Degradation but Not Cognitive Load

Adjunctive Hyperbaric Oxygen Therapy for Severe Traumatic Limb Injuries: A Systematic Review and Meta-Analysis

The Effectiveness of Group-based Vestibular Rehabilitation in Adults With Central or Peripheral Vestibular Dysfunction: A Systematic Review

Innovative Methods for Teaching Health Literacy Concepts in Academic Programs

IDH-Mutant Diffuse Glioma: From Metabolic Origins to Targeted Therapy

Prediction and Progression Stratification of Type II Endoleak After EVAR Using Clinical, Anatomical, and Ultrasound Parameters

REHABILITATION AS A MEANS OF RETURNING TO A FULL LIFE

Yifeixiaoji decoction as an adjunct to osimertinib therapy in advanced EGFR-mutated NSCLC: protocol for a randomized, double-blind, placebo-controlled trial

Ultrahigh DAR Antibody–Drug Conjugates: Advancing the Next Generation of Targeted Therapy

Neonatal Kawasaki Disease with Progressive Coronary Artery Aneurysms Requiring Infliximab Therapy: A Case Report

A scoping review of high-flow nasal cannula therapy in advanced cancer: implications for quality of life, psychological well-being, and family-centered decision-making

Clinical and Pathophysiological Rationale for Topical Therapy in Rosacea.

Association Between Pregnant Women's Risk Perception and Uptake of Antenatal Care Practices

Assessment of Ozonated Sunflower Seed Oil Gel as an Adjunctive Therapy to Mechanical Debridement in the Treatment of Stage II Periodontitis: A Randomized Clinical Trial

Evaluation of the biodistribution of [99mTc]Tc-PSMA-GCK01 SPECT/CT in a prospective, intraindividual comparison with [68Ga]PSMA-11 PET/CT for phenotyping in mCRPC prior to PSMA-targeted radioligand therapy

Differential Rates of Guideline-Directed Medical Therapy Modification in C-MIC and Control Patients: Results from the C-MIC II Trial

Reversing KDM6A phosphorylation-driven epigenetic suppression restores pyroptosis and synergizes with anti-PD-1 therapy in HNSCC

Effects of a worksite health promotion program on cardiometabolic risk factors among healthcare workers in Taiwan

Low-Hysteresis Sericin-Based Composite Conductive Hydrogel as a Wearable Sensor for Joint Motion Monitoring in Rehabilitation Training

Effectiveness of lung flute and acapella devices in pulmonary tuberculosis rehabilitation: a randomized controlled trial

IgG glycosylation dynamics in active lupus nephritis during the first year of immunosuppressive therapy

Neoadjuvant, adjuvant, and perioperative systemic therapy in urothelial cancers: Evolving paradigms and future directions

Dissociable Effects of Dysarthria Etiology and Severity on the Minimally Detectable Change of Speech Intelligibility