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24 neue Nachweise auf dieser Seite Publiziert in den letzten 30 Tagen Neueste zuerst Crossref DOI
13.08.2026journal-article

BMC Psychiatry

The association between childhood exposure to inter-parental violence and depression in middle-aged and older adults: an empirical analysis from China

Dongxu Li, Wenhui Li, Weile Zhang, Tianjiao Zhang, Zelin Liu, Min Su, Xi Guo

Abstract Background The association between exposure to inter-parental violence (IPV) and depression remains to be further explored. This study aimed to explore the association between childhood exposure to IPV and depression in middle-aged and older adults, and to explore the mediating roles between the two. Methods Using data from the 2011, 2013, 2015, 2018, and 2020 China Health and Retirement Longitudinal Study (CHARLS), and the 2014 Life History Survey Questionnaire. Generalized estimating equation was used to …

13.08.2026journal-article

Life

Comparative Analysis by Machine Learning of Geriatric Frailty and Alzheimer’s Disease Classification Using Independent Datasets

Lăcrămioara Luminița Apescaritei Apostol, Claudia Simona Ștefan, Mihai Grecu, Simona Moldovanu, Gabriela Isabela Verga, Mihaela Lungu, Gabriel Ioan Prada, Aurelia Romila

Frailty syndrome and Alzheimer’s disease are prevalent conditions in the elderly that are associated with aging, decreased quality of life, and a significant healthcare burden. Evidence for a relationship between physical frailty and neurodegenerative decline is accumulating. This study analyzed two independent datasets, a frailty dataset based on gait and mobility parameters and an AD dataset with clinical, functional and lifestyle variables, in order to evaluate and compare their classification performance using …

13.08.2026journal-article

npj Aging

Aging-induced hepatocyte CD44 drives IL6/STAT3 signaling that associates with impaired function of neighboring T cells

Armin Gandhi, Kathryn Lande, Kelly Yichen Li, Filipe A. Hoffmann, Michael LaPorte, Shirong Tan, K. Garrett Evensen, Benji Portillo, Marcos Garcia Teneche, Rouven Arnold, Adarsh Rajesh, Jessica Proulx, Shanshan Yin, Aaron Havas, Angela Liou, Allen Lee, Helene Martini, Xue Lei, Charlene Miciano, Qian Yang, Elizabeth W. Smoot, Sainath Mamde, Andrew Davis, Rebecca Porritt, Alessandra Sacco, João F. Passos, Kevin M. Tharp, Kevin Yip, Allen Wang, Bing Ren, April Williams, Susan Kaech, Peter D. Adams

Abstract Liver cancer incidences increase dramatically beyond 55 years of age, suggesting that age-associated changes contribute critically to tumor initiation. However, the mechanisms linking liver aging and cancer initiation remain incompletely defined. This study investigated the role of CD44, a marker of liver tumor-initiating cells (TICs), in age-associated liver pathophysiology. To define the role of CD44 in aged livers, we profiled CD44-expressing hepatocytes in young and aged livers by targeted and unbiased …

13.08.2026journal-article

PLANTS, PEOPLE, PLANET

Fonio ( Digitaria exilis and Digitaria iburua ) in Nigeria: Regional cultivation patterns, landrace diversity, and farmer knowledge for conserving a climate‐resilient indigenous cereal

Ishaq Muawiyya, Abubakar Bello, George P. Burton, Philippa Ryan, Maria S. Vorontsova

Societal Impact Statement Fonio ( Digitaria exilis and Digitaria iburua ) cereals are valued for their drought resilience, adaptability to poor soils, and cultural importance. In Nigeria, where both species are cultivated, fonio has declined due to labor‐intensive processing, lower yields, and changing livelihood choices. By documenting 21 landraces (15 D. exilis and 6 D. iburua ), this study highlights the need to conserve farmer‐managed diversity while improving processing and market opportunities. Strengthening …

13.08.2026journal-article

Journal of Enterprising Communities: People and Places in the Global Economy

Digital financial literacy, inclusion, and training as drivers of Muslim women’s entrepreneurial performance

Goso Goso, Harun Alrasyid, Mohamad Hazeem Sidik, Syamsu Alam

Purpose This study aims to develop and test an integrative framework examining how digital financial literacy, financial inclusion, entrepreneurial training and access to finance influence Muslim women’s entrepreneurial performance, with entrepreneurial self-efficacy as a mediator and socio-cultural norms as a moderator. Design/methodology/approach Survey data were collected from 441 Muslim women micro, small and medium enterprise entrepreneurs in Indonesia using purposive sampling. The proposed relationships were …

13.08.2026journal-article

Frontiers in Dementia

Diagnostic and treatment strategies in a memory clinic for older adults in a region with a predominantly low-income population

Patricia Solis, Ines Mintz, Nancy Medel, Zulma Sevillano, Julieta Lisso, Nicolas Irureta, Mauricio Federico Zalazar-Jaime, Brenda Giagante, Maria Carolina Dalmasso, Silvia Kochen

Background Early detection and interdisciplinary management of cognitive impairment are essential, particularly in socioeconomically vulnerable populations with limited access to specialized care. To address this need, a Memory Clinic was established in 2016 within the Argentine public healthcare system in Florencio Varela. This region reflects a condition of structural poverty, where 16.2% of the population lives in poverty according to Unsatisfied Basic Needs (UBN) and over 60% of residents lack essential service …

13.08.2026journal-article

Vaccines

The Epidemiological and Economic Burden of Vaccine-Preventable Respiratory Diseases Among Adults Aged 65 Years and Older in the Nordic Countries

Nicoline Weinreich Reinstrup, Renée Hangaard Gidsel, Terho Heikkinen, Anne Margarita Dyrhol-Riise, Lars-Åke Levin, Lars Jørgen Østergaard, Lars Holger Ehlers

Background: Despite the increasing availability of tailored vaccines, vaccine-preventable respiratory diseases (VPRDs), including influenza, respiratory syncytial virus (RSV), COVID-19, and pneumococcal disease (PD), continue to impose a significant health and economic burden. This study assessed the epidemiological and economic burden of VPRD among adults aged ≥65 across four Nordic countries (Denmark, Sweden, Norway, and Finland). Methods: Data on incidence, hospital admissions, and mortality were obtained from n …

13.08.2026journal-article

BMC Geriatrics

Non-pharmacological interventions for older adults with mild cognitive impairment: an umbrella review

Diana C. Tiga-Loza, Edwing A. Urrea-Vega, Raquel Rivera-Carvajal, William A. Alvarez-Anaya, Jhosman A. Buitrago-Buitrago, Ana M. Hernández-Martínez, Paul A. Camacho-López

Abstract Background Mild cognitive impairment (MCI) is an intermediate stage between normal aging and dementia in which preventive interventions may help delay cognitive decline. Multicomponent non-pharmacological interventions (NPTs) combining physical, cognitive, and psychosocial components have shown promising results; however, the available evidence remains heterogeneous. Objective Synthesize evidence from systematic reviews and meta-analyses (SRMAs) evaluating multicomponent, non-pharmacological interventions …

13.08.2026journal-article

PLOS One

Achieving the triple endpoint of body weight reduction thresholds, systolic blood pressure reduction ≥5 mmHg and non-HDL cholesterol <130 mg/dL with tirzepatide in people with obesity: A post hoc analysis from the SURMOUNT trials

Naveed Sattar, Reshmi Srinath, Luis-Emilio García-Pérez, Clare J. Lee, Chrisanthi A. Karanikas, Xinyue Chen, Arian Plat

Background Modest body weight reduction can greatly improve many health-related outcomes. In the SURMOUNT clinical trial program, once-weekly tirzepatide resulted in substantial body weight reductions in people with obesity, without and with type 2 diabetes. Objective This post-hoc analysis assessed the proportion of participants achieving body weight reduction thresholds (≥5%, ≥10%, ≥15%), systolic blood pressure reduction ≥5 mmHg, and non-high-density lipoprotein cholesterol (non-HDL-C) <130 mg/dL with tirzepatid …

13.08.2026journal-article

Journal of Clinical Medicine

Biologics in Older Adults with Chronic Obstructive Pulmonary Disease: A Narrative Review

Simone Scarlata, Alessio Marinelli, Panaiotis Finamore, Vitaliano Nicola Quaranta, Giulia Amoroso, Alessandra Tomasello, Claudio Sorino, Giovanna Elisiana Carpagnano, Nicola Scichilone, Silvano Dragonieri

Background: Chronic obstructive pulmonary disease (COPD) disproportionately affects older adults. While targeted biologic therapies have shown efficacy in type 2 eosinophilic endotypes, elderly patients remain underrepresented in pivotal clinical trials. This narrative review examines the pathophysiological rationale, efficacy data, and unique geriatric challenges of biologic therapies in older adults. Methods: A literature search was conducted in PubMed and Scopus for phase II and III randomized controlled trials …

13.08.2026journal-article

Frontiers in Nutrition

Serum 25-hydroxyvitamin D and cognitive performance in hospitalized older adults: a cross-sectional study from Central Poland

Ganna Kravchenko, Serena S. Stephenson, Julia Dmuchowska, Tomasz Kostka, Bartłomiej K. Sołtysik

Introduction Dementia constitutes a major and rapidly growing public health challenge worldwide. The identification of its risk factors and potential contributors has therefore become a major focus of research. This study aimed to investigate the association between serum 25(OH)D concentration and cognitive performance, as well as the odds of cognitive impairment and documented dementia in a hospitalized geriatric population. Materials and methods This cross-sectional study included 1,539 hospitalized individuals a …

13.08.2026journal-article

Physiotherapy Research International

Association Between Cervical Range of Motion and Swallowing Speed in Older Women After Total Hip Arthroplasty: A Cross‐Sectional Study

Katsuya Nakamura, Shinsuke Nagami, Akio Shimizu, Shinya Fukunaga, Shusaku Kanai

ABSTRACT Background and Purpose Total hip arthroplasty (THA) may induce acute alterations in spinopelvic alignment and compel the cervical spine to compensate for postural balance. Although these changes may biomechanically affect swallowing speed, the relationship between cervical range of motion (ROM) and swallowing speed in older adults after THA remains unclear. Therefore, this study aimed to investigate the relationship between cervical ROM and swallowing speed in older women after THA. Methods This cross‐sect …

13.08.2026journal-article

AGING MEDICINE

Beneficial Body Mass Index for Age‐Related Kidney Function in Males and Females

Lu Wei, Yao Ma, Xueqi Chen, Xinran Ni, Yu Zhang, Bei Zhu, Qun Zhang, Weihong Zhao

ABSTRACT Objectives Kidney function declines with aging, leading to a high prevalence of age‐related disease. Concurrently, the increasing prevalence of overweight and obesity may influence age‐related kidney changes. This study aims to clarify the relationship between body mass index (BMI) and kidney function in the Chinese population, with a focus on sex differences. Methods We conducted a retrospective cross‐sectional study involving 343,040 Chinese adults, stratified by sex and age. Glomerular filtration rate ( …

13.08.2026journal-article

The Gerontologist

Safe at Home Alone with Dementia: A Scoping Review of Evidence and Technological Maturity in Real-Time Alerting

Kimi E Kobayashi-Cuya, Ryota Sakurai, Shuichi Awata

Abstract Background and Objectives Monitoring technologies with real-time alerting have the potential to support aging in place for older adults with dementia who live alone, yet concerns remain regarding scientific rigor, usability, and practical implementation. This scoping review synthesized published evidence on real-time alerting systems for older adults with dementia living alone and assessed their technological maturity and suitability. Research Design and Methods Following PRISMA-ScR guidelines, we searched …

13.08.2026journal-article

Neuroscience Insights: Advances in Brain Studies

Bipolar Disorder in Older Adults: Clinical Presentation, Challenges, and Management Strategy

Michel Bourin

Bipolar disorder (BD) in older adults is a signifi cant yet under-recognized mental health concern. The clinical presentation in this population often diff ers from younger individuals, with increased cognitive impairment, comorbid medical conditions, and heightened sensitivity to medications. Accurate diagnosis is frequently complicated by overlapping symptoms with neurodegenerative disorders and age-related mood changes. This review examines epidemiology, clinical features, diagnostic challenges, and treatment st …

13.08.2026journal-article

SLEEP Advances

The Association of Sleep Health with Epigenetic Aging in Early Adolescence: Exploratory Insights from the HOME Study

Smriti Maskey, Jennifer Arzu, Aimin Chen, Karl T Kelsey, Scott M Langevin, Kim M Cecil, Kimberly Yolton, Joseph M Braun, Clara G Sears

Abstract Study Objectives Sleep during adolescence may influence biological aging, yet few studies have examined this association using objective sleep measures. We examined the associations between accelerometry-based sleep characteristics and epigenetic age (EA), epigenetic age acceleration (EAA), and the pace of biological aging. Methods For this preliminary analysis, we used data from the HOME Study (Cincinnati, OH). At age 12 years (2016-2019), we used accelerometers to assess total sleep time, sleep efficienc …

13.08.2026journal-article

Cellular and Molecular Life Sciences

Comparative analysis of neuronal proteolytic pathways reveals neuron-specific and sub-compartmental-specific capacities with aging

Mira Sleiman, Dimitra Ranti, Sudarson Baskaran, Patricia Kreis, Saskia Muth, Christian Gallrein, Agnieszka Münster-Wandowski, Norman Rahnis, Emilio Cirri, Britta J. Eickholt, Janine Kirstein

Abstract Proteostasis is essential for maintaining neuronal function, and its dysregulation is a hallmark of aging and neurodegeneration. The ubiquitin–proteasome system (UPS) and macroautophagy are the two major proteolytic pathways responsible for protein degradation. However, their capacity and regulation differ between cell types and across aging. To elucidate the activity of both proteolytic pathways with aging, we performed a comparative analysis of the activity of UPS and macroautophagy in distinct neuronal …

13.08.2026journal-article

Working with Older People

Working with complexity in later life: co-occurrence of physical, mental/emotional and social needs across SHARE countries

Javier García García

Purpose This study aims to examine the co-occurrence of physical, mental/emotional and social needs among people aged 65 and over across SHARE countries. Design/methodology/approach Cross-sectional data from SHARE Wave 9 were analysed for 41,437 respondents with complete information on three standardised need indices. Pearson correlations assessed associations between dimensions. Upper-quartile scores identified high need in each domain, enabling calculation of accumulated need and cross-country comparisons. Chi-sq …

13.08.2026journal-article

Frontiers in Public Health

Cognitive impairment and associated factors among community-dwelling older adults with hypertension in tropical China

Liyu Peng, Xiuru Wang, Wenting Cao, Ping Zhang, Dee Yu, Huajiang Liu, Yong You, Binwen Huang, Jindong Ding Petersen

Background Cognitive impairment (CI) is highly prevalent among older adults with hypertension and imposes substantial burdens on individuals, families, and healthcare systems. Identifying factors associated with CI is essential for developing targeted prevention strategies, yet evidence from tropical regions of China remains limited. Objective To examine the prevalence of CI and factors associated with CI among community-dwelling older adults with hypertension in tropical China. Methods This community-based cross-s …

13.08.2026journal-article

Desenvolvimento e Meio Ambiente

Bioculturalidade do povo Tembé: um estudo de caso sobre estratégias de r-existência na Terra Indígena Alto Rio Guamá (TIARG), no Pará, Brasil

Carlos do Socorro Guerreiro Vaz, Márlia Regina Coelho-Ferreira, Flávia Cristina Araújo Lucas

Este artigo analisa a bioculturalidade como estratégia de resistência dos indígenas Tembé-Tenetehar, diante das ameaças ambientais e territoriais que incidem sobre a Terra Indígena Alto Rio Guamá (TIARG), no Pará. A bioculturalidade, entendida como a interdependência entre biodiversidade, cultura e diversidade linguística, é essencial para a compreensão da relação dos povos indígenas com seus territórios e para a manutenção da identidade e sobrevivência dos povos indígenas. A pesquisa, de abordagem qualitativa, bas …

13.08.2026journal-article

OTJR: Occupational Therapy Journal of Research

Culturally Meaningful Leisure Among Caribbean Diaspora Older Adults in the United States: A Qualitative Study

Nardia Aldridge, Mikayla Dunn, Reagan Smith, Jada Wood, Brittnie Milhomme

Leisure participation supports well-being and positive aging; however, limited research has examined culturally meaningful leisure among Caribbean older adults living in diaspora communities. This qualitative phenomenological study explored the lived experiences of culturally relevant leisure and its relationship to well-being and quality of life among community-dwelling Caribbean older adults in the United States. Ten participants completed in-depth semi-structured interviews examining leisure participation, cultu …

13.08.2026journal-article

Journal of Applied Gerontology

Age Identities and Health Among Older Adults: Empirical Evidence From China

Yawen Fan, Wenwen Liu, Xiaohui Zhang, Chenyu Yan

This study uses data from the 2018 and 2020 waves of the China Longitudinal Aging Social Survey (CLASS) to examine the association between age identities and health among older Chinese adults. Findings show that a relatively younger age identity is significantly linked to better self-rated health. Mechanism analysis identifies three behavioral pathways: increased voluntary labor participation, greater digital inclusion, and more active social connections. These attitudes act as psychological assets that encourage p …

13.08.2026journal-article

Family Relations

Latent Patterns of Older Parents' Perceived Intergenerational Relationships in Urban China: The Role of Coresidence

Bin Lian, Ning Wang

ABSTRACT Objective This study examines latent patterns of older parents' perceived intergenerational relationships (PIR) in urban China and their associations with living arrangements, particularly the gender and marital status of coresiding adult children. Background Intergenerational relationships are often studied through support exchanges, but older parents' subjective perceptions of relationships remain less understood, especially in non‐Western contexts. Method Using data from the 2021 Shanghai Family Cohort …

13.08.2026journal-article

Annals of Clinical and Translational Neurology

Anti‐ CD20 Discontinuation Versus Continuation in People Aged Over 50 With Non‐Active Multiple Sclerosis

Alexia Moukhine, Fabien Rollot, Romain Casey, Nicolas Collongues, Sandra Vukusic, Guillaume Mathey, Anne Laure Dubessy, Jonathan Ciron, Jérôme De Seze, Aurélie Ruet, Pierre Labauge, Arnaud Kwiatkowski, Hélène Zephir, Caroline Papeix, Gilles Defer, Christine Lebrun‐Frenay, David Axel Laplaud, Eric Berger, Eric Thouvenot, Jean Pelletier, Abdullatif Al Khedr, Olivier Casez, Bertrand Bourre, Abir Wahab, Laurent Magy, Jean‐Philippe Camdessanché, Ines Doghri, Solène Moulin, Mariana Sarov Rivière, Karolina Hankiewicz, Amélie Dos Santos, Corinne Pottier, Eric Manchon, Jennifer Aboab, Maia Tchikviladze, Thomas David, Gilles Edan, Emmanuelle Le Page, Laure Michel, Anne Kerbrat

ABSTRACT Objective To determine whether discontinuing anti‐CD20 therapy in people with relapsing‐onset MS aged over 50 is associated with an increased risk of relapse, inflammatory activity, confirmed disability accrual, and serious infection compared with continuing therapy. Methods This observational, multicenter, retrospective cohort study included 2283 patients from the French MS registry aged > 50, who had received at least two cycles of anti‐CD20 and had experienced no relapses or MRI activity for at least on …